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Synthesis And Biological Activity Of 4-(4-Hydroxybenzylidene)-2- (Substituted Styryl) Oxazol-5-Ones And Their O-Glucosides, Vijay Taile, Kishor Hatzade, Pravin Gaidhane, Vishwas Ingle

Turkish Journal of Chemistry

The 4-(4-hydroxybenzylidene)-2-methyl oxazol-5-ones 1 were treated with various aldehydes in the presence of acetic acid to form 4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones 2a-i, which were glucosylated using \alpha-acetobromoglucose as a glucosyl donor to afford 4-(4-o-\beta-d-tetra-o-acetyl-glucoxybenzylidene)-2- (substituted styryl) oxazol-5-ones 3a-i, which were deacetylated using zinc acetate in absolute methanol to form 4-(4-o-\beta-d-glucoxybenzylidene)- 2-(substituted styryl) oxazol-5-ones 4a-i. The compounds showed good antimicrobial and antifungal activity.

Spectroscopic And Structural Study Of Ni(Ii) Dipicolinate Complex With 2-Amino-4-Methylpyrimidine, İclal Bulut, İbrahi̇m Uçar, Canan Kazak

Turkish Journal of Chemistry

Nickel(II) dipicolinate complex containing 2-amino-4- methylpyrimidine (2A-4Mpy), [Ni(2A-4Mpy)(dpc) (H_2O)_2] . 2H_2O was synthesized in solid state and its structural and spectroscopic properties were determined by XRD, IR, and UV-Vis techniques. The crystal data revealed that the Ni complex is in triclinic crystal systems with space group P-1 and Z = 2. The Ni(II) ion is bonded to dipicolinate ligand through pyridine N atom together with one O atom of each carboxylate group, 2 aqua ligands, and the N atom of 2-amino-4-methylpyrimidine, forming distorted octahedral geometry. IR and UV-Vis spectra of the complexes all agree with the observed crystal structure.

Synthesis And Antimicrobial Activity Of Dinaphtho[2,1-B]Furan-2-Yl-Methanone And Their Oxime Derivatives, Cumhur Kirilmiş, Murat Koca, Süleyman Servi̇, Seher Gür

Turkish Journal of Chemistry

The reaction of 2-hydroxy-1-naphthaldehyde with 1,3-dichloroacetone and potassium carbonate was used to prepare dinaphtho[2,1-b]furan-2-yl-methanone (1) as starting reagents. In order to obtain dinaphtho[2,1-b]furan-2-yl-methanole (2), compound 1 was reduced with NaBH_4. N-oxime derivative of this compound (3) was synthesized by the reaction of the compound 1 with hydroxylamine. Alkyl and acyl substituted N-oxime ethers (4-11) were obtained by the reaction compound 3 with various halogen containing compounds. Compound 12 was obtained by reflux of the compound 11 with hydrazine monohydrate in ethanol. Compound 13 was synthesized by the reaction of the compound 11 with NaOH. The synthesized compounds were tested for …

Synthesis And In Vitro Anti-Helicobacter Pylori Activity Of 2-(Substituted Benzylthio)-5-(5-Nitro-2- Furyl)-1, 3, 4-Thiadiazole Derivatives, Negar Mohammadhosseini, Ali Asadipor, Bahram Letafat, Mohsen Vosooghi, Farideh Siavoshi, Abbas Shafiee, Alireza Foroumadi

Turkish Journal of Chemistry

Starting from (5-nitrofuran-2-yl)methylene diacetate, a new series of 2-[(substituted benzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles (6a-n) were synthesized and the structures of the compounds were determined using spectroscopic methods including mass spectrometry, ^1H-nuclear magnetic resonance, infrared spectroscopy, and elemental analysis. The in vitro anti-Helicobacter pylori activity of the synthesized compounds was evaluated by the disk diffusion method against the clinical isolates of Helicobacter pylori. The results indicated that most of the synthesized compounds exhibited significant inhibitory activity against H. pylori with respect to standard drug metronidazole. Compound 6l, containing the 2-chloro-6-fluorobenzylthio moiety, was the most potent compound tested.

