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Industry/Regulator Dialogue On Knowledge Management Is Intensifying In Wake Of Ich’S Q12 Initiative, ( Ipq )

Level 3

No abstract provided.

Analyzing Physics Students’ Misconceptions About Simple Electrical Circuits, Sapta Adiguna, Shinta Dewi Susanti, Sentot Kusairi, Iwan Setiawan

Jurnal Pendidikan Sains

This study investigates the prevalence and types of misconceptions among first-year Physics Education students regarding simple electrical circuits using the Simple Electric Circuits Diagnostic Test (SECDT). Employing a quantitative descriptive approach, the research analyzes responses from a sample of 42 students, selected through convenience sampling. The SECDT, a three-tier diagnostic instrument with a reliability of 0.69, identifies student misconceptions by categorizing responses into scientific knowledge, misconceptions, no understanding, and lack of knowledge. The results indicate significant gender differences in the types and prevalence of misconceptions. Male students exhibited a higher percentage of misconceptions (77.5%) compared to female students (62.8%). Notably, …

Identification Of Scientific Argumentation Ability Of High School Students On Optical Instrument Material, Rais Muktamar Amin, Parno Parno, Sentot Kusairi, Marlina Ali

Jurnal Pendidikan Sains

Optical instruments play a crucial role in physics education, providing essential material for students to understand complex concepts. This study aims to evaluate the scientific argumentation abilities of high school students regarding optical instruments. Conducted as a quantitative descriptive study, the research involved 60 eleventh-grade MIPA students from SMA Laboratorium UM. The research instrument was a scientific argumentation test comprising 12 essay questions, designed according to the Toulmin Argumentation Pattern (TAP) adaptation indicators, with a reliability coefficient of 0.332. Student responses were classified into five levels of scientific argumentation based on the TAP model, as developed by Sampson, Enderle, and …

The Investigation Of The Antimicrobial And Biofilm-Disrupting Properties Of Synthesized Hemibastadin Derivatives, Antonio Harvey, Andrew A. Yeagley

Longwood Senior Thesis Proposal

We want to investigate structural changes to the core hemibastadin structure while attempting to make these derivatives biologically safer. Since these modifications have never been done before, we will need to design a synthesis of these new molecules. Due to the nature of the molecules (dimers), a divergent synthesis that allows for the creation of both halves simultaneously seems most appropriate. A successful synthesis of these compounds will allow us to further investigate these derivatives for their antimicrobial and biofilm-disrupting properties.

Identifying Students’ Incorrect Common-Sense Knowledge In Forces And Motion: Recommendations For Developing Computer-Based Learning Media, Ahmad Ridlotul Adha, Sutopo Sutopo, Nasikhuddin Nasikhuddin

Jurnal Pendidikan Sains

Conceptual understanding is a crucial area in physics education research, focusing on students’ comprehension of fundamental principles. Force and motion, integral topics within this field, are inherently linked to students’ daily experiences. Numerous studies have identified the persistence of common sense knowledge among students. This research presents a literature review aimed at identifying such consistently held misconceptions. We analyzed 17 papers sourced from Publish or Perish 8, Google Scholar, and Scopus. Our analysis revealed that the concepts of impetus and active force are the most persistent forms of common sense knowledge, influenced by real-life experiences. Additionally, students’ difficulties with kinematics …

Sustainable Food House Area (Sfha): Analysis Of Community Knowledge And Behavior, Delvi Adri, Mimien Henie Irawati, Sueb Sueb

Jurnal Pendidikan Sains

This research aimed to assess the knowledge and behavior of the community regarding the Sustainable Reserve Food Garden (SRFG) program. The study was conducted in July 2016 in Jorong Lubuk Agam, Kenagarian Ampang Kuranji Koto Baru, Dharmasraya, West Sumatra. Utilizing a descriptive quantitative approach, data were collected using Accidental Random Sampling, involving 33 heads of families as respondents. The findings revealed that community knowledge and behavior related to the SRFG program were generally insufficient, with 44.1% and 47.27% of respondents, respectively, demonstrating a lack of understanding and practice. The study concludes that approximately one-third of the population has limited knowledge …

Preface, Anne Greene, Martin Lipa, Bill Paulson

Level 3

No abstract provided.

Regulators Are Exploring With Industry How To Strengthen Quality Risk Management Practices, With Revision Of Ich Q9 A Key Focal Point, ( Ipq )

Level 3

No abstract provided.

