Digital Commons Network^™

Signquote: A Remote Testing Facility For Eliciting Signed Qualitative Feedback, Jerry Schnepp, Rosalee Wolfe, Brent Shiver, John Mcdonald, Jorge Toro

Visual Communications and Technology Education Faculty Publications

Sign synthesis is still an evolving technology and improving it requires the elicitation of qualitative feedback from users. Current options for acquiring qualitative feedback are limited. Face-toface tests conducted in sign language are expensive. On the other hand, remote tests do not use the preferred language of the test participants. A new tool, SignQUOTE, (Signed Qualitative Usability Online Testing Environment) is a configurable, cross platform remote testing system based entirely on sign language. It includes an innovative method for capturing qualitative feedback in sign language via webcam. In a comparison study, participants viewed animations of American Sign Language and gave …

Design, Fabrication, And Implementation Of A Wireless, Passive Implantable Pressure Sensor Based On Magnetic Higher-Order Harmonic Fields, Ee Lim Tan, Andrew Derouin, Brandon D. Pereles, Keat Ghee Ong

Michigan Tech Publications, Part 1

A passive and wireless sensor was developed for monitoring pressure in vivo. Structurally, the pressure sensor, referred to as the magneto-harmonic pressure sensor, is an airtight chamber sealed with an elastic pressure membrane. A strip of magnetically-soft material is attached to the bottom of the chamber and a permanent magnet strip is embedded inside the membrane. Under the excitation of an externally applied AC magnetic field, the magnetically-soft strip produces a higher-order magnetic signature that can be remotely detected with an external receiving coil. As ambient pressure varies, the pressure membrane deflects, altering the separation distance between the magnetically-soft strip …

The Santa Clara, 2024-10-11, Santa Clara University

The Santa Clara

No abstract provided.

Green Residential Stormwater Management Demonstration: An Integrated Stormwater Management And Graywater System To Reduce The Quantity And Improve The Quality Of Residential Water Discharges, Post Co Data Analysis, Ni-Bin Chang, Martin Wanielista, Manoj Chopra, Mike Hardin, Matthew Allen Goolsby

BMP Trains Research and Publications

No abstract provided.

Application Of Engineered Porosity And Modified Effective Moduli To The Design Of Orthopaedic Implants, John Anthony Choren

Dissertations (1934 -)

Commercially available orthopaedic implants have a bending stiffness (flexural rigidity) that is at least 10 times greater than cortical bone. Effects of this stiffness mismatch have been extensively studied relative to total hip arthroplasty (THA). Clinical experience with THA has shown that stiffness mismatch is the primary cause of accelerated bone resorption due to the stress shielding, resulting in sub-optimal bone loading, aseptic loosening and inadequate bone support for a future revision implant.

Attempts to incorporate design features that reduce the flexural rigidity of implants have yielded inconsistent results or failures due to biomaterial incompatibilities and practical manufacturing complications. The …

Investigation Of Spatio-Temporal Effects Of Fmri Visual Field Mapping Techniques On V1, John J. Janik

Dissertations (1934 -)

Blood oxygenation level dependent functional magnetic resonance imaging has been used extensively for mapping the representation of the visual field within the human brain. Visual field mapping using fMRI has been used clinically to assess patients with cortical pathology and to plan surgical treatment impacting the visual system. The accuracy of fMRI-based visual field mapping methods needs to be better understood for clinical use. This accuracy can be important for presurgical mapping of brain function near a tumor resection site since inaccurate rendition of the underlying neural function could lead to inappropriate resection of viable brain tissue. The most widely …

Quantitative Evaluation Of Redox Processes In Intact Rat Lungs And Endothelial Cells And The Effect Of Hyperoxia, Zhuohui Gan

Dissertations (1934 -)

A common initial treatment of hypoxemia in patients with lung failure secondary to acute lung injury (e.g., adult respiratory distress syndrome) is oxygen (O₂) therapy (hyperoxia). However, prolonged O₂ therapy causes lung O₂ toxicity, which can further impair lung functions. The rat model of lung O₂ toxicity replicates key features of human lung O₂ toxicity. In addition, rats develop tolerance or susceptibility to 100% O₂ by pre-exposing them to 85% O₂ (hyper-85) or 60% O₂ (hyper-60) for 7 days, respectively. Therefore, the long-term objectives of this study are to elucidate mechanisms …

