Digital Commons Network^™

Left Ventricle Function And Post-Transcriptional Events With Exercise Training In Pigs, Stephanie L. Samani, Shayne C. Barlow, Lisa A. Freeburg, Traci L. Jones, Marlee Poole, Mark A. Sarzynski Facsm, Michael R. Zile, Tarek Shazly, Francis G. Spinale

Faculty Publications

Background

Standardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly diastolic function and relation to post-transcriptional molecular pathways (microRNAs (miRs)) are poorly understood. This project tested the central hypothesis that adaptive LV remodeling resulting from a large animal exercise training protocol, would be directly associated with specific miRs responsible for regulating pathways relevant to LV myocardial stiffness and geometry.

Methods and results

Pigs (n = 9; 25 Kg) underwent a 4 week exercise training protocol (10 degrees elevation, 2.5 mph, 10 min, 5 days/week) whereby LV chamber stiffness (KC) …

Point-Of-Care Diagnostic Test For Beta-Thalassemia, Ran An, Umut A. Gurkan

Faculty Scholarship

Hemoglobin (Hb) disorders are among the most common monogenic diseases affecting nearly 7% of the world population. Among various Hb disorders, approximately 1.5% of the world population carries β-thalassemia (β-Thal), affecting 40,000 newborns every year. Early screening and a timely diagnosis are essential for β-thalassemia patients for the prevention and management of later clinical complications. However, in Africa, Southern Europe, the Middle East, and Southeast Asia, where β-thalassemia is most prevalent, the diagnosis and screening for β-thalassemia are still challenging due to the cost and logistical burden of laboratory diagnostic tests. Here, we present Gazelle, which is a paper-based microchip …

Mathematical Model Of Oxygen, Nutrient, And Drug Transport In Tuberculosis Granulomas, Meenal Datta, Mccarthy Kennedy, Saeed Siri, Laura Via, James W. Baish, Lei Xu, Veronique Dartois, Clifton Barry, Rakesh Jain

Faculty Journal Articles

Physiological abnormalities in pulmonary granulomas–pathological hallmarks of tuberculosis (TB)–compromise the transport of oxygen, nutrients, and drugs. In prior studies, we demonstrated mathematically and experimentally that hypoxia and necrosis emerge in the granuloma microenvironment (GME) as a direct result of limited oxygen availability. Building on our initial model of avascular oxygen diffusion, here we explore additional aspects of oxy- gen transport, including the roles of granuloma vasculature, transcapillary transport, plasma dilution, and interstitial convection, followed by cellular metabolism. Approximate analytical solutions are provided for oxygen and glucose concentration, interstitial fluid velocity, interstitial fluid pressure, and the thickness of the convective zone. …

Quaternary Ammonia Compounds In Disinfectant Products: Evaluating The Potential For Promoting Antibiotic Resistance And Disrupting Wastewater Treatment Plant Performance, Zihao Lu, Anna K. Mahony, William A. Arnold, Christopher Marshall, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Quaternary ammonium compounds (QACs) are a class of compounds that were widely used as disinfectants during the COVID-19 pandemic and continue to be used as disinfecting agents. After consumer usage, QAC concentrations are diluted in wastewater as they enter wastewater treatment plants. At sub-inhibitory concentrations, QACs may have unintended repercussions, including increased antibiotic resistance and inhibition of process performance in wastewater treatment plants. This review first summarizes how QACs inhibit bacteria and then highlights the mechanisms by which QACs can promote antibiotic resistance in general. Reported environmental concentrations of QACs are compared to concentrations that are suspected to impact antibiotic …

Us Public Opinion About The Safety Of Gene Editing In The Agriculture And Medical Fields And The Amount Of Evidence Needed To Improve Opinions, Brandon R. Mcfadden, Joy N. Rumble, Kathryn A. Stofer, Kevin M. Folta

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Introduction: Implementation of gene editing in agriculture and medicine hinges on public acceptance. The objectives of this study were to explore U.S. public opinion about gene editing in agricultural and medical fields and to provide more insight into the relationship between opinions about the safety of gene editing and the potential impact of evidence to improve opinions about safety.

