Digital Commons Network^™

Du Undergraduate Showcase Abstracts: Research, Scholarship, And Creative Works, Kabe Aberle, Nadia Kako, Kateri Mcrae, Brooke Agulnek, Sky Palmon, Yasmine Ramirez, Francisca Aguirre Beltran, Ashley Juarez, Bridget Kim, Tessa Appel, Sterling Kerr, Spencer Ingley, Gabe Meyer, Robin Tinghitella, Dale Broder, Lily Baeza, Chloe Beers, Julia Coakley, Whitney Kelsey, Sydney Gainforth, Gabi Wing, Audrey Martin, Aaliyah Amore Berry, Brooke Watley, Kiruthika Venkatesan, Rachel Bienstock, Annabella Brotherston, Madison Bryant, Mia Burgener, Emma P. Lieb, Rachel A. Johnson, Jennifer L. Hoffman, Kania Campbell, Kiena Campbell, Courtney Cassidy, Sage Krzyzkowski, Maddox Jones, Skylar Abookire, Luke Hawkins, Sunnah Yoon, Andrea Chu, Yan Qin, Nyah Cubbison, Brian Gearity, Daniel Mcintosh, Mariely Cruz, Edward Garrido, Grady Dionne, Nicole Doris, Lyndsie Salvagio, Ann-Charlotte Granholm-Bentley, Anna Dymov, Hannah Eckert, Gabrielle Welsh, Erica Larson, Charlie Ernst, Anna Zhou, Sarah Watamura, Larissa Fedorovich-Klein, Georgie Fields, Kimberly A. Guevara, Aven Mccall, Ben Peltier, Feruz Yahia, Patrick Flores, Jadyn Floyd, Sophia Forcier, J. Von R. Monteza, Peter Sokol-Hessner, Gwendolyn Geiger, Scott Nichols, Camryn Gunter, Kendal Hengst, Charlie Bednarz, Issy Garside, Addison Baker, Rachel Mina, Brooke Hermanson, Amanda Klingler, William Highfill, Sydney Jaques, Kerstin Lewey, Allison Grossery, Daniel Linseman, Ethan Lim, Jagger Livengood, Owen Mantelli, Gabby Pappas, Abby Mcdonald, Madeleine Dierking, Eve Miller, Emma Loeber, Anna Marlow, Michael Kerwin, Ella Mathews, Hillary Hamann, Khadija Mohamed, Vivian Nguyen, Gabri Notov, Ifunayachi Ogbonna-Ukuku, Sunil Kumar, Charles Baysah, Sarah Olson, Don Sullivan, Anna Paradiso, Jay Parrish, Mira Pronobis, Alisha Pravasi, Kerstin Haring, Diego Ramirez, Christopher Reardon, Juliana Ramirez, Casey Doherty, Ella Kestner, Teagan Weindel, Cate Billings, Pablo Torre-Walter, Lucy Rand, Samantha Reynolds, Mark Siemens, Khadeeja Rashid, Laine Satterlee, Piper Heilbronner, Lily Pound, Ben Whitehurst, Anna Respet, Lizzie Lesoing, Sydney Hertel, Aya Saad-Masri, Brooke Ballenger, Max Proske, Hannah Rosenberg, Ellia Nakahara, Sophia Espinoza, Ivan Woolhouse, Simon Ruland, Gorkem Er, Timothy Sweeny, Melaku Saketa, Michela Schenk, Maren Lynch, Madi Hamm, Grace Schroeder, Michelle Rozenman, Rana Seif, Jackson Hall, Marisela Simental, Daniel Paredes, Aaron Mena, Preston Spaan, Evelyn Stovin, David Andrew Swartz, Anh Tran, Daniel Pittman, Luke Farchione, Emily Boyer, Ukari Verner, Lacey Conrad, Jonathan Velotta, James Weiner, Jagger Gossett, Noah Sherry, Sam Proud, Ben Block, Avi Narayana, Zoey Weiss, Alyssa Wilson, Gabrielle Walsh, David Zonana, Keely Wright, Kena Riveria, Lillybelle Deer, Jena Doom, Elysia Davis, Isabelle Yaremenko, Caitlyn Young

DU Undergraduate Research Journal Archive

Abstracts from the DU Undergraduate Research Showcase.

