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Articles 4291 - 4320 of 15561
Full-Text Articles in Entire DC Network
The Effect Of H$_{2}$O On The Sulfation Of Havelock Limestone Under Oxy-Fuel Conditions In Athermogravimetric Analyser, Murat Varol, Edward John Anthony, Arturo Macchi
The Effect Of H$_{2}$O On The Sulfation Of Havelock Limestone Under Oxy-Fuel Conditions In Athermogravimetric Analyser, Murat Varol, Edward John Anthony, Arturo Macchi
Turkish Journal of Chemistry
A gas mixture representing oxy-fuel combustion conditions was employed in a thermogravimetric analyser to determine the effect of water vapor and SO$_{2}$ concentration on limestone sulfation kinetics over the temperature range of 800 to 920 °C. Here, experiments used small samples of particles (4 mg), with small particle sizes (d$_{p}$ < 38 μm) and large gas flow rates (120 mL/min@ NTP) in order to minimize mass transfer interferences. The gas mixture contained 5000 ppm$_{v}$ SO$_{2}$, 2% O$_{2}$, and the H$_{2}$O content was changed from 0% to 25% with the balance CO$_{2}$. When water vapor was added to the gas mixture at lower temperatures (800-870 °C), the limestone SO$_{2}$ capture efficiency increased. However, as the temperature became higher, the enhancement in total conversion values decreased. As expected, Havelock limestone at higher temperatures (890 °C, 920 °C, and 950 °C) experienced indirect sulfation and reacted at a faster rate than for lower temperatures (800-870 °C) for direct sulfation over the first five minutes of reaction time. However, the total conversion of Havelock limestone for direct sulfation was generally greater than for indirect sulfation.
Synthesis Of Some Nh- And Nh,S- Substituted 1,4-Quinones, Ayşeci̇k Kaçmaz
Synthesis Of Some Nh- And Nh,S- Substituted 1,4-Quinones, Ayşeci̇k Kaçmaz
Turkish Journal of Chemistry
A series of NH-substituted-1,4-quinones, possessing one, two, three or not chlorine, were synthesized by the reaction between different quinones (p-chloranil (1), p-toluquinone (2), or 2,3-dichloro-1,4-naphthoquinone (3)) and (-)-cis-myrtanylamine (5) via nucleophilic reactions. Moreover, 2-bromo-1,4-naphthoquinone (4) was reacted with 2-(methylthio)ethylamine (11) to produce aminosubstituted naphthoquinones (12 and 13), bearing with bromine and not bromine. In addition, 2-bromo-1,4-naphthoquinone (4) was reacted with 4?-aminodibenzo-18-crown-6 (14) and 4'-aminobenzo-18-crown-6 (16) to yield crown-containing 1,4-naphthoquinones (15 and 17), respectively. New compounds were characterized, providing 1H NMR, 13C NMR, FTIR, MS-ESI, UV/Vis and elemental analysis.
Rhenium/Rhenium Oxide Nanoparticles Production Using Femtosecond Pulsed Laserablation In Liquid, Abdullah Kepceoğlu, Yasemi̇n Gündoğdu, Adem Sarilmaz, Mustafa Ersöz, Faruk Özel, Hamdi̇ Şükür Kiliç
Rhenium/Rhenium Oxide Nanoparticles Production Using Femtosecond Pulsed Laserablation In Liquid, Abdullah Kepceoğlu, Yasemi̇n Gündoğdu, Adem Sarilmaz, Mustafa Ersöz, Faruk Özel, Hamdi̇ Şükür Kiliç
Turkish Journal of Chemistry
In this study, rhenium/rhenium oxide nanoparticles (Re / ReO$_{3}$ NPs) have been produced for the first time in ultrapure water by using Femtosecond Pulsed Laser Ablation in Liquid (fsPLAL) method. X-Ray Diffraction (XRD) measurements and results obtained for NPs show the existence of well-crystallized peaks and preferred phases. Re NPs have hexagonal structure while ReO$_{3}$ NPs have the perovskite-like cubic crystal structures. The Re / ReO$_{3}$ ratio is also determined to be 53 / 47 with ~ 20 nm crystallite size, while pure ReO$_{3}$ crystallite sizes were measured to be ~ 25 nm. The TEM results have shown that the …
