Digital Commons Network^™

Investigating Potential Novel Angiogenic And Immunogenic Properties Of Heme Oxygenase-1, Carl Antonio Frizell

All ETDs from UAB

INVESTIGATING POTENTIAL NOVEL ANGIOGENIC AND IMMUNOGENIC PROPERTIES OF HEME OXYGENASE-1 According to the American Heart Association and Centers of Disease Control and Prevention, cardiovascular diseases comprise the primary causes of death in the United States. Heme oxygenase-1 (HO-1), an inducible microsomal enzyme, catalyzes the rate limiting step in heme degradation releasing equimolar amounts of biliverdin, iron and carbon monoxide. Importantly, the induction of HO-1 is an adaptive response that affords protection in these disease states and several others. Expression of HO-1 has been demonstrated in several disease states and pathophysiological processes, including ischemia-reperfusion, inflammation and organ transplantation. This protection is …

Modulation Of Morpho-Functional Characteristics Of Astrocytes Using Chemically-Functionalized Water-Soluble Single-Walled Carbon Nanotubes, Manoj K. Gottipati

All ETDs from UAB

In this thesis, I report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power.

Computationally Efficient Finite Element Models Of The Lumbar Spine For The Evaluation Of Spine Mechanics And Device Performance, Sean D. Smith

Electronic Theses and Dissertations

Finite Element models of the lumbar spine are commonly used for the study of spine mechanics and device performance, but have limited usefulness in some applications such as clinical and design phase assessments due to long analysis times. In this study a computationally efficient L4-L5 FSU model and a L1-Sacrum multi-segment model were developed and validated. The FSU is a functional spine unit consisting of two adjacent vertebral bodies, in this case L4 and L5. The multi-segment model consists of all lumbar vertebrae and the sacrum. The models are able to accurately predict spine kinematics with significantly reduced analysis times, …

Development Of Photographic Dynamic Measurements Applicable To Evaluation Of Flapping Wing Micro Air Vehicles, Jeremy C. Murray

Theses and Dissertations

Developments in the area of flapping wing micro air vehicles (FWMAVs) of a small size and with limited range. This has lead to a great deal of interest in biomimetric designs based on flapping wing flyers, including the North American Hawkmoth (Manduca Sexta). By utilizing high speed photography and photogrammetry the dynamic flapping of the wing can be characterized for comparison with mathematical models, namely computational fluid dynamics (CFD) and finite element analysis (FEA).To successfully utilize high speed image capture, a method of successfully digitizing many data points in a short period of time needs to be developed. The effort …

Adapting To Climate Change While Planning For Disaster: Footholds, Rope Lines, And The Iowa Floods, Robert R.M. Verchick, Abby Hall

BYU Law Review

No abstract provided.

Analysis Of Biomass/Coal Co-Gasification For Integrated Gasification Combined Cycle (Igcc) Systems With Carbon Capture, Henry A. Long Iii

LSU New Orleans Theses and Dissertations

In recent years, Integrated Gasification Combined Cycle Technology (IGCC) has become more common in clean coal power operations with carbon capture and sequestration (CCS). Great efforts have been spent on investigating ways to improve the efficiency, reduce costs, and further reduce greenhouse gas emissions. This study focuses on investigating two approaches to achieve these goals. First, replace the subcritical Rankine steam cycle with a supercritical steam cycle. Second, add different amounts of biomass as feedstock to reduce emissions. Finally, implement several types of CCS, including sweet- and sour-shift pre-combustion and post-combustion.

Using the software, Thermoflow®, this study shows that utilizing …

Data Exploration Interface For Digital Forensics, Varun Dontula

LSU New Orleans Theses and Dissertations

The fast capacity growth of cheap storage devices presents an ever-growing problem of scale for digital forensic investigations. One aspect of scale problem in the forensic process is the need for new approaches to visually presenting and analyzing large amounts of data. Current generation of tools universally employ three basic GUI components—trees, tables, and viewers—to present all relevant information. This approach is not scalable as increasing the size of the input data leads to a proportional increase in the amount of data presented to the analyst.