Covalent Inhibition Of Enzyme Sortase A As A New Pathway Against Bacterial Resistance Of Staphylococcus Aureus, Umyeena Bashir

Master's Theses

The continued rise of antibiotic-resistant bacteria, such as MRSA (methicillin-resistant Staphylococcus aureus), has made the discovery of novel antibiotics critical. While bacteriostatic and bactericidal antibiotics inevitably exert evolutionary pressure on bacteria to develop resistance, small molecules that target mechanisms of bacterial virulence present a promising alternative for treatment. Sortase A (Srt A), a cysteine protease of S. aureus, promotes bacterial virulence by covalently attaching proteins such as pilin to the bacterial surface, enabling bacterial adhesion to mammalian cells. Inhibitory studies of this enzyme have gained prominent interest as a new pathway for drug development since blocking this enzyme's ability to …

Conversion Of Cellulose To 5-Hydroxymethylfurfural As Sustainable Energy: A Bibliometric Analysis By Vosviewer, Royyan Faradis, Ardiansyah Bagus Suryanto, Irmina Kris Murwani

Journal of Environmental Science and Sustainable Development

The developments of the global economy and society impact resources and the environment. This condition requires an alternative to find new, safe, and sustainable energy types. The conversion of cellulose to 5-hydroxymethylfurfural (5-HMF) has become a significant area of research interest. It has triggered the development of research directions related to biomass and energy because it can be an intermediary source for making polymers, solvents, pharmaceuticals, and biofuels. The primary objective of this study is to give a bibliometric analysis of 1753 reports on the development of research on cellulose conversion to 5-HMF from 1965 to 2021. The data were …

Assessing The Performance Of Newly Developed Silica Nanoparticles Against Lead And Phosphate Ion Removal From Contaminated Solutions Using Adsorption Isotherm, Hasan Shamseddine, Nour Abi Aad, Rami Oweini, Ghassan Younes

BAU Journal - Science and Technology

This study investigates the removal of Lead and Phosphate ion from aqueous solution using new silica nanoparticles doped with europium (H1) which was characterized using Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), Fourier-transform Infrared Spectroscopy (FTIR). The aim of this research is to develop a novel adsorbent material that can efficiently remove contaminated ions from wastewater or aqueous solutions. The adsorption of lead and phosphate ion onto the silica nanoparticles is investigated, and the efficiency of this removal is evaluated. Equilibrium data analysis reveals linear fitting with Langmuir isotherm with 24.76 mg/g Lead ion uptake, while for phosphate the …

Bromination And Conversion Of Tetrahydro-1h-Indene To Bisoxirane With A New Approach: Synthesis, Structural Characterization By Spectroscopic And Theoretical Methods, And Biological Analysis Supported By Dft And Docking, Raşi̇t Fi̇kret Yilmaz, Sultan Erkan, Sali̇h Ökten, Ahmet Tutar, Ertan Şahi̇n

Turkish Journal of Chemistry

In this study, a new method for synthesizing diepoxides is proposed. Tetrahydroindene 1 was brominated with NBS in the presence of LiClO4 and acetic acid, resulting in the formation of dibromodiacetate derivatives 2 and 3. Treatment of compounds 2 and 3 with NaOH in methanol produced a mixture of diepoxides 4 and 5. Additionally, direct bromination of tetrahydro-1H-indene yielded tetrabromo octahydroindene isomers 6 and 7. The structures of the compounds were characterized using spectroscopic techniques such as 1H NMR, 13C NMR, APT, COSY, and XRD. The new method provides an easy and selective route to access epoxides for the synthesis …

Ph Responsive Curcumin Released From Urea-Amine Group Functionalized Mesoporous Organosilica Nanoparticles, Osman Tayyar Arli, Yaşar Gök, Hali̇l Zeki̇ Gök

Turkish Journal of Chemistry

Studies on natural products with anticancer properties have gained more importance in recent years in order to not damage healthy tissues during cancer treatments or to perform the treatment causing the least damage. Curcumin is a common natural product with anticancer properties, but its low solubility, instability, and bioavailability have limited its use in clinical applications in cancer research. As a proposed solution to this problem, a new mesoporous organosilica nanocarrier (MON-A) functionalized with a 1,2-diphenylethane-1,2-diamine structure capable of pH-controlled release was prepared in this study. MON-A was characterized by TGA, BET, XRD, FT-IR, and SEM-EDS analyses. Dispersion of MON-A …

Scope And Limitations Of The Preparation Of Xanthones Using Eaton’S Reagent, Johann Bosson

