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Synthesis And Characterization Of Polymeric Antioxidant Delivery Systems, Paritosh P. Wattamwar

Theses and Dissertations--Chemical and Materials Engineering

Even though the role of oxidative stress in a variety of disease states is known, strategies to alleviate this oxidative stress by antioxidants have not been able to achieve clinical success. Particularly, treatment of oxidative stress by small molecule antioxidants has not received due attention because of the challenges associated with its delivery. Antioxidant polymers, where small molecule antioxidants are incorporated into the polymer backbone, are an emerging class of materials that can address some of these challenges.

In this work, biodegradable polymers incorporating phenolic antioxidants in the polymer backbone were synthesized. Antioxidant polymers were then characterized for their in …

Quantitative Carré Differential Interference Contrast Microscopy To Assess Phase And Amplitude, Donald D. Duncan, David G. Fischer, Amanda Dayton, Scott A. Prahl

Electrical and Computer Engineering Faculty Publications and Presentations

We present a method of using an unmodified differential interference contrast microscope to acquire quantitative information on scatter and absorption of thin tissue samples. A simple calibration process is discussed that uses a standard optical wedge. Subsequently, we present a phase-stepping procedure for acquiring phase gradient information exclusive of absorption effects. The procedure results in two-dimensional maps of the local angular (polar and azimuthal) ray deviation. We demonstrate the calibration process, discuss details of the phase-stepping algorithm, and present representative results for a porcine skin sample.

Biometic Self-Assembled Nanomatrix For Bone Tissue Regeneration, Joel Matthew Anderson

All ETDs from UAB

Formation of the native bone extracellular matrix (ECM) provides an attractive template for bone tissue engineering. At the cellular level, structural support and biological complexity of bone ECM are provided within a composite microenvironment that consists of an organic fibrous network reinforced by inorganic hydroxyapatite (HA) nanostructured crystals. To synthetically recreate this biphasic assembly, a bone ECM analogous scaffold comprised of self-assembling peptide amphiphile (PA) nanofibers and interspersed HA nanoparticles was investigated. The PAs have been endowed with biomolecular ligand signaling using synthetically inscribed peptide sequences (i.e. RGDS, DGEA) derived from the native bone ECM and integrated with HA nanoparticles …

Functional Imaging Of Excitable Cells: Retinal Neurons And Pancreatic Islet Beta Cells, Yichao Li

All ETDs from UAB

Stimulus-evoked fast intrinsic optical signals (IOSs) have time courses comparable to electrophysiological kinetics, and thus promise a sub-cellular and sub-second resolution method for functional evaluation of excitable biological tissues. The objective of my thesis research is to validate and characterize IOS imaging of stimulus-evoked activities in the retina and pancreatic islet ß-cells. In order to achieve this objective, three sets of experiments have been conducted. 1) Simultaneous measurement of retinal neurons functioning can enhance our understanding of the visual signal processing. In this stage of my study, I propose to demonstrate IOS imaging of retina slices that allows simultaneous monitoring …

Decision Aid Models For Resource Sharing Strategies During Global Influenza Pandemics, Alfredo Santana Reynoso

USF Tampa Graduate Theses and Dissertations

Pandemic influenza outbreaks have historically entailed significant societal and economic disruptions. Today, our quality of life is threatened by our inadequate preparedness for the imminent pandemic. The key challenges we are facing stem from a significant uncertainty in virus epidemiology, limited response resources, inadequate international collaboration, and the lack of appropriate science-based decision support tools. The existing literature falls short of comprehensive models for global pandemic spread and mitigation which incorporate the heterogeneity of the world regions and realistic travel networks. In addition, there exist virtually no studies which quantify the impact of resource sharing strategies among multiple countries. This …

Effects Of Acute Rho Kinase Inhibition On Chronic Hypoxia-Induced Changes In Proximal And Distal Pulmonary Arterial Structure And Function, Rebecca R. Vanderpool, Ah Ram Kim, Robert C. Molthen, Naomi Chesler

Biomedical Engineering Faculty Research and Publications

Hypoxic pulmonary hypertension (HPH) is initially a disease of the small pulmonary arteries. Its severity is usually quantified by pulmonary vascular resistance (PVR). Acute Rho kinase inhibition has been found to reduce PVR toward control values in animal models, suggesting that persistent pulmonary vasoconstriction is the dominant mechanism for increased PVR. However, HPH may also cause proximal arterial changes, which are relevant to right ventricular (RV) afterload. RV afterload can be quantified by pulmonary vascular impedance, which is obtained via spectral analysis of pulsatile pressure-flow relationships. To determine the effects of HPH independent of persistent pulmonary vasoconstriction in proximal and …

Multimodality Imaging Of Abnormal Vascular Perfusion And Morphology In Preclinical 9l Gliosarcoma Model, Moses M. Darpolor, Robert C. Molthen, Kathleen M. Schmainda

Biomedical Engineering Faculty Research and Publications

This study demonstrates that a dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) perfusion parameter may indicate vascular abnormality in a brain tumor model and reflects an effect of dexamethasone treatment. In addition, X-ray computed tomography (CT) measurements of vascular tortuosity and tissue markers of vascular morphology were performed to investigate the underpinnings of tumor response to dexamethasone.

Development Of A New Evolutionary Algorithm Based On Adaptive Echolocation Applied To A Multi Objective Version Of The Redundancy Allocation Problem, Karla Rocio Gutierrez

Open Access Theses & Dissertations

The intention of this research is to develop a new algorithm that it is mainly focus in the principle of echolocation or also called biosonar. This principle is active in many animals such as: birds, shrews, dolphins and bats, these last ones are going to be a fundamental part of our study. These animals use it as radar in order to find food, obstacles or just to locate objects.

These animals use ultrasound beams with a certain degree of angle and multiple receivers; such as the two ears that are located slightly apart, so at the time of the returning …

Analysis Of Indoor And Outdoor Particulate Matter At Various Residences In The El Paso Region, Joseph Christopher Pinon

Open Access Theses & Dissertations

This thesis is a presentation of particulate matter data collected from February 2007 to June 2008. Personal environment monitors (PEM), which measured 7-day PM2.5 concentrations, had been deployed at 14 homes during the 2007 year and deployed in 16 different homes during the 2008 sampling year. Within each sampling year, sampling occurred for two one-week (7-day) periods during each season. In addition to PEM sampling, a tapered element oscillating microbalance (TEOM) continuous sampler had been deployed in both indoors and outdoors at one pre-selected household per week. Gravimetric, chemical, and black carbon analysis had been performed on the PEM PM2.5 …

A Framework For Strategic Sustainable Supply Chain Design, Abril Paola Vazquez

Open Access Theses & Dissertations

Sustainable supply chain management has raised interest considerably in recent years; due to environmental concerns from society as well industries. There is a high interest in the industries to solve this problem but many of the frameworks are directed to specific situation or structure. A strategic sustainable supply chain design framework is presented with the purpose of providing many companies, including small and big industries, the means to maintain an eco-friendly operation. These include; industry plants, distribution centers, and retailers.

Residential Recycling Study, Richard Adams

Open Access Theses & Dissertations

The purpose of this study is to gain baseline performance figures and statistics for El Paso's curbside recycling program. With these baseline statistics the effectiveness of changes for promotion and outreach can be evaluated once implemented. In addition, operational changes such as to every other week recycling collection rather then every week or a "pay as you throw" system could be evaluated.

A Novel Cable-Driven Robotic Training Improves Locomotor Function In Individuals Post-Stroke, Ming Wu, Jill M. Landry, Sheng-Che Yen, Brian D. Schmit, T. George Hornby, Miriam Rafferty

Biomedical Engineering Faculty Research and Publications

A novel cable-driven robotic gait training system has been tested to improve the locomotor function in individuals post stroke. Seven subjects with chronic stroke were recruited to participate in this 6 weeks robot-assisted treadmill training paradigm. A controlled assistance force was applied to the paretic leg at the ankle through a cable-driven robotic system. The force was applied from late stance to mid-swing during treadmill training. Body weight support was provided as necessary to prevent knee buckling or toe drag. Subjects were trained 3 times a week for 6 weeks. Overground gait speed, 6 minute walking distance, and balance were …

Improved Joining Method For Segmental Prestressed Structures, Ralph Warren Jensen