Positive And Negative Parity States Of 226-236th Isotopes, Ali A. Mezban, Falih H. Al-Khudair

Karbala International Journal of Modern Science

The level scheme of the ^226-236Th nuclei is analyzed using the Interacting Boson Model (IBM-1). The ground state band (g. s.-band), beta band (β-band), gamma band (γ-band) have been described in the sd model space. To calculate the negative parity energy levels, the model space is extended to sdf by adding the f-boson (L=3). A sequence of states in energy bands up to 3.5 MeV has been obtained. The decay of negative states below 1 MeV built on an octupole vibration modes is investigated. The transition probabilities in-band and inter-band are calculated using the wave function of the …

Implementing A Sustainability Approach By Converting Plastic Bottle Waste From A Mischievous Substance To A Beneficial Material By Means Of Zero Residue Level Concept, Younus Mohammed Abed, Fatima Allawi, Shahad Mudhafar Ali, Salem Jawad Alhamd, Thekra Atta Ibrahim, Mohammed Nsaif Abbas

Karbala International Journal of Modern Science

Plastic waste represents a serious environmental and health hazard due to its non-biodegradability and toxic leachates. This study investigates the potential conversion of plastic waste into a sustainable raw material for producing a useful substance. This investigation focuses on repurposing PET beverage bottles—a major contributor to microplastic pollution—into high-value activated carbon (AC) for water treatment, aligning with circular economy principles. The chemical preparation method for AC using phosphoric acid as an activating agent was evaluated. Results demonstrated the successful conversion of 68% of plastic waste into AC under the following conditions: pyrolysis temperature of 700°C, pyrolysis time of 7 hours, …

Correction: Turn-On Fluorescent Glucose Transport Bioprobe Enables Wash-Free Real-Time Monitoring Of Glucose Uptake Activity In Live Cells And Small Organisms, Monica S. Hensley, David Hutchings, Abdelrahman Ismail, Micaela Rayne Geborkoff, Thomas Werner, Marina Tanasova

Michigan Tech Publications

Correction for “Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms” by Monica S. Hensley et al., RSC Chem. Biol., 2025, 6, 987–995, https://doi.org/10.1039/D4CB00239C.

The authors regret that two contributors, Micaela Rayne Geborkoff and Professor Dr Thomas Werner, were inadvertently omitted from the original author list of this article. Both individuals made significant contributions to the research reported.

Micaela Rayne Geborkoff was involved in the design, planning, and execution of the Drosophila experiments, specifically in the growth and treatment of fruit fly larvae. Professor Dr Thomas Werner provided …

Synthesis And Evaluation Of Novobiocin Analogues As Potential Inhibitors Of Polymerase Theta Polθ In Dna Damage And Repair, Mohammed Essam Albuhluli

Theses and Dissertations

Killing tumors while leaving normal cells unharmed is the goal of precision cancer therapy, a challenging feat that is enabled by targeting tumor-specific vulnerabilities [1]. Targeting Polθ potentiates PARP inhibitors (PARPi) in specifically killing homology-directed repair (HDR)-deficient tumor cells and re-sensitize PARPi resistant tumor cells [1]. The induced essentiality between Polθ and HDR-deficiency underscores the value of Polθ as a therapeutic target in the context of tumors with HDR genetic mutations [1]. The helicase-like domain (HLD) is a super family 2 (SF2)-type domain with DNA-dependent ATPase activity [1]. We previously discovered that the antibiotic NVB acts as an inhibitor of …