Methods: Data were from two samples of U.S. respondents: 1,442 respondents in 2021 and 3,125 respondents in 2022. Survey respondents provided their opinions about the safety of gene editing in the agricultural and medical fields and answered questions about the number …

Nanoparticles For Applications In Specific Diagnostics And Precision Medicine, Naxhije Berisha

Dissertations, Theses, and Capstone Projects

Heterogeneity is common in the expression of cancer and treatment response. Precision medicine enables healthcare providers to tailor medical care to an individual's distinct genetic and environmental makeup. This customization has the potential to result in more efficient treatments while minimizing side effects. We believe that by studying the interface of nanotechnology and cancer medicine we can elucidate innovative solutions that address the challenges of disease heterogeneity. This includes advancements in drug delivery, formulations development, and diagnostic sensing. We highlight three studies that use nanotechnology for applications in precision medicine. In Chapter 2, we highlight design optimization of drug formulations …

Vaccine Immunogenicity Versus Gastrointestinal Microbiome Status: Implications For Poultry Production, Chrysta N. Beck, Jiangchao Zhao, Gisela F. Erf

Poultry Science Faculty Publications and Presentations

At the turn of the 21st century, the importance of maintaining a balanced microbiome was brought to the forefront of the microbiology, immunology, and physiology research fields. Exploring the complex interactions between vaccine administration, mucosal microbiome, oral tolerance, and enteric inflammation in health and disease is challenging since environmental factors (such as diet and sanitation) have major influences on gut microbiota composition. High enteric pathogen load has been shown to contribute to dampened cell-mediated and humoral immune responses to vaccines in human case studies, either through elevated enteric inflammation or increased tolerance to environmental microbes. Although antibiotic and probiotic interventions …

Accelerating Neurotechnology Development Using An Agile Methodology, Anil Kumar Thota, Ranu Jung

Biomedical Engineering Faculty Publications and Presentations

Novel bioelectronic medical devices that target neural control of visceral organs (e.g., liver, gut, spleen) or inflammatory reflex pathways are innovative class III medical devices like implantable cardiac pacemakers that are lifesaving and life-sustaining medical devices. Bringing innovative neurotechnologies early into the market and the hands of treatment providers would benefit a large population of patients inflicted with autonomic and chronic immune disorders. Medical device manufacturers and software developers widely use the Waterfall methodology to implement design controls through verification and validation. In the Waterfall methodology, after identifying user needs, a functional unit is fabricated following the verification loop (design, …

Development Of Monitoring Systems Using Computer Vision Techniques For Precise Fish Farming, Abinaya N.S

Theses and Dissertations

Fish farm is a biosystem with diversity and uncertainties demanding, an intelligent manual monitoring process, which is labor-intensive, invasive, costly, discontinuous, and persistent. The proposed work aims to develop Computer Vision (CV) -based monitoring techniques for precise fish farming to address these problems. Three major monitoring operations namely (i) Fish behavior analysis, (ii) Fish Classification (FC) and (iii) Biomass estimation have been investigated.

Fish schooling activity has been monitored using an overhead vision camera. Problems associated with fish occlusion are addressed using the weighted K-means clustering technique which provides an accurate estimation of fish school locations. Temporal variations of these …

Development Of An Electromagnetic System For Wireless Magnetic Manipulation Of Soft Capsule Endoscope For Drug Delivery Applications, Nada Ashraf Hussein Mahmoud

Theses and Dissertations

Wireless capsule endoscopy (WCE) is a remarkable diagnostic device that examines the gastrointestinal (GI) tract. The WCE is a small capsule integrated with a camera that is used to visualize the inner mucosa of the GI tract. WCE has been proven to be the most effective method to diagnose GI diseases and GI cancers. The procedure reduces the discomfort and risk compared to conventional endoscopy methods. However, current WCEs lack the ability to take a biopsy or deliver a drug to a specific location. Those therapeutic functions can be introduced by wirelessly controlled WCEs. This thesis introduces an electromagnetic system …

Cardiac Active Tension Modeling Via Genetic Algorithm-Optimized Fractional Order Systems, Afnan Khaled Elhamshari

Theses and Dissertations

Developing a computational model to model cardiac activity has been increasingly important in recent decades. Accurate cell-level active tension modeling for cardiomyocytes is critical to understanding cardiac functionality on a patient-specific basis and developing an effective in-silico cardiac model. However, cell-level models in the literature fail to account for viscoelasticity and inter-patient variations in active tension. This research proposes a genetic algorithm-optimized, fractional order system to model cell-level active tension by extending Land’s state-of-the-art model of cardiac contraction. The model features the (left) Caputo derivative of six state variables that identify the mechanistic origins of viscoelasticity in a myocardial cell …

A 3d Imaging-Based Critique Of Wire Arc Additive Manufacturing (Waam) Simulations, Omar Oraby

