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Alteration Of Peripheral Cytokines In Alzheimer’S Disease, Zhengshi Yang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer’s disease (AD) is a progressive neurodegenerative disease with the clinical symptoms of gradual cognitive decline and memory loss. Biologically, abnormal accumulation of Aβ (Aβ) plaque and tau tangles in the brain are the core pathological hallmarks in AD. Although inflammatory response is not specific to AD, emerging evidence suggests that the disrupted innate immune system within the central nervous system, particularly microglial activation, might act as the bridge linking Aβ aggregation to pathological phosphorylation and aggregation of tau. The inflammatory response was suggested to initially have a neuroprotective role of attempting to clear Aβ plaques, and then become neurotoxic …

Teaching Learning Newsletter Vol 4 Issue 2, Sastra Deemed To Be University

TLC Newsletter

No abstract provided.

Feasibility Study On Microwave Glucose Level Monitoring, Ricardo Cepeda

Theses and Dissertations

Diabetes management heavily relies on regular blood glucose monitoring, which traditionally involves invasive techniques. In recent years, significant research has been directed towards developing non-invasive glucose monitoring methods, particularly using electromagnetic waves. This study explores the feasibility of detecting blood glucose levels non-invasively by measuring the resonant frequency shifts of an antenna, influenced by the dielectric properties of blood. Microwave measurement techniques have garnered attention due to their ability to safely penetrate human tissue and detect biochemical markers like glucose. While previous studies have established a link between glucose concentration and dielectric properties, many techniques suffer from poor sensitivity or …

Assessing Reproducibility Challenges In Clinical Metabolics, Darcy Lin Cochran

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Current metabolomics research is expanding to be multiplatform and interdisciplinary. Metabolomic analysis has the potential to provide detailed insight into any biological system of interest to analyze the underlying molecular mechanisms of variables like environment, disease, and genetics. Human clinical metabolomics is a major research area that is often focused on finding biomarkers or panels of biomarkers for different diseases. However, results are difficult to compare across different laboratories since the field of metabolomics has yet to widely adopt best practices for sample preparation, data acquisition and data processing, results are difficult to compare across different laboratories.

This thesis focuses …

Demonstrating Feasibility Of Ultrasound-Sensitive Microbubbles Delivery To Treat Disruptions In The Blood Brain Barrier Endothelium, Rubens Jourdain

Theses and Dissertations

Vascular cognitive impairment and dementia (VCID) is one of the main causes of dementia. VCID is caused by age and other genetic factors that lead to disruptions in the blood brain barrier (BBB) and allow blood components to enter the brain. The currently available treatments of VCID include opening the BBB with high-frequency-ultrasound to deliver drugs to the brain. However, this only treats the already developed disease. Consequently, we developed a new drug delivery system whose goal is to restore the brain capillary endothelial cells (BCEC) lining the blood vessel. The objective of this study was to demonstrate the feasibility …

3d Bioprinted Coaxial Tubule Optimization For Human Aortic Endothelial Cell Growth, Ilse Gabriela Perez Garcia

Theses and Dissertations

This paper introduces a research study of printing parameter optimization of extruded, cell-laden, 3D bioprinted coaxial tubules, as well as cell interaction observations. Optimization of printing parameters seeks to reduce variability of the tubules’ inner and outer diameters. The tubules were manufactured from a 0.4% Collagen I - 1.6% NaC6H7O6 (Sodium Alginate) bioink, that reaches gelation through interaction with a 3.2% CaCl2 (Calcium Chloride) solution. The bioinks were extruded through a dual syringe pump mechanism connected to a coaxial nozzle, which is mounted on an adapted 3D FDM (Fused Deposition …

Assessing Khumbu Region Glaciers Mass Balance Change Using Geospatial Techniques From 2012 To 2024, Yashvi Jagatbhai Shah

Electronic Theses, Projects, and Dissertations

The glaciers in the Hindu Kush Himalaya are critical for sustaining the water supply of South Asia's major rivers, upon which over 230 million people, both in the mountainous regions and lowland areas, depend. Climate change is driving rapid glaciers melt near the summit of Mount Everest, located at an elevation of approximately 7,906 meters (25,938 feet). This has resulted in glacier thinning occurring up to 80 times faster than the original ice formation. However, due to their disposition in a complex topographic setting and inaccessible terrain, continuous glacier observations pose significant challenges.