Purification Of Uranium Tetrafluoride Using Ammonium Bifluoride, Kyle R. Foster, Juliano Schorne-Pinto, Ronald E. Booth, Annabelle Husek, Mina Aziziha, Hunter B. Tisdale, Bernie W.N. Fitzpatrick, Hans Conrad Zur Loye, Markus H.A. Piro, Theodore M. Besmann

Faculty Publications

A method of purification for UF₄ utilizing NH₄HF₂ was investigated to remove oxygen and hydrate impurities from the salt. The original salt exhibited a melting point at 915–920 °C, which corresponds to the eutectic temperature of the UF4-UO2 system, showing clear signs of oxygen contamination. To purify the salt, an air-tight reaction vessel inside an argon glovebox was used to react UF4/NH4HF2 mixtures at elevated temperatures under a continuous flow of inert gas. The process yielded a significantly purer UF4 salt as confirmed via inert gas fusion, X-ray diffraction, differential scanning calorimetry and inductively coupled plasma-optical …

Crystal Growth, Thermal, Optical, Magnetic And Electrochemical Properties Of Mo2Ta2O11, Md Abdullah Al Muhit, Alevtina A. Maksimova, Sean C. Wechsler, Habiba Binte Kashem, Gopabandhu Panigrahi, Gregory Morrison, Morgan Stefik, Hans Conrad Zur Loye

Faculty Publications

Single crystals of the transition metal oxide Mo2Ta2O11 were grown for the first time using molten flux synthesis. The compound crystalizes in the trigonal space group R 3‾m (no. 166) with lattice parameters a = b = 5.6267(1) Å and c = 25.1424(6) Å and a unit cell volume of 689.36(3) ų. The structure of Mo2Ta2O11 is composed of alternating layers of TaO6 octahedra and MoO4 tetrahedra connected via corner-sharing. CaH2 was used to achieve a partial low temperature reduction of Mo2Ta2O11. The electrochemical lithiation of polycrystalline Mo2Ta2O11 was also investigated for the first time. Mo2Ta2O11 underwent a …

Electrochemistry Behind Pfas: Mechanistic And Analytical Approach For Sensing And Degradation Strategies, Jonathan Josue Calvillo Solis

Open Access Theses & Dissertations

Understanding the fundamental electrochemistry of perfluoroalkyl substances (PFAS) is key to developing effective water remediation and sensing strategies. This work explores the thermodynamics and kinetics of perfluorooctanoic acid (PFOA) electroreduction, focusing on C-F bond cleavage. These insights were applied to design a highly sensitive electrochemical sensor for detecting trace levels of PFOA in water. This dissertation focuses on the electrochemical investigation of the reduction reaction of PFOA in aqueous and organic media employing different electrode materials. This exploration allows to understand the defluorination reaction of PFAS to further propose potential strategies for water treatment and PFOA electrosensing. Through electrochemical, spectroscopical …

Electrocatalytic Degradation Of Methylene Blue Using Graphene Oxide, Antimony Oxide, And Graphene Oxide-Supported Antimony Oxide Ink-Based Electrodes, Maria Irene Myers Armas

Theses and Dissertations

This study investigates the electrocatalytic degradation of methylene blue (MB) using copper mesh electrodes coated with graphene oxide (GO), antimony oxide (Sb₂O₃), and their composite (GO/Sb₂O₃). These materials were evaluated across a pH range of 2 to 8 using sodium sulfate as the supporting electrolyte. UV-Vis spectroscopy at 665 nm confirmed dye degradation, with removal efficiencies reaching up to 95% at pH 2. However, degradation decreased at higher pH, with 40 – 60% removal at pH 8, depending on the electrode. Kinetic analyses revealed optimum performance under acidic conditions. GO/Sb₂O₃ electrodes demonstrated the most consistent and effective performance across all …

Quantifying Biomass Burning Impacts On Soil Nox Emissions And Reactive Nitrogen Cycling, Olivia Rae Steinbeck

Theses and Dissertations

Nitrogen oxides (NOx = NO + NO₂) are trace gases that play a critical role in the atmosphere by influencing air quality, oxidation chemistry, and the deposition of fixed nitrogen. Historically, NOx emissions have been primarily linked to anthropogenic sources such as fossil fuel combustion, industrial activities, and agriculture. However, as successful legislation has significantly reduced these emissions, the relative importance of natural NOx sources has become an increasing concern. Soil NOx emissions are of particular interest due to their strong temperature dependence and their connection to global climate change. Rising global temperatures are expected to accelerate soil NOx emissions …

Quinone-Mediated Extracellular Electron Transfer In Escherichia Coli During Glucose Oxidation Metabolism, Megan Danielle Whisonant

Theses and Dissertations

The growing global demand for energy, ongoing reliance on fossil fuels, and increasing water pollution from industrial and anthropogenic sources present significant environmental challenges. In response to these issues, renewable and sustainable energy sources offer substantial potential for reducing dependence on fossil fuels and ensuring access to clean water. Microbial electrochemical systems (MESs) have emerged as promising, eco-friendly solutions for energy-efficient wastewater treatment and bioremediation. A key challenge in MESs development is facilitating effective electron transfer between microorganisms and electrode surfaces. The first chapter of this thesis discusses the fundamentals of MES types, explains mechanisms of extracellular electron transfer, and …

The Potential Importance Of Microenvironment On Polymer Bound Chemical Reagents, Nathan Joseph Halsteter

Theses and Dissertations

In this thesis will provide a brief history of polymer bound reagents, their uses, and advancements. The importance of polymer microenvironments will be explored using a model kinetic resolution reaction utilizing polymer bound reagents to observe how changes in a polymer’s microenvironment effects the yield and selectivity of a reaction. It was found that there are copious factors that affect polymer bound reagents, and no direct conclusion could be drawn from the study.

Characterizing Dissolved Organic Matter Composition In A Southeastern United States Watershed, Gwendolyn Marcelette Hopper

Theses and Dissertations

Dissolved organic matter (DOM) has important roles in many biogeochemical cycles. DOM is primarily composed of dissolved organic carbon (DOC), nitrogen, and phosphorus, and the processing of DOM is important for nutrient regulation and carbon cycling. In the coastal plains of the southeastern United States, there are many rivers and streams known as “blackwaters” with exceptionally high concentrations of chromophoric dissolved organic matter (CDOM) leached from terrestrial soils, coinciding with a region experiencing some of the nation’s highest rates of development. As changes in land use and climate continue to occur, DOM composition from natural to anthropogenically impacted systems can …

In Vivo Analysis Of Fe-S Cluster Assembly And Iron Homeostasis In Escherichia Coli, Dexter Mclaurin Reasons

Theses and Dissertations

Iron-sulfur (Fe-S) clusters are an essential cofactor for a wide range of cellular processes, and their assembly and storage require tight regulation.

In Escherichia coli (E. coli), there are two pathways of Fe-S cluster assembly, the Isc and the Suf pathways. The Isc pathway is used under good growth conditions, and the Suf pathway is used under iron starvation and oxidative stress conditions. Once the cluster has been assembled on the scaffold protein of either pathway, it is transferred to Fe-S cluster trafficking proteins. In E. coli, the monothiol glutaredoxin GrxD and the BolA-type proteins BolA and IbaG …

Evaluating The Influence Of Carbon Quantum Dots On Starch-Based Bioplastics: Toward Potential Food Packaging Applications, Shima Jafarzadeh, Mitra Golgoli, Zeinab Qazanfarzadeh, Mehrdad Forough, Peng Wu, Wendy Timms, Colin J. Barrow, Minoo Naebe, Masoumeh Zargar