Theses and Dissertations

Residual stresses play a critical role in the mechanical behavior and structural integrity of engineered components. Understanding and quantifying these stresses are essential for ensuring the reliable performance and durability of materials and structures. Traditionally destructive methods are used that involve sample sectioning and material removal. However, non-destructive methods have gained popularity due to their advantages in preserving the specimen's integrity for further testing and material waste reduction. Among these techniques, Digital Image Correlation (DIC) stands out as a powerful non-contact and full-field measurement approach. DIC captures displacements and strain distributions by analyzing the deformation of speckle patterns on the …

Ai And 6g Into The Metaverse: Fundamentals, Challenges And Future Research Trends, Muhammad Zawish, Fayaz Ali Dharejo, Sunder Ali Khowaja, Saleem Raza, Steven Davy, Kapal Dev, Paolo Bellavista

Articles

Since Facebook was renamed Meta, a lot of attention, debate, and exploration have intensified about what the Metaverse is, how it works, and the possible ways to exploit it. It is anticipated that Metaverse will be a continuum of rapidly emerging technologies, usecases, capabilities, and experiences that will make it up for the next evolution of the Internet. Several researchers have already surveyed the literature on artificial intelligence (AI) and wireless communications in realizing the Metaverse. However, due to the rapid emergence and continuous evolution of technologies, there is a need for a comprehensive and in-depth survey of the role …

Virtual Test Beds For Image-Based Control Simulations Using Blender, Akkarakaran Francis Leonard, Govanni Gjonaj, Minhazur Rahman, Helen E. Durand

Chemical Engineering and Materials Science Faculty Research Publications

Process systems engineering research often utilizes virtual testbeds consisting of physics- based process models. As machine learning and image processing become more relevant sensing frameworks for control, it becomes important to address how process systems engineers can research the development of control and analysis frameworks that utilize images of physical processes. One method for achieving this is to develop experimental systems; another is to use software that integrates the visualization of systems, as well as modeling of the physics, such as three-dimensional graphics software. The prior work in our group analyzed image-based control for the small-scale example of level in …

Aerodynamic Investigation Of Naca 0020 Airfoil With Extended And Serrated Trailing Edge At Various Turbulent Intensities, Livya E

Theses and Dissertations

Lift (upward force) is a significant aerodynamic component that directly relates to the aerodynamic efficiency (lift-to-drag ratio) of the airfoil. Enhancement of airfoil lift is important for industries like wind turbines, aircraft, and turbo machinery. The present study investigates the NACA series airfoil by modifying the trailing edge in the form of extension and serration. The angle of attack was changed from 0° to 35° instep of 5°, and the airflow Reynolds number was fixed as 2.14 × 105. To figure out the flow behavior, surface pressure has been collected from the 50 pressure ports provided over the airfoil surface. …

A Multi-Criteria Decision Making Model For Sustainable And Resilient Supplier Selection And Management, Samah Ibrahim Abdel Aal

Neutrosophic Systems with Applications

Sustainable and resilient supplier selection and management are essential to building environmentally responsible and resilient supply chains. Selecting sustainable and resilient suppliers enables organizations to ensure the long-term viability of the supply chain. To do that, there is a need to identify suitable suppliers that align with sustainability and resilience goals. This study aims to provide an overview of the requirements and criteria for selecting and managing sustainable and resilient suppliers and emphasizes the significance of integrating sustainability and resilience principles throughout the supply chain. Multi-criteria decision-making (MCDM) is used to deal with various criteria. The double normalization-based multi-aggregation (DNMA) …

Foundation Of Appurtenance And Inclusion Equations For Constructing The Operations Of Neutrosophic Numbers Needed In Neutrosophic Statistics, Florentin Smarandache

Neutrosophic Systems with Applications

We introduce for the first time the appurtenance equation and inclusion equation, which help in understanding the operations with neutrosophic numbers within the frame of neutrosophic statistics. The way of solving them resembles the equations whose coefficients are sets (not single numbers).

Digital Transformation And Design For Maintainability In Industrial Design, Ahmed Tarek Mohamed Fathy, Salwa El Ghareeb, Yasser Shaban

Journal of Art, Design and Music

In this paper, we explore the impact of the rapid digital transformation in Applied Arts and Design and its influence on the realm of Maintainability. We examine how CAD, 3D modeling, have revolutionized the conceptualization and prototyping stages, enabling precise idea communication and immersive representations. Specifically, we focus on Design for Maintainability (DfMn) and its critical aspects such as repairability, serviceability, maintainability, and reliability, which significantly affect cost and user satisfaction. By leveraging this tool, designers can create highly maintainable and user-friendly products. The transformative potential of this tool in industrial design is highlighted, providing promising avenues for future research …