Electrochemical Investigation Of The Interaction Of 2,4-D And Double Stranded Dna Using Pencil Graphite Electrodes, Gülşah Çongur
Electrochemical Investigation Of The Interaction Of 2,4-D And Double Stranded Dna Using Pencil Graphite Electrodes, Gülşah Çongur
Turkish Journal of Chemistry
2,4-dichlorophenoxyacetic acid (2,4-D) is an auxinic herbicide used to control broadleaf weeds. It is also a threatening factor for not only aquatic life but also human health due to its genotoxicity and endocrine disruptive property. Herein, the interaction between 2,4-D and double stranded DNA was investigated by using single-use pencil graphite electrodes (PGE) in combination with electrochemical techniques. The detection mechanism was based on the monitoring of the changes at the guanine oxidation signal obtained before/after surface-confined interaction of 2,4-D and DNA at the surface of PGE. The electrochemical characterization of the interaction was studied by using microscopic and electrochemical …
Synthesis And Biological Evaluation Of New Pyrazolebenzene-Sulphonamides As Potentialanticancer Agents And Hca I And Ii Inhibitors, Mehtap Tuğrak, Hali̇se İnci̇ Gül, Hi̇roshi̇ Sakagami̇, Rüya Kaya, İlhami̇ Gülçi̇n
Synthesis And Biological Evaluation Of New Pyrazolebenzene-Sulphonamides As Potentialanticancer Agents And Hca I And Ii Inhibitors, Mehtap Tuğrak, Hali̇se İnci̇ Gül, Hi̇roshi̇ Sakagami̇, Rüya Kaya, İlhami̇ Gülçi̇n
Turkish Journal of Chemistry
Cancer is a disease characterized by the continuous growth of cells without adherence to the rules that healthy normal cells obey. Carbonic anhydrase I and II (CA I and CA II) inhibitors are used for the treatment of some diseases. The available drugs in the market have limitations or side effects, which bring about the need to develop new drug candidate compound(s) to overcome the problems at issue. In this study, new pyrazole-sulphonamide hybrid compounds 4-[5-(1,3-benzodioxol-5-yl)-3-aryl-4,5-dihydro-1Hpyrazol- 1-yl]benzenesulphonamides (4a - 4j) were designed to discover new drug candidate compounds. The compounds 4a - 4j were synthesized and their chemical structures were …
Integrated 3d-Qsar, Molecular Docking, And Molecular Dynamics Simulation Studies On 1,2,3-Triazole Based Derivatives For Designing New Acetylcholinesterase Inhibitors, Khalil El Khatabi, Ilham Aanouz, Reda El-Mernissi, Atul Kumar Singh, Mohammed Aziz Ajana, Tahar Lakhlifi, Shashank Kumar, Mohammed Bouachrine
Integrated 3d-Qsar, Molecular Docking, And Molecular Dynamics Simulation Studies On 1,2,3-Triazole Based Derivatives For Designing New Acetylcholinesterase Inhibitors, Khalil El Khatabi, Ilham Aanouz, Reda El-Mernissi, Atul Kumar Singh, Mohammed Aziz Ajana, Tahar Lakhlifi, Shashank Kumar, Mohammed Bouachrine
Turkish Journal of Chemistry
Alzheimer's disease (AD) is a multifactorial and polygenic disease. It is the most prevalent reason for dementia in the aging population. A dataset of twenty-six 1,2,3-triazole-based derivatives previously synthetized and evaluated for acetylcholinesterase inhibitory activity were subjected to the three-dimensional quantitative structure-activity relationship (3D-QSAR) study. Good predictability was achieved for comparative molecular field analysis (CoMFA) (Q2 = 0.604, R2 = 0.863, rext2 = 0.701) and comparative molecular similarity indices analysis (CoMSIA) (Q2 = 0.606, R2 = 0.854, rext2 = 0.647). The molecular features characteristics provided by the 3D-QSAR contour plots were quite useful for designing and improving the activity of …