Research outputs 2022 to 2026

Developing biodegradable food packaging films is crucial for reducing dependence on petroleum-based plastics. In this study, nitrogen-doped carbon quantum dots (CDs) were synthesized from citric acid and ethylenediamine via hydrothermal treatment and incorporated into sago starch films at concentrations of 0.5 %, 1 %, 3 %, and 4 % w/w of total solids using a solution casting method. The effects of CDs on structural, thermal, antioxidant, optical, and physicochemical properties were systematically investigated. CD addition enhanced the UV-shielding ability of the films. At 4 % CD content, UV transmittance decreased by 56.4 % (UVA), 66.7 % (UVB), and 73.9 % …

Contextual Approach To Improve Problem Solving Skills In Ipas Subject At Elementary School: A Study Development Of Teaching Materials, Nur Hidayah, Sumarno Sumarno, Joko Siswanto

Jurnal Pendidikan Sains

The objective of this study is to assess the validity, practicality, and efficacy of instructional materials. We refer to this research as research and development, with a focus on the creation of teaching materials. The research design proposed by Borg and Gall consists of six steps: identification of potential and difficulties, data collecting, product design, design validation, design revision, and product trial. The utilized instruments comprise expert and practitioner validity sheets, teacher and student response surveys, and validation sheets for teaching materials and modules, as well as pretest and posttest questions. Experts performed the validity assessment, attaining a score of …

The Effort To Improve Students’ Problem-Solving Ability: Physics E-Modules For High School Students, Hidayatullah Hana Putra, Edi Supriana, Nasikhuddin Nasikhuddin, Annisa U. Yana, Suhailee Sohnui

Jurnal Pendidikan Sains

Physics teachers in Indonesia still face obstacles during learning, such as students who are less active and have difficulty in solving physics problems. The physics learning media used are also still not very interesting and are not based on authentic problem solving. Therefore, this study focuses on the development of PBL-based e-modules on work and energy to improve the physics problem-solving abilities of high school students. This research and development used the ADDIE design and was tested on 90 high school students in High School 1 Sumber Pucung Malang in the 2022/2023 academic year. The questionnaire instrument was used in …

Differentiated Teaching Module Using Problem Solving Model: Numerical Ability Of Elementary School Students, Risa Alifatin, Agus Sutono, Ida Dwijayanti

Jurnal Pendidikan Sains

This study aims to develop a differentiated teaching module using the problem-solving model that is valid, practical, and effective to improve students' numerical abilities. This study uses the ADDIE Model research and development approach. The sample in this study was class III of elementary school Tenggulangharjo as an experimental class totaling 22 students and class III of elementary school Karangtengah as a control class totaling 19 students. Data analysis used the t-test and N-Gain test. The study found that (1) the average validity score of the three parts of the Differentiated Teaching Module was 3.74, which is 93.62%, placing it …

Ethnoscience-Based Science Learning Through Composite Board Making Utilizing Eggshell Waste And Water Hyacinth Fiber (Eichornia Crassipes), Asep Khaidir Arpan, Yulia Sukmawardani, Pina Pitriana, Ade Yeti Nuryantini

Jurnal Pendidikan Sains

The demand for boards continues to increase every year, while overexploitation of wood leads to environmental degradation and forest loss. On the other hand, eggshell and water hyacinth waste continues to grow without optimal utilization. This research aims to make composite boards based on eggshell waste and water hyacinth fibers and analyze the potential of ethnoscience in science learning. This research used a qualitative descriptive method with a literature and documentation study approach. The materials used in this experiment are eggshell waste, water hyacinth fiber, and polyester resin. The composite board was made by mixing water hyacinth fiber and eggshell …

Analysis Of Students' Creative Thinking Skills In Learning Hydrocarbons By Using Daily Life-Based Practicum Method, Yenni Kurniawati, Laras Dyaz Handayani, Dea Ramadani, Nurhikmah Sari

Jurnal Pendidikan Sains

Creative thinking skill is a competence of the 21st century that is needed very much and needs to be increased by utilizing chemistry in life. This research aimed at analyzing student creative thinking skills in experimental and control groups and finding out the effect of the daily life-based practical work learning method on student creative thinking skills. This research was conducted in the eleventh grade at High School 1 Pekanbaru on the hydrocarbon lesson. The quasi-experimental method was used in this research with pretest-posttest and non-equivalent control group designs. The instruments used in this research were essay tests, observation, and …