We present an alternative approach, which leverages data visualization techniques to provide a more …

Simvastatin Improves Spinal Fusion In Rats, Bora Bostan, Taner Güneş, Murat Aşçi, Cengiz Şen, Mehmet Halidun Keleştemur, Mehmet Erdem, Reşit Doǧan Köseoǧlu, Ünal Erkorkmaz

Faculty Publications - Mechanical Engineering

Objective: Statins stimulate bone formation by inducing the expression of bone morphogenetic proteins (BMP-2). The aim of our study was to investigate the effects of orally administered simvastatin on spinal fusion in rats. Methods: Twenty rats were randomized into a spinal fusion group (SF) (n=10) or a spinal fusion and oral simvastatin administered group (SFS) (n=10). A spinal fusion was performed between L4-L6 representing two levels. Simvastatin (120 mg/kg/day) was administered orally in the SFS group. The rats were killed at the end of the 12 week study period. Results: Manual palpation revealed two moderate fusions in the SF group. …

Dynamic Coupling Of Multi-Phase Fluids With A Moving Obstacle, Tso-Ren Wu, Chih-Jung Huang, Mei-Hui Chuang, Chung-Yue Wang, Chia-Ren Chu

Journal of Marine Science and Technology–Taiwan

In this paper, we present a two-way coupled moving solid algorithm with discrete element method (DEM) to simulate dynamic fluid-solid interaction. This model allows obstacles moving in the multi-phase fluids to generate realistic motion for both the fluids and obstacles. We discretize the NavierStokes equation using finite volume method (FVM) for the fluid part. The volume-of-fluid (VOF) method is used to track the fluid-fluid and fluid-solid interfaces. This algorithm is useful in the fields of Engineering and Earth Sciences, such as structure collapse and landslide generated tsunamis. Examples of landslide tsunami and floating cubes are demonstrated using the algorithm.

A Novel Device And Nanoparticle-Based Approach For Improving Diagnosis And Treatment Of Pelvic Inflammatory Disease, Natasha Faith Cover

USF Tampa Graduate Theses and Dissertations

Pelvic Inflammatory Disease (PID) is one of the most common causes of morbidity in women. PID is a polymicrobial infection of the female reproductive tract, and is associated with pelvic pain, abnormal uterine bleeding, and tubal damage that can lead to ectopic pregnancies and infertility. It is curable but the effects of PID can be permanent if not properly diagnosed and treated. PID presents as a spectrum of disease and is often missed at early stages; even acute PID can be difficult to diagnose, as there is no single conclusive diagnostic test. Currently, PID is identified and treated syndromically because …

Powersearch: Augmenting Mobile Phone Search Through Personalization, Xiangyu Liu

Computer Science and Computer Engineering Undergraduate Honors Theses

Cell phone has become a fundamental element of people's life. People use it to call each other, browse websites, send text messages, etc. Among all the functionalities, the most important and frequently used is the search functionality. Based on ComScore, in July 2008, Google was estimated to host 235 millions searches per day. However, unlike the search on desktop, the search on cell phone has one critical constrain: battery. Cell phone performing a normal Google search, the battery drains very fast. The reason is that when sending a query to and fetching the results from Google, cell phone keeps communicating …

Physicochemical And Microbiological Quality Of Water From A Pilot Domestic Rainwater Harvesting Facility In Ireland., Sean O'Hogain, Liam Mccarton, Niamh Mcintyre, Jenny Pender, Anna Reid

Articles

DTC Research Group, Dublin Institute of Technology personnel were commissioned in 2005 by the Department of Environment, Heritage and Local Government in Ireland to assess the feasibility of utilising harvested rainwater to replace treated mains water, for non-potable uses. A pilot project was set up. The project involved the design, installation, commissioning and monitoring of rainwater harvesting facilities in a rural housing development. A monitoring program was carried out to examine the physico-chemical and microbiological quality of the harvested rainwater. Harvested rainwater was sampled monthly and tested. Analysis of the harvested rainwater quality showed a consistently high quality of raw …

49th Conference On Senior Engineering Design, College Of Engineering And Applied Sciences

Senior Engineering Design Conference

The 49th Conference on Senior Engineering Design Projects was held on December 6, 2011 at the College of Engineering and applied Sciences on the Parkview Campus of Western Michigan University. The college sponsors the conference to showcase the work of its graduating seniors, who are required to complete a capstone project that puts into practice what they have learned. Many of the projects are sponsored by business and industry.

A Computational Investigation For Potential Improvements, Angela Grujicic

All Theses

Mild traumatic brain injury (mTBI), colloquially known as a concussion, is the most common injury in modern wars. This domination of mTBI is hypothesized to be due to a combination of unconventional explosives and better protection and care of the patients, increasing survivability. While the majority of the body is covered in armor, the head is left relatively unprotected. The current Advanced Combat Helmet (ACH) has been designed to protect the warfighter against ballistic impacts and impacts against a hard surface, with little to no regard to blast loading. Polyureas, a class of microsegregated, elastomeric copolymers, has been shown to …

Ethnic Difference In Healthcare Delivery, Benny Mathew Varghese

Department of Industrial and Management Systems Engineering: Dissertations, Theses, and Student Research

Quality in healthcare is a very important aspect; this is obtained when there is proper care provided to the patients without any discrimination. The healthcare system in the US can be improved in the fields of patient’s care, the amount of money spent and proper advice, if proper responsibilities are taken. Quality has been improving over the years, but the median by which there is an increase is too small. The other main factor is access to the healthcare system, which has over the year, has not progressed. Studies in healthcare quality should be conducted on a regular base, so …

A New Approach To Dynamic Modeling Of Continuum Robots, Nivedhitha Giri

All Theses

ABSTRACT
In this thesis, a new approach for developing practically realizable dynamic models for continuum robots is proposed. Based on the new dynamic models developed, a novel technique for analyzing the capabilities of continuum manipulators to be employed in various real world applications has also been proposed and developed.
A section of a continuum arm is modeled using lumped model elements (masses, springs and dampers). It is shown that this model, although an approximation to a continuum structure, can be used to conveniently analyze the dynamics of the arm with suitable tradeoff in accuracy of modeling. This relatively simple model …

Executable System Architecting Using Systems Modeling Language In Conjunction With Colored Petri Nets In A Model-Driven Systems Development Process, Renzhong Wang, Cihan H. Dagli

Engineering Management and Systems Engineering Faculty Research & Creative Works

This work proposes an executable system architecting paradigm for discrete-event system modeling and analysis through integration of a set of modeling tools, executable formalisms, analytical tools, and animation tools. the essential step is converting SysML-Based specifications into colored Petri nets through a conversion scheme proposed here. Such a paradigm permits rigorous static and dynamic system analysis, as well as formal verification of the behavior and functionality of the SysML-Based design. This paper also compares the capabilities of the proposed executable system architecting paradigm with other executable formalisms. Further, it discusses the basic principles of executable architecture specification and analysis for …

Implementation Of Medicinal Leech Preparation To Investigate The Connection Between The Motor Neuron And Muscle Fiber Via Sharp Electrode Electrophysiology, Chandra Nikole Miller

Master's Theses

There are forty registered organophosphates in the United States and they range from pesticides and insecticides to nerve agents or neurotoxins such as sarin. Organophosphates (OP’s) have been used in chemical warfare for years and tend to lead to death due to an attack on the nervous system. Chemical assays and mass microscopy have been used to assess the concentration of OP’s in the environment, but both methods require the body to metabolize the OP first, which can be detrimental to the victim. It is crucial to come up with a method to investigate and detect these neurotoxins without causing …