Improving Cardiovascular Stent Design Using Patient-Specific Models And Shape Optimization, Timothy J. Gundert

Master's Theses (2009 -)

Stent geometry influences local hemodynamic alterations (i.e. the forces moving blood through the cardiovascular system) associated with adverse clinical outcomes. Computational fluid dynamics (CFD) is frequently used to quantify stent-induced hemodynamic disturbances, but previous CFD studies have relied on simplified device or vascular representations. Additionally, efforts to minimize stent-induced hemodynamic disturbances using CFD models often only compare a small number of possible stent geometries. This thesis describes methods for modeling commercial stents in patient-specific vessels along with computational techniques for determining optimal stent geometries that address the limitations of previous studies.

An efficient and robust method was developed for virtually …

2011 (Fall) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department

ENSI Informer Magazine Archive

The ENSI Informer Magazine published in the fall of 2011.

Experimental Investigation And Cfd Simulation Of Active Damping Mechanism For Propellant Slosh In Spacecraft Launch Systems, Dhawal Leuva

Doctoral Dissertations and Master's Theses

Motion of propellant in the liquid propellant tanks due to inertial forces transferred from actions like stage separation and trajectory correction of the launch vehicle is known as propellant slosh. If unchecked, propellant slosh can reach resonance and lead to complete loss of the spacecraft stability, it can change the trajectory of the vehicle or increase consumption of propellant from the calculated requirements, thereby causing starvation of the latter stages of the vehicle. Predicting the magnitude of such slosh events is not trivial. Several passive mechanisms with limited operating range are currently used to mitigate the effects of slosh. An …

Modification Of Digital Music Files For Use In Human Temporary Threshold Shift Studies, C. G. Le Prell, Q. Yang, J. G. Harris

Electrical and Computer Engineering Faculty Research & Creative Works

An exposure that is reproducible across clinical/laboratory environments, and appealing to subjects, is described here. Digital music files are level-equated within and across songs such that playlists deliver an exposure that is consistent across time. Modified music is more pleasant to listen to than pure tones or shaped noise and closely follows music exposures subjects may normally experience. Multiple therapeutics reduce noise-induced hearing loss in animals, but human trial design is complicated by limited access to noise-exposed subject populations. The development of standard music exposure parameters for temporary threshold shift studies would allow comparison of protection across agents with real-world …

Ranolazine Reduces Ca2+ Overload And Oxidative Stress And Improves Mitochondrial Integrity To Protect Against Ischemia Reperfusion Injury In Isolated Hearts, Mohammed Aldakkak, Amadou K.S. Camara, James S. Heisner, Meiying Yang, David F. Stowe

Biomedical Engineering Faculty Research and Publications

Ranolazine is a clinically approved drug for treating cardiac ventricular dysrhythmias and angina. Its mechanism(s) of protection is not clearly understood but evidence points to blocking the late Na⁺ current that arises during ischemia, blocking mitochondrial complex I activity, or modulating mitochondrial metabolism. Here we tested the effect of ranolazine treatment before ischemia at the mitochondrial level in intact isolated hearts and in mitochondria isolated from hearts at different times of reperfusion. Left ventricular (LV) pressure (LVP), coronary flow (CF), and O₂ metabolism were measured in guinea pig isolated hearts perfused with Krebs-Ringer’s solution; mitochondrial (m) O_{2 …}

A Compressed Sensing Algorithm For Sparse-View Pinhole Single Photon Emission Computed Tomography, Paul Arthur Wolf, Emil Y. Sidky, Taly Gilat Schmidt

Biomedical Engineering Faculty Research and Publications

Single Photon Emission Computed Tomography (SPECT) systems are being developed with multiple cameras and without gantry rotation to provide rapid dynamic acquisitions. However, the resulting data is angularly undersampled, due to the limited number of views. We propose a novel reconstruction algorithm for sparse-view SPECT based on Compressed Sensing (CS) theory. The algorithm models Poisson noise by modifying the Iterative Hard Thresholding algorithm to minimize the Kullback-Leibler (KL) distance by gradient descent. Because the underlying objects of SPECT images are expected to be smooth, a discrete wavelet transform (DWT) using an orthogonal spline wavelet kernel is used as the sparsifying …

