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Adenosine Type 1 (A ) Receptors Mediate Protection Against Myocardial 1 Infarction Produced By Chronic, Intermittent Ingestion Of Ethanol In Dogs, Franz Kehl, John G. Krolikowski, John F. Ladisa, Judy R. Kersten, David C. Warltier, Paul S. Pagel

Biomedical Engineering Faculty Research and Publications

Background: Chronic consumption of small amounts of ethanol protects myocardium from ischemic injury. We tested the hypothesis that adenosine type 1 (A₁) receptors mediate these beneficial effects.

Methods: Dogs (n=37) were fed with ethanol (1.5 g/kg) or water mixed with dry food twice per day for 12 weeks, fasted overnight before experimentation, and instrumented for measurement of hemodynamics. Dogs received intravenous drug vehicle (50% polyethylene glycol in 0.1 N sodium hydroxide and 0.9% saline over 15 min) or the selective A₁ receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX, 0.8 mg/kg over 15 min) and were subjected …

Voice Activated Display Of American Sign Language For Airport Security, Glenn Lancaster, Karen Alkoby, Jeff Campen, Roymieco Carter, Mary Jo Davidson, Dan Ethridge, Jacob Furst, Damien Hinkle, Bret Kroll, Ryan Layesa, Barbara Loeding, John Mcdonald, Nedjla Ougouag, Jerry Schnepp, Lori Smallwood, Prabhakar Srinivasan, Jorge Toro, Rosalee Wolfe

Visual Communications and Technology Education Faculty Publications

Conference proceedings from the Technology and Persons with Disabilities Conference-2003.

California State University at Northridge, Los Angeles, CA March 17-22, 2003.

An Analysis Of Microbial Contamination In Military Aviation Fuel Systems, Harold W. Graef

Theses and Dissertations

Military aviation fuel systems can be an ideal environment for microorganisms. Microbial growth in hydrocarbon fuel systems arises because of the impracticality of keeping fuel tanks sterile and the inevitable presence of water from condensation. Microbial contaminants in aviation fuel systems are a concern because of their potential to degrade the fuel, accelerate tank corrosion, and threaten flight safety. This research addresses the concern of using more environmentally friendly Fuel System Icing Inhibitors (FSII), which are also biocidal. Are significant levels of microorganisms growing in military aviation fuel systems, and if so, are there any common variables? Forty aviation fuel …

Flight Physician - March, 2003, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twenty page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

The Development Of Relationships Between Constituent Concentrations And Generic Hydrological Variables, Carmen T. Agouridis, Dwayne R. Edwards

Biosystems and Agricultural Engineering Faculty Publications

The collection and analysis of samples from storm events constitutes a large portion of the effort associated with water quality research. Estimating concentrations or loads from these events is often difficult. The equipment necessary to analyze the samples and the required laboratory resources are typically significant expenses incurred by the researcher. One potential method to reduce these costs is through the development of generic relationships between concentrations and easily measured variables such as dimensionless flow rate or time. The benefits recognized from such an effort include a reduction in the number of required samples, resulting in a reduction in cost. …

Search Theory And U-Boats In The Bay Of Biscay, Ronald Gregory Carl

Theses and Dissertations

Threats to our nation's resources and forces are becoming increasingly lethal and mobile. Therefore, our ability to locate and interdict these threats is more important than ever. Search theory is one tool that is vital to countering the increasing threat. This research presents a multi-agent simulation, built around the Allied search for U-boats in the Bay of Biscay during World War II, which extends several classic search theory algorithms. Comparison of techniques is based on the effectiveness of finding high- valued, mobile assets. A JAVA-based multi-agent simulation model is designed, built and tested, and used to demonstrate the existence of …

Simulation Of Autonomic Logistics System (Als) Sortie Generation, Paul D. Faas

Theses and Dissertations

The Air Force needs tools for analysis and evaluation of new logistic operational concepts. The purpose of this research was to conflict a discrete event simulation model of the aircraft sortie generation process to permit what-if analyses of these concepts. The current Air Force logistics operations system is reactive in nature meaning that after the aircraft detects a part failure, the maintenance person must perform fault isolation procedures and then steps are taken to repair or replace the faulty item. The Autonomic Logistics System (ALS) concept changes the reactive process into a proactive one with the employment of technologies such …

Analysis Of Cooperative Behavior For Autonomous Wide Area Search Munitions, Orhan Gozaydin