Open Access Theses & Dissertations

This dissertation addresses the need for more robust and materially efficient structures, specifically structures that absorb higher levels of energy, can self-erect and which have variable reaction capabilities. These structures can take much higher levels of strain and loading compared to current technologies in reinforced concrete and carbon fiber composites. These structures are made using a novel method of joining segmental elements. A great advantage with this segmental structural system is it's survivability under overloaded conditions. During an impact, or concentrated pressure load, the structure will wrap around the impact zone thereby widely distributing the contact stresses. This function or …

Assessment Of Intra-Urban Traffic-Related Air Pollution On Asthmatic Children's Exposure At Schools In The Paso Del Norte Region, Amit Ugamraj Raysoni

Open Access Theses & Dissertations

Traffic-related air pollution can be a major public health concern in any urban area. This problem is compounded in the Paso del Norte region that has experienced rapid economic growth, and a substantial number of people living in close vicinity of major roadways. The desert surroundings, arid weather, frequent temperature inversions, heavy border traffic at the international ports of entry between El Paso and Ciudad Juárez, and poorly maintained vehicle fleet further exacerbates this problem. A growing body of air quality and epidemiologic research has discerned the linkage between traffic emissions and respiratory disorders.

Initial health investigations in the Paso …

Utepcam: A Scalable Wireless Vision Sensor Architecture For Computational, Power And Bandwidth Constrained Scenarios, Ricardo Zepeda

Open Access Theses & Dissertations

UTEPcam is a low cost and power vision sensor node system. UTEPcam is composed of an Atmel atmega32 8-bit microcontroller, a CY7C09099V static RAM chip, an OV6620 CMOS image sensor, a XBEE transceiver and a SD Flash memory card, and four logic gates. UTEPcam's simple yet efficiently architecture enables it to capture video at one frame per second. At its absolute highest, it is estimated that UTEPcam consumes only 1.321 Amps. When in standby, UTEPcam consumes 21 microamps. Furthermore, UTEPcam's program takes up only 1Kbyte of memory space.

UTEPcam's CPU, a simple 8-bit MCU, is unlike most vision sensor node …

Analysis Of Endocrine Disrupting Compounds In Wastewater Treatment Plants: A Perspective Of Trans-Boundary Waterborne Pollution, Roberto De La Torre

Open Access Theses & Dissertations

Recent decades have brought an increasing concern of potential adverse human and ecological health effects resulting from Endocrine Disruptor Compounds (EDCs). In particular from new emerging compounds such as natural estrogens (e.g., 17©¬-estradiol, estrone), synthetic estrogens (e.g., 17Â¥á-ethynylestradiol), bisphenol A (BPA), nonylphenol ethoxylates (NPEOS), and nonylphenol (NP). These chemicals which are also known as organic wastewater contaminants are released directly to the environment after passing through wastewater treatment plants (WWTPs), which often are not designed to remove them from the effluent. The occurrence of the aforementioned compounds in surface water is becoming of increasing concern worldwide, and has led to …

Photocatalytic Destruction Of Halogenated Organic Compounds In Water With A New Photocatalyst, Mabruka Hadidan

Open Access Theses & Dissertations

In this research, a newly developed high surface area semiconductor porous material was synthesized from potassium titanium niobium mixed oxide (KTiNbO5) to be used as a photo catalyst in the presence of UV light to degrade halogenated organic compounds in water. The goal of the project was to investigate the catalytic activity of the material for its effectiveness in the degradation of the halogenated organic compounds, and it is the first investigation of this new photocatalyst with halogenated compounds. Model compounds dichloromethane, 1-chlorobutane, chlorobenzene, and trifluoroacetic acid in aqueous solutions were tested with the photocatalyst under ultraviolet light irradiation, using …

Mixed-Signal Distributed Feature Extraction For Classification Of Wide-Band Acoustic Signals On Sensor Networks, Humberto Santacruz

Open Access Theses & Dissertations

This thesis proposes a distributed/collaborative scheme for the classification of wide-band acoustic events within the context wireless sensor networks (WSNs). The proposed method is characterized by a mixed-signal processing scheme for the extraction of feature vectors which reduces the processing, memory allocation, and power requirements of the sensor nodes. The mixed-signal scheme assumes that nodes have an analog frontend consisting of a microphone, a bandpass filter, a squaring element and an integrator. This chain of components produces an estimate of the energy over the frequency subband extracted by the filter. The WSN has the ability to form a distributed filter …

Bioprinting Oxygen Releasing Microparticles For Improved Cell Tissue Viability, Daniel Reyna

Open Access Theses & Dissertations

A major challenge in regenerative medicine/tissue engineering is the difficulty of providing adequate oxygen to all cells within implanted engineered tissues before full vascularization is achieved. To overcome this limitation, a variety of oxygen-releasing particles have been developed to improve cell and tissue survival. However, most of these particles are used in random mixtures within scaffolding materials, which usually leads to an uneven distribution of oxygen in bioengineered tissues. An ideal oxygen supply requires a precise depositing control of oxygen-releasing particles in scaffolds. Cell bioprinting is a novel tissue fabrication approach, in which the bio-printer can be programmed to deposit …

The Synthesis And Host-Guest Applications Of Synthetic Receptor Molecules, Zachary Richard Osner

Dissertations

Host-guest chemistry involves the complimentary binding between two molecules. Host molecules have been synthesized to bind negative, positive, and neutral molecules such as proteins and enzymes, and have been used as optical sensors, electrochemical sensors, supramolecular catalysts, and in the pharmaceutical industry as anti-cancer agents.1 The field of nanoscience has exploited guest-host interactions to create optical sensors with colloidal gold and Dip-Pen nanolithography technologies. Gold nanoparticles, have been functionalized with DNA, and have been developed as a selective colorimetric detection system, that upon binding turns the solution from a red to blue in color.2

Cyclotriveratrylene (CTV) 1 is a common …

A Shock Tube Technique For Blast Wave Simulation And Studies Of Flow Structure Interactions In Shock Tube Blast Experiments, Nicholas N. Kleinschmit

Department of Engineering Mechanics: Dissertations, Theses, and Student Research

Improvised explosive devices (IED’s) are widely used against US and allied forces fighting in Iraq and Afghanistan. Exposure to IED blast may cause blast-induced traumatic brain injury (bTBI). The injury mechanisms are however not well understood. A critical need in bTBI-related research is the ability to replicate the loading conditions of IED blast waves in a laboratory environment. In this work, experimental studies have been carried out to explore the use of the shock tube technique for generating air shock waves that mimic the temporal and spatial characteristics of free-field blast waves and to investigate the blast wave-test sample interactions …

Development Of Novel Copolyoxetanes: Antimicrobial Agents, Allison King

Theses and Dissertations

This thesis focuses on solution antimicrobial effectiveness for copolyoxetanes with quaternary ammonium and PEG-like side chains. Ring opening copolymerization of 3-((4-bromobutoxy)methyl)-3-methyloxetane (BBOx) and 3-((2-(2-methoxyethoxy) ethoxy) methyl)-3-methyloxetane (ME2Ox) yielded random copolymers with 14-100 (m) mole% BBOx designated P[(BBOx-m)(ME2Ox)]. Reaction of P[(BBOx-m)(ME2Ox)] with dodecyl dimethylamine gave the corresponding quaternary P[(C12-m)(ME2Ox)] polycation salts, designated C12-m. Mole ratios and molecular weights were obtained from 1H-NMR and end group analysis. Differential scanning calorimetry (DSC) studies showed Tg’s between 69 and -34 °C. Minimum inhibitory concentrations (MIC) against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa showed MIC decreasing with increasing C12 mole% reaching a minimum between …

Mechanistic Modeling Of Photocatalytic Water Disinfection, Omatoyo Kofi Dalrymple

USF Tampa Graduate Theses and Dissertations

The main goal of this research was to develop a mechanism-based model for photocatalytic disinfection of bacteria in water using suspended catalyst pthesiss in batch reactors. The photocatalytic disinfection process occurs as a semiconductor photocatalyst, most commonly titanium dioxide (TiO₂), is irradiated with light of wavelength less than 380 nm to produce hydroxyl radicals and other highly reactive oxidants which can inactivate microorganisms. Photocatalytic disinfection involves a complex interaction of many fundamental mechanisms such as light absorption and scattering by semiconductor pthesiss, electrochemical surface reactions, and heterogeneous colloidal stability. Current models, based largely on chemical reacting systems, do …

Accessible Rich Internet Applications: The Search Engine Challenge, Angela Kielthy

Conference papers

The perception that Rich Internet Applications (RIAs) and Accessible Rich Internet Applications (ARIAs) are inaccessible to search engines is perhaps one of the main factors that hinder their wider adoption by the web development community. Recent announcements that RIAs and ARIAs are becoming more search engine friendly is provoking web developers to look for further information and evidence that will support or refute these announcements.