Exploring Students’ Perceptions Of Science Laboratory Practices: A Comparative Study Between Rural And Urban Schools, Safrida Dwiningsih, Ina Lestari, Roma Ismi, Sri Wahyu Rahmadina, Masdalena Sinaga, M. Rahmad

Jurnal Pendidikan Sains

This study aims to analyze students' perceptions of the implementation of science laboratory practicums at public middle school 020 Pekanbaru and public middle school 7 Pangkalan Kuras, Riau Province. Using a quantitative survey method, this study involved 75 student respondents. The instrument used was a questionnaire consisting of 26 statements, analyzed descriptively. The results show that students' perceptions of the preparation, implementation, and conclusion stages of the practicum fall into the "good" category, with urban schools having a higher percentage. In conclusion, the implementation of practicums in urban schools is better than in rural schools, bringing attention to the need …

Digital Comic Learning Media (E-Comic) To Increase Student Learning Interest In Reaction Rate Material At High School, Berliana Afsohin Nabila, Achmad Lutfi

Jurnal Pendidikan Sains

This study aims to develop digital comic learning media that is effective in increasing students' interest in learning about reaction rate material, focusing on the media's validity, practicality, and overall effectiveness. This research utilizes the research and development method with the ADDIE model. Research instruments were used, including validity sheets to assess the media's validity, student activity observations, and student response questionnaires to evaluate the media's practicality, as well as student interest questionnaires and learning outcomes to measure the effectiveness of the learning media. The findings show that validity results showed a mode score of 4, indicating a very valid …

Teaching Materials Containing Kse To Support Character Education In Mathematics Subjects In Elementary Schools, Kunaenah Kunaenah, Rasiman Rasiman, Bagus Ardi Saputro

Jurnal Pendidikan Sains

The purpose of the study was to determine the validity, practicality, and effectiveness of teaching materials containing KSE to support character education in mathematics lesson content. This study employs a development research approach based on Borg and Gall's research design. The subjects of the study were in class V at public elementary school Kaliboyo. The data collection instruments used were validity sheets, response questionnaires, validation sheets, and observation sheets. The findings show that experts carried out the validity test, achieving a value of 93.30% in the very valid category. The practicality test results were derived from various sources: students' questionnaires, …

Development Of Differentiated Teaching Modules With A Scientific Approach To Improve Elementary School Students’ Science Literacy, Supriyanto Supriyanto, Joko Sulianto, Achmad Buchori

Jurnal Pendidikan Sains

The study aim is to determine the validity, practicality, and effectiveness of teaching materials. This type of research involves the development and creation of teaching module products. The research design used is ADDIE (Analysis, Design, Development, Implementation, Evaluation). The instruments used are validity sheets for experts and practitioners, teacher response questionnaires, teaching module validation sheets, and pretest and posttest questions. The findings show that experts conducted the validity test, achieving a score of 92.22 in the very valid category. The practicality test was obtained from the teacher questionnaire, which was stated as practical with an average value of 91.25, and …

Analysis Of Misconceptions In Learning Biology Mutation Material At High School, Fitri Hayati Kurnia, Tri Wahyu Agustina, Wahyuni Handayani

Jurnal Pendidikan Sains

This research aims to analyze student misconceptions regarding mutation material in class XII. The research method uses a descriptive approach with mixed methods, which combines qualitative and quantitative methods. Qualitative data was obtained through interviews with biology teachers, while quantitative data was obtained through questionnaires and essay tests on students. The research results indicate that the material that students like is growth and development, while the material they don't like is gene mutation and genetic material. Students' misconceptions occur due to preconception aspects, associative thinking, and a lack of understanding of genetic concepts. It was found that students' understanding of …

Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly

Karbala International Journal of Modern Science

Background: Vitamin D3  over-supplementation can induce toxicity through the development of hypercalcemia and may disturb immune modulation. This study examines the relationship between hypercalcemia  resulting from Vitamin D3 Overdose and serum Interleukin-6 (IL-6) levels in patients diagnosed with staphylococcal arthritis.