Theses and Dissertations

This research investigates the effectiveness of autonomous wide area search munitions using cooperative and non-cooperative behavior algorithms under various scenarios. The scenarios involve multiple autonomous munitions searching for an unknown number of targets with different priorities at unknown locations. For the cooperative cases, communications are allowed between the munitions to help locate, identify, and decide to pursue an attack on a target or to continue searching the rest of the battlefield. For non cooperative cases, munitions independently search, detect, identify and decide to attack an identified target or continue to search. Performance of the cooperative munitions depends on numerous parameters …

Hybrid Control Strategies For Rapid, Large Angle Satellite Slew Maneuvers, David B. French

Theses and Dissertations

This research investigated hybrid control strategies for rapid satellite pointing. First, a detailed computer simulation model of AFIT's SIMSAT satellite simulator was constructed. Control strategies were developed to enable the system to perform large-angle, 3-axis slewing maneuvers using a combination of both thrusters and reaction wheels. To handle the non-linear model, a State Dependent Riccati Equation controller was programmed and successfully controlled the computer-modeled satellite for any given slewing maneuver. A simpler PD controller was then programmed and demonstrated on the computer simulation of SIMSAT, using a combination of thruster and reaction wheel control inputs for large-angle single axis maneuvers …

A Simulation-Based Analysis Of The Impact Of In-Sourcing A Major Process Element On The Coast Guard Hh-601 Depot Maintenance Process, Steven E. Vigus

Theses and Dissertations

Leaders at the United States Coast Guard's Aircraft Repair and Service Center (ARSC) in Elizabeth City, North Carolina recently formalized their planning and analysis functions by adding a dedicated branch to their command structure. The Planning and Analysis Branch intends to apply computer modeling and simulation to study the impact of process changes to the various Programmed Depot Maintenance (PDM) lines. This research considers the applicability of this type of modeling and simulation, using ARENA to study the current HH-6OJ PDM process. The contribution of this research is a methodology specific to ARSC needs, an analysis of methodology based on …

Optimizing An In Situ Bioremediation Technology To Manage Perchlorate-Contaminated Groundwater, Mark R. Knarr

Theses and Dissertations

Combining horizontal flow treatment wells (HFTWs) with in situ biodegradation is an innovative approach with the potential to remediate perchlorate-contaminated groundwater. A technology model was recently developed that combines the groundwater flow induced by HFTWs with in situ biodegration processes that result from using the HFTWs to mix electron donor into perchlorate-contaminated groundwater. A field demonstration of this approach is planned to begin this year. In order to apply the technology in the field, project managers need to understand how contaminated site conditions and technology design parameters impact technology performance. One way to gain this understanding is to use the …

The Air Force Operational Risk Management Program And Aviation Safety, Matthew G. Cho

Theses and Dissertations

Aviation mishaps are extremely costly in terms of dollar value, public opinion, and human life, The Air Force drastically reduced Class A mishap rates in its formative years. The rate plummeted from 44.22 mishaps per 100,000 flight hours in 1947 to 2.33 mishaps in 1983 and has held steady around 1.5 mishaps since. The Air Force implemented the Operational Risk Management (ORM) program in 1996 in an effort to protect their most valuable resources: aircraft and aviators. An AFIT thesis conducted in 1999 by Capt Park Ashley studied the Army similar Risk Management (RM) program. Ashley concluded that since his …

Groundwater Flow Through A Constructed Treatment Wetland, Jack A. Blalock

Theses and Dissertations

This study is an analysis of the flow of water through a constructed treatment wetland at Wright-Patterson AFB, OH. The purpose of the treatment wetland is to biodegrade perchioroethylene, which is present in the groundwater as a contaminant. Contaminated water enters the bottom of the wetland and flows upward, exiting the wetland from a weir at one end. The wetland is designed for water to move vertically through the soil layers composing the wetland. The main purpose of this study is to characterize the water flow through the different layers of soil in the wetland. In this study, hydraulic parameters …

Modeling Catalytic Destruction Of Subsurface Contaminants In Recirculating Wells, Kerry J. Cadena

Theses and Dissertations

Groundwater and soil contamination is a significant problem throughout the nation, with approximately 300,000 to 400,000 sites affected (National Research Council, 1994). Examples of groundwater contaminants of special interest to DoD and AF installations include fuel hydrocarbons, chlorinated hydrocarbons, and nitroaromatic compounds. Traditional remediation technologies, which include pump-and-treat, permeable reactive barriers, and natural attenuation, have numerous drawbacks associated with them. These drawbacks have prompted researchers to look for innovative contamination clean-up methods. The technology investigated in this thesis, reticulating horizontal flow treatment wells (HFTWs) with in-well palladium (Pd) catalyst reactors, offers the potential for destruction of groundwater contaminants commonly found …

Measuring The Effect Of Airway Pressure On Pulmonary Arterial Diameter In The Intact Rat Lung, Robert C. Molthen, Steven Thomas Haworth, Amy Heinrich, Christopher A. Dawson

Biomedical Engineering Faculty Research and Publications

To study the relationship between transpulomnary [sic] pressure (Ptp), intravascular pressure (Pv), and the pulmonary arterial tree structure, morphometric measurements of pulmonary arterial trees were made in intact lungs from Sprague-Dawley rats. Using cone beam micro-CT and techniques we developed for imaging small animal lungs, volumetric CT data were acquired for Ptp from 0 - 12 mmHg and Pv from 5 - 30 mmHg. The diameter, D (measured range approximately 0.08-2.0 mm), vs. pressure, P, relation can be described by D(P) = D(0)(1+ α P), where α is a distensibility coefficient. Unlike studies performed in larger animals, where changes in …

Spect Imaging Of Pulmonary Blood Flow In A Rat, Christian Wieholt, Robert C. Molthen, Roger H. Johnson, Christopher A. Dawson, Anne V. Clough

Biomedical Engineering Faculty Research and Publications

Small animal imaging is experiencing rapid development due to its importance in providing high-throughput phenotypic data for functional genomics studies. We have developed a single photon emission computed tomography (SPECT) system to image the pulmonary perfusion distribution in the rat. A standard gamma camera, equipped with a pinhole collimator, was used to acquire SPECT projection images at 40 sec/view of the rat thorax following injection of Tc99m labeled albumin that accumulated in the rat's lungs. A voxel-driven, ordered-subset expectation maximization reconstruction was implemented. Following SPECT imaging, the rat was imaged using micro-CT with Feldkamp conebeam reconstruction. The two reconstructed image …

Twinscan: A Software Package For Homology-Based Gene Prediction, Paul Flicek

All Computer Science and Engineering Research

A complete mapping from genome to proteome would constitute a foundation for genome-based biology and provide targets for pharmaceutical and therapeutic intervention. This is one reason gene structure prediction has been a major subfield of computational biology for over 20 years. Many of the widely used gene prediction systems were developed in the 1990s and are unable to take advantage of the revolution in comparative genomics brought on by the sequencing of the entire genomes of an increasing numbers of vertebrates. Twinscan is a new system for high-throughput gene-structure prediction that exploits the patterns of conservation observed in alignments between …

Transgenic Non-Human Mammals Expressing Human Coagulation Factor Viii And Von Willebrand Factor, Henryk Lubon, William N. Drohan, William H. Velander

Papers in Biotechnology

A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human Factor VIII protein and a signal peptide, where the cis-acting regulatory units are active in mammary gland cells and the signal peptide is active in directing newly expressed Factor VIII into the milk of the animal. The promoter may be a milk protein promoter such as for whey acidic protein, casein, lactalbumin, or beta-lactoglobulin promoter. The transgenic mammals are preferably farm animals, for example, …

University Of Nevada, Las Vegas Transmutation Research Program: Quarterly Report, Second Quarter Year 2 (June 2002 To August 2002), Anthony Hechanova

Transmutation Research Program Reports (TRP)

This Quarterly Report is a primary deliverable from the University of Nevada, Las Vegas (UNLV) Transmutation Research Program (TRP) Director to the U.S. Department of Energy (DOE) as described in the UNLV Advanced Accelerator Applications (AAA) proposal, and AAA FY02 Work Package. Note: during this quarter, the AAA national program changed names to the Advanced Fuel Cycle Initiative (AFCI) and the UNLV AAA University Participation Program changed its name to the Transmutation Research Program. The new names will be used in future references.

The TRP Director implements the program’s administration using staff from the Harry Reid Center for Environmental Studies …

Detection Of Cracks At Rivet Holes In Thin Plates Using Lamb-Wave Scanning, Roberto A. Osegueda, Vladik Kreinovich, Soheil Nazarian, Enrique Roldan

Departmental Technical Reports (CS)

This paper describes a Lamb-wave scanning method for the detection of notches simulating cracks at rivet holes in thin plates. The approach requires the generation of an ultrasonic So-Mode Lamb wave using an incident transmitter excited with a tone burst centered at a near non-dispersive frequency. Area scans are performed of a plate with a hole with a notch to generate times series information which is used to create animations illustrating the wave propagation characteristics. The time series are subject to a sifting process to obtain intrinsic mode functions which contain narrow frequency banded information of the signals. The Hilbert-Huang …

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Building Services Engineering

No abstract provided.