This study evaluated the mass balance of …

Application Of Lossy And Lossless Compression To Dicom Files, Yizhe Yang

All Theses

The Digital Imaging and Communications in Medicine (DICOM) standard is widely utilized for the management, storage, and transfer of medical images. However, the substantial file sizes associated with DICOM data present challenges in terms of storage and data transmission. Data reduction techniques help address these challenges by minimizing the size of the data while preserving its integrity. This thesis examines various compression methods aimed at reducing the size of DICOM files. We evaluate five lossless compressors and four lossy compressors on DICOM data to compare and assess their performance. Through an analysis of each compressor’s compression efficiency and resulting image …

Life Cycle Assessment Approach For Energy Usage In Animal Rendering Plants, Abel Binoy Mathew

All Theses

The animal rendering industry plays a crucial role in transforming waste products from livestock production and meat processing facilities into valuable and economically beneficial products, promoting both resource efficiency and sustainability. This study uses a life cycle assessment (LCA) approach to evaluate energy usage and greenhouse gas emissions in animal rendering plants, focusing on electricity and natural gas as the main energy inputs for plant operation. This research examines three distinct rendering facilities, each processing different raw materials, to quantify the environmental impacts of rendering operations. Site visits, data collection, and real-time monitoring were used to capture energy use across …

On Neutrosophic Pδs-Irresolute Functions In Neutrosophic Topological Spaces, Bishnupada Debnath, Anjan Mukherjee

Neutrosophic Systems with Applications

In general topology the notion of pds-irresolute and aδs-irresolute functions were introduced by Beceren and Noiri. In the present paper, these concepts of pδs-irresolute (briefly, Npδs-irresolute) and aδs-irresolute (briefly, Naδs-irresolute) functions are explored for the first time in neutrosophic topological spaces (NTS) as generalized version. We proved that every Naδs-irresolute function is Npδs-irresolute function but not conversely. Some characterizations, counter examples, and fundamental features are also presented. By neutrosophic pre-open, neutrosophic δ-open, and neutrosophic δ-semi-open sets, some new fundamental properties of such functions are provided. Furthermore, under Npδs-irresolute functions, the behavior of neutrosophic semi-connected, neutrosophic pre-connected, neutrosophic pre-T2, neutrosophic δ-semi-T2, …

Comparative Analysis Of Multi-Criteria Techniques In Neutrosophic Environment And Their Applications To Economic Condition Assessment, Asmaa Elsayed, Mai Mohamed

Neutrosophic Systems with Applications

In economic decision-making, the challenge of evaluating multiple, often conflicting criteria necessitates advanced Multi-Criteria Decision-Making (MCDM) techniques. Traditional methods can struggle with the inherent uncertainty, ambiguity, and imprecision of real-world data. This paper addresses these challenges by investigating the effectiveness of various MCDM techniques within neutrosophic environments, with a particular focus on the Criteria-wise Alternatives Ranking and Correlation Analysis for Composite Scoring (CARCACS) method. Neutrosophic sets, which incorporate truth, falsity, and indeterminacy, provide a robust framework for addressing the vagueness and inconsistencies found in economic indicators such as GDP growth, employment levels, inflation rates, trade balances, investment activity, and government …

Compact Solar-Powered Plasma Water Generator: Enhanced Germination Of Aged Seed With The Corona Dielectric Barrier Discharger, Yiting Xiao, Yang Tian, Haizheng Xiong, Ainong Shi, Jun Zhu

Biological and Agricultural Engineering Faculty Publications and Presentations

Seed aging adversely affects agricultural productivity by reducing germination rates and seedling vigor, leading to significant costs for seed banks and companies due to the need for frequent seed renewals. This study demonstrated the use of plasma-activated water (PAW), generated by a solar-powered corona dielectric barrier discharger, to enhance germination rates of spinach seeds that had been stored at 4 °C for 23 years. Treating seeds with PAW at 17 kV for 15 min improved germination (by 135%) and seedling growth compared to untreated seeds. Through detailed analysis, beneficial PAW properties for seed development were identified, and a molecular mechanism …

Adsorption Of Harmful Algal Bloom Toxins Using Biochar, Cadianne Chambers

Theses and Dissertations

Harmful Algal Bloom (HAB) events involve the proliferation of microalgae which discharge lethal toxins into fresh and brackish water bodies due to anthropogenic and climatic activities. Common examples of HABs include causative organisms such as Cyanobacteria, Pyrodinium bahamense and more. These genera are known to release potent toxins including Microcystins, and Saxitoxins, respectively, which can seriously endanger human and marine health. Ingestion of these toxins can result in several health problems, such as nausea, vomiting, gastroenteritis, skin irritation, liver damage, paralysis, and respiratory arrest. The Great Lakes, Gulf of Maine, Florida’s coasts, Lake Erie, and Lake Okeechobee have all been …

The Design And Implementation Of A Modular Tissue Engineering Test Bed To Pursue An Alternate Pathway Of Cell Culture Based Research, Ryley Patrick Griffin

Theses and Dissertations

The development of a Modular Automated Tissue Engineering Test Bed (MATETB) is the next step in the development of cheap and easily available in vitro cell regulatory systems for both academic and industrial purposes. This project outlined the framework and requirements for a device that could automatically regulate and collect data on a cell culture through the manipulation of its liquid environment. From this framework, a prototype was built. The device would fulfill cell culture needs while collecting data automatically and allowing for live viewing and imaging of cells. The device was comprised of a mechanical skeleton (MS), an environmental …

Fabrication And Charcaterization Of Pullulan-Collagen Nanofibers Via Forcespinning, Valeria Leon Leal

Theses and Dissertations

Extensive research on collagen has spurred advancements in tissue engineering and biomaterial development, given collagen´s pivotal role in regulating various tissue structures across diverse organisms. This study delves into fabricating nanocomposites utilizing collagen, along with silver nanoparticles, chondroitin sulfate and pullulan, for potential applications in antibacterial medical devices, and cell regeneration. Collagen, abundant in the extracellular matrix, provides essential structural support, while silver nanoparticles and chondroitin confer antimicrobial properties, crucial for combating infections. Pullulan, a polysaccharide polymer, serves as a biocompatible carrier for silver nanoparticles whilst being the starting nanofiber forming material. Utilizing Forcespinning® technology, composite nanofibers were successfully synthesized. …

Optimization Of Polymeric Micelles As A Delivery System For Crispr/Cas9 Ribonucleoprotein, Lucian Williams

All Dissertations

Clustered regularly interspaced short palindromic repeats (CRISPR) is an adaptive immune system in bacteria that has been harnessed to perform precise genetic modifications in mammalian cells. Among CRISPR-associated (Cas) proteins, Cas9 has emerged as a transformative tool in gene editing due to its simplicity, high specificity, and versatility compared to the other Cas proteins and gene-editing technologies. Despite its potential to cure genetic disorders, the clinical application of Cas9 has been hindered by challenges such as immunogenicity, off-target effects, and low delivery efficiency. To address these issues, this dissertation explores using polymeric nanoparticle systems to encapsulate and protect Cas9 and …

Protocol Transformations Across Osi Network Stack Layers For Attack, Evasion, And Defense, Nathan Tusing

All Dissertations

Network endpoints frequently contend with errors and deviations within protocols. Many factors account for these deviations including noise, tampering, and algorithm implementations. Intermediate nodes are expected to modify instantiated protocols and not guarantee correctness. This ability to modify traffic enables all sides of network security to alter security and performance properties of protocols, and we define this intermediary modification of an instantiated protocol as a transformation. Protocol transformations traverse layers of the OSI reference model and changes a protocol's time series byte sequence. Within this thesis, we show that this framework applies to multiple domains and protocols. Common examples of …

Neutrosophic Cox Proportional Hazards Model For Robust Variable Selection In Survival Analysis, Ibrahim Yasser, Aya A. Abd El-Khalek, A. A. Salama, Doaa A. Abdo

Neutrosophic Systems with Applications

This paper introduces a novel approach for variable selection in survival analysis by integrating neutrosophic logic into the Cox Proportional Hazards (Cox PH) model to address the limitations of recent studies related to high dimensionality. Neutrosophic logic, is a mathematical framework that allows for uncertainty, indeterminacy, and inconsistency, and particularly well suited for handling the complexity and often-ambiguous nature of biological data. By incorporating neutrosophic sets into the Cox PH model, we aim to enhance model robustness, improve variable selection, and address the curse of dimensionality. We compare the performance of the neutrosophic-enhanced Cox PH model with traditional variable selection …

Multi-Criteria Decision-Making Approach Based On Correlation Coefficient For Multi-Polar Interval-Valued Neutrosophic Soft Set, Hamza Naveed, Saalam Ali

Neutrosophic Systems with Applications

The correlation coefficient between two factors is crucial in statistical computation, indicating the extent and evolution of the appropriate link. The precision of applicability evaluations frequently relies on the thoroughness and caliber of data obtained from a certain dataset. Statistical research sometimes entails data marked by intrinsic trade-offs and uncertainty. This study seeks to present m-polar interval-valued neutrosophic soft sets (mPIVNSSs) through the integration of m-polar fuzzy sets with interval-valued neutrosophic soft sets. The suggested mPIVNSS structure is a significantly generalized version of m-polar neutrosophic soft sets and serves as a substantial extension of interval-valued neutrosophic soft sets. In this …

