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Structure/Function Analyses Of Human Serum Paraoxonase (Hupon1) Mutants Designed From A Dfpase-Like Homology Model, David T. Yeung, Denis Josse, James D. Nicholson, Akhil Khanal, Christopher W. Mcandrew, Brian B. Bahnson, David E. Lenz, Douglas M. Cerasoli

United States Army: Publications

Human serum paraoxonase (HuPON1) is a calcium-dependent enzyme that hydrolyzes esters, including organophosphates and lactones, and exhibits anti-atherogenic properties. A few amino acids have been shown to be essential for the enzyme’s arylesterase and organophosphatase activities. Until very recently, a three-dimensional model was not available for HuPON1, so functional roles have not been assigned to those residues. Based on sequence-structure alignment studies, we have folded the amino acid sequence of HuPON1 onto the sixfold β-propeller structure of squid diisopropylfluorophosphatase (DFPase). We tested the validity of this homology model by circular dichroism (CD) spectroscopy and site-directed mutagenesis. Consistent with predictions from …

Santa Clara Magazine, Volume 46 Number 3, Winter 2004, Santa Clara University

Santa Clara Magazine

8 - AN ARTIST WITH A MISSION By Elizabeth Kelley Gillogly '93. In his latest series, Howard Anderson '71 created paintings of the 21 California missions.

10 - THE SPIRITUALITY OF GIFT GIVING By Tom Beaudoin. Is it possible to turn our gift giving into a spiritual exercise?

14 - RAISING ARIZONA By Susan Shea. Arizona Governor Janet Napolitano '79, a rising political star, uses the lessons learned at SCU to serve her state.

20 - LEAVING COMMUNISM BEHIND By Jane Curry. An SCU professor and Fulbright Scholar researches forgiveness and justice in post-communist Poland.

Graduate School Of Computer And Information Sciences Master's Degree Programs 2004, Nova Southeastern University

College of Engineering and Computing Course Catalogs

No abstract provided.

Detection Of Antibodies To Squalene Iii. Naturally Occurring Antibodies To Squalene In Humans And Mice, Gary R. Matyas, Mangala Rao, Phillip R. Pittman, Robert Burge, Iris E. Robbins, Nabila M. Wassef, Brandie Thivierge, Carl R. Alving

United States Army: Publications

An ELISA-based assay is described for the measurement of antibodies to squalene (SQE) in human serum and plasma. The assay was adapted from the previously described assay for murine antibodies to SQE (J. Immunol. Methods 267 (2002) 119). Like the murine SQE antibody assay, the human antibody assay used sterile cell culture 96-well plates coated with SQE (20 nmol/well). Phosphate-buffered saline (PBS)–0.5% casein was used as both a blocking agent and dilution buffer. The assay has a high through-put capacity and is reproducible and quantitative. This assay was used to evaluate samples from three different human cohorts. The first cohort …

Biomimetic Model Of Skeletal Muscle Isometric Contraction: I. An Energetic–Viscoelastic Model For The Skeletal Muscle Isometric Force Twitch, C. A. Phillips, D. W. Repperger, A. T. Neidhard-Doll, D. B. Reynolds

United States Air Force: Publications

This paper describes a revision of the Hill-type muscle model so that it will describe the chemo-mechanical energy conversion process (energetic) and the internal-element sti2ness variation (viscoelastic) during a skeletal muscle isometric force twitch contraction. The derivation of this energetic–viscoelastic model is described by a 3rst-order linear ordinary di2erential equation with constant energetic and viscoelastic coe5cients. The model has been implemented as part of a biomimetic model, which describes the excitation–contraction coupling necessary to drive the energetic–viscoelastic model. Finally, the energetic–viscoelastic model is validated by comparing its isometric force–time pro3le with that of various muscles reported in the literature.