Fuzzy Modeling Of Skin Permeability Coefficients, Angela K. Pannier, Rhonda M. Brand, David D. Jones

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Purpose. The purpose of this work was to determine whether a new modeling methodology using fuzzy logic can predict skin permeability coefficients that are given compound descriptors that have been proven to affect percutaneous penetration.
Methods. Three fuzzy inference models were developed using subtractive clustering to define natural structures within the data and assign subsequent rules. The numeric parameters describing the rules were refined through the use of an Adaptive Neural Fuzzy Inference System implemented in MatLab. Each model was evaluated using the entire data set. Then predicted outputs were compared to the published experimental data.
Results. All databases produced …

Development Of A Web-Based Mass Transfer Processes Laboratory: System Development And Implementation, Yusong Li, Eugene J. Leboef, P. K. Basu, Louis Hampton Turnver Iv

Department of Civil and Environmental Engineering: Faculty Publications

A web-based environment is utilized as a means to introduce advanced mass transfer processes concepts in environmental engineering and science courses. System development and implementation is presented, including detailed descriptions of the techniques employed to link software written in high level computer languages such as C++ and FORTRAN to an internet-based, user-friendly graphical user interface for both program input and output.

The Development Of A Biodegradable Scaffold For A Tissue Engineered Heart Valve, Thomas Adam Alheidt

Theses

In the current state of medical technology, there exists the need for a quality medical device to replace a failing heart valve. Presently, mechanical valves as well as donor tissue valves, either from humans or animals are used to replace failing heart valves. These valves although they can operate in the heart satisfactorily are not equal to the body replacing its own valve. Tissue Engineering in simple terms is the field of helping the body replace its own failing organ. In scientific terms, Tissue Engineering is a relatively young field, a majority of the major advancements have come in the …

Technological Innovation: An Option In The Ms In Technology Program, James R. Gray

Teaching Entrepreneurship to Engineering Students

The Technological Innovation (TI) option of the Masters of Science in Technology program emphasizes the research, development and technical management of the technological innovation process within the technology-based organization. It is structured to aid the industrial and engineering professional that is responsible for the design and development of technical processes and products. This option includes the technical management of innovation processes, research and development, information technologies, and process technologies. Participants in this option come from a wide range of technological disciplines and draw on an extensive array of theoretical and applied knowledge. This paper presents the development and implementation of …

Computational Simulation And Piv Measurements Of The Laminar Vortical Flowfield For A Delta Wing At High Angle Of Attack, Russell M. Cummings, Scott A. Morton, Stefan G. Siegel

Aerospace Engineering

The low-speed, laminar flowfield for a 70°-sweep delta wing is investigated. Solutions to the unsteady, three-dimensional, compressible Navier-Stokes equations were obtained on an unstructured grid to match results from an experiment performed in a water tunnel. The experiment was conducted with the delta wing at an angle of attack of 35° and the freestream flow at a root-chord Reynolds number of 40,700. The computational results are analyzed and compared with the experimental results in order to show how computations and experiments can be conducted in a synergistic fashion. Details about the primary vortex location, vortex burst, secondary vortex, and shear …

Sizes And Shapes Of 10-Ma Distal Fall Pyroclasts In The Ogallala Ggroup, Nebraska, William I. Rose, C. M. Riley, S. Dartevelle

Department of Geological and Mining Engineering and Sciences Publications

Size distributions of distal ashfall particles from correlated 10-Ma layers in Nebraska, measured using laser diffraction methods, are lognormal with mode diameters of ∼90 mm. This ashfall is ∼100% bubble-wall shards of rhyolite glass and apparently represents a distal ashfall from an eruption 1400 km away. Measured terminal velocities of these ash particles are 0.2–18 cm/s, consistent with Stokes Law settling of spherical particles with diameters of 9–50 mm. Surface area of the ash particles, measured with gas adsorption, is 20–30 times the surface area of equivalent Stokes spheres. These results highlight the effects of shape and atmospheric drag in …

Flight Physician - January, 2003, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twenty page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Recommended Strategies For Odor Control In Confinement Beef Cattle Operations, Kent Tjardes, Alvaro Garcia, Hans Stein, Charles Ullery, Stephen Pohl, Christopher Schmit

SDSU Extension Special Series

Odors coming off a beef feeding operation are generated from three different sources: the feedlot facility, waste storage, and the land where the manure is applied. In some operations, the feedlot facility may also serve as the primary waste storage area. To reduce the total amount of odor generated from a beef feeding operation, odor generation and emission by each of these three sources needs to be reduced.

Kentucky Water Resources Research Institute Annual Technical Report Fy 2002, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The FY 2002 Annual Technical Report for Kentucky consolidates reporting requirements of the Section 104(b) base grant award in a single technical report that includes: 1) a synopsis of each research project supported during the period, 2) a list of related reports, 3) a description of information transfer activities, 4) a summary of student support during the reporting period, and 5) notable achievements and awards during the year.