A Google Earth-Based Framework For Visualization Of The Chesapeake Bay Operational Forecast System, Gary Lawson

Computational Modeling & Simulation Engineering Theses & Dissertations

For the persons who live near and travel the waters of the Chesapeake Bay, the data provided by the Chesapeake Bay Operational Forecast System (CBOFS) is invaluable. The information provided includes measurements and forecasts of surface wind velocity, water current velocity, salinity levels, water level, and temperature. Currently, this information is freely available on the CBQ_FS website hosted by the National Oceanographic and Atmospheric Administration (NOAA). It is offered as Nowcast, measured data, and Forecast data and is visualized using 2D images which describe a subset of the data in an easy to read chart. However, if the data were …

The Irrigation Sector Shift From Construction To Modernization: What Is Required For Success?, Charles M. Burt

BioResource and Agricultural Engineering

External pressures related to environmental protection, commodity prices, energy availability, larger populations, and climate change have combined to require an immediate and substantial improvement in agricultural irrigation performance. Worldwide progression towards modernized irrigation projects has been uneven and slower than desired, but decades of irrigation modernization development have clarified certain requirements for success, as well as illuminated indicators of project failure. Of particular importance are required shifts within the state and national irrigation bureaucracies, as well as universities.

Comparison Of Four Chip-Seq Analytical Algorithms Using Rice Endosperm H3k27 Trimethylation Profiling Data., Brandon M. Malone, Feng Tan, Susan M. Bridges, Zhaohua Peng

BCoE Publications

Chromatin immunoprecipitation coupled with high throughput DNA Sequencing (ChIP-Seq) has emerged as a powerful tool for genome wide profiling of the binding sites of proteins associated with DNA such as histones and transcription factors. However, no peak calling program has gained consensus acceptance by the scientific community as the preferred tool for ChIP-Seq data analysis. Analyzing the large data sets generated by ChIP-Seq studies remains highly challenging for most molecular biology laboratories.Here we profile H3K27me3 enrichment sites in rice young endosperm using the ChIP-Seq approach and analyze the data using four peak calling algorithms (FindPeaks, PeakSeq, USeq, and MACS). Comparison …

Design And Control Of Flapping Wing Micro Air Vehicles, Michael L. Anderson

Theses and Dissertations

Flapping wing Micro Air Vehicles (MAVs) continues to be a growing field, with ongoing research into unsteady, low Re aerodynamics, micro-fabrication, and fluid-structure interaction. However, research into flapping wing control of such MAVs continues to lag. Existing research uniformly consists of proposed control laws that are validated by computer simulations of quasi-steady blade-element formulae. Such simulations use numerous assumptions and cannot be trusted to fully describe the flow physics. Instead, such control laws must be validated on hardware. Here, a novel control technique is proposed called Bi-harmonic Amplitude and Bias Modulation (BABM) which can generate forces and moments in 5 …

Using Reputation Based Trust To Overcome Malfunctions And Malicious Failures In Electric Power Protection Systems, Jose E. Fadul

Theses and Dissertations

This dissertation advocates the use of reputation-based trust in conjunction with a trust management framework based on network flow techniques to form a trust management toolkit (TMT) for the defense of future Smart Grid enabled electric power grid from both malicious and non-malicious malfunctions. Increases in energy demand have prompted the implementation of Smart Grid technologies within the power grid. Smart Grid technologies enable Internet based communication capabilities within the power grid, but also increase the grid's vulnerability to cyber attacks. The benefits of TMT augmented electric power protection systems include: improved response times, added resilience to malicious and non-malicious …

Extreme Distributions On Intervals, Monchaya Chiangpradit, Wararit Panichkitkosolkul, Hung T. Nguyen, Vladik Kreinovich

Departmental Technical Reports (CS)

One of the main tasks of interval computation is to analyze situations in which we only know the lower and upper bounds on the desired quantity, i.e., we only know an interval that contains this quantity. One of the objectives of such analysis is to make decisions. According to decision theory, a consistent decision making procedure is equivalent to assigning probabilities to different values within each interval. Thus, we arrive at the problem of describing a natural probability distribution on an interval. In this paper, we describe such a distribution for the practically important case of the "weakest link" arrangement, …

Opportunistic Validation Of Sulfur Dioxide In The Sarychev Peak Volcanic Eruption Cloud, S. Carn, T. M. Lopez

Michigan Tech Publications, Part 1

We report attempted validation of Ozone Monitoring Instrument (OMI) sulfur dioxide (SO 2) retrievals in the stratospheric volcanic cloud from Sarychev Peak (Kurile Islands) in June 2009, through opportunistic deployment of a ground-based ultraviolet (UV) spectrometer (FLYSPEC) as the volcanic cloud drifted over central Alaska. The volcanic cloud altitude (∼12-14 km) was constrained using coincident CALIPSO lidar observations. By invoking some assumptions about the spatial distribution of SO 2, we derive averages of FLYSPEC vertical SO 2 columns for comparison with OMI SO 2 measurements. Despite limited data, we find minimum OMI-FLYSPEC differences within measurement uncertainties, which support the validity …

Thirdhand Tobacco Smoke: Emerging Evidence And Arguments For A Multidisciplinary Research Agenda, Georg E. Matt, Penelope J. Quintana, Hugo Destaillats, Lara A. Gundel, Mohamad Sleiman, Brett C. Singer, Peyton Jacob, Jonathan P. Winickoff, Prue Talbot, Suzaynn Schick, Yinsheng Wang, Bo Hang, Manuela Martins-Green, James F. Pankow, Melbourne F. Hovell, Neal L. Benowitz, Virender K. Rehan, Jonathan M. Samet

Civil and Environmental Engineering Faculty Publications and Presentations

There is broad consensus regarding the health impact of tobacco use and secondhand smoke exposure, yet considerable ambiguity exists about the nature and consequences of thirdhand smoke (THS). We introduce definitions of THS and THS exposure and review recent findings about constituents, indoor sorption-desorption dynamics, and transformations of THS; distribution and persistence of THS in residential settings; implications for pathways of exposure; potential clinical significance and health effects; and behavioral and policy issues that affect and are affected by THS. Physical and chemical transformations of tobacco smoke pollutants take place over time scales ranging from seconds to months and include …

Nonholonomic Feedback Control Among Moving Obstacles, Stephen Gregory Armstrong

Doctoral Dissertations and Master's Theses

A feedback controller is developed for navigating a nonholonomic vehicle in an area with multiple stationary and possibly moving obstacles. Among other applications the developed algorithms can be used for automatic parking of a passenger car in a parking lot with complex configuration or a ground robot in cluttered environment. Several approaches are explored which combine nonholonomic systems control based on sliding modes and potential field methods.

Protective Effects Of Milk Phospholipids Against Uv Photodamage In Human Skin Equivalents, Zyra Achay

Master's Theses

The ultraviolet (UV) spectrum has been known to cause damage to skin in varying degrees. UVB radiation (290-320 nm) in particular, has been proven to be highly mutagenic and carcinogenic in many animal experiments compared to either UVA or UVC. The alarming rate of increase in skin cancer incidence has prompted many investigators to pursue other alternatives to sunscreens including changes in lifestyle habits and dietary consumption in order to boost our efforts in tackling this widespread disease. Previous studies employing confocal reflectance, MTT assay and histology suggest that milk phospholipids may possess protective properties against UVB-mediated damage but the …

Impaired Resistance Artery Reactivity Following Arteriogenesis, Michael (Mike) Machado

Biomedical Engineering

No abstract provided.

Computational Simulations Demonstrate Altered Wall Shear Stress In Aortic Coarctation Patients Previously Treated By Resection With End-To-End Anastomosis, John F. Ladisa, Ronak Jashwant Dholakia, Alberto Figueroa, Irene E. Vignon-Clementel, Frandics P. Chan, Margaret M. Samyn, Joseph Richard Cava, Charles A. Taylor, Jeffrey A. Feinstein

Biomedical Engineering Faculty Research and Publications

Background.  Atherosclerotic plaque in the descending thoracic aorta (dAo) is related to altered wall shear stress (WSS) for normal patients. Resection with end-to-end anastomosis (RWEA) is the gold standard for coarctation of the aorta (CoA) repair, but may lead to altered WSS indices that contribute to morbidity.