Unveiling Efficiency: Investigating Distance Measures In Wastewater Treatment Using Interval-Valued Neutrosophic Fuzzy Soft Set, Muhammad Saeed, Kinza Kareem, Fatima Razzaq, Muhammad Saqlain

Neutrosophic Systems with Applications

To reduce the threats that wastewater poses to human health and the environment, water treatment techniques must be improved. The use of a procedure that includes preparation, testing, primary and secondary treatments, filtration, disinfection, and continuous monitoring is therefore required. The objective of this research is to create a hybrid notion that extends the idea of an interval-valued neutrosophic fuzzy soft set (IVNFSS) to an interval-valued neutrosophic fuzzy set. Operations like complement, union, and integration are included in the idea. To improve decision-making accuracy, a quality-assessment distance measure is incorporated, offering a numerical representation of the disparity between various factors. …

Synthesis And Characterization Of Cellulose Microfibril-Reinforced Polyvinyl Alcohol Biodegradable Composites, Fatemeh Mahdiyeh-Boroujeni, Gabriella Fioravanti, Ronald Kander

School of Design and Engineering Papers

The pursuit of an environmentally sustainable manufacturing process requires the substitution of less damaging and recyclable solutions for harmful reagents. This study aims to assess the effectiveness of using cellulose microfibrils synthesized via different hydrolysis reactions as reinforcing agents in polyvinyl alcohol (PVA) at varying concentrations. The investigation explores the morphology, thermal properties, and chemical behavior of the cellulose particles. The cellulose microfibrils (CMFs) produced using citric acid exhibited the highest yield and aspect ratio. Notably, particles from organic acids demonstrated greater thermal stability, with oxalic acid-derived particles displaying the maximum thermal degradation temperature. Subsequently, cast films of PVA reinforced …

Impacts Of Farrowing Pen Design, Season, And Sow Parity On Litter Performance And Piglet Mortality, Verônica Madeira Pacheco, Tami M. Brown-Bandl, Gary A. Rohrer, Rafael Vieira De Sousa, Luciane Silva Martello

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Piglet mortality during lactation is a significant concern in swine production, influenced by complex interactions involving sow, piglet, environmental, and management factors. While crushing by the sow may be the ultimate cause of piglet mortality, there are many factors influencing the outcome, including parity, thermal stress, and animal housing systems. New farrowing systems are continuously being developed; however, it is difficult for producers to make decisions without any scientific basis. This study aimed to assess the impact of different farrowing pen layouts on piglet performance, considering parity and season. A total of 546 sows and 9123 piglets were monitored across …

Fibrin Glue Acutely Blocks Distal Muscle Contraction After Confirmed Polyethylene Glycol Nerve Fusion: An Animal Study., Alec H Fisher, Parker H Johnsen, Andrew Simon, Cameron J Burns, Vineeth Romiyo, Elliot B Bodofsky, Sebastian Vega, David A Fuller

Cooper Medical School of Rowan University Departmental Research

BACKGROUND: Polyethylene glycol (PEG) is a synthetic, biodegradable, and hyperosmotic material promising in the treatment of acute peripheral nerve injuries. Our team set out to investigate the impact of fibrin glue upon PEG fusion in a rat model.

METHODS: Eighteen rats underwent sciatic nerve transection and PEG fusion. Electrophysiologic testing was performed to measure nerve function and distal muscle twitch. Fibrin glue was applied and testing repeated. Due to preliminary findings, fibrin glue was applied to an uncut nerve in five rodents and testing was conducted before and after glue application. Mann-Whitney U tests were used to compare median values …

Iequity: An Augmented Reality Theatre Production, Amy Pan, Kristina Arnold Dr, Alan White, Truth Tran

Posters-at-the-Capitol

Augmented reality is commonly seen being used in game development and design, typically seen through a mobile device such as a phone. However, it has rarely been tested and pushed to its limits in other settings. The main focus of this project was trying to deploy augmented reality in settings that are seen as more traditional. This will be done by taking a play, pre-written and performed by a professor at Western Kentucky University, and building an augmented reality set for the play in the background. The main software that will be used is Unity and Blender. Unity will be …

Neutrosophic Statistical Analysis Of Temperatures Of Cities In The Southeastern Anatolia Region Of Turkey, Hacer Şengül Kandemir, Nazlım Deniz Aral, Murat Karakaş, Mikail Et

Neutrosophic Systems with Applications

In the paper, neutrosophic statistical analysis of temperature data of different cities in the southeastern Anatolia region of Turkey is given. The neutrosophic mean and neutrosophic coefficient of variation are computed using the temperature data. From the analysis, it is concluded that the temperatures of Mardin and Şanlıurfa cities are more consistent than the other cities in Turkey. In addition, the neutrosophic results are compared with results under classical statistics. Based on the comparative study, it can be concluded that neutrosophic statistical results are more adequate, flexible, and more informative than classical statistics.