Impact Of Collateral Enlargement On Smooth Muscle Phenotype, Alexander Jerome Bynum

Master's Theses

Peripheral Artery Disease is a very serious disease characterized by an arterial occlusion due to atherosclerotic plaques. In response to an arterial occlusion, arteriogenesis occurs, causing smooth muscle cells to transition from a contractile to synthetic state. Also following an arterial occlusion, functional impairment was seen in the collateral circuit. An immunofluorescence protocol was developed in order to assess the impact of collateral enlargement (arteriogenesis) on smooth muscle phenotype at various time points. Smooth muscle α-actin was used to mark all smooth muscle cells, Ki-67 was used to label proliferating smooth muscle cells, and a fluorescent nuclear stain was used …

Water Quality Models For Stormwater Runoff In Two Lincoln, Nebraska Urban Watersheds, Jake Fisher

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Water quality monitoring was conducted in two urban watersheds (Colonial Hills and Taylor Park) located in southeast Lincoln, NE over a three year period spanning from October 2008 through September 2011. In-line probes continuously measured for turbidity, conductivity, dissolved oxygen, and water temperature while other water quality constituents were analyzed for discrete water samples collected using grab and automatic sampling techniques. The water quality data was used to calculate event mean concentrations (EMCs) for sixteen storm events sampled over the duration of the project period. Three types of stormwater quality multiple linear regression models were developed for the estimation of …

Water Quality Monitoring Of An Urban Stream For Total Maximum Daily Load Assessment, Jeffrey K. Mihulka

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

The purpose of this research project was to assess the water quality of an urban stream for total maximum daily load assessment in Omaha, Nebraska. This was accomplished by sampling the water quality at four different sites. These sites included sampling upstream, within, and downstream of the city. These samples were conducted throughout 2010 and 2011.

The results showed that concentrations of Escherichia coli (E. coli) are routinely above established criteria for the state of Nebraska. Concentrations of E. coli that exist in the Papillion Creek Watershed upstream of the City of Omaha have also been shown to be above …

Design, Analysis, And Testing Of In Vivo Surgical Robots, Tyler David Wortman

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Advances in technology have shaped the history of surgical procedures. Recent developments have allowed surgical procedures to become less invasive than traditional open procedures. The transition to Minimally Invasive Surgery (MIS) has resulted in decreased recovery times, improved cosmetic results, and reduced costs. For these reasons, there is interest in further reducing the invasiveness of surgical procedures by accessing the abdominal cavity through a single incision, such as with Laparoendoscopic Single-Site (LESS) surgery. Added complexities, such as unintuitive controls and limited dexterity, prevent the widespread adoption of LESS for complex surgical procedures. Multi-functional in vivo surgical robots have been designed …

Printing Carbon Nanotube Based Supercapacitors For Packaging, Alexandra Hartman

All Theses

Living in a world full of portable electronics, there is great need for energy storage devices. Currently, limitations for storage involve power inefficiencies as well as bulkiness. This is why printable charge storage devices that display good electrochemical performance are needed. It is for this reason that research into the production and packaging of carbon nanotube based super capacitors was carried out.
A super capacitor can be built by using high surface area multi-walled carbon nanotubes suspended in an ionic liquid. The two active electrodes are made from a combination of the multi-walled carbon nanotubes and an ionic liquid, ground …

The Design Of A Haptic Device For Training And Evaluating Surgeon And Novice Laparoscopic Movement Skills, Ryan Bontreger

All Theses

As proper levels of force application are necessary to ensure patient safety, and training hours with an expert on live subjects are difficult, enhanced computer-based training is needed to teach the next generation of surgeons. Considering the role of touch in surgery, there is a need for a device capable of discerning the haptic ability of surgical trainees. This need is amplified by minimally invasive surgical techniques where a surgeon's sense of tissue properties comes not directly through their own hands but indirectly through the tools. A haptic device capable of producing a realistic range of forces and motions that …

Modeling Impacts Of Foothills Parkway Construction On Stream Water Quality Using Real-Time Remote Monitoring, Clark Chewning

All Theses

ABSTRACT
The need to monitor surface water quality has been increasingly recognized in recent years in environmental and natural resource management. The advent of real-time remote monitoring technologies has accelerated and enhanced this process. Field observations of water quality data are able to be conducted and analyzed in ways that were previously unavailable.
The objectives of this research were to deploy and test a real-time remote monitoring system for three small watersheds (Hembree, Dunn, and Rudd Hollows) in the Great Smoky Mountains. The watersheds ranged in size from 12 to 19 ha. Real-time remote monitoring stations were established in three …

Robust Design And Monitoring Tools For Sustainable And Resilient Structural Design And Infrastructure Management, Sarah Dalton

All Theses

Structural systems are subject to inherent uncertainties due to the variability in many hard-to-control `noise factors' that include but are not limited to external loads, material properties, and construction workmanship. Two design methodologies have been widely accepted in the practicing engineering realm to manage the variability associated with operational structures: Allowable Stress Design (ASD) and Load and Resistance Factor Design (LRFD). These traditional approaches explicitly recognize the presence of uncertainty; however, they do not take robustness against this uncertainty into consideration. Overlooking this robustness against uncertainty in the structural design process has two drawbacks. First, the design may not satisfy …

Beyond Lean: Simulation In Practice, Charles R. Standridge Ph.D.

Open Textbooks

Lean thinking, as well as associated processes and tools, have involved into a ubiquitous perspective for improving systems particularly in the manufacturing arena. With application experience has come an understanding of the boundaries of lean capabilities and the benefits of getting beyond these boundaries to further improve performance. Discrete event simulation is recognized as one beyond-the-boundaries of lean technique. Thus, the fundamental goal of this text is to show how discrete event simulation can be used in addition to lean thinking to achieve greater benefits in system improvement than with lean alone. Realizing this goal requires learning the problems that …

Vortex Tilting And The Enhancement Of Spanwise Flow In Flapping Wing Flight, Spencer Frank

HIM 1990-2015

In summary the tilting mechanism helps to explain the overall flow structure and the stability of the leading edge vortex.; The leading edge vortex has been identified as the most critical flow structure for producing lift in flapping wing flight. Its stability depends on the transport of the entrained vorticity into the wake via spanwise flow. This study proposes a hypothesis for the generation and enhancement of spanwise flow based on the chordwise vorticity that results from the tilting of the leading edge vortex and trailing edge vortex. We investigate this phenomenon using dynamically scaled robotic model wings. Two different …

Investigation On Interactions Of Unsteady Wakes And Film Cooling On An Annular Endwall, Matthew J. Golsen

HIM 1990-2015

In recent decades, greater interest in the effect of rotational wakes on gas turbine film cooling applications has produced increasing numbers of studies on these unsteady phenomena. Wakes are primarily shed from upstream components such as transition duct walls, stator vanes, and rotors. Studies have shown that in areas of unsteady flow, the best performing parameters in conventional steady investigations may not be the best for unsteady applications. One common method of modeling the unsteady wake interaction in subsonic flows is the use of spoke wheel type wake generators using cylindrical rods to produce the velocity detriment and local increase …

Development Of A Simulation Tool For Analysis Of Freeway Crashes Due To Cell Phone Usage, Sourabh Sriom

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research shows that drivers are susceptible to numerous distractions while driving which can be held responsible as the reason of a crash. Usage of cell phones, i.e. talking or texting while driving is considered one of the prominent distractions which causes a crash. This dissertation aims to study the number of crashes occurring on the freeways and their relation with the drivers of these cars using cell phones while they are driving. Since crashes occur relatively less frequently, the study of crashes is done using what is called the "rare event" theory. Java based simulations are done to model a …