Digital Commons Network^™

Imine Crosslinked, Injectable, And Self-Healing Fucoidan Hydrogel With Immunomodulatory Properties, Asma Talib Qureshi, Shajia Afrin, Saad Asim, Muhammad Rizwan

Michigan Tech Publications

Biomaterials with inherent anti-inflammatory properties and the ability to foster a pro-regenerative environment hold significant promise for enhancing cell transplantation and tissue regeneration. Fucoidan, a sulfated polysaccharide with well-documented immune-regulatory and antioxidant capabilities, offers strong potential for creating such biomaterials. Yet, there is a lack of engineered fucoidan hydrogels that are injectable and provide tunable physicochemical properties. In this study, the ability of fucoidan to undergo periodate-mediated oxidation is leveraged to introduce aldehydes into backbone (oxidized fucoidan, OFu), enabling the formation of reversible, imine-crosslinks with amine-containing molecules such as gelatin. The imine-crosslinked OFu-gelatin hydrogel provided excellent control over gelation rate …

Measuring The Effects Of The Leaves On Stalk Strength And Dynamic Response In Maize, Grant C. Ogilvie

Theses and Dissertations

Maize is one of the most widely cultivated grains in the world, making it crucial to world food security and important economically. One major problem in maize production is stalk lodging (greensnap), which results in billions of dollars in lost harvests annually for maize farmers in the US alone. Understanding the mechanical properties of maize plants is crucial to addressing this problem. Previous studies have suggested that the leaf blades and leaf sheaths affect maize mechanical properties. The objectives of this thesis are twofold: to present measurement techniques for the stalk bending strength, damping ratio, and natural frequency of maize …

Hybrid Treatment Method Of Biofiltration Preceded With Advanced Oxidation Process For The Removal Of Emerging Contaminants From The Wastewater Treatment Plant Effluent, Anjali Mohan Payathuparambil

Thesis/ Dissertation Defenses

Renewable energy systems face significant challenges in ensuring stability, efficiency, and The global demand for potable quality water has been on a continuous rise. Consequently, water reuse is now considered as an alternative to significantly expand supplies of freshwater in communities facing water shortages. Most of the conventional wastewater treatment plants (WWTP) are not efficient in the removal of emerging contaminants from the water, which will cause serious issues to the environment, human and animal life. This research investigated the possibilities of treating wastewater for reuse. First, the feasibility of utilizing a biofiltration system without pre-treatment for removing emerging contaminants …

Using Human Computation And Harmonic Expansions For Characterization And Design Of Grain Boundary Networks, Christopher W. Adair

Theses and Dissertations

Grain Boundary Networks (GBNs) are a high-dimensional feature in polycrystalline microstructural materials that are formed from the crystallographic degrees of freedom. This feature affects multiple material properties such as diffusivity, fracture, elasticity, heat transfer, and others. The link between the crystallography and the material properties is called the structure-property linkage, and allows for simulation and design of materials. While it is possible to use the structure-property linkage to design materials for better performance, the high-dimensional nature of the interconnected grain boundaries preclude the use of many common optimization algorithms for efficiency or local minima considerations. This work shows how the …

Enhancing Frequency Event Detection In Power Systems Using Two Optimization Methods With Variable Weighted Metrics, Hussain A. Alghamdi, Midrar A. Adham, Umar Farooq, Robert B. Bass

Electrical and Computer Engineering Faculty Publications and Presentations

This research presents a novel technique that refines the performance of a frequency event detection algorithm with four adjustable parameters based on signal processing and statistical methods. The algorithm parameters were optimized using two well-established optimization techniques: Grey Wolf Optimization and Particle Swarm Optimization. Unlike conventional approaches that apply equally weighted metrics within the objective function, this work implements variable weighted metrics that prioritize specificity, thereby strengthening detection accuracy by minimizing false-positive events. Realistic small- and large-scale frequency datasets were processed and analyzed, incorporating various events, quasi-events, and non-events obtained from a phasor measurement unit in the Western Interconnection. An …

Applications Of Clustered Regularly Interspaced Short Palindromic Repeats In Food Security And Nutraceuticals, Rukayat Abiodun Oyegoke, Jahswill Toluwanimi Osifade, Adenike Temidayo Oladiji

Al-Bahir

The CRISPR/Cas9 system is a revolutionary genome-editing tool that enables precise and inheritable modifications, transforming plant genetic engineering. Previous literature has indicated that, in agriculture, CRISPR has improved crop yield, biofortification, and resistance to environmental stressors, fostering resilient and high-yielding crops essential for sustaining a growing global population. In nutraceuticals, CRISPR has enhanced the biosynthesis of bioactive compounds such as anthocyanins, flavonoids, and omega-3 fatty acids, improving the nutritional and therapeutic value of crops.

Despite its immense potential, CRISPR technology faces technical, ethical, and regulatory challenges, including off-target effects, accessibility concerns, and public acceptance. Addressing these issues is crucial for …

Sustained Release Of Antifibrotic Nintedanib From Polymer Microparticles Reduces Dosing Frequency While Reducing Inflammation In Murine Idiopathic Pulmonary Fibrosis, Emmanuel Einyat Opolot, Filip Goshevski, Rahul Chaudhary, Horst A. Von Recum, Amar B. Desai

Faculty Scholarship

Purpose: Idiopathic pulmonary fibrosis (IPF) is a life-threatening, progressive lung disease with limited therapeutic options, often resulting in poor patient outcomes. Current treatments, such as Nintedanib (NTB) and Pirfenidone (PFD), require frequent administration, leading to adverse effects and low patient adherence. The purpose of this study was to investigate a sustained-release drug delivery system utilizing microparticles (MPs) composed of insoluble beta-cyclodextrin (β-CD) polymers to enhance the bioavailability and extend the release of NTB and PFD. Methods: A multidisciplinary approach, including in silico modeling, in vitro assays, and in vivo studies, was employed to assess the efficacy of β-CD-polymer MPs as …

Sustainable Poultry Farming: A Concept Of Iot-Based Poultry Management System For Small-Scale Farmers, Ayodeji Akinsoji Okubanjo, Ignatius Kema Okakwu, Olufemi Peter Alao, Nurudeen Samuel. Lawal, Ayoola Abiola Babalola, Abisola Olayiwola

Al-Bahir

Conventional poultry management techniques are failing to meet increased demand for poultry products as the population continues to grow. As a result, this issue has become a major concern for small-scale farmers, particularly those in low-income areas, in terms of food security. One of the main reasons for this is that the farmers rely on intensive farming methods which are inefficient for automating daily poultry operations. However, intensive farming methods pose major environmental concerns to ecosystems and poultry health. Also, the environmental conditions, welfare, and productivity of poultry operations may be harmed by the global climate crisis and poultry waste …

Visualizing Chattanooga’S Freeway Accidents: An Interactive Dashboard Built On Us National Laboratory Data*, Joshy Kasahara

Campus Research Month

Despite the availability of a freeway accident dataset collected by Oak Ridge National Laboratory, National Renewable Energy Laboratory, and Tennessee Department of Transportation (TDOT), there is no interactive visualization of the data that is easily accessible to the public. Consequently, the local community's awareness of accident trends is very limited. The contribution of this research project is a dashboard that allows the visualization of traffic accidents patterns in Chattanooga, Tennessee, using datasets from national laboratory researchers. By creating an interactive web dashboard with animated and color-mapped geographical map, the project seeks to enhance community awareness of accident trends.

Utilizing Enzymatic Microalgae Hydrolysates For Cellular Agriculture, Maelyn Andreasen, Sophia Hessami, Eli Sheley, Elise Barton

Student Research Symposium

UPSIDE Foods is working to produce chicken products to address the growing global food insecurity crisis.¹ Industrial scalability is limited due to the requirements of cell culture. Through collaboration with the company, we are working to supplement their existing media to drive costs down and improve cell viability.

Aqueous Extracts Of Zingiber Officinale Rhizomes And Hibiscus Sabdariffa Leaves Enhanced Plasmodium Berghei-Infected Mice's Hematological Parameters., Fatimah Aluko Abubakar, Raliat Abimbola Aladodo, Aremu Abubakar

Al-Bahir

Malaria remains a global health challenge, leading to severe hematological complications. Natural alternatives such as Zingiber officinale and Hibiscus sabdariffa, known for their antioxidant and bioactive properties, are being investigated for their therapeutic potential. This study examines the hematological benefits of Z. officinale and H. sabdariffa in mice infected with the common malaria research model, NK65 chloroquine-sensitive Plasmodium berghei. Forty-two albino mice, averaging 24.5 ± 1.23g, were randomly divided into six groups. Mice in group A were uninfected which served as the normal control group. Mice in groups B, C, D, E, and F were inoculated intraperitoneally with P. …

Cyber Physical Emulation Of Power Grids: Co-Simulation Of Exata Cps And Hypersim, Mckayla Snow

Electrical and Computer Engineering ETDs

This thesis explores the use of cyber-physical emulation of power grids to analyze the impact of different types of cyberattacks. It outlines the co-simulation process of HYPERSIM and EXata CPS within the OPAL-RT real-time digital simulator, demonstrating various cyberattacks on two power system models. The first model is a simple communication-focused testbed for easy demonstration of co-simulation setup, while the second is a power system model of a secondary network used to assess the cybersecurity of network protector units in low-voltage networks through a hardware-in-the-loop (HIL) testbed. Using this testbed, the cybersecurity of the direct transfer trip (DTT) scheme is …

A Neutrosophic Micro Vague Correlation Measure: Application To Multi-Criteria Decision Making Problems, Vargees Vahini T, Trinita Pricilla M

Neutrosophic Systems with Applications

Statistical methods called correlation measures are employed to express the degree of association or relationship between two variables. The correlation coefficient which may be computed in a variety of ways is the most often used kind of correlation measure in many disciplines including biology, psychology, economics, and finance. Knowing the correlations between variables is essential for analysis and decision-making. This paper aims to commence a novel type of correlation measure called Neutrosophic Micro vague Correlation Measure and Neutrosophic Micro Vague Weighted Correlation Measure. Further demonstrates the implementation of the Neutrosophic Micro Vague correlation measure in the MCDM Problem. By adopting …

Improved Estimator For Population Mean Utilizing Known Medians Of Two Auxiliary Variables Under Neutrosophic Framework, Rajesh Singh, Shobh Nath Tiwari

Neutrosophic Systems with Applications

In the context of classical statistics, the estimation of the population mean is done with determinate, precise, and crisp data when auxiliary information is available. However, there are instances where dealing with uncertain, indeterminate, and imprecise data in interval form is required. To overcome this issue, Florentin Smarandache introduced neutrosophic statistics as a novel approach. This paper introduces a neutrosophic modified ratio-cum-product log-type estimator for the estimation of the population mean using known medians of two auxiliary variables in the neutrosophic context. The bias and mean squared error (MSE) for the proposed estimators are computed to the first-order approximation. The …

Some Graph Parameters For Superhypertree-Width And Neutrosophictree-Width, Takaaki Fujita, Florentin Smarandache

Neutrosophic Systems with Applications

Graph characteristics are often studied through various parameters, with ongoing research dedicated to exploring these aspects. Among these, graph width parameters—such as treewidth—are particularly important due to their practical applications in algorithms and real-world problems. A hypergraph generalizes traditional graph theory by abstracting and extending its concepts [77]. More recently, the concept of a SuperHyperGraph has been introduced as a further generalization of the hypergraph. Neutrosophic logic [133], a mathematical framework, extends classical and fuzzy logic by allowing the simultaneous consideration of truth, indeterminacy, and falsity within an interval. In this paper, we explore Superhypertree-width, Neutrosophic treewidth, and t-Neutrosophic tree-width.

Mbj-Neutrosophic Structure Applied To Bp-Algebras: Bp-Subalgebras And Α-Ideals, Bavanari Satyanarayana, Shake Baji, Anjaneyulu Naik K.

Neutrosophic Systems with Applications

In this article, we introduce the concepts of MBJ-neutrosophic BP-subalgebras and MBJ-neutrosophic α-ideals in BP-algebra by applying MBJ-neutrosophic logic to algebraic structure BP-algebra. We prove that the intersection of two MBJ-neutrosophic α-ideals and the inverse image of an MBJ-neutrosophic α-ideal are also MBJ-neutrosophic α-ideals. Furthermore, we prove an MBJ-neutrosophic set is an MBJ-neutrosophic BP-subalgebra if and only if its level sets are BP-subalgebras.

Solving N-Players Continuous Differential Games Under Neutrosophic Environment, M. G. Brikaa

Neutrosophic Systems with Applications

Uncertainty plays a crucial role in decision-making problems, particularly in game theory. Various forms of uncertainty have been explored in the literature, including fuzzy, soft, rough, and interval-based approaches. Game theory has been extensively studied under these uncertainty models, with researchers addressing vagueness, and imprecision from multiple perspectives. More recently, neutrosophic sets have emerged as an alternative framework for handling uncertainty. Neutrosophic numbers effectively incorporate indeterminacy in decision-making by considering factors such as intuition, assumptions, judgment, behavior, evaluation, and preferences of decision-makers. This paper presents a novel approach to solving a new class of n-player continuous differential games within a …

Einstein Aggregate Operators Under Q-Rung Orthopair Fuzzy Hypersoft Sets With Machine Learning, Muhammad Gulistan, Muhammad Abid

Neutrosophic Systems with Applications

Thailand with its impressive 15.5% global share of renewable energy production, has a small 1% share of bitcoin mining. At the same time, the country is dealing with the severe effects of climate change, which emphasizes the necessity of taking proactive steps to solve environmental issues. This research integrates machine learning techniques and Einstein Aggregate Operators under q-rung orthopair fuzzy hypersoft set (q-ROFHS)-based multi-criteria decision-making technique to present a new method for analyzing CO₂ impacts and mitigation solutions in Thailand. We evaluate the environmental impacts of bitcoin mining and the incorporation of renewable energy sources using an interdisciplinary framework, …

Neutrosophic Automata And Its Algebraic Properties, Anil Kr. Ram, Anupam K. Singh

Neutrosophic Systems with Applications

This research endeavors to elucidate the interrelationships among various classes of operators, including neutrosophic successor/neutrosophic source/neutrosophic core operators of neutrosophic automata based on neutrosophic resituated lattices. Furthermore, it delves into the characterization of algebraic properties such as neutrosophic subsystem, neutrosophic connectivity, and neutrosophic separability of a neutrosophic automaton using these operators. Finally, we study the concepts of neutrosophic primaries of the given neutrosophic automata using neutrosophic core operators.

An Approach For Hybridizing N-Subalgebra With Quantified Neutrosophic Set Using G-Algebra, Neha Andaleeb Khalid, Muhammad Saeed

Neutrosophic Systems with Applications

Neutrosophic sets are a generalized form of fuzzy sets as well as intuitionistic fuzzy sets, as they address the uncertainty factor as an independent component along with truthfulness and falsity. However, traditional neutrosophic approaches often struggle with effectively managing and quantifying indeterminate elements in complex algebraic structures. To address this limitation, this paper employs an expanded version of the neutrosophic set, incorporating a subalgebra. The proposed research is multifaceted: firstly, the new concept of N-Subalgebra (NSU) is proposed. This is the modified setting in the family of subalgebras whose proposed name is the representation of the author's initial name. Secondly, …

Impulse, Spring 2025, Jill Fier, Micayla Standish, Jerome J. Lohr College Of Engineering

Impulse (Jerome J. Lohr College of Engineering Publication)

2 | Faculty, Staff Honored
4 | The State of Lithium
6 | 100 Years of Ag and Biosystems Engineering
8 | Major Milestones
12 | Distinguished Engineer Geldert-Murphy
14 | Distinguished Engineering Heitkamp
16 | By the Numbers
18 | Space Grant Consortium at SDSU
20 | Healthcare Systems Engineering Program
22 | Ridgway Three-Peat
23 | Aerospace Club Launches
24 | Power and Energy Scholarships
25 | More Take Part in Nasa Challenges
26 | Weber Recognized as Student Leader
30 | Wild Hare Racing Ready
32| Sebern’s Success as Sole Operator
34 | Meink: From Prairie to …

Turning Farm Waste Into Energy: Pragmatic Approaches For Cleaner Midwestern American Communities, Rebecca Gaisie

Selected or Submitted Student Research Papers/Projects

Mismanagement of farm waste in the Midwest of the United States has resulted in significant methane emissions, water contamination, and public health concerns. The present manure management rules are still inconsistent, underfunded, and insufficient to motivate individuals to behave in a way that benefits the environment, despite increasing concerns about the environment. This policy study investigates anaerobic digestion as a potential means to convert waste into energy that could support rural and environmental development. Some of the problems with the federal and state legislation examined in this study under an EPI framework are a lack of incentives, inadequate technical support, …

Pajaro River Levee Remedial Design For Climate Resiliency, Anna Krebs, Karina Martin, Olivia Leonardis

Civil, Environmental and Sustainable Engineering Senior Theses

With climate change causing extreme weather events, low-income, underrepresented residents living in Pajaro, California need a more resilient flood mitigation solution because existing infrastructure– the Pajaro River Levee– has recently failed. A hydraulic analysis and overtopping analysis was performed to evaluate potential levee cross sections for a 1.7 mile stretch along the Pajaro River in California. These cross-sections were assessed based on both their material costs and ability to provide sufficient evacuation time.

Zooplankton Protect Viruses From Sunlight Disinfection, J. A. Wang, O. Aryal, L. N. Brownstein, H. Shwwa, A. L. Rickard, A. E. Stephens, M. Lanzarini-Lopes, Niveen S. Ismail

Engineering: Faculty Publications

Sunlight disinfection is an important inactivation process for enteric viruses in water. Understanding how dark biotic processes, such as zooplankton filter feeding, impact sunlight disinfection for viruses has important implications for public health. This research quantifies the uptake of MS2, a model for enteric viruses, by the filter feeder Branchionus plicatilis (rotifer) and the effects of such uptake on subsequent sunlight inactivation of MS2. Experiments co-incubating MS2 with rotifers showed 2.6 log viral removal over 120 hours. Viable virus was recovered from rotifer bodies after co-incubation, indicating incomplete viral inactivation via ingestion. When live rotifers were co-incubated with MS2 and …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Shear-Thinning Hydrogel For Delayed Delivery Of A Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling, Joshua E. Mealy, William M. Torres, Lisa A. Freeburg, Shayne C. Barlow, Alison A. Whalen, Chima V. Maduka, Tarek Shazly, Jason A. Burdick, Francis G. Spinale

Faculty Publications

No abstract provided.

Cybermapping Solutions: A Unified Approach In Us/Nato Military Applications And Development, Nicholas Macrino

Electrical & Computer Engineering Projects for D. Eng. Degree

[First paragraph] Cyber threats are evolving in complexity and frequency, posing significant challenges for cybersecurity professionals in identifying, categorizing, and responding to attacks in real time. Unlike traditional warfare, where battlefield awareness is based on fixed geographic warfare, cyber operations involve abstract attack vectors, non-linear threat escalation, and rapidly changing network conditions. Modern cyber threats, such as advanced persistent threats (APTs), polymorphic malware, and distributed denial-of-service (DDoS) attacks, require adaptive visualization techniques that provide real-time awareness and facilitate rapid decision-making. However, existing symbology standards, such as MIL-STD-2525D, were not designed to accommodate the dynamic nature of cyber warfare. The inability …

Aimr-Brainstorm: Ai-Enhanced Interactive Mixed Reality For Collaborative Ideation, Yuchuan Ma

Dartmouth College Master’s Theses

This study investigates the potential of an AI-enhanced Mixed Reality (MR) brainstorming system, named AIMR-Brainstorm, in comparison to traditional sticky notes for creative ideation. By integrating real-time idea extraction through ChatGPT with immersive, physics-based visualizations, the system aims to transform analog brainstorming workflows into dynamic, interactive digital experiences. Using a within-subject experimental design, 30 participants engaged in paired brainstorming sessions with both AIMR and sticky notes. Quantitative measures of efficiency, engagement, creativity, and user satisfaction were collected through between-session and post-study surveys, while qualitative feedback provided additional insights into user experiences. Conclusively, while traditional sticky notes were generally preferred for …

Analysis Of Responder-Involved Struck-By Crashes, Jacob Wilhelm

Doctoral Dissertations and Master's Theses

Emergency responders face significant risks of injury and death from struck-by crashes while operating on or near roadways. Annually, about 50 responders are killed, and hundreds more are injured, leading to operational disruptions and damage to life-saving equipment (ERSI, 2024). This study takes a data-driven approach to identify key risk factors and effective countermeasures for reducing the severity of struck-by crashes. Key findings indicate that struck-by crashes most frequently occur on weekends during late-night hours (2 AM–4 AM), often at crash scenes or disabled vehicle scenes on limited-access highways. Driver behavior – particularly “D” drivers (distracted, drugged, drowsy, disgruntled) – …