Synthesis And Antioxidant Activities Of New Nickel(Ii) Complexes Derived From 4-Benzy¬Loxysalicylidene-S-Methyl/Propyl Thiosemicarbazones, Songül Eğlence Bakir
Synthesis And Antioxidant Activities Of New Nickel(Ii) Complexes Derived From 4-Benzy¬Loxysalicylidene-S-Methyl/Propyl Thiosemicarbazones, Songül Eğlence Bakir
Turkish Journal of Chemistry
Six nickel(II) complexes of the N2O2 chelating thiosemicarbazones were synthesized using N1-4-benzyloxysalicylidene-S-methyl/propyl thiosemicarbazone and methoxy-substitute-salicylaldehydes in the presence of Ni(II) ion by template reaction. The structures of thiosemicarbazones and nickel(II) complexes were characterized by elemental analysis, UV-Vis, IR, and 1H-NMR spec¬troscopies. The structure of the N1-4-benzyloxysalicylidene-S-propyl thiosemicarbazone (2) was determined by X-ray single-crystal diffraction method. The total antioxidant capacities of synthesized compounds were evaluated by using cupric reducing antioxidant capacity (CUPRAC) method. The thiosemicarbazones exhibited more potent antioxidant capacity than Ni(II) complexes. Trolox equiv¬alent antioxidant capacity (TEAC) of 1c was found highest in tested nickel(II) complexes. In addition, antioxidant activities …
Spectrophotometric And Colorimetric Determination Of Gallium (Iii) With P-Aminohippuricacid-Functionalized Citrate Capped Gold Nanoparticles, Asi̇ye Aslihan Avan
Spectrophotometric And Colorimetric Determination Of Gallium (Iii) With P-Aminohippuricacid-Functionalized Citrate Capped Gold Nanoparticles, Asi̇ye Aslihan Avan
Turkish Journal of Chemistry
A new technique for sensing Ga(III) concentration based on polyvinyl alcohol-citrate capped gold nanoparticle-p-aminohippuric acid hybrid (or three-layer core-shell configurations) has been demonstrated. The p-aminohippuric acid capped citrate-gold nanoparticles were comfortably agglomerated in the presence of Ga(III), and the color of the reaction quickly turned from red to violet or blue. Under the detection conditions, a good linear relationship was ideally obtained between the ratio of the absorbance intensity at 620 nm to that at 520 nm (A620/A520). The linear response range, the detection, and quantification limit was 34.9-418.3 μg/L and 7.6 μg/L, and 25 μg/L, respectively. To reflect the …
Synthesis, Spectroscopic, Thermal, Crystal Structure Properties, And Characterization Of New Hofmann-Td-Type Complexes With 3-Aminopyridine, Zeki̇ Kartal, Onur Şahi̇n
Synthesis, Spectroscopic, Thermal, Crystal Structure Properties, And Characterization Of New Hofmann-Td-Type Complexes With 3-Aminopyridine, Zeki̇ Kartal, Onur Şahi̇n
Turkish Journal of Chemistry
In this study, synthesis of two new tetracyanocadmate(II) and tetracyanozincate(II) complexes based on 3-aminopyridine (3AP) and investigation of their structural properties were reported. These complexes were characterized by using vibration spectroscopy, elemental, thermal analysis and single crystal X-ray diffraction (SC-XRD) techniques. Investigation of the elemental, spectral and single crystal data of these complexes showed that the formulas [Cd(3AP)2Zn(μ4-CN)4]n (1) and [Cd(3AP) 2Cd(μ4-CN)4]n (2) fully explained their crystal structure. General information about the structural and chemical properties of these complexes obtained in single crystal form was obtained by observing the changes in the characteristic peaks of the 3AP with the [Zn(μ4-CN)4]2- …
Soils Varying Importance And Differences, Kylie Fouss
Soils Varying Importance And Differences, Kylie Fouss
Natural Sciences Student Research Presentations
No abstract provided.