Turkish Journal of Chemistry

Xanthones comprise a large family of heterocycles displaying fascinating biological properties. Many synthetic protocols have been developed for the preparation of natural and nonnatural xanthone derivatives. Among them, condensation reactions between salicylic acid derivatives and phenol partners are highly desirable. Those reactions can be satisfactorily performed using Eaton’s reagent (P2O5 in CH3SO3H). Despite being highly effective with a variety of substrates, this approach presents limitations that depend on the electronic nature of the reaction precursors. The scope and limitations of the Eaton’s reagent-mediated preparation of xanthones are herein presented and discussed. In short, this approach is limited to the utilization …

Comparison Of Metal-Carbenoid Reactions Of Β-2-Five-Membered Heteroaryl Substituted Α,Β-Unsaturated Ketones, Kumsal Eroğlu, Olcay Anaç, Füsun Şeyma Kişkan

Turkish Journal of Chemistry

In this study, β-2-heteroaryl substituted (N-methyl 2-pyrrolyl, 2-thiophenyl, 2-furyl) α,β-unsaturated ketones were reacted with two α-diazo carbonyl compounds that had different characteristics (dimethyl diazo malonate and 1-diazo-1-phenyl-propane-2-one) in the presence of both copper and rhodium catalysts. In the case of reactions with N-methyl 2-pyrrolyl α,β-unsaturated ketones, the major product was the insertion derivative. However, in the reactions of 2-thiophenyl and 2-furyl α,β-unsaturated ketones with dimethyl diazomalonate (acceptor-acceptor disubstituted), only dihydrofuran products were formed over carbonyl ylides. When 2-thiophenyl and 2-furyl α,β-unsaturated ketones were reacted with 1-diazo-1-phenyl-propane-2-one (donor-acceptor disubstituted), 1-phenylpropane-1,2-dione was obtained under our reaction conditions.

Synthesis Of Silane- And Quaternary Ammonium-Bearing Copolymers And Application As A Coating Resin On Cotton Fabric, Ayşe Marti̇n, Nazgül Güler, İlknur Yerli̇, Hande Hançer, Tüli̇n Özbek, Tarik Eren

Turkish Journal of Chemistry

In this study, silane and quaternary ammonium functional methacrylate monomers were synthesized and used to construct a copolymer using an emulsion polymerization technique to control the reaction rate. The copolymer was then designed using different ratios of silane and quaternary ammonium groups to investigate the relationship between the structure and properties. The presence of the ethoxy silane group in the copolymer series provided covalent bonding through the silanol group onto cotton fabric. The presence of cationic groups also helped to cover the fabric surface. After coating the cotton textile fabric, the resistance of the dye on the fabric surface to …

Phytochemical Investigation On The Aerial Parts Of Veratrum Versicolor F. Viride Nakai And Their Biological Activities, Seong Su Hong, Jae Yeon Lee, Yeon Woo Jeong, Ji Eun Lee, Yun-Hyeok Choi, Wonsik Jeong, Eun-Kyung Ahn, Chun Whan Choi, Il Ho Ahn, Joa Sub Oh

Turkish Journal of Chemistry

Veratrum spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (1), three stilbenoids (2–4), and five flavonoids (5–9), were isolated from the aerial parts of Veratrum versicolor f. viride Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from V. versicolor f. viride for the first time in the study. Among them, two flavone aglycone tricetins (7 and 9) have never been isolated from the genus Veratrum or the family Melanthiaceae. The ethanol extract …

Exploring The Photocatalytic And Photodynamic Effects Of Bodipy-Linked Titanium Dioxide Nanoparticles, Seda Demi̇rel Topel

Turkish Journal of Chemistry

This study aimed to investigate the photocatalytic and photodynamic actions of a 2,6-diiodinated-BODIPY (2,6-diI2-Bod) photosensitizer (PS) covalently linked to TiO2 nanoparticles (NPs). The TiO2 NPs were synthesized utilizing the hydrothermal technique, yielding an average particle size of 4–5 nm as ascertained by transmission electron microscopy and 6.4 nm as determined by dynamic light scattering measurements. The integration of the nonsoluble Bod PS to TiO2 NPs provided increased dispersibility in physiological media, making it more applicable to photodynamic therapy applications. Bod-TiO2 NPs exhibited moderate efficiency of 56.9% in singlet oxygen generation. Additionally, the photocatalytic behavior of the TiO2 NPs was evaluated …

Removal Of Toxic Cr(Vi) From Aqueous Medium With Effective Magnetic Carbon-Based Nanocomposites, Ferda Ci̇van Çavuşoğlu, Gülsüm Özçeli̇k, Şahi̇ka Sena Bayazi̇t