Analysis Of Bck/Bci-Algebras Based On Bipolar Complex Intuitionistic Fuzzy Soft Ideals, Zeeshan Ali

Neutrosophic Systems with Applications

In this article, we design an informative and reliable technique of bipolar complex intuitionistic fuzzy soft sets with numerous operational laws by merging the model of soft sets, complex fuzzy sets, and bipolar intuitionistic fuzzy sets to handle imprecise data. In addition, an ideal in a BCK-algebra is derived based on bipolar complex intuitionistic fuzzy soft set theory are proposed which can capture the information of hesitancy, vagueness, and non-membership information within the circumstance of BCK-algebra. Moreover, we design union, intersection, AND, and OR based on bipolar complex intuitionistic fuzzy soft ideal and simplify it with the help of numerous …

Development Of A Surface-Mounted Strong Post For The Midwest Guardrail System, Gnyarienn Selva Kumar

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

This research investigated the development of a surface-mounted strong post for the Midwest Guardrail System (MGS), designed to replicate the behavior of the standard MGS post, a W6 x8.5, 72-in. long post embedded 40 in. into strong soil. The MGS is a strong post, W-beam guardrail system that has been successfully evaluated in many applications using crashworthiness criteria described in the American Association of State Highway and Transportation Officials (AASHTO) Manual for Assessing Safety Hardware (MASH). However, in some locations, conventional soil-embedded posts are impossible to install due to subgrade obstructions like concrete slabs, mow strips, utilities, and limited right-of-way. …

Investigating The Role Of Cd44 In Her2+ Breast Cancer Cells During Cancer Cell Redirection, Holly Caroline Jordan Campbell

All Dissertations

Despite a rise in survival rates of breast cancer patients due to advances in modern medicine, breast cancer is the most common type of cancer in women and is the second leading cause of cancer death in the United States. Early detection and a more personalized treatment of breast cancer has slowly improved patient outcomes. Nevertheless, there are impediments to better patient outcomes due to the complexity of the disease physiology. Therefore, there is a demand for a comprehensive understanding of cancer development as well as a need to understand tumor progression for enhanced therapies for patients.

Previous in vivo …

Analysis Of Learning Mechanisms In Spiking Neural Networks With R(T) Elements And Memristive Synapses, Farhana Afrin

Boise State University Theses and Dissertations

As Moore's law ends, the conventional von Neumann computer architecture with binary-coded data representation has reached its bottleneck because of having separate computing and memory modules. In this architecture, continuous power is required due to sequential processing, making it challenging to improve efficiency further. The human brain can be regarded as the most energy-efficient computer architecture. In the brain, data is represented as small voltage pulses as spikes. That is why the neural units are called spiking neural networks (SNN). In SNNs, energy is required only when there is a spike, making it more energy efficient than the von-Neumann computer …

Model Reference Adaptive Control For Mobile Manipulators And Beyond, Srivatsan Srinivasan

All Dissertations

In recent years, robotics has expanded into various sectors, including manufacturing, transportation, and household services, making the integration of autonomy a critical area of research. This shift aims to ensure safety and enhance the utility of autonomous systems. Traditionally, robotic applications focused separately on mobility, like automated guided vehicles, and manipulation, such as serial-chain arms in manufacturing. Today, however, we see a merging of these capabilities in the growing field of mobile manipulator robots that combine movement with purposeful interactive functionalities.

A typical mobile manipulator is a robotic arm mounted on a wheeled base. This thesis focuses on advancing control …

Developing A Bioengineered Nanoparticle For Improving Oral Absorption Of Iron Supplements., Mila Biswas

Open Access Theses & Dissertations

Iron deficiency (ID) and iron deficiency anemia (IDA) are widespread nutritional issues, affecting millions globally. Conventional iron supplements often suffer from low absorption rates and gastrointestinal side effects. We investigated β-glucan derivatives as potential carriers to enhance iron absorption and mitigate these drawbacks. This study explored a novel β-glucan-based carrier system loaded with ferrous sulfate heptahydrate. In-vitro studies demonstrated sustained iron stability for over six hours in simulated gastric fluids due to the carrier's affinity for stomach mucin. Particle size analysis and scanning electron microscopy (SEM) images confirmed this specific binding. Additionally, drug release studies revealed a pH-dependent release profile, …