Methods.  Computational fluid dynamics (CFD) models were created from imaging and blood pressure data for control subjects and age- and gender-matched CoA patients treated by RWEA (four males, two females, 15 ± 8 years). CFD analysis incorporated downstream vascular resistance and compliance to generate blood flow velocity, time-averaged WSS (TAWSS), and oscillatory shear …

The Impact Of Dynamic And Passive Standing On Bone Mineral Density And Appositional Growth In Immobilized Children, Megan Diane Damcott

Dissertations

The first discovery of the potential role that mechanical loading has on determining the strength of bone occurred in 1892. However, for almost a century after this discovery, the specific mechanisms influenced by mechanical loading remained locked in a mysterious 'black box'. Then in the 1960s, the 'black box' was opened and continued work has now unlocked the basic mechanisms involved in mechanical loading and whole-bone strength. This increased knowledge has spurred clinicians and researchers to investigate the impact of weight-bearing interventions on individuals with an increased risk of osteoporosis. The most common weight-bearing clinical intervention used in non-ambulant populations …

Use Of Fluorescent Micropsheres To Measure Coronary Flow Reserve In Rat Animal Model, Riddhi Harsh Shah

Theses

Heart attacks result from reduced or blocked blood flow through major coronary arteries, resulting in permanent damage to heart muscle. Coronary blood flow (CBF) is thus important to measure in experimental animal models of heart disease. A standard method to measure CBF uses tracer microspheres (Ø = 15 µm) injected into the left ventricle that flow through coronary arteries but cannot pass through capillaries and so become trapped in heart muscle. Previously, radioactive or colored microspheres have quantified the number of tracers trapped in the muscle. Fluorescent microspheres offer a more recent and more sensitive measurement mode. However, fluorescent microspheres …

On The Effects Of Graph Based Evolutionary Algorithms For Training Finite State Classifiers, Steven M. Corns

Engineering Management and Systems Engineering Faculty Research & Creative Works

This work presents a method for evolving finite state machines for the classification of polymerase chain reaction primers in mice using graph based evolutionary algorithms. using these machine learning tools we can compensate for many lab, organism, and chemical specific factors that can cause these primers to fail. using Finite State Classifiers can help to decrease the number of primers that fail to amplify correctly. for training these classifiers, fifteen different graph based evolutionary algorithms were used in two different experiments to explore the effects of diversity preservation on the development of these classifiers. by controlling the rate at which …

Runx2 Protein Expression Utilizes The Runx2 P1 Promoter To Establish Osteoprogenitor Cell Number For Normal Bone Formation, Julie C. Liu, Christopher J. Lengner, Tripti Gaur, Yang Lou, Sadiq Hussain, Marci D. Jones, Brent Borodic, Jennifer L. Colby, Heather A. Steinman, Andre J. Van Wijnen, Janet L. Stein, Stephen N. Jones, Gary S. Stein, Jane B. Lian

School of Chemical Engineering Faculty Publications

The Runt-related transcription factor, Runx2, is essential for osteogenesis and is controlled by both distal (P1) and proximal (P2) promoters. To understand Runx2 function requires determination of the spatiotemporal activity of P1 and P2 to Runx2 protein production. We generated a mouse model in which the P1-derived transcript was replaced with a lacZ reporter allele, resulting in loss of P1-derived protein while simultaneously allowing discrimination between the activities of the two promoters. Loss of P1-driven expression causes developmental defects with cleidocranial dysplasia-like syndromes that persist in the postnatal skeleton. P1 activity is robust in preosteogenic mesenchyme and at the onset …

Sustainable Development, Jane Qiong Zhang, Linda Vanasupa

Materials Engineering

This document is a set of learning materials to support the teaching of Sustainable Development issues particularly related to sustainability in engineering. It is designed for the general engineering or science audience. Its design is based on the framework of the Fink Taxonomy of Significant Learning. The document is a fully-editable set of slides in open source format (pptx) that includes references to targeted learning objectives on each slide and annotations in the notes section of each slide.