Turkish Journal of Chemistry

Cr(VI), which has toxic effects, is a heavy metal and it must be removed from the environment due to the various damages it causes. In this study, the removal of Cr(VI) pollutants from aqueous solutions with Fe3O4-based materials using a batch adsorption technique was investigated. Magnetically modified graphene nanoplatelet (GNP)-based nanocomposites were prepared and their structures were characterized by FTIR, XRD, SEM, BET, and TGA techniques. The effects of various physicochemical parameters such as adsorbent dose, contact time, initial Cr(VI) solution concentration, pH, and the presence of coexisting ions (NaCl) on the adsorption process were investigated. Accordingly, the optimum conditions …

Production Of Gelatin Fibrous Mats Using Different Nanofiber Production Methods For Medical Applications And Comparison Of Their Properties, Melike Güngör, Kevser Sağlamkol, Zeynep Yağmur Baydemi̇r, Ali̇ Kiliç

Turkish Journal of Chemistry

In the literature, there are studies on medical applications using different nanofiber production methods with natural polymers. However, each system has different fiber-forming capabilities. For this reason, in this study, we investigated the production of nanofibers from a biodegradable natural polymer, gelatin, using four separate nanofiber production methods, namely electrospinning (ES), electroblowing (EB), solution blowing (SB), and centrifugal spinning (CS). Our aim was to determine the most suitable fibrous web structure for medical applications and contribute to science in this respect. It was observed that the thinnest fibers (386 nm) and the heaviest mats (15.975 g m–2) were produced by …

Quaternized Chitosan/Pva/Natural Bioactive Agent Electrospun Wound Scaffolds: Production, Characterization, And Investigation Of Release Kinetics, Ezgi Eren Belgin, Cankiz Gi̇zem Deli̇balta

Turkish Journal of Chemistry

Quaternized chitosan (HTCC) was synthesized and characterized to increase chitosan solubility. Then HTCC was electrospun with poly (vinyl alcohol) (PVA) and prepared natural bioactive agent (Calendula officinalis) extract was loaded onto fibers for wound scaffold applications. Morphological, structural, and mechanical characterization of the produced wound scaffolds was performed and their in vitro bioactive component release behavior was investigated. As a result, it was observed that the degree of quaternization of chitosan was 0.89, and synthesized HTCC was soluble in acidic, basic, alkaline media and could be electrospun with PVA in the presence of a natural bioactive agent. The presence of …

Search For Osme Bonds With Π Systems As Electron Donors, Xin Wang, Qingzhong Li, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

The Osme bond is defined as pairing a Group 8 metal atom as an electron acceptor in a noncovalent interaction with a nucleophile. DFT calculations with the ωB97XD functional consider MO₄ (M = Ru, Os) as the Lewis acid, paired with a series of π electron donors C₂H₂ , C₂H₄ , C₆H₆ , C₄H₅N, C₄H₄O, and C₄H₄S. The calculations establish interaction energies in the range between 9.5 and 26.4 kJ/mol. Os engages in stronger interactions than does Ru, …

Variables Affecting The Extraction Of Antioxidants In Cold And Hot Brew Coffee: A Review, Brian Yust, Frank Wilkinson, Niny Rao

College of Life Sciences Faculty Papers

Coffee beans are a readily available, abundant source of antioxidants used worldwide. With the increasing interest in and consumption of coffee beverages globally, research into the production, preparation, and chemical profile of coffee has also increased in recent years. A wide range of variables such as roasting temperature, coffee grind size, brewing temperature, and brewing duration can have a significant impact on the extractable antioxidant content of coffee products. While there is no single standard method for measuring all of the antioxidants found in coffee, multiple methods which introduce the coffee product to a target molecule or reagent can be …

Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang

Michigan Tech Publications

Long oligodeoxynucleotides (ODNs) are segments of DNAs having over one hundred nucleotides (nt). They are typically assembled using enzymatic methods such as PCR and ligation from shorter 20 to 60 nt ODNs produced by automated de novo chemical synthesis. While these methods have made many projects in areas such as synthetic biology and protein engineering possible, they have various drawbacks. For example, they cannot produce genes and genomes with long repeats and have difficulty to produce sequences containing stable secondary structures. Here, we report a direct de novo chemical synthesis of 400 nt ODNs, and their isolation from the complex …

Synthesis And Characterization Of Porphyrin And Phthalocyanine-Based Photosensitizers For Energy And Biomedical Applications, Mavis Forson

Theses and Dissertations

Porphyrins have been widely used as photosensitizers in research due to their important role in many biological processes. Phthalocyanines have also gained interest in biological applications such as photodynamic therapy (PDT). This dissertation is focused on the synthesis of different photosensitizers for various applications. This dissertation's first section focuses on research involving synthesizing covalently bonded donor-acceptor systems as photosensitizers. Specifically in this work, two porphyrin-fullerene dyads were synthesized using a modified tetraphenyl porphyrin with varying bridges between the porphyrin and fullerene. Metal was incorporated in the porphyrin core to enhance the properties of the dyads as photosensitizers. Detailed photophysical properties, …

Investigation Of Zinc And Iron In Wildflower Honey, Savannah Simpson

Honors Theses

Honey acts as a valuable food source for both animals and humans. When found in contaminated environments, there is an increased likelihood that honey samples will have high metal concentrations. It has been discovered that honey concentrations in metals can be different based on location. This experiment aims to determine the amount of two valuable metals, zinc, and iron, in various honey sources. These metals can be important to the human body because they help boost immunity and allow the body to carry out the functions required for survival. However, if these elements are present in copious quantities, then it …

Castor Oil Polyol-Based Adhesives With Additional Crosslinker For Improvement In Mechanical And Thermal Properties., Yash Desai

Electronic Theses & Dissertations

Polyurethanes (PU) have been promising polymeric materials with many applications, including adhesives. Projecting an estimated revenue from 42.8 billion $ in 2021 to 61.5 billion $ by 2026. However, a large number of PU adhesives are sourced from petroleum products. Therefore, to lower the dependence on non-renewable resources and provide sustainable and affordable alternatives. In this work will synthesize bio-based adhesives of polyurethane from modified castor oil-based polyol. Generally, polyurethane reaction depends on the properties of polyol and isocyanates. The most important aspect of these reactions is the OH number of the polyol, which is responsible for the crosslinking and …

Celestial Bodies, Rebecca L. Rand, Mark Popinchalk

Capstones

Most of us will never come close to touching space. But space touches us every day. On Celestial Bodies, journalist Rebecca Rand and astronomer Mark Popinchalk explore the ways outer space interacts with life on earth.

In Episode 1, hosts Rebecca Rand and Mark Popinchalk explore how, for millions of years, trees have been recording celestial events in space. Within the rings of their trunks, trees store radiation from solar flares, supernovae, and changes in the earth’s magnetic field. The hosts talk to Dr. Ben Pope to learn more about what we can discover by looking at radioactive molecules …

Mutational Analysis Of The Nitrogenase Carbon Monoxide Protective Protein Cown Reveals That A Conserved C‑Terminal Glutamic Acid Residue Is Necessary For Its Activity, Dustin L. Willard, Joshuah J. Arellano, Mitch Underdahl, Terrence M. Lee, Avinash S. Ramaswamy, Gabriella Fumes, Agatha Kliman, Emily Y. Wong, Cedric P. Owens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nitrogenase is the only enzyme that catalyzes the reduction of nitrogen gas into ammonia. Nitrogenase is tightly inhibited by the environmental gas carbon monoxide (CO). Many nitrogen fixing bacteria protect nitrogenase from CO inhibition using the protective protein CowN. This work demonstrates that a conserved glutamic acid residue near the C-terminus of Gluconacetobacter diazotrophicus CowN is necessary for its function. Mutation of the glutamic acid residue abolishes both CowN’s protection against CO inhibition and the ability of CowN to bind to nitrogenase. In contrast, a conserved C-terminal cysteine residue is not important for CO protection by CowN. Overall, this work …

Differentiation Of Human, Dog, And Cat Hair Fibers Using Dart Tofms And Machine Learning, Laura Ahumada, Erin R. Mcclure-Price, Chad Kwong, Edgard O. Espinoza, John Santerre

SMU Data Science Review

Hair is found in over 90% of crime scenes and has long been analyzed as trace evidence. However, recent reviews of traditional hair fiber analysis techniques, primarily morphological examination, have cast doubt on its reliability. To address these concerns, this study employed machine learning algorithms, specifically Linear Discriminant Analysis (LDA) and Random Forest, on Direct Analysis in Real Time time-of-flight mass spectra collected from human, cat, and dog hair samples. The objective was to develop a chemistry- and statistics-based classification method for unbiased taxonomic identification of hair. The results of the study showed that LDA and Random Forest were highly …