Myofibroblast Targeted Liposomes For The Treatment Of Skin Fibrosis, Elfa Beaven

Open Access Theses & Dissertations

Continuous overactivation of myofibroblasts leads to excessive deposition of profibrotic proteins, which in turn causes tissue stiffness and, ultimately, organ failure. One of those proteins, Cadherin-11 (CDH11), is reported to be overexpressed in the tissue of fibrotic skin, specifically on myofibroblasts. Similarly, chronic inflammation drives fibrosis progression in autoimmune-related illnesses like systemic sclerosis (SSc). Therefore, it is hypothesized that CDH11 could be a target for cell-specific delivery of antifibrotic therapies to fibrotic skin tissue. Here, a CDH11 peptide conjugated liposome loaded with Tofacitinib, a JAK inhibitor, was developed to understand the potential of targeted therapies to treat skin fibrosis. The …

Neural Network Architecture Search Enabled Wide-Deep Learning (Nas-Wd) Integrated Hyperspectral Imaging Understanding For Woody Breast In Poultry Processing, Chaitanya Kumar Reddy Pallerla

Graduate Theses and Dissertations

The development and implementation of a Wide & Deep (WD) learning model tailored for classification and regression tasks utilizing spectral data provides a robust solution to evaluate woody breast (WB) conditions in poultry fillets. This process begins with thorough data preprocessing, which includes loading spectral and classification datasets, imputing missing values with medians, and splitting the data into training and testing sets to ensure rigorous model evaluation. The WD model architecture integrates wide linear models and deep neural networks to harness the strengths of both approaches. The wide component excels at memorizing sparse feature interactions, while the deep component captures …

Wind Tunnel Investigation Of The Along-Wind Dispersion In Finite-Duration Neutrally Buoyant Gas Releases, Daniel Williams

Graduate Theses and Dissertations

This thesis investigates the along-wind dispersion of hazardous gas releases within a turbulent boundary layer using controlled experiments in an ultra-low-speed wind tunnel, recognizing the limitations of numerical modeling and field tests. This study utilizes a neutrally buoyant gas mixture and dual Flame Ionization Detectors (FIDs) to capture representative, repeatable data on gas cloud behavior over finite durations. Ensemble averaging of 65 trials across varying release durations and downwind distances provided detailed insights into gas dispersion and the distinct time phases within finite-duration releases. Analysis revealed that along-wind dispersion coefficients depend on turbulence and vertical wind shear, with normalized coefficients …

Characterization And Performance Nanofiltration Membranes In Water Quality For Goldfish (Carassius Auratus) Aquaculture, Inpita Casuarina Eqisetia Utari, Uun Yanuhar, Asus Maizar Suryanto Hertika, Heru Suryanto, Jibril Maulana, Nico Rahman Caesar, Mahrus Ismail, Leong-Seng Lim

Journal of Mechanical Engineering Science and Technology (JMEST)

Water quality is an important factor in aquaculture activities, including goldfish (Carassius auratus) farming. One approach to improving water quality is the use of nanofilters. This study aims to evaluate the performance of nanofilters made from Sargassum sp. with the addition of copper oxide nanoparticles. The method used involves the fermentation of bacterial cellulose from Acetobacter xylinum using Sargassum sp. extract as a medium, followed by homogenization and the addition of CuO-NPs at concentrations of 0.5%, 1%, and 1.5%, and subsequent oven drying. The nanofilter membrane will then be analyzed using SEM, XRD, and FTIR to characterize its properties. Performance …

Synthesis And In Vitro Testing Of Mg-6zn-Xhap Biocomposites From Beef Bone As Biodegradable Bone Implant Material, Jojor Lamsihar Manalu, Francisca Tjhay, Theodora Kristoforus, Sovian Aritonang

Journal of Mechanical Engineering Science and Technology (JMEST)

This study aimed to develop biodegradable Mg-6Zn hydroxyapatite (Mg-6Zn HAp) biocomposites for potential use in bone replacement applications. The hydroxyapatite (HAp) powders, sourced from cow bone, were synthesized through an eco-friendly and cost-effective process, leveraging bioresources for material sustainability. The Mg-6Zn and HAp powders were mechanically mixed through ball milling for six hours to ensure homogeneity. The resultant powder mixture was then subjected to isostatic pressing at a high pressure of 570 MPa, forming a dense coin-shaped composite with a 1.5 cm diameter. This coin was consolidated in a capsule furnace at elevated temperatures for one hour to enhance material …