Digital Commons Network^™

Oral Delivery Of Peptide Drugs For Mitigation Of Crohn's Disease, Paul Blichmann

All Theses

Protein drugs are typically administered intravenously, but this practice has clear disadvantages such as widespread circulation and swift clearance from the body. Orally delivered protein drugs are not yet available but potentially offer improved distribution, retention, and activity by use of protective matrices and cell-specific targeting. Much work has been done on delayed release formulations for the upper intestine, but there has not been overwhelming evidence of protection of peptides from gastric conditions. In many instances the large intestine may be a better release target due to lower proteolytic activity. Afflictions of the colon such as Inflammatory Bowel Disease and …

The Formulation Of A Bone Targeted Drug Delivery System Of Poly(Glycolic Acid)-Poly(Ethylene Glycol) Coated Hydroxyapatite Nanoparticles For The Delivery Of Statins, Erika Jelen

All Theses

Bone is a form of mineralized connective tissue that provides strength and rigidity to the skeleton. The two primary components within bone tissue are an organic extracellular matrix, containing type I collagen, and an inorganic mineral component composed mainly of calcium phosphate hydroxyapatite crystals. Over time the microarchitecture of bone can break down due to a variety of different factors, mainly the onset of osteoporosis in post-menopausal women, Paget's disease, and the experience of a loss of gravity during space flight. Currently there are about ten million people in the United States alone suffering from osteoporosis.
The prevention of further …

Experimental Studies Of Vertical Mixing In An Open Channel Raceway For Algae Biofuel Production, Ram Sudheer Voleti

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The USU BioEnergy Center has been successful in developing algae feedstocks for renewable biofuels and bioproducts. The concept is to utilize and maximize algae feedstocks for liquid transportation fuels, biomass for burning and digestion, and high value co-products. It is theorized that increasing the mixing in open and closed algal production systems improves the productivity of the algae culture. A raceway cultivation system was chosen to examine the phenomena of mixing. Vertical mixing will provide more uniform exposure to sunlight for all of the algae in the raceway. The main focus of this research was to increase vertical mixing. Delta …

Design And Testing Of A Biological Microelectromechanical System For The Injection Of Thousands Of Cells Simultaneously, Gregory Herlin Teichert

Theses and Dissertations

The ability to inject DNA and other foreign particles into cells, both germ cells (e.g. to produce transgenic animals) and somatic cells (e.g. for gene therapy), is a powerful tool in genetic research. Nanoinjection is a method of DNA delivery that combines mechanical and electrical methods. It has proven to have higher cell viability than traditional microinjection, resulting in higher integration per injected embryo. The nanoinjection process can be performed on thousands of cells simultaneously using an array of microneedles that is inserted into a monolayer of cells. This thesis describes the needle array design requirements and the fabrication process …

Nox Control Systems And Methods For Controlling Nox Emissions, Maruthi Devarakonda, Gordon Parker, John Johnson

Michigan Tech Patents

An exhaust aftertreatment system comprising a selective reduction catalyst, a NO_x sensor or an NH₃ sensor, a urea injector, and a dosing control unit, wherein the dosing control unit calculates the rate of urea injection by estimating the concentrations of NO and NO₂ in the exhaust downstream of the SCR catalyst.

The Effect Of A Navigational Aid On Training Of A Minimally Invasive Surgery Camera Task, Ketan Vidwans

Theses and Dissertations

Minimally Invasive Surgery (MIS) differs from Open Surgery as surgeons view the surgical site indirectly on a monitor. The view shown is typically from an angled endoscope off to one side of the surgery (i.e., uncollocated with the view of the hands). This makes camera navigation a challenging ability to learn. MIS thus requires longer training periods, more practice and mental effort to achieve proficiency. Current training setups and Operating Room (OR) environments lack appropriate real-time visual cues for navigation and other perception related information that could help with learning and performance in the OR. The purpose of this research …

Use Of Building Information Modelling In Responding To Low Carbon Construction Innovations: An Irish Perspective., Barry Mcauley, Alan V. Hore, Roger West

Conference papers

At present the Irish construction industry is facing one of its most uncertain and challenging periods and will see major cuts in all areas of the economy in 2012. Despite this, Ireland pushes forward in sustainability initiatives with the Government ruling that environmentally-friendly policies are to get priority in competing for State contracts worth up to €16 billion a year. This and further initiatives are in place, so as to reduce greenhouse gas emissions by up to 20% by the year 2020.By the end of 2018 the public sector must own or rent only buildings with high energy-saving standards and …

Development Of Magnetic Fabrics With Tunable Hydrophobicity, Thu Ho

Theses and Dissertations

Polystyrene (PS) fiber mats incorporating iron (Fe) particles were fabricated by electrospinning and the hydrophobicity of the resulting magnetic fabrics was investigated with and without an applied magnetic field. The results show that the hydrophobicity (as measured using water droplet contact angle) increases in the presence of a magnetic field and the hysterisis in the advancing/receding contact angle (a measure of the stickiness of the surface) decreases in the presence of a magnetic field. It is also shown that the contact angle and hysterises increase with decreasing fiber diameter and mat thickness.

Life History Switch Point Plasticy In Response To Pond Drying Alyers Metamorph Allometry And Jumping Performance, Julie Charbonnier

Theses and Dissertations

Animals with complex life cycles can cope with environmental uncertainty by altering life history switch points through developmental plasticity. Pond drying is an important factor which may alter life history switch points in aquatic organisms. Many amphibians can plastically respond to changes in pond drying by emerging earlier, but few studies have examined the post-metamorphic consequences for performance. To investigate the potential carry-over effects of plasticity to pond drying, we studied the túngara frog, Physalaemus pustulosus, a tropical anuran that breeds in highly ephemeral habitats. We conducted a field study with three different water depth treatments in 60 L mesocosms …

Design, Analysis And Testing Of Haptic Feedback System For Laparoscopic Graspers In In Vivo Surgical Robots, Nikhil Salvi

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Laparo-Endoscopic Single Site (LESS) Robotics Surgery is an advanced technology in the field of Minimally Invasive Surgery (MIS). The LESS surgical robots significantly improve the surgeon’s accuracy, dexterity and visualization, and reduce the invasiveness of surgical procedure results in faster recovery time and improved cosmetic results. In a standard robotic endosurgery, the palpation of tissues is performed by laparoscopic graspers located at the end effectors. The master-slave configuration in robotic surgery leads in remote access to the operation site. Therefore, surgeon’s ability to perceive valuable sensory information is severely diminished. Sensory information such as haptics, which is essential for safe …

Data Consistency And Conflict Avoidance In A Multi-User Cax Environment, Robert Aaron Moncur

Theses and Dissertations

This research presents a new method to preserve data consistency in a multi-user CAx environment. The new method includes three types of constraints which work by constraining and controlling both features and users across an entire multi-user CAx platform. The first type of constraint includes locking or reserving features to enable only one user at a time to edit a given feature. The second type of constraint, collaborative feature constraints, allows flexible constraining of each individual feature in a model, and the data that defines it. The third type of constraint, collaborative user constraints, allows the constraining of user permissions …

Lock And Hold Structured Light Illumination, Laurence G. Hassebrook, Daniel L. Lau, Charles J. Casey

Electrical and Computer Engineering Faculty Patents

A method, system, and associated program code, for 3-dimensional image acquisition, using structured light illumination, of a surface-of-interest under observation by at least one camera. One aspect includes: illuminating the surface-of-interest, while static/at rest, with structured light to obtain initial depth map data therefor; while projecting a hold pattern comprised of a plurality of snake-stripes at the static surface-of-interest, assigning an identity to and an initial lock position of each of the snake-stripes of the hold pattern; and while projecting the hold pattern, tracking, from frame-to-frame each of the snake-stripes. Another aspect includes: projecting a hold pattern comprised of a …

A Portable Wireless Particulate Sensor System For Continuous Real-Time Environmental Monitoring, James A. Hall Jr., Sin Ming Loo, Dale Stephenson, Ross Butler, Michael Pook, Joshua Kiepert, Jordan Anderson, Nicholas Terrell

Electrical and Computer Engineering Faculty Publications and Presentations

Airborne particulate matter has been shown to be associated with morbidity and mortality, and may interfere with certain sensitive experiment. Understanding the levels and movements of particulate matter in an enclosed space can lead to a reduction in the impact of this material on health and experimental results. A system of environmental sensors including particulate matter, selected gasses, humidity, temperature, and pressure can be used to assist in tracking air movement, providing real-time mapping of potential contaminants as they move through a space. In this paper we present a system that is capable of sensing these environmental factors, collecting data …

A Critical Examination Of The Construct Validity Of The Tti Performance DnaTm Survey For The Purpose Of Differentiating The Entrepreneurially-Minded Engineer, Sandra L. Dietrich

Master's Theses and Doctoral Dissertations

The United States needs workers with more than technical skills to meet the demands of global competition; more specifically, a new breed of engineer is necessary, one who possesses leadership skills and business acumen in addition to the technical engineering skills. One Midwestern foundation has recognized this challenge and is working with engineering universities to enhance programs to create entrepreneurially-minded engineers (EMEs). To this end, the Target Training International, Ltd. (TTI) Performance DNATM survey has been developed to measure the behaviors, values, and professional skills of these EMEs. Currently, the Foundation has collected data using this survey with engineering students …

Culvert Roughness Elements For Native Utah Fish Passage: Phase Ii, Suzanne Kim Monk

Theses and Dissertations

Native fishes have become an increasingly important concern when designing fish passable culverts. Many operational culverts constrict waterways which increase velocities and prevent upstream passage of small fish species. The current method to ensure fish passage is to match the average cross sectional velocity to the sustained swim speed of the fish. This study investigates the passage rates of leatherside chub (Lepidomeda aliciae) and speckled dace (Rhinichthys osculus) at three sites (an arch culvert with substrate bottom, box culvert with bare bottom, and a stream section with no culvert) located on Salina Creek near Salina, UT. It was found that …

Interdisciplinary Modeling: Water-Related Issues And Changing Climate - New Mexico State University, Laurel Saito, Alexander Fernald, Timothy Link

All ECSTATIC Materials

Graduate course in interdisciplinary modeling: water-related issues and climate change offered at University of Nevada, Reno in Summer 2012.

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing, Navid Djassemi

Master's Theses

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing

Navid Djassemi

Tissue engineering blood vessel mimics has been proposed as a method to analyze the endothelial cell response to intravascular devices that are used in today’s clinical settings for the treatment of cardiovascular disease. Thus, the development of in vitro blood vessel mimics (BVMs) in Cal Poly’s Tissue Engineering Lab has introduced the possibility of assessing the characteristics of cellular response to past, present, and future intravascular devices that aim at treating coronary artery disease.

This thesis aimed at improving the methods and procedures utilized in …

The Double Pendulum: Construction And Exploration, Benjamin J. Knudson

Physics

The exploration of a nonlinear mechanical system, the Double Pendulum, a physical pendulum on the end of a physical pendulum, using analytic and experimental approaches. Also included discussion of the design and construction of the Double Pendulum apparatus to work with Vernier LabPro and LoggerPro. The apparatus outputs live data of the angles to a LoggerPro which collects and produces time evolution graphs as well as a corresponding animation lending itself to comparison with theoretical models. Normal mode frequencies are found both analytically and experimentally for the the general (real) double pendulum. Examples of both simple (periodic) and complex (chaotic) …

A Large-Scale Mathematical Model Of The Rat Pulmonary Circulation And The Effect Of Chronic Hypoxia, Loolu Rafeeq

Master's Theses (2009 -)

Mathematical models are useful for developing understanding of the behavior of complex biological systems. Recent work on a “physiome” project is aimed at using computational modeling to analyze integrative biological function by developing a simulation system for hypothesis testing (Borg & Hunter, 2003). To date, extensive work on cardiovascular, endocrine and nervous system models has been undertaken. Our objective here is to contribute to this effort by further developing a comprehensive integrative model of the pulmonary circulation. A computational model of the dog pulmonary circulation was originally developed by Haworth et al. (Haworth S. T., 1996; Haworth, Linehan, Bronikowski, & …

Relating Methanogen Community Structure And Function In Anaerobic Digesters, Benjamin T.W. Bocher

Dissertations (1934 -)

A deeper understanding of how microbial community structure relates to process function would help improve anaerobic digester design. This dissertation describes both qualitative and quantitative relationships between anaerobic digester function and microbial community structure. Community structure was characterized using banding pattern intensities from denaturing gradient gel electrophoresis (DGGE) for the mcrA gene of methanogenic Archaea. The first project compared a single-stage continuously mixed stirred tank reactor (CSTR) and staging with an acidogenic CSTR followed by a methanogenic CSTR. After seeding with the same biomass, these unique process configurations exhibited different function and qualitatively different methanogen communities. Compared to a single-stage …

Life Cycle Boundaries And Greenhouse Gas Emissions From Beef Cattle, Quentin M. Dudley

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Beef cattle are estimated to directly contribute 26% of U.S. agricultural greenhouse gas (GHG) emissions, and future climate change policy may target reducing these emissions. Life cycle assessment (LCA) of GHG emissions from U.S. feedlot beef cattle was conducted to compare methods of the U.S. Environmental Protection Agency (EPA) with a more complete evaluation of emissions. The inclusion of emissions from crop production for feed, associated land use change, and other minor factors nearly doubled GHG emissions associated with beef feedlots from the EPA Annual Inventory estimate of 1611 kgCO₂e hd^-1 yr^-1 to 3182 ± 167 …

Integration Of Eeg-Fmri In An Auditory Oddball Paradigm Using Joint Independent Component Analysis, Jain Mangalathu Arumana

Dissertations (1934 -)

The integration of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) can contribute to characterizing neural networks with high temporal and spatial resolution. The overall objective of this dissertation is to determine the sensitivity and limitations of joint independent component analysis (jICA) within-subject for integration of ERP and fMRI data collected simultaneously in a parametric auditory oddball paradigm. The main experimental finding in this work is that jICA revealed significantly stronger and more extensive activity in brain regions associated with the auditory P300 ERP than a P300 linear regression analysis, both at the group level and within-subject. The results …

Quantitative Biomechanical Evaluation Of Upper Extremity: Strain Behavior Of The Humerus Diaphysis Under Loading, Prateek Grover

Dissertations (1934 -)

While mechanical behavior of the adult human lower extremity long bones under loading has been studied extensively, the same is not true for the adult human humerus. Mechanical data reported for cadaveric humeri and anatomic humerus models are limited to stiffness and rigidity. Strain characteristics of the humerus diaphysis as a function of loading provide a valuable addition to the currently limited knowledge. The objective of this dissertation was to accomplish this goal, using numerical/finite element (FE) methods applied to a standard anatomic humerus model (Reference-Humerus) that was developed from the NIH Visible Human Project for this purpose. Four phases …

Demand Responsive Signal Control Strategy (Drsc) Incorporating Queue Length Information In Real-Time Signal Control, Rahul Rajbhara

Civil & Environmental Engineering Theses & Dissertations

Most of the existing vehicle detection systems, namely inductive loops, video cameras etc. are incapable of measuring the queue lengths at signalized intersections. However, with the advent of modern technology, newer detection methods such as probe vehicles equipped with wireless communications (Connected Vehicles), particularly under the Vehicle Infrastructure Integration [52), and radar detection currently provide this capability [53). This thesis presents a Demand Responsive Signal Control Strategy (termed as DRSC) for an isolated signalized intersection. The control strategy incorporates real-time queue length information (obtained from probe vehicles) into the signal control logic. Demand based maximum green time for each upcoming/new …

Nonlinear Mechanical Behavior Of The Human Common, External And Internal Carotid Arteries In Vivo, Alexey Kamenskiy, Yuris A. Dzenis, Jason N. Mactaggart, Thomas G. Lynch, Syed A. Jaffar Kazmi, Iraklis I. Pipinos

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction—The mechanical environment and properties of the carotid artery play an important role in the formation and progression of atherosclerosis in the carotid bifurcation. The purpose of this work was to measure and compare the range and variation of circumferential stress and tangent elastic moduli in the human common (CCA), external (ECA) and internal (ICA) carotid arteries over the cardiac cycle in vivo.

Methods—Measurements were performed in the surgically exposed proximal cervical CCA, distal ECA and distal ICA of normotensive patients (n = 16) undergoing carotid endarterectomy. All measurements were completed in vivo over the cardiac cycle …

Development Of In Vitro Tissue Engineered Blood Vessel Mimics In Complex Geometries For Coronary Stent Testing, Robert Dalton Chavez

Master's Theses

Coronary heart disease is the leading cause of death in the United States and occurs when plaque occludes coronary arteries. Coronary stents, which may be used to treat coronary occlusions, are small metal tubes that are implanted in coronary arteries to restore blood flow. After stent implantation, endothelial cells grow over the stent so that blood contacts the endothelial cells instead of the stent surface; this event is known as re-endothelialization. Re-endothelialization prevents blood from clotting on the stent surface and is a good predictor of stent success. Blood vessel mimics (BVMs) are in vitro tissue engineered models of human …

Characterization Of Tight Junction Formation In An In-Vitro Model Of The Blood-Brain Barrier, Michael Robert Machado

Master's Theses

Active and passive transport of substances between the microcirculation in the brain and the central nervous system is regulated by the Blood-Brain Barrier (BBB). This barrier allows for chronic and acute modulation of the CNS microenvironment, and protects the brain from potentially noxious compounds carried in the circulatory system. In-vitro modeling of the BBB has become the target of much research over the past decade, as there are many unanswered questions regarding modulations in the permeability of this barrier. Additionally, the development of a practical and inexpensive model of the BBB would facilitate a much more efficient drug development process. …

Development And Characterization Of An In-House Custom Bioreactor For The Cultivation Of A Tissue Engineered Blood-Brain Barrier, Amin Hadi Mirzaaghaeian

Master's Theses

The development of treatments for neurological disorders such as Alzheimer’s and Parkinson’s disease begins by understanding what these diseases affect and the consequences of further manifestation. One particular region where these diseases can produce substantial problems is the blood-brain barrier (BBB). The BBB is the selective diffusion barrier between the circulating blood and the brain. The barrier’s main function is to maintain CNS homeostasis and protect the brain from the extracellular environment. The progression of BBB research has advanced to the point where many have modeled the BBB in vitro with aims of further characterizing and testing the barrier. Particularly, …

Evaluation And Development Of Unmanned Aircraft (Uav) For Udot Needs, Steven L. Barfuss, Austin Jensen, Shannon Clemens

Publications

This research involved the use of high-resolution aerial photography obtained from Unmanned Aerial Vehicles (UAV) to aid the Utah Department of Transportation (UDOT) in monitoring and documenting State Roadway structures and associated issues. Using geo-referenced UAV high resolution aerial photographic imagery, the project documented the before, during and after stages of the Southern Parkway construction near the new Saint George International airport, in addition to photographing and classifying wetland plant species in the Utah Lake wetland mitigation bank on the North East corner of Utah Lake.

Design And Implementation Of The Kinect Controlled Electro-Mechanical Skeleton (K.C.E.M.S), Jason Richard Ekelmann

Doctoral Dissertations and Master's Theses

Mimicking real-time human motion with a low cost solution has been an extremely difficult task in the past but with the release of the Microsoft Kinect motion capture system, this problem has been simplified. This thesis discusses the feasibility and design behind a simple robotic skeleton that utilizes the Kinect to mimic human movements in near real-time. The goal of this project is to construct a 1/3-scale model of a robotically enhanced skeleton and demonstrate the abilities of the Kinect as a tool for human movement mimicry. The resulting robot was able to mimic many human movements but was mechanically …