Chemical Constituents And Mushroom Tyrosinase Inhibition Activity Of Chloroxylon Swietenia Leaves, G. Venkatateswara Rao, K. Sambasiva Rao, Tiruganasambandham Annamalai, Narayanasamy Radhakrishnan, Triptikumar Mukhopadhyay

Turkish Journal of Chemistry

From the leaves of Chloroxylon swietenia DC., 5 known secondary metabolites, namely 6, 8-diprenylumbelliferone (1), bergaptan (2), isopimpinellin (3), tritriacontanol (4), and isoquercetrin (5), were isolated from a folklore medicinal plant. Three compounds were isolated for the first time from this genus. The structures of these compounds were elucidated by UV, IR, 1D and 2D NMR techniques. Different fractions from the leaves of C. swietenia were investigated for their tyrosinase inhibition activity.

Zeolite Catalyzed Efficient Synthesis Of Perimidines At Room Temperature, Akbar Mobinikhaledi, Naser Forughifar, Nemat Bassaki

Turkish Journal of Chemistry

Arylperimidines, 3(a-l), were synthesized in good yields by cyclocondensation reaction of 1,8-diaminonaphthalene and aromatic aldehydes in the presence of NaY zeolite as a catalyst. The simple environmentally benign nature, reusability of the catalyst, and the easy work-up reaction are some of the advantages of this protocol.

Synthesis Of Methyl (E)-2',4''-Thiazachalcones And Their N-Alkyl Derivatives, Photochemistry With Theoretical Calculations And Antimicrobial Activities, Asu Usta, Ahmet Yaşar, Nuran Yayli, Şengül Alpay Karaoğlu, Nuretti̇n Yayli

Turkish Journal of Chemistry

A series of 9 new (E)-thiazachalcones (1-3), and their N-alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that \delta-truxinic type dimer is the most stable isomer.

A Systematic Study On The Absorption And Fluorescence Properties Of 2,4,6-Triaryl And Tripyridylpyridines, Esra Findik, Mustafa Arik, Mustafa Ceylan

Turkish Journal of Chemistry

Eight different 2,4,6-triaryl, and tripyridylpridines compounds were synthesized and their fluorescent properties were studied by using steady-state and time-resolved fluorescence and UV-Vis absorption spectroscopy techniques in 6 different solvents. Especially, 2,4,6-triarylpyridines showed strong fluorescence properties with high fluorescence quantum yields but small Stokes shifts.

Reactions Of The Solvent-Stabilized Compound [Moocl_2(Thf)_2] With Aromatic Nitrogen Donor Ligands: Spectroscopic Characterization And Semiempirical Am1* Calculations, Gülşah Kiliçkaya, Başak Doğan, Nursel Acar, Işil Topaloğlu Sözüer

Turkish Journal of Chemistry

Reaction of the solvent-stabilized dioxo-molybdenum(VI) compound [MoO_2Cl_2(THF)_2] with PPh_3 yielded the oxomolybdenum(IV) species [MoOCl_2(THF)_2] (1) by the removal of one oxygen atom as PPh_3O. The complexes [MoOCl_2(=NC_6H_4CN)] 2, [MoOCl_2(CNC_6H_4OH)] 3, [MoOCl_2(=NC_6H_4NH_2)] 4, and [MoOCl_2(=NC_6H_4OCH_3)] 5, were synthesized by the reactions of [MoOCl_2(THF)_2] with XC_6H_4Y (X = NH_2, Y = CN; X= CN, Y = OH; X = Y = NH_2; X = NH_2, Y = OCH_3). All the new compounds were characterized by elemental analyses, and FTIR, UV-Vis, and ^1H- and ^{13}C-NMR spectra. Geometrical parameters and molecular orbital calculations showed that compounds 2-5 are stabilized by a charge transfer between …

Synthesis, Characterization, And Antibacterial Activity Of Some Transition Metals With The Schiff Base N-(2-Furanylmethylene)-3-Aminodibenzofuran, Aurora Reiss, Stelian Florea, Theodor Caproiu, Nicolae Stanica

Turkish Journal of Chemistry

This paper presents the structure and antibacterial properties of some complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) with a new Schiff base N-(2-furanylmethylene)-3- aminodibenzofuran. The structure of each complex was characterized by spectroscopic methods (IR, UV-Vis, ^1H-NMR, and ESR), conductometric and magnetic data, and thermogravimetric and elementary analysis. According to these data, we propose an octahedral geometry for Co(II), Ni(II), and Cu(II) complexes, and a tetrahedral geometry for Zn(II), Cd(II), and Hg(II) complexes. Antibacterial activity of the ligand and its complexes was tested against selected bacteria. The ligand and all the complexes possess antimicrobial activity, and antimicrobial activity …

4h-Pyran-4-One Derivatives:; Leading Molecule For Preparation Of Compounds With Antimycobacterial Potential, Demet Us, Ece Gürdal, Barkin Berk, Si̇nem Öktem, Tanil Kocagöz, Berrak Çağlayan, Işil Aksan Kurnaz, Di̇lek Demi̇r Erol

Turkish Journal of Chemistry

A series of 3-hydroxy-6-methyl-2-((4-substitutedpiperazin-1- yl)methyl)-4H-pyran-4-one structured compounds were synthesized by reacting 5-hydroxy-2-methyl-4H-pyran-4-one with suitable piperazine derivatives using Mannich reaction conditions. Antibacterial activities of the compounds for E. coli, S. paratyphi, S. flexneri, E. gergoviae, and M. smegmatis were assessed in vitro by using broth dilution for determination of the minimum inhibitory concentration (MIC). In addition, their inhibitory effects over DNA gyrase enzyme were evaluated using a DNA gyrase supercoiling assay. Among the synthesized compounds; compound 7 showed a 4 \mu g/mL MIC value for M. smegmatis, whereas the other compounds demonstrated moderate to high activity. Those tested in the supercoiling …

Antioxidant And Anticholinesterase Constituents Of Salvia Poculata, Ufuk Kolak, Işil Hacibeki̇roğlu, Mehmet Öztürk, Fevzi̇ Özgökçe, Gülaçti Topçu, Ayhan Ulubelen

Turkish Journal of Chemistry

Two triterpenoids, namely 2\alpha,3\alpha-dihydroxy-24-nor- 4(23),12-oleanadien-28-oic acid (1) and ursolic acid (2); 4 flavonoids, namely 5-hydroxy-7,4'-dimethoxyflavone (3), cirsimaritin (4), eupatilin (5), and salvigenin (6); a diterpenoid, namely sclareol (7); and a steroid, namely \beta-sitosterol (8), were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species. Total phenolic and flavonoid contents of the crude extract were determined as pyrocatechol and quercetin equivalents, respectively. The antioxidant activity of the crude extract and the isolated compounds (2-8) was established using \beta-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity. In addition, the anticholinesterase activity of the crude …

Derivatization Of Porphyrins For Dna And Metal Ion Binding, Especially By Employing Secondary Sulfonamide Links, Janet Manono

LSU Doctoral Dissertations

Porphyrins are of exceptional importance in nature, science and technology: For instance, as ligands for metals in supramolecular synthesis, as photosenstizers in photodynamic therapy (PDT), and as building blocks for electronic devices. In addition to their application in cancer therapy, porphyrin species also exhibit antiviral activity. New meso-tetraarylporphyrins (TArP, Ar = -C₆H₄-) of the general formula, T(R¹R²NSO₂Ar)P, with R¹ = N-py-n-CH₂ (n = 2, 3 or 4) or SO₃^- and R² = H or CH₃ were synthesized. These groups were linked to the …

Liquid Chromatography-Tandem Mass Spectrometry For The Determination Of Methylprednisolone In Rat Plasma And Liver After Intravenous Administration Of Its Liver-Targeted Dextran Prodrug, Shuang-Qing Zhang, Helen R. Thorsheim, Suman Penugonda, Venkateswaran C. Pillai, Quentin R. Smith, Reza Mehvar

Pharmacy Faculty Articles and Research

A specific and sensitive liquid chromatography (LC)-tandem mass spectrometric method for quantitative determination of methylprednisolone (MP) in rat plasma and liver was developed and validated using triamcinolone acetonide as an internal standard. Liquid-liquid extraction using tert-butyl methyl ether was used to extract the drug and the internal standard from plasma and liver. The separation of MP was performed on a C(18) column with a mobile phase of acetonitrile:0.5% formic acid aqueous solution (85:15, v/v) over 4 min. The assay was based on the selected reaction monitoring transitions at m/z 375 -> 161 for MP in plasma, 375 -> 357 for …

A Novel Synthesis And Characterization Of Fluorescein Isothiocyanate Labeled Poly(Styrenesulfonate Sodium Salt), Xiaowei Tong

LSU Master's Theses

The diffusion of polyelectrolytes in low-salt or salt-free aqueous solutions is a controversial question. It has been intensively discussed since it was discovered in 1978. Most previous experimental data were obtained from dynamic light scattering (DLS), whose precision, however, was reduced by stringent sample preparation and weak scattering of polyelectrolyte in low-salt solution. For the most commonly studied polyelectrolyte, poly(styrenesulfonate sodium salt) (NaPSS), the harsh polymerization condition and the manufacturing procedure lead to hydrophobic defects and aggregations, which also block a correct insight about the diffusion of polyelectrolyte. In contrast to DLS, fluorescence photobleaching recovery (FPR) directly looks on the …

A Study Of The Self-Assembly Of Water-Soluble Porphyrins In Aqueous Solution, Javoris Hollingsworth

LSU Master's Theses

In nature, self-assembly processes of biologically active organic molecules often occur, resulting in formation of dimers and higher oligomers of various and sometimes complex structures. This natural occurrence of self-organization has been the subject of research, with the aim of understanding and possibly modulating the aggregation behavior of biological molecules. The meso-tetrakis(4-phosphonatophenyl) porphyrin, H2TPPP was synthesized, purified, and characterized. Its self-assembly was studied in aqueous solutions as a function of pH and time. The variations on the λmax and shape of the Soret band of this porphyrin in the absorption spectra when altering the pH indicated the pH dependency in …

A Simple Spectrophotometric Method For The Determination Of Iron(Ii) Aqueous Solutions, M. Jamaluddin Ahmed, Uttam Kumer Roy

Turkish Journal of Chemistry

An ultra-sensitive and highly selective non-extractive spectrophotometric method is presented for the rapid determination of iron(II) at trace levels using 2', 3, 4', 5, 7-Pentahydroxyflavone (morin) as a new spectrophotometric reagent in slightly acidic solution (0.0001-0.0002 M H_2SO_4). The reaction is instantaneous and absorbance remains stable for over 24 h (\lambda_{max} = 415 nm). The molar absorptivity was found to be 6.85 \times 10^4 L mol^{-1} cm^{-1}. Linear calibration graphs were obtained for 0.01-10 \mu g mL^{-1} of Fe^{II}. The stoichiometric composition of the chelate is 1:2 (Fe:morin). Large excesses of over 50 cations, anions, and complexing agents (e.g., tartrate, …

A Density Functional Study Of The Relative Stability Of Intermediates In A Mcmurry Coupling Reaction, Andrew Jozef Livingston

Senior Honors Theses and Projects

Reductive cyclization via McMurry coupling is a common way to form pyrrolizidine rings. In this work we investigate the titanium-catalyzed McMurry coupling reaction leading to a pyrrolizidine alkaloid using density functional methods. Specifically, we compare the relative energies of all possible pinacolate intermediates at the UB3LYP/6-31G level of theory. The most stable intermediate is found to be the one resulting from C-O bond insertion in the ester group. The McMurry product is not predicted to form.

Faculty Should Consider Peer Review As A Means Of Improving Students' Scientific Reasoning Skills, Briana Timmerman, Denise Strickland

Journal of the South Carolina Academy of Science

No abstract provided.

The Integrated Biomedical Science Graduate Program At The University Of South Carolina, Richard Hunt

Journal of the South Carolina Academy of Science

No abstract provided.

Synthesis Of Fatty Acid Binding Protein Inhibitors: A New Approach For Diabetes Treatment, Shekelia Baccus, M. Perry Davis Jr, David R. Magnin

Journal of the South Carolina Academy of Science

No abstract provided.

Generation Of A Retroviral Vector That Expresses An Anti-Hiv-1 Tat Hammerhead Ribozyme, Lindsey E. Padgett, William H. Jackson

Journal of the South Carolina Academy of Science

No abstract provided.

The Effect Of Incubation Time On The Generation Of Benzene In Sierra Mist Free, Sarah Law

Journal of the South Carolina Academy of Science

No abstract provided.

Downregulation Of Hiv-1 Vif By A Hammerhead Ribozyme Expressed From A Retroviral Vector, Audrey M. Hendley, William Jackson

Journal of the South Carolina Academy of Science

No abstract provided.

Effect Of Thaw Temperature On Murine Blastocyst Development, Heather M. Barton, H. Lee Higdon Iii, Ph.D., Jennifer E. Graves-Herring M.S., William R. Boone, Ph.D.

Journal of the South Carolina Academy of Science

No abstract provided.

The Effects Of Growing Method And The Food Processing System On Bacterial Concentration In Spinach, Thad S. Moore, Lisa W. Norman

Journal of the South Carolina Academy of Science

No abstract provided.

Temperature Changes Resulting From A Gaalas Laser In The Decontamination Of A Failing Dental Implant, Adam B. Oppenheimer

Journal of the South Carolina Academy of Science

No abstract provided.

Where Do Mouse Embryos Thrive Best? Comparison Of Mammalian Embryo Development Under Varying Laboratory Environments, Yvonne K. Kao, H. Lee Higdon Iii, Ph.D, Jennifer E. Graves-Herring , M.S., William R. Boone Ph.D

Journal of the South Carolina Academy of Science

No abstract provided.

Alterations Of Zinc Transporters In Alzheimer's Disease, Ganna Lyubartseva

University of Kentucky Doctoral Dissertations

Alzheimer’s disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests the etiology of AD may involve disruptions of zinc (Zn) homeostasis. We hypothesize that disruption of Zn homeostasis leads to alterations of Zn transporter (ZnT) proteins, resulting in increased production of neurotoxic amyloid beta (Aβ) peptide in AD brain. To address this hypothesis we carried out the following studies.

1. We characterized alterations of ZnT-1, ZnT-4 and ZnT-6 in the brain of preclinical AD (PCAD) subjects, who show no overt clinical manifestations of AD but demonstrate …

Vibrational Spectroscopy Of Isotopically Labeled Indoles And Electron Transfer Involving Indole (Tryptophan) Radicals, Senghane Dominique Dieng

Theses, Dissertations and Culminating Projects

Vibrational spectroscopy of tryptophan can be used as a probe for local protein conformation and to study protein electron transfer. For the interpretation of the vibrational spectra, the proper assignment of the vibrational bands to normal modes is essential. We report the experimentally measured infrared and Raman spectra of tryptophan, indole and 3-methylindole as well as of several of their isotope substituted forms; tryptophan indole-d₅ and -¹⁵N₂, and indole 2-¹³C. The effect of the exchange of the indole NH to ND on the vibrational spectra of these molecules was also determined. The measurements …