Determination Of Volatile Compounds In Yellow Curry Paste Using From-Two-To-One Dimensional Gas Chromatography-Mass Spectrometry, Natsuda Singtothog
Determination Of Volatile Compounds In Yellow Curry Paste Using From-Two-To-One Dimensional Gas Chromatography-Mass Spectrometry, Natsuda Singtothog
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this work, an approach to allow improved analysis with one-dimensional GC-MS (1D GC-MS) was established and demonstrated for analysis of a pool of yellow curry paste samples. The approach involved initial application of comprehensive heart cut two-dimensional GC-MS (CH/C 2D GC-MS) to obtain a full volatile profile by comparing the experimental mass spectrum and retention index of each compound with the mass spectra and retention indices of standard compounds from a database. The obtained volatile profile was then used to generate a selected ion monitoring (SIM) method, which was then applied with 1D GC-MS using a SIM mode. This …
Functionalization Of Novel Pp5 Inhibitors, Hope P. Hill
Functionalization Of Novel Pp5 Inhibitors, Hope P. Hill
Honors Theses
The overexpression of protein phosphatase 5 has been correlated to tumor cell reproduction making it a candidate for small molecule drug therapy. Selective and potent inhibition of protein phosphatase 2A (PP2A) enzyme has been previously achieved through the development of the molecule fostriecin with key functionality being a lactone and unsaturated linear chain. The large synthetic overhead of fostriecin has led to exploration of other small molecule inhibitors that could mirror fostriecin’s interaction with the active site in the catalytic domain of PP5. The naturally occurring inhibitor, cantharidin, is functionalized with an epoxy containing eleven carbon chain to optimize binding …
Design, Synthesis And Applications Of Nanoparticles In Suppression Of Mosquito-Born Flaviviridae Viruses, Maria R. Blahove
Design, Synthesis And Applications Of Nanoparticles In Suppression Of Mosquito-Born Flaviviridae Viruses, Maria R. Blahove
College of Graduate Studies: Theses & Dissertations
Recently, nanoparticles have become an origin of exploration in the chemistry field due to their unique medical uses. The current drug delivery models of nanoparticles often include a metal base with a drug conjugated to its surface. However this raises concerns regarding toxicity. A novel approach to solving this dilemma is the development of nanosized biocompatible polymer-based micelles, created from PEG-PCL-PEG triblock polymer, and formed around a drug of choice. The goal is to create a drug carrier nanoparticle system that is labile at a specific intracellular pH, without undue toxicity to the cell. This creates a drug-loaded nanoparticle that …
High Throughput Analysis To Study Emerging Pollutants And Nanoparticle Fate In Biological Systems, Xiaolong He
High Throughput Analysis To Study Emerging Pollutants And Nanoparticle Fate In Biological Systems, Xiaolong He
Doctoral Dissertations
”The increasing applications of emerging and fugitive contaminants (EFCs) and engineered nanoparticles (ENPs) attract significant research interest for their potential risks to human health and the environment. In order to assess the health risks of these emerging contaminants, rapid and reliable analytical methods to measure the concentrations and fates of these contaminants are imperative. This dissertation focuses on the developments of advanced analytical methods and their applications to study those emerging contaminants in crop plant and simulated gastric fluid (SGF). Three types of mass spectrometry based methodologies have been developed, one is freeze-thaw/centrifugation extraction followed by high performance liquid chromatography …
Quercetin Enhances Vitamin D2 Stability And Mitigate The Degradation Influenced By Elevated Temperature And Ph Value, Sukkum Ngullie Chang, Jeong Jun Lee, Hyun Jin Kim, Sun Chul Kang
Quercetin Enhances Vitamin D2 Stability And Mitigate The Degradation Influenced By Elevated Temperature And Ph Value, Sukkum Ngullie Chang, Jeong Jun Lee, Hyun Jin Kim, Sun Chul Kang
Turkish Journal of Chemistry
Vitamin D2 (vit. D2) is a nutraceutical essentially needed for good health. However, it is susceptible to oxygen and high temperature. The use of natural products such as bioflavonoids possessing anti-degradative effect of vit. D2 degradation has not been described before. A combinational effect of vit. D2 with quercetin showed a positive effect and inhibited vit. D2 degradation when exposed to high temperature (50 oC and 75 oC) at different time points. The results obtained revealed vit. D2 degradation was drastically increased with longer incubation under thermal treatment. However, quercetin and vit. D2 groups were able to significantly inhibit the …
Analysis Of Sexual Lubricants As A Form Of Trace Evidence For Sexual Assault Cases, Brooke Baumgarten
Analysis Of Sexual Lubricants As A Form Of Trace Evidence For Sexual Assault Cases, Brooke Baumgarten
Electronic Theses and Dissertations, 2020-2023
A major gap in sexual assault casework is demonstrated when DNA is not recovered. Oftentimes, if DNA evidence is not present on the collection swabs, the sexual assault kit (SAK) is not further analyzed. Due to the "CSI effect," DNA is commonly understood as highly identifiable evidence, potentially leading to increased condom usage to eliminate or reduce DNA transfer during a sexual assault. Therefore, the analysis of condoms and sexual lubricants is pertinent. The purpose of this research is to develop analytical protocols to potentially connect unknown substances recovered in a SAK to known lubricant reference samples. Sexual lubricants were …
College Of Natural Sciences 2021 Year-End Publication, College Of Natural Sciences
College Of Natural Sciences 2021 Year-End Publication, College Of Natural Sciences
College of Natural Sciences Newsletters and Reports
Page 2 Welcome, Table of Contents
Page 3 Our Departments: Highlights From 2021
Page 4 Overview of the College
Page 5 Overview of Bold & Blue
Pages 6, 7 Announcing the First Endowed Professorship in the College of Natural Sciences
Page 8 Spooky Science, Astronomy Outreach, SDSU Chemistry Research Features on Journal Cover
Page 9 Students Win Business Plan Competition With Aims to Improve Shelf Life of Produce, Summer Researchers
Page 10 NIH Grant Helps Unravel Rare Inflammatory Genetic Disorders, International Excellence in South Dakota
Page 11 The Next Frontier of Science Education: Virtual Reality, SDSU Researchers Uncover how Cancer …
Investigation Into The Source Of Contamination Of Surface Waters Flowing Through The Wright State University Woods, Nnadozie Kennedy Okeke
Investigation Into The Source Of Contamination Of Surface Waters Flowing Through The Wright State University Woods, Nnadozie Kennedy Okeke
Browse all Theses and Dissertations
This investigative research was carried out with the purpose of determining the source of contaminants present in the surface waters flowing through the Wright State University woods. Five sample sites going from upstream to downstream namely; Inflow to Nutter Center Pond (INNCP), Nutter Center Pond (NCP), Outfall 21 (OTF 21), Burley, and Outfall 15 (OTF 15), were sampled over a time period spanning from June 2020 to January 2021. Samples collected were analyzed for Escherichia coli (E. coli) using 3M™ Petrifilm™ E. coli/Coliform Count (EC) plates, select anions (Phosphate PO43-, Nitrate NO3-, Sulfate SO42-, Fluoride F- and Chloride Cl-) using …
การประยุกต์ใช้เทคโนโลยีพลาสมาเพื่อฆ่าจุลินทรีย์ก่อโรค, ตันติกร เหล่าสุข
การประยุกต์ใช้เทคโนโลยีพลาสมาเพื่อฆ่าจุลินทรีย์ก่อโรค, ตันติกร เหล่าสุข
Chulalongkorn University Theses and Dissertations (Chula ETD)
ปัจจุบันการแพร่ระบาดของเชื้อก่อโรคมีความรุนแรงเพิ่มมากขึ้น ทำให้ผู้บริโภคให้ความสนใจเกี่ยวกับสุขลักษณะที่ดี นำมาสู่ความสนใจในเทคโนโลยีกำจัดจุลินทรีย์ที่อยู่ในสภาพแวดล้อมในอุปกรณ์เครื่องมือชีวิตประจำวัน ได้แก่ เครื่องปรับอากาศ และเครื่องฟอกอากาศ ซึ่งปัจจุบันบริษัท บิทไว้ส์ (ประเทศไทย) จำกัด ผู้ผลิตเครื่องปรับอากาศได้มีการพัฒนาเทคโนโลยี 2 ชนิด ได้แก่ negative ion generator (NIG) และพลาสมาชนิด dielectric barrier discharge (DBD plasma) เพื่อตอบโจทย์ผู้บริโภคดังกล่าว งานวิจัยนี้มีวัตถุประสงค์เพื่อหาภาวะที่เหมาะสมในการทดสอบประสิทธิภาพในการกำจัดจุลินทรีย์ ด้วยเทคโนโลยีพลาสมา และทดสอบประสิทธิภาพการกำจัดจุลินทรีย์สำคัญในกลุ่มแบคทีเรีย รา และไวรัส ด้วยเทคโนโลยีพลาสมา พร้อมทั้งทดสอบผลของเทคโนโลยีพลาสมาต่อเซลล์มนุษย์ โดยสร้างกล่องทดลองอะคริลิค ที่ติดตั้ง NIG กำลังไฟ 1 วัตต์ และสร้าง กล่องทดลองอะคริลิค ที่ติดตั้งพลาสมาชนิด DBD กำลังไฟ 15 วัตต์ เพื่อใช้ในการทดสอบ ซึ่งในการทดสอบแบคทีเรียนั้นใช้แบคทีเรียแกรมบวก แบคทีเรียแกรมลบ และแบคทีเรียที่ทนต่อสารปฏิชีวนะ ได้แก่ Escherichia coli ATCC25922, Staphylococcus aureus ATCC6538P และ Pseudomonas aeruginosa ATCC9027 ตามลำดับ โดยเลี้ยงและนำมากระจายเชื้อบนอาหารแข็งชนิด LB จากนั้นนำมาสัมผัส NIG และพลาสมาชนิด DBD เป็นเวลา 60 นาที พบว่าพลาสมาชนิด DBD สามารถกำจัดแบคทีเรียทั้ง 3 ชนิดได้ 100% แต่ NIG ไม่มีประสิทธิภาพในการกำจัดแบคทีเรียดังกล่าว ในการทดสอบผลต่อยีสต์โดยเลือก Saccharomyces cerevisiae ATCC4105 เป็นตัวแทนเนื่องจากโครงสร้างใกล้เคียงยีสต์ที่ก่อโรคในมนุษย์ โดยทดสอบนำยีสต์มากระจายเชื้อบนอาหารแข็งชนิด YPD และสัมผัส NIG และพลาสมาชนิด DBD เป็นเวลา 60 นาที พบว่าพลาสมาชนิด DBD มีประสิทธิภาพในการฆ่ายีสต์ 100% และ NIG ไม่มีประสิทธิภาพในการฆ่ายีสต์ …
Desulfurization Of Thiourea Into Guanidines And Benzoxazoles Using Electrochemical Oxidation Processes, Thao Huynh Nguyen Thanh
Desulfurization Of Thiourea Into Guanidines And Benzoxazoles Using Electrochemical Oxidation Processes, Thao Huynh Nguyen Thanh
Chulalongkorn University Theses and Dissertations (Chula ETD)
2-Aminobenzoxazoles and guanidines are important building block for therapeutic agents. The general synthetic strategies of 2-aminobenzoxazoles and guanidines from thioureas rely on the use of excess or stoichiometric amount of oxidizing agents, multiple-step route, and harsh reaction conditions. Hence, in this research, the synthesis of 2-aminobenzoxazole and guanidines will be developed under mild electrochemical oxidation processes using sodium iodide. Based on optimization study, we were able to synthesize 29 examples of 2-aminobenzoxazoles in good to high yields from 2-aminophenols and isothiocyanates in one pot under electro-cyclization using NaI/NaCl in catalytic amount. Moreover, 20 examples of guanidines were prepared in good …
Cytoviva Hyperspectral Imaging For Comparing The Uptake And Transformation Of Agnps And Ag+ In Mitochondria, Kristina Steingass
Cytoviva Hyperspectral Imaging For Comparing The Uptake And Transformation Of Agnps And Ag+ In Mitochondria, Kristina Steingass
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Nanomaterials have attracted significant attention in the last decade, with applications in everyday products. Amongst all known nanomaterials in use, silver is the leading metal, present in 531 different types of products, owing to their unique optical, electrical, antimicrobial, and thermal properties. Though silver nanoparticles (AgNPs) come in contact regularly with the general population, there is little known about their toxicity mechanism due to limited techniques for thorough analysis. CytoViva Hyperspectral Imaging (HSI) shows potential for filling these gaps. In this study, borohydride-capped AgNPs with an approximate diameter of 10 nm were synthesized using the modified Creighton method and characterized …
Structual Analysis Of The Cl-Par-4 Tumor Suppressor As A Function Of Ionic Environment, Krishna K. Raut, Komala Ponniah, Steven M. Pascal
Structual Analysis Of The Cl-Par-4 Tumor Suppressor As A Function Of Ionic Environment, Krishna K. Raut, Komala Ponniah, Steven M. Pascal
Chemistry & Biochemistry Faculty Publications
Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown to be predominantly intrinsically disordered in vitro. In vivo, Par-4 is cleaved by caspase-3 at Asp-131 to generate the 25 kDa functionally active cleaved Par-4 protein (cl-Par-4) that inhibits NF-κB-mediated cell survival pathways and causes selective apoptosis in tumor cells. Here, we have employed circular dichroism (CD) spectroscopy and dynamic light scattering (DLS) to assess the effects of various monovalent and divalent salts upon the conformation of cl-Par-4 in vitro. We have …
Biolability Of Fresh And Photodegraded Pyrogenic Dissolved Organic Matter From Laboratory-Prepared Chars, K. W. Bostick, A. R. Zimmerman, A. I. Goranov, S. Mitra, P. G. Hatcher, A. S. Wozniak
Biolability Of Fresh And Photodegraded Pyrogenic Dissolved Organic Matter From Laboratory-Prepared Chars, K. W. Bostick, A. R. Zimmerman, A. I. Goranov, S. Mitra, P. G. Hatcher, A. S. Wozniak
Chemistry & Biochemistry Faculty Publications
Pyrogenic dissolved organic matter (pyDOM) is known to be an important biogeochemical constituent of aquatic ecosystems and the carbon cycle. While recent studies have examined how pyDOM production, composition, and photolability varies with parent pyrogenic solid material type, we lack an understanding of potential microbial mineralization and transformation of pyDOM in the biogeosphere. Thus, leachates of oak, charred at 400 °C and 650 °C, as well as their photodegraded counterparts were incubated with a soil‐extracted microbial consortium over 96 days. During the incubation, significantly more carbon was biomineralized from the lower versus higher temperature char leachate (45% vs. 37% lost, …
Aggregation And Degradation Of Dispersants And Oil By Microbial Exopolymers (Addomex): Toward A Synthesis Of Processes And Pathways Of Marine Oil Snow Formation In Determining The Fate Of Hydrocarbons, Antonietta Quigg, Peter H. Santschi, Chen Xu, Kai Ziervogel, Manoj Kamalanathan, Wei-Chun Chin, Adrian B. Burd, Andrew Wozniak, Patrick G. Hatcher
Aggregation And Degradation Of Dispersants And Oil By Microbial Exopolymers (Addomex): Toward A Synthesis Of Processes And Pathways Of Marine Oil Snow Formation In Determining The Fate Of Hydrocarbons, Antonietta Quigg, Peter H. Santschi, Chen Xu, Kai Ziervogel, Manoj Kamalanathan, Wei-Chun Chin, Adrian B. Burd, Andrew Wozniak, Patrick G. Hatcher
Chemistry & Biochemistry Faculty Publications
Microbes (bacteria, phytoplankton) in the ocean are responsible for the copious production of exopolymeric substances (EPS) that include transparent exopolymeric particles. These materials act as a matrix to form marine snow. After the Deepwater Horizon oil spill, marine oil snow (MOS) formed in massive quantities and influenced the fate and transport of oil in the ocean. The processes and pathways of MOS formation require further elucidation to be better understood, in particular we need to better understand how dispersants affect aggregation and degradation of oil. Toward that end, recent work has characterized EPS as a function of microbial community and …
Synthesis And Self-Assembling Properties Of Peracetylated Β-1 Triazolyl Alkyl D Glucosides And D-Galactosides, Pooja Sharma, Anji Chen, Dan Wang, Guijun Wang
Synthesis And Self-Assembling Properties Of Peracetylated Β-1 Triazolyl Alkyl D Glucosides And D-Galactosides, Pooja Sharma, Anji Chen, Dan Wang, Guijun Wang
Chemistry & Biochemistry Faculty Publications
Carbohydrate-based low-molecular-weight gelators (LMWGs) are useful classes of compounds due to their numerous applications. Among sugar-based LMWGs, certain peracetylated sugar beta-triazole derivatives were found to be effective organogelators and showed interesting self-assembling properties. To further understand the structural influence towards molecular assemblies and obtain new functional materials with interesting properties, we designed and synthesized a library of tetraacetyl beta-1-triazolyl alkyl-D-glucosides and D-galactosides, in which a two or three carbon spacer is inserted between the anomeric position and the triazole moiety. A series of 16 glucose derivatives and 14 galactose derivatives were synthesized and analyzed. The self-assembling properties of these new …
Potentiometric Biosensing Of Ascorbic Acid, Uric Acid, And Cysteine In Microliter Volumes Using Miniaturized Nanoporous Gold Electrodes, Christopher J. Freeman, Borkat Ullah, Md. Shafiul Islam, Maryanne M. Collinson
Potentiometric Biosensing Of Ascorbic Acid, Uric Acid, And Cysteine In Microliter Volumes Using Miniaturized Nanoporous Gold Electrodes, Christopher J. Freeman, Borkat Ullah, Md. Shafiul Islam, Maryanne M. Collinson
Chemistry & Biochemistry Faculty Publications
Potentiometric redox sensing is a relatively inexpensive and passive approach to evaluate the overall redox state of complex biological and environmental solutions. The ability to make such measurements in ultra-small volumes using high surface area, nanoporous electrodes is of particular importance as such electrodes can improve the rates of electron transfer and reduce the effects of biofouling on the electrochemical signal. This work focuses on the fabrication of miniaturized nanoporous gold (NPG) electrodes with a high surface area and a small footprint for the potentiometric redox sensing of three biologically relevant redox molecules (ascorbic acid, uric acid, and cysteine) in …
Applications Of The Match Model To Analyze Student Problem-Solving, Barbara Chiu
Applications Of The Match Model To Analyze Student Problem-Solving, Barbara Chiu
Honors Undergraduate Theses
Problem-solving has been recognized as a critical skill that students lack in the current education system, due to the use of algorithmic questions in tests that can be simply memorized and solved without conceptual understanding. Research on student problem-solving is needed to gain deeper insight into how students are approaching problems and where they lack proficiency so that instruction can help students gain a conceptual understanding of chemistry. The MAtCH (methods, analogies, theory, context, how) model was recently developed from expert explanations of their research and could be a valuable model to identify key components of student problem-solving. This project …
Classification Of Ground-Truth Fire Debris Samples Using Neural Networks, Nicholas Thurn
Classification Of Ground-Truth Fire Debris Samples Using Neural Networks, Nicholas Thurn
Electronic Theses and Dissertations, 2020-2023
Fire debris samples are currently analyzed according to ASTM E1618-19, which is the "Standard Test Method for Ignitable Liquid Residues in Extracts from Fire Debris Samples by Gas Chromatography-Mass Spectrometry." This method requires that an analyst make a visual comparison to an appropriate reference sample using the total ion and the extracted ion chromatograms. The analyst then provides an opinion about whether an ignitable liquid residue is present in the sample. The method is inherently subjective due to the visual interpretation that is needed. In order to automate this process, this work uses neural networks and a subset of the …
2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition By Organometallic Vanadium Complexes: A Potential New Paradigm For Studying Cns Degeneration, David C. Platt, Jonathan Rink, Kamaljit Braich, Craig C. Mclauchlan, Marjorie A. Jones
2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition By Organometallic Vanadium Complexes: A Potential New Paradigm For Studying Cns Degeneration, David C. Platt, Jonathan Rink, Kamaljit Braich, Craig C. Mclauchlan, Marjorie A. Jones
Faculty Publications – Chemistry
The enzyme, 2′-3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) has been known for over fifty years. Nevertheless, the roles this membrane-bound enzyme play have yet to be described completely. Recently, there has been renewed interest in the study of this enzyme due to studies that suggest that CNPase plays a role in the mediation of cellular inflammatory responses in renal and nervous system tissues. Also, this enzyme, found in oligodendrocytes of the nervous system, has been reported to participate in significant regulatory changes associated with age which may be involved in age-related CNS degeneration. Consequently, development of CNPase inhibitors is of interest and …
Subsumption Reduces Dataset Dimensionality Without Decreasing Performance Of A Machine Learning Classifier, Donald C. Wunsch, Daniel B. Hier
Subsumption Reduces Dataset Dimensionality Without Decreasing Performance Of A Machine Learning Classifier, Donald C. Wunsch, Daniel B. Hier
Chemistry Faculty Research & Creative Works
When Features in a High Dimension Dataset Are Organized Hierarchically, There is an Inherent Opportunity to Reduce Dimensionality. Since More Specific Concepts Are Subsumed by More General Concepts, Subsumption Can Be Applied Successively to Reduce Dimensionality. We Tested Whether Sub-Sumption Could Reduce the Dimensionality of a Disease Dataset Without Impairing Classification Accuracy. We Started with a Dataset that Had 168 Neurological Patients, 14 Diagnoses, and 293 Unique Features. We Applied Subsumption Repeatedly to Create Eight Successively Smaller Datasets, Ranging from 293 Dimensions in the Largest Dataset to 11 Dimensions in the Smallest Dataset. We Tested a MLP Classifier on All …