Methods: Forty male patients (mean age: 31 years; range: 17–45 years) were enrolled from Dec. 2024 to Feb. 2025. Twenty cases of staphylococcal arthritis were compared with twenty healthy male controls. Serum concentrations of Vitamin D3, calcium, IL-6, and other biochemical markers (urea, creatinine, ESR, WBC, and potassium) were analyzed. Staphylococcus aureus was isolated from synovial fluid and confirmed using …

Pm Irras Studies Of Organized Molecular Films At A Gold Electrode Surface, Zhang-Fei Su, Ai-Cheng Chen, Jacek Lipkowski

Journal of Electrochemistry

This feature article illustrates the potential of polarization modulation infrared reflection absorption spectroscopy (PM IRRAS) to provide molecular-level information about the structure, orientation and conformation of constituents of thin films at electrode surfaces. PM IRRAS relies on the surface selection rules stating that the p-polarized IR beam is enhanced, while the s-polarized beam is attenuated at the metal surface. The difference between p- and s-polarized beams eliminates the background of the solvent and provides IR spectra at a single electrode potential. In contrast, two other popular in situ IR spectroscopic techniques, namely, subtractively normalized interfacial Fourier transform infrared spectroscopy (SNIFTIRS) …

Chemical And Physical Characterization Of Verbenaceae Essential Oils Using Modern Analytical Methods And Chemometrics, Aleksandra N. Hilliard

Master's Theses

Essential oils have been used for generations to treat various health issues, including mitigating insomnia, reducing stress, inflammation, and preserving foods, to mention a few. Essential oils have complex chemistry, which defines the essence of the host plant. Recently, increased commercial uses of essential oils have prompted attention at the governmental level to monitor the chemical, physical, or biological activity of essential oils. This study is an attempt to add new information for consumers to the understanding of the composition of essential oils.

Modern analytical techniques including FTIR-ATR, GC-MS, LC-MS-MS, multivariate analysis statistics, and physio-chemical techniques (electrochemistry, DPPH, TRC, and …

Potent Acridone Antimalarial Against All Three Life Stages Of Plasmodium, Papireddy Kancharla, Rozalia A. Dodean, Yuexin Li, Xiaowei Zhang, Sean Kelly, Jordan Charlton, Angley Binauhan, Laurize Garcia, Diana Caridha, Jane X. Kelly, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

New antimalarial therapeutics ideally should target all three major life cycle stages. Here we present an acridone antimalarial chemotype that is potent against blood, liver, and mosquito stages of malaria parasites, with the potential for single-dose cure of bloodstream infections, radical cure of liver infections, and blocking of transmission to mosquitoes. Attributes of lead candidate T111 include potent in vitro activity against cultured parasites, ex vivo activity against clinical isolates, oral single dose cure in an asexual blood stage rodent model, inhibition of sexual blood stage parasites, activity against relapsing parasites in non-human primate liver cells, prevention of parasite development …

The Synthesis Of A Photo-Affinity Probe Library For The Fatty Acid Amide Proteome And The Endocannabinoid System Within, Robert E. Feeney Iii

USF Tampa Graduate Theses and Dissertations

Fatty acid amides are a large family of endogenous metabolites with significant biological activity, including that of the endocannabinoid system. Currently little is known about how this system of tightly regulated compounds works within humans. This work lays the foundation to explore the structure-activity relationship driving the selectivity of ligand-protein interactions involved with fatty acid amides. A library of activity-based proteomic profiling probes for fatty acid amides has been synthesized to this end. Additionally, progress towards phytocannabinoid probes has been made as well.