The Influence Of Green Building Design On Tourists' Intention To Stay In Eco-Friendly Hotels: A Study On Perceptions And Preferences, Enas Al Sayed Salama Dr., Gehad Nasr Abdelsalam Dr.

Journal of Engineering Research

Green building design involves integrating sustainable and environmentally friendly practices into the construction and operation of buildings, including hotels, with the goal of minimizing the adverse impact on the environment. This paper delves into the pivotal role of green building design and eco-service provision within the context of green hotels. The aim is to investigate the interconnections among tourists' environmental concerns, their perceived significance of green building design, and their intention to choose green hotels.

To enhance the understanding of tourist behavior and its implications for tourism in Egypt, a questionnaire was administered in Sharm El Sheikh, a prominent Egyptian …

Visual Privacy As An Approach To Improve Human Needs In Residential Buildings In Egypt, Inas Samir Ibrahim, Walaa Nour, Mustafa Alwan

Journal of Engineering Research

Architecture reflects a nation’s cultural, social, and environmental characteristics. As a result of the recent globalization, countries have lost their distinctive architectural identities; due to this, it is difficult to identify A country’s unique identity locally and regionally. Specifically, in Egypt, houses in the traditional style are considered one of the most iconic architectural styles. There is an amazing local identity and a unique spatial quality in the region that characterizes Egypt. On the other hand, Western influences have caused many of the values and attributes of houses to fade. One of the most prominent values is the home’s loss …

Biophilic Urbanism As A Tool To Conserve Urban Waterfront Of Submerged Heritage Cities, Fatma Ahmed Alashwah, Ayman Abdel Tawab Professor, Ingy Eldarwish Professor, Wesam Mehanna

Journal of Engineering Research

The Urban waterfronts of submerged heritage cities hold significant cultural and natural value that necessitates preservation. However, these sites suffer from a disconnection between nature and culture in heritage conservation practices, negatively impacting heritage sites, ecosystems, and human well-being. Biophilic urbanism offers a valuable tool to address this gap, creating healthier cities. This paper explores how to implement biophilic urbanism elements in conserving urban waterfronts of submerged heritage cities. Through a comprehensive literature review, the study discusses the gap between heritage and nature in conservation practices and explores the perception of biophilic urbanism elements in conserving the urban waterfront of …

Opportunities And Challenges Of Generative Ai In Construction Industry: Focusing On Adoption Of Text-Based Models, Prashnna Ghimire, Kyungki Kim, Manoj Acharya

Durham School of Architectural Engineering and Construction: Faculty Publications

In the last decade, despite rapid advancements in artificial intelligence (AI) transforming many industry practices, construction largely lags in adoption. Recently, the emergence and rapid adoption of advanced large language models (LLMs) like OpenAI’s GPT, Google’s PaLM, and Meta’s Llama have shown great potential and sparked considerable global interest. However, the current surge lacks a study investigating the opportunities and challenges of implementing Generative AI (GenAI) in the construction sector, creating a critical knowledge gap for researchers and practitioners. This underlines the necessity to explore the prospects and complexities of GenAI integration. Bridging this gap is fundamental to optimizing GenAI’s …

Scaffold-Based 3d Cell Culture Models In Cancer Research, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions …

Engineering Neurotoxin-Functionalized Exosomes For Targeted Delivery To The Peripheral Nervous System, Mena Asha Krishnan, Olawale A. Alimi, Tianshu Pan, Mitchell Kuss, Zeljka Korade, Guoku Hu, Bo Liu, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

The administration of therapeutics to peripheral nerve tissue is challenging due to the complexities of peripheral neuroanatomy and the limitations imposed by the blood–nerve barrier (BNB). Therefore, there is a pressing need to enhance delivery effectiveness and implement targeted delivery methods. Recently, erythrocyte-derived exosomes (Exos) have gained widespread attention as biocompatible vehicles for therapeutics in clinical applications. However, engineering targeted Exos for the peripheral nervous system (PNS) is still challenging. This study aims to develop a targeted Exo delivery system specifically designed for presynaptic terminals of peripheral nerve tissue. The clostridium neurotoxin, tetanus toxin-C fragment (TTC), was tethered to the …