This paper outlines research undertaken and tests performed to establish if RIAs and ARIAs developed using Adobe Flex are crawlable and indexable by the Google search engine by default.

The conclusion drawn from testing is …

Artificial Neural Network Based Fault Location For Transmission Lines, Suhaas Bhargava Ayyagari

University of Kentucky Master's Theses

This thesis focuses on detecting, classifying and locating faults on electric power transmission lines. Fault detection, fault classification and fault location have been achieved by using artificial neural networks. Feedforward networks have been employed along with backpropagation algorithm for each of the three phases in the Fault location process. Analysis on neural networks with varying number of hidden layers and neurons per hidden layer has been provided to validate the choice of the neural networks in each step. Simulation results have been provided to demonstrate that artificial neural network based methods are efficient in locating faults on transmission lines and …

Modeling And Quantitative Analysis Of White Matter Fiber Tracts In Diffusion Tensor Imaging, Xuwei Liang

University of Kentucky Doctoral Dissertations

Diffusion tensor imaging (DTI) is a structural magnetic resonance imaging (MRI) technique to record incoherent motion of water molecules and has been used to detect micro structural white matter alterations in clinical studies to explore certain brain disorders. A variety of DTI based techniques for detecting brain disorders and facilitating clinical group analysis have been developed in the past few years. However, there are two crucial issues that have great impacts on the performance of those algorithms. One is that brain neural pathways appear in complicated 3D structures which are inappropriate and inaccurate to be approximated by simple 2D structures, …

Optimization Of Coagulation And Syneresis Processes In Cheesemaking Using A Light Backscatter Sensor Technology, Tatiana Gravena Ferreira

University of Kentucky Master's Theses

Curd syneresis, a critical step in cheesemaking, directly influences the quality of cheese. The syneresis process is empirically controlled in cheese manufacturing plants. A sensor technology for this step would improve process control and enhance cheese quality. A light backscatter sensor with a Large Field of View (LFV) was tested using a central composite design over a broad range of cheese process conditions including milk pH, calcium chloride addition level, milk fat to protein ratio, temperature, and a cutting time factor (β). The research objectives were to determine if the LFV sensor could monitor coagulation and syneresis steps …

Influence Of Fan Operation On Fan Assessment Numeration System (Fans) Test Results, Gabriela Munhoz Morello

University of Kentucky Master's Theses

The use of velocity traverses to measure in-situ air flow rate of ventilation fans can be subject to significant errors. The Fan Assessment Numeration System (FANS) was developed by the USD-ARS Southern Poultry Research Laboratory and refined at the University of Kentucky to measure air flow of fans in-situ. The procedures for using the FANS unit to test fans in-situ are not completely standardized. This study evaluated the effect of operating fan positions relative to the FANS unit for ten 1.22 m diameter fans in two types of poultry barns, with fans placed immediately next to each other and …

Perch Landing Maneuvers And Control For A Rotating-Wing Mav, Jonathan Louis Lubbers

University of Kentucky Master's Theses

This thesis addresses flight control of the perch landing maneuver for micro-aerial vehicles. A longitudinal flight model is constructed for a pigeon-sized aircraft. In addition to a standard elevator control surface, wing-rotation also considered as a non-standard actuator for increasing low-speed aerodynamic braking. Optimal state and control trajectories for the perch landing maneuver are computed using commercial software. A neighboring optimal control law is then developed and implemented in a set of flight simulations. Simulations are run with both a quasisteady and an unsteady aerodynamic model. The effectiveness of wing rotation and of the neighboring optimal control law is discussed, …

Three Dimensional Modeling And Animation Of Facial Expressions, Alice J. Lin

University of Kentucky Doctoral Dissertations

Facial expression and animation are important aspects of the 3D environment featuring human characters. These animations are frequently used in many kinds of applications and there have been many efforts to increase the realism. Three aspects are still stimulating active research: the detailed subtle facial expressions, the process of rigging a face, and the transfer of an expression from one person to another. This dissertation focuses on the above three aspects.

A system for freely designing and creating detailed, dynamic, and animated facial expressions is developed. The presented pattern functions produce detailed and animated facial expressions. The system produces realistic …