Land For Maine's Future Program: Increasing The Return On A Sound Public Investment, Richard Barringer, Hugh Coxe, Jack Kartez, Catherine Reilly, Jonathan Rubin

Economics and Finance

Maine is nowhere a more special place than in the quality of its landscape and the traditions of its land use. Among the mo st privately-owned of all the states, Maine’s natural diversity and beauty combine with its traditions of resource stewardship, open access, and appreciation of nature to distinguish it in the public mind and national imagination. In recent decades, however, these traditions have come under assault from the forces of economic and social change; and the people of Maine have responded. In 1986, Governor Joseph Brennan’s Special Commission on Outdoor Recreation recognized the growing threats to Maine’s natur …

Chromium Speciation And Mobility In A High Level Nuclear Waste Vadose Zone Plume, John M. Zachara, Calvin Ainsworth, Gordon Brown Jr., Jeffery Catalano, James Mckinley, Odeta Qafoku, Steven Smith, James Szecsody, Sam Traina, Jeffrey Warner

United States Department of Energy: Publications

Radioactive core samples containing elevated concentrations of Cr from a high level nuclear waste plume in the Hanford vadose zone were studied to assess the future mobility of Cr. Cr(VI) is an important subsurface contaminant at the Hanford Site. The plume originated in 1969 by leakage of self-boiling supernate from a tank containing REDOX process waste. The supernate contained high concentrations of alkali (NaOH ≈ 5.25 mol/L), salt (NaNO₃/NaNO₂ >10 mol/L), aluminate [Al(OH)₄ ⁻ = 3.36 mol/L], Cr(VI) (0.413 mol/L), and ¹³⁷Cs⁺(6.51 X 10^-5 mol/L). Water and acid extraction of the oxidized …

Heterotrophic Plate Count Bacteria—What Is Their Significance In Drinking Water?, Martin J. Allen, Stephen C. Edberg, Donald J. Reasoner

United States Environmental Protection Agency: Publications

While the literature documents the universal occurrence of heterotrophic plate count (HPC) bacteria in soils, foods, air, and all sources of water, there is a lingering question as to whether this group of organisms may signal an increased health risk when elevated populations are present in drinking water. This paper reviews the relevant literature on HPC bacteria in drinking water, the lack of clinical evidence that elevated populations or specific genera within the HPC flora pose an increased health risk to any segment of the population, and the appropriate uses of HPC data as a tool to monitor drinking water …

Assessing Effectiveness Of Personality Style In Documentation, Kenneth Sayles, David G. Novick

Departmental Papers (CS)

This paper extends previous work by other researchers that indicated that users of computers preferred a computer with a personality that was similar to theirs. We conducted a similar experiment, but looking beyond preference to see if the personality of documentation would make a difference in the user’s performance. Our data suggest did not indicate that personality match affects performance; and if such a relationship exists it is likely to be weak. We discuss the related research, describe our methodology, present our results, and describe their implications and limitations.

Hydrogen Sulfide Flux Measurements And Dispersion Modeling From Constr, Sangho Eun

Electronic Theses and Dissertations

Odor problems are a common complaint from residents living near landfills. Many compounds can cause malodorous conditions. However, hydrogen sulfide (h2s) has been identified as a principal odorous component from construction and demolition (c&d)debris landfills. Although several studies have reported the ambient concentrations of h2s near c&d landfills, few studies have quantified emission rates of h2s. The most widely used and proven technique for measuring gas emission rates from landfills is the flux chamber method. Typically the flux chamber is a cylindrical enclosure device with a spherical top which limits the gas emission area. Pure zero grade air is introduced …

Adaptive Intelligent User Interfaces With Emotion Recognition, Fatma Nasoz

Electronic Theses and Dissertations

The focus of this dissertation is on creating Adaptive Intelligent User Interfaces to facilitate enhanced natural communication during the Human-Computer Interaction by recognizing users' affective states (i.e., emotions experienced by the users) and responding to those emotions by adapting to the current situation via an affective user model created for each user. Controlled experiments were designed and conducted in a laboratory environment and in a Virtual Reality environment to collect physiological data signals from participants experiencing specific emotions. Algorithms (k-Nearest Neighbor [KNN], Discriminant Function Analysis [DFA], Marquardt-Backpropagation [MBP], and Resilient Backpropagation [RBP]) were implemented to analyze the collected data signals …

Expression Morphing Between Different Orientations, Tao Fu

Electronic Theses and Dissertations

How to generate new views based on given reference images has been an important and interesting topic in the area of image-based rendering. Two important algorithms that can be used are field morphing and view morphing. Field morphing, which is an algorithm of image morphing, generates new views based on two reference images which were taken at the same viewpoint. The most successful result of field morphing is morphing from one person's face to the other one's face. View morphing, which is an algorithm of view synthesis, generates in between views based on two reference views which were taken at …

Impulse, Dave Graves, Kyle Johnson

Impulse (Jerome J. Lohr College of Engineering Publication)

Features:
[Page] 2 SDSU engineers restore Solberg Hall to active duty: From donors to the project manager, this effort was the project of alumni.
[Page] 4 Unique funding spawns new Solberg Hall: At $1, Solberg was the best purchase the State ever made.
[Page] 6 Back from Iraq: Guard members tell their story about the restoration of Iraq.
[Page] 8 Inquisitive nature leads Barnett to 'quality' career: Andy Barnett was living in a monastery when he decided to be an engineer
[Page] 10 Mobile classroom brings science to students: Retired teachers drive the truck and an SDSU instructor steers the …

Statistical Procedures For Evaluating Daily And Monthly Hydrologic Model Predictions, Marilyn E. Coffey, Stephen R. Workman, Joseph L. Taraba, Alex W. Fogle

Biosystems and Agricultural Engineering Faculty Publications

The overall study objective was to evaluate the applicability of different qualitative and quantitative methods for comparing daily and monthly SWAT computer model hydrologic streamflow predictions to observed data, and to recommend statistical methods for use in future model evaluations. Statistical methods were tested using daily streamflows and monthly equivalent runoff depths. The statistical techniques included linear regression, Nash-Sutcliffe efficiency, nonparametric tests, t-test, objective functions, autocorrelation, and cross-correlation. None of the methods specifically applied to the non-normal distribution and dependence between data points for the daily predicted and observed data. Of the tested methods, median objective functions, sign test, autocorrelation, …

Retention And Viability Characteristics Of Mammalian Cells In An Acoustically Driven Polymer Mesh, Zhaowei Wang, Paul Grabenstetter, Donald L. Feke, Joanne M. Belovich

Chemical & Biomedical Engineering Faculty Publications

A processing approach for the collection and retention of mammalian cells within a high porosity polyester mesh having millimeter-sized pores has been studied. Cell retention occurs via energizing the mesh with a low intensity, resonant acoustic field. The resulting acoustic field induces the interaction of cells with elements of the mesh or with each other and effectively prevents the entrainment of cells in the effluent stream. Experiments involving aqueous suspensions of polystyrene particles were used to provide benchmark data on the performance of the acoustic retention cell. Experiments using mouse hybridoma cells showed that retention densities of over 1.5 × …

Wear Mechanisms In Ceramic Hip Implants, M. Slonaker

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The wear in hip implants is one of the main causes for premature hip replacements. The wear affects the potential life of the prosthesis and subsequent removals of in-vivo implants. Therefore, the objective of this article is to review various joints that show lower wear rates and consequently higher life. Ceramics are used in hip implants and have been found to produce lower wear rates. This article discusses the advantages and disadvantages of ceramics compared to other implant materials. Different types of ceramics that are being used are reviewed in terms of the wear characteristics, debris released, and their size …

Wear Mechanisms In Ceramic Hip Implants, M. Slonaker, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The wear in hip implants is one of the main causes for premature hip replacements. The wear affects the potential life of the prosthesis and subsequent removals of in-vivo implants. Therefore, the objective of this article is to review various joints that show lower wear rates and consequently higher life. Ceramics are used in hip implants and have been found to produce lower wear rates. This article discusses the advantages and disadvantages of ceramics compared to other implant materials. Different types of ceramics that are being used are reviewed in terms of the wear characteristics, debris released, and their size …

Online Reverse Auctions: An Overview, Ching-Chung Kuo, Pamela Rogers, Richard E. White

Journal of International Technology and Information Management

Electronic commerce (e-commerce) is the fastest growing area in the U.S. economy with electronic procurement (e-procurement) being a major component, and online reverse auctions (ORAs) have emerged as a key e-procurement tool. Since the mid-1990s, ORAs have been gaining in popularity because of their potentially significant positive impact on the profitability of both the buyers and the sellers. Much has been written about the new purchasing paradigm and numerous stories have been reported recently. This paper is aimed at providing a critical review of ORAs by examining their historical developments, different forms, advantages, and disadvantages. In addition, 10 important factors …

Kentucky Traffic Collision Facts 2004 Report, Kentucky Transportation Center, Kentucky State Police

Kentucky Transportation Center Research Report

KENTUCKY’S TRAFFIC COLLISION FACTS report for 2004 is based on collision reports submitted to the Kentucky State Police Records Branch. As required by Kentucky Revised Statutes 189.635, “every law enforcement agency whose officers investigate a vehicle accident of which a report must be made...shall file a report of the accident...within ten days after investigation of the accident upon forms supplied by the bureau.” The stated purpose of this requirement is to utilize data on traffic collisions for such purposes as will improve the traffic safety program in the Commonwealth. Data contained in this report are based solely on the observations …

Kentucky Water Resources Research Institute Annual Technical Report Fy 2003, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The FY2003 Annual Technical Report for Kentucky consolidates reporting requirements of the Section 104(b) base grant award in a single technical report that includes: 1) a synopsis of each research project supported during the period, 2) a list of related reports, 3) a description of information transfer activities, 4) a sumarry of student support during the reporting period, and 5) notable achievements and awards during the year.

Evaluation Of The Et2000 Guardrail End Treatment, Kenneth R. Agent

Kentucky Transportation Center Research Report

The objective of this study was to report the results of the monitoring of the performance of the ET2000 guardrail end treatment in traffic crashes. This end treatment has an energy absorbing design in which a vehicle will push a guardrail extruder back as posts designed to breakaway are broken. The W-beam guardrail is flattened as it goes through the extruder and exits a slot away from traffic.

Data for a total of 135 collisions involving the ET 2000 were identified. A crash report was obtained in the majority of crashes and the damaged guardrail was inspected in almost all …

Modeling Impacts On Populations: Fathead Minnow (Pimephales Promelas) Exposure To The Endocrine Disruptor 17Β-Trenbolone As A Case Study, David H. Miller, Gerald T. Ankley

United States Environmental Protection Agency: Publications

Evaluation of population-level impacts is critical to credible ecological risk assessments. In this study, a predictive model was developed to translate changes in fecundity of the fathead minnow (Pimephales promelas) in a short-term laboratory toxicity test to alterations in population growth rate. The model uniquely combines a Leslie population projection matrix and the logistic equation. Application of the model requires only a life table for the organism of interest, a measure of carrying capacity for the given population, and an estimation of the effect of a stressor on vital rates. The model was applied to investigate population dynamics …

The Open Assembly Model For The Exchange Of Assembly And Tolerance Information: Overview And Example, M. M. Baysal, U. Roy, R. Sudarsan, R. D. Sriram, K. W. Lyons

Mechanical and Aerospace Engineering - All Scholarship

In early design phases an effective information exchange among CAD (Computer Aided Design) tools depends on a standardized representation for the product data in all PLM (Product Lifecycle Management) tools. The NIST Core Product Model (CPM) and its extension are proposed to provide the required base-level product model that is open, non-proprietary, generic, extensible, independent of any one product development process and capable of capturing the full engineering context commonly shared in product development [1]. The Open Assembly Model (OAM) Model extends CPM to provide a standard representation and exchange protocol for assembly. The assembly information model emphasizes the nature …

The Open Assembly Model For The Exchange Of Assembly And Tolerance Information: Overview And Example, M. M. Baysal, U. Roy, R. Sudarsan, R. D. Sriram, K. W. Lyons

Mechanical and Aerospace Engineering - All Scholarship

In early design phases an effective information exchange among CAD (Computer Aided Design) tools depends on a standardized representation for the product data in all PLM (Product Lifecycle Management) tools. The NIST Core Product Model (CPM) and its extension are proposed to provide the required base-level product model that is open, non-proprietary, generic, extensible, independent of any one product development process and capable of capturing the full engineering context commonly shared in product development [1]. The Open Assembly Model (OAM) Model extends CPM to provide a standard representation and exchange protocol for assembly. The assembly information model emphasizes the nature …

Optimal Beaver Population Management Using Reduced Order Distributed Parameter Model And Single Network Adaptive Critics, Radhakant Padhi, S. N. Balakrishnan

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Using a distributed parameter model for beaver population that accounts for their spatial and temporal behavior, an optimal control for a desired distribution of the animals is presented. Optimal solutions are obtained through a "single network adaptive critic" (SNAC) neural network architecture. The objective of this research is to design an "optimal" beaver harvesting scheme for a region of interest.

Mapping Of Thermo-Fluids Laboratory Experiments Into Web-Based Experiments, Sushil Chaturvedi, Rick Mckenzie, O. A. Akan, A. Priyadershini

Mechanical & Aerospace Engineering Faculty Publications

A methodology is being developed for transforming physical experiments from the undergraduate thermo-fluids laboratory into a web-based virtual experiments. Important characteristics of physical experiments are identified in order to preserve them in physical to virtual domain mapping. Several commercially available software are employed to incorporate in the web-based experiments characteristics such as recreation of physical phenomenon in the virtual domain, measurement of physical quantities on a computer screen, assembly of virtual probes and coupling of the virtual experiment with a data acquisition software. A virtual reality software has been incorporated to enable web-based students to navigate through the virtual laboratory, …

Partitioning A Graph In Alliances And Its Application To Data Clustering, Khurram Hassan-Shafique

Electronic Theses and Dissertations

Any reasonably large group of individuals, families, states, and parties exhibits the phenomenon of subgroup formations within the group such that the members of each group have a strong connection or bonding between each other. The reasons of the formation of these subgroups that we call alliances differ in different situations, such as, kinship and friendship (in the case of individuals), common economic interests (for both individuals and states), common political interests, and geographical proximity. This structure of alliances is not only prevalent in social networks, but it is also an important characteristic of similarity networks of natural and unnatural …

Affordances In The Design Of Virtual Environments, David Charles Gross

Electronic Theses and Dissertations

Human-computer interaction design principles largely focus on static representations and have yet to fully incorporate theories of perception appropriate for the dynamic multimodal interactions inherent to virtual environment (VE) interaction. Theories of direct perception, in particular affordance theory, may prove particularly relevant to enhancing VE interaction design. The present research constructs a conceptual model of how affordances are realized in the natural world and how lack of sensory stimuli may lead to realization failures in virtual environments. Implications of the model were empirically investigated by examining three affordances: passability, catchability, and flyability. The experimental design involved four factors for each …

Predicting Traffic Conditions At Indiana Signalized Intersections, Rafael I. Perez-Cartagena, Andrzej P. Tarko

JTRP Technical Reports

All of the methods for predicting traffic conditions at intersections provide default values for saturation flow rates and their adjustment factors, lost times, and other parameters. Because these parameters are difficult to measure, the use of the default values is a common practice and it can cause significant bias in the results if the actual local values are different. The main objective of this research was to investigate the variability of capacity and delay parameters used in engineering tools for predicting delays and for determining level of service (LOS) at signalized intersections in Indiana. The variability investigation produced Indiana default …

Analysis And Evaluation Of A Bioengineered Submerged Breakwater, Matthew Dwain Campbell

LSU Master's Theses

Louisiana's coastline has received national attention due to rapid erosion rates estimated from approximately 60 to 100 square kilometers per year. The disappearance of coastal areas jeopardizes public and private infrastructure, property values, aquatic ecosystems, and standards of living. In order to resolve the erosion problem, innovative solutions have been explored that may improve effectiveness and cost efficiency. This research involves a technology, termed an "oysterbreak," which is a bioengineered submerged breakwater. This structure promotes oysters to form a dense structure that dissipates wave energy. Since the structure is biologically dominated, initial material use is modest. The oysterbreak was evaluated …