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A Review On The Ethnobotanical, Phytochemistry, And Pharmacological Activities Of Aristolochia Longa L., Oluwafemi Adeleke Ojo, Matthew Iyobhebhe, Bukola Atunwa, Adebola Busola Ojo Aug 2022

A Review On The Ethnobotanical, Phytochemistry, And Pharmacological Activities Of Aristolochia Longa L., Oluwafemi Adeleke Ojo, Matthew Iyobhebhe, Bukola Atunwa, Adebola Busola Ojo

Karbala International Journal of Modern Science

Aristolochia longa L. is a plant native to Algeria and Morocco that has been used by the locals to combat different arrays of infections and diseases found among them. This particular plant is well-known for its therapeutic qualities that could be traced back to the presence of many effective phytochemicals that have been extrapolated from the different parts of the plant, like the leaves and roots: flavonoids, saponins, tannins, 4-hydroxybenzoic acid, β-carotenes, limonenes, and palmitic acids. This plant has been identified in different research articles to be able to manage diseases effectively because it possesses some pharmacological attributes such as; …

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Applicability Limits Of The End Face Fiber-Optic Gas Concentration Sensor, Based On Fabry-Perot Interferometer, S.M.R.H. Hussein, A.Zh. Sakhabutdinov, O.G. Morozov, V.I. Anfinogentov, J.A. Tunakova, A.R. Shagidullin, A.A. Kuznetsov, K.A. Lipatnikov, A.R. Nasybullin Aug 2022

Applicability Limits Of The End Face Fiber-Optic Gas Concentration Sensor, Based On Fabry-Perot Interferometer, S.M.R.H. Hussein, A.Zh. Sakhabutdinov, O.G. Morozov, V.I. Anfinogentov, J.A. Tunakova, A.R. Shagidullin, A.A. Kuznetsov, K.A. Lipatnikov, A.R. Nasybullin

Karbala International Journal of Modern Science

The mathematical model of the fiber-optic sensor for gas concentration analysis is under study. The sensor is imple-mented as Fabry-Perot interferometer at the end face of the optical fiber by applying a thin polymer film, which permit-tivity depends on the tested gas concentration. It is shown, that a change in the properties of the optical fiber or the at-mosphere permittivity leads mainly to the spectrum contrast changing and does not change the period and the wave-length shift of its comb. The influence of the polymer film thickness, the environment temperature and humidity on the Fabry-Perot spectrum is analyzed. The necessity …

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Molecular Docking Reveals Phytoconstituents Of The Methanol Extract From Muntingia Calabura As Promising Α-Glucosidase Inhibitors, Nurlena Andalia, Muhammad N. Salim, Nurdin Saidi, Muhammad Ridhwan, Muhammad Iqhrammullah, Ummu Balqis Aug 2022

Molecular Docking Reveals Phytoconstituents Of The Methanol Extract From Muntingia Calabura As Promising Α-Glucosidase Inhibitors, Nurlena Andalia, Muhammad N. Salim, Nurdin Saidi, Muhammad Ridhwan, Muhammad Iqhrammullah, Ummu Balqis

Karbala International Journal of Modern Science

Inhibition of α-glucosidase has been used as a management of type 2 diabetes mellitus, where studies are focused on finding more efficacious and safe drugs. Herein, the research aimed to unveil the potential of phytoconstituents contained in methanol extract of Muntingia calabura leaves in inhibiting α-glucosidase through molecular docking simulation. From a systematic search (Scopus), we found 5 eligible articles and identified 28 phytocompounds. Fisetin, pinostrobin, and rhamnetin identified in M. calabura extract were predicted to have good bioavailability. Finally, fisetin was revealed as the most potential α-glucosidase inhibitor candidate with a binding affinity of -7.5 kcal/mol.

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Assessing The Indigenous Arbuscular Mycorrhizal Fungi (Amf) Community Associated With Sea Oats Along The Georgia Coast At Jekyll And Tybee Islands, Kylie Stover Aug 2022

Assessing The Indigenous Arbuscular Mycorrhizal Fungi (Amf) Community Associated With Sea Oats Along The Georgia Coast At Jekyll And Tybee Islands, Kylie Stover

Master of Science in Integrative Biology Theses

Coastal sand dunes are fragile ecosystems that serve as natural defenses to protect the adjacent mainland by absorbing the impacts and energy from severe storms. Different efforts have been taken to restore coastal sand dunes, focusing on foredunes. However, there are many strategies involved with coastