Digital Commons Network^™

Mental Toll, Madison Abood

Community Reflections

This is a short reflection on my experience with Covid-19, virtual school, and anxiety throughout the pandemic. This is a reflection of the years 2020 and early 2021.

Senior Night, Anonymous

Community Reflections

This content refelcts on my experience because as the world seemed to be going back to normal, COVID-19 ruined my special night of senior year in 2021 that I looked forward to since being a freshman.

Covid Stress, Anonymous

Community Reflections

My COVID-19 experience was definitely something that I will never forget. At the time with me working in the healthcare field, being a CNA. It brought much stress and especially chaos. After coming home from long shifts helping with elderly patients who were sickened by covid, it definitely was hard to see and it took a toll on me.

Byproduct Of Covid, Anonymous

Community Reflections

No abstract provided.

Covid- 19 Reflection, Anonymous

Community Reflections

I wrote about what was going through my head and what I want people to know about how it affected me.

Covid Pandemic Reflection, Anonymous

Community Reflections

At first feelings of shock, confusion and disappointment started flooding my mind, but over'me as more and more media coverage on the virus surfaced this original two week shut down became a much more serious and scary reality. At first so called “zoom school” didn’t seem so bad, but then the crushing realiza'on of not being able to go out, see friends or even show our faces without a mask quickly came over me.

Hidden Benefit, Anonymous

Community Reflections

During the COVID-19 pandemic, everything that was normal for me was no longer normal.

My Covid Blessing, Anonymous

Community Reflections

If you asked the 7.8 billion people who were alive during covid about their experience during isolation, you would hear 7.8 billion different stories because every single person experienced something new . Everyone was subject to their own homes and had to deal with whatever their family situation was like. For me personally, my family was pretty fortunate to have no deaths due to covid, however, the rollercoaster of emotions that the time period had put us all on is indescribable.

Covid 19 And The Plague, Anonymous

Community Reflections

As time went on being so isolated started to take a toll mentally. Going into the summer the restrictions started to lighten up and I was able to see my friends outside for the first time in months. Many people were still very scared of getting covid, my parents included.

A New Way Of Living, Anonymous

Community Reflections

Life was very different for me as a high school student during the Covid-19 epidemic. It was a frightening moment when a virus that no one understood suddenly engulfed the whole planet. One of the significant adjustments was going to school.

Covid, Cancer And Chaos, Anonymous

Community Reflections

Right before COVID, my mother was diagnosed with stage three colon cancer, and needed to undergo chemotherapy while quarantining at home. During quarantine, people’s stories were that they stayed inside all day and did nothing, but for me, it was the complete opposite. My mom was very sick and weak, which meant that me and my sisters needed to step up.

Covid-19'S Impact On My Final Two Years Of High School, Robert Bevilacqua

Community Reflections

This document primarily concerns COVID-19's impact on my final two years of high school (NY) and its repercussions on my academic career.

Remembering Covid, Anonymous

Community Reflections

My content expresses how I felt during the time of the Covid lockdown. I reflect back on my emotions during March 2020, and what life was like during that time. I also reflected on the fact that life was different in different parts of America. New York vs. Florida during peak Covid time was like living in two completely different worlds, which is explained in more detail in the document.

Impact Of Quarantine, Anonymous

Community Reflections

Quarantine was quite the defining moment in my life and when I reflect back on almost 3 years ago now I can recognize that their were negative and positive moments as well.

Challenging Breast Cancer Through Novel Sulfonamide–Pyridine Hybrids: Design, Synthesis, Carbonic Anhydrase Ix Inhibition And Induction Of Apoptosis., Amira Khalil, Nashwa H. Zaher, Reham Mm Elhazek, Ahmed E. Gouda, Marwa G. Elgazzar

Pharmacy

Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide–pyridine hybrids (2–12) were designed, synthesized and biologically evaluated for their potential use in targeting breast cancer. Methods & results: The para chloro derivative 7 reported the highest cytotoxic activity against the three breast cancer cell lines used. In addition, compound 7 was found to induce cell cycle arrest and autophagy as well as delaying wound healing. The IC50 of compound 7 against carbonic anhydrase IX was 253 ± 12 nM using dorzolamide HCl as control. Conclusion: …

How I Want Future Generations To Remember Covid-19, Anonymous

Community Reflections

For the future generations, I want them to know that COVID-19 wasn’t just “two weeks off from school”, I want them to know and realize that life was troublesome for many people and families still haven’t recovered years later.

Covid- 19, Anonymous

Community Reflections

Many aspects of our daily lives were thrown into disarray because of the COVID-19 pandemic. Even until January 2023, no one knew what true, long-term consequences it would have. It would introduce new customs that many of us had never experienced before, like wearing masks, keeping six feet apart, and not shaking each other's hands to introduce ourselves. We have not seen such an outbreak since the 1980s with HIV and AIDS in the U.S., where there was so much paranoia within our society that we were constantly sanitizing our hands and quarantining when someone was infected with COVID-19.

My Covid Lesson, Anonymous

Community Reflections

What was supposed to be a two-week break turned into months of quarantining and not seeing any of my close friends. Covid-19 was hard on many people. During this time, I found who I am on my own.

Covid Birthday, Anonymous

Community Reflections

Covid 19 was a shock to us all. No one knew what to expect. It was a new way of living for everyone.

My Brutal Covid Experience, Anonymous

Community Reflections

Within weeks, Covid 19 was present in the United States. It affected everyone in the world. Nobody knew what to do at the start of this, and nobody completely knew what was going on.

My Account Of Covid- 19, Ryan Anonymous

Community Reflections

It was March 13, 2020, when the first encounter happened. The Coronavirus was still new to many of us, so we really did not know the true severity that this virus had in store. One morning, during second period, the entire school was called down to the auditorium for an impromptu assembly. With the recent closings of neighboring schools, we were certain that we were the next to close; everyone was ecstatic.

Covid 19 And Other Pandemics, Anonymous

Community Reflections

The Coronavirus was a global pandemic that spread from China to the United States in March 2020. In March, it was announced to us that the United States had to go into lockdown for two weeks. Little did we know that this two-week lockdown was going to turn into almost a year. This news was found to be very surprising by everyone because it has been so many years since we had a pandemic that affected everyone.

Family Experience, Anonymous

Community Reflections

It started with whispers in the hallway. Hearing rumors from peers that we would have two weeks off from school and then return to share stories from those glorious 14 days. In hindsight, it was naïve to think that Covid-19 would have such little impact on my life, but it eventually struck my family as it did thousands of others.

Remembering Covid, Anonymous

Community Reflections

This is a short reflection on my experience as a firefighter during the COVID-19 pandemic.

My Covid Experience, Anonymous

Community Reflections

Each person today has had such different covid experiences, in this paragraph I will be going into depth my own covid experience. My sophomore year of high school, I was homeschooled, taking classes at home for months due to several different circumstances.

My Covid Reflection, Anonymous

Community Reflections

March 2020 is a year that I will never forget. Covid-19 was becoming more known, but it did not affect my dance team trip. My team and I were in Orlando, Florida for NDA Dance Nationals. I felt so drained and feverish, a sickness I have never had before.

Covid Reflection, Anonymous

Community Reflections

The Covid-19 pandemic was an unforgettable time in the lives of anybody who had the ability to form memories. It was an absolutely unprecedented event that scared the entire world into locking themselves inside for months at a time to avoid risk of a very dangerous condition that could affect anybody enough to hospitalize them. When many of us who lived through this era think about the pandemic, we can reflect on it as a time when the world stopped moving.

Improving Traditional Registrational Trial End Points: Development And Application Of A Desirability Of Outcome Ranking End Point For Complicated Urinary Tract Infection Clinical Trials, Jessica Howard-Anderson, Toshimitsu Hamasaki, Weixiao Dai, Deborah Collyar, Daniel Rubin, Sumathi Nambiar, Tori Kinamon, Carol Hill, Steven P Gelone, David Mariano, Takamichi Baba, Thomas L Holland, Sarah B Doernberg, Henry F Chambers, Vance G Fowler, Scott R Evans, Helen W Boucher

Faculty, Staff and Student Publications

BACKGROUND: Traditional end points used in registrational randomized, controlled trials (RCTs) often do not allow for complete interpretation of the full range of potential clinical outcomes. Desirability of outcome ranking (DOOR) is an approach to the design and analysis of clinical trials that incorporates benefits and risks of novel treatment strategies and provides a global assessment of patient experience.

METHODS: Through a multidisciplinary committee of experts in infectious diseases, clinical trial design, drug regulation, and patient experience, we developed a DOOR end point for infectious disease syndromes and demonstrated how this could be applied to 3 registrational drug trials (ZEUS, …

Association Of Circulating Mtdna With Cvd In Hemodialysis Patients And In Vitro Effect Of Exogenous Mtdna On Cardiac Microvascular Inflammation, Zhen Fan, Ya Feng, Li Zang, Yi Guo, Xiao-Yi Zhong

Faculty, Staff and Student Publications

BACKGROUND: Chronic kidney disease (CKD) patients sustain a fairly high prevalence of cardiovascular disease (CVD). Microvascular inflammation is an early manifestation of CVD, and the released mitochondrial DNA (MtDNA) has been proposed to be a crucial integrator of inflammatory signals. Herein, the aim of this study was to determine the relationship between CVD, microvessel, and circulating MtDNA in the settings of uremia.

METHODS: Forty-two maintenance hemodialysis (MHD) patients and 36 health controls were enrolled in this study. Plasma cell-free MtDNA was detected by TaqMan-based qPCR assay. CVD risk markers including high-sensitive C-reactive protein (Hs-CRP), monocyte chemoattractant protein-1 (MCP-1), fibrinogen, and …

Combination Sodium Nitrite And Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity In A “2-Hit” Murine Model, Kyle B. Lapenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, David J. Lefer

School of Medicine Faculty Publications

BACKGROUND: Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). Other studies have suggested that endothelial NO synthase (eNOS) dysfunction and attenuated NO bioavailability contribute to HFpEF morbidity and mortality. We sought to further investigate dysregulated NO signaling and to examine the effects of a NO-based dual therapy (sodium nitrite+hydralazine) following the onset of HFpEF using a “2-hit” murine model. METHODS AND RESULTS: Nine-week-old male C57BL/6 N mice (n=15 per group) were treated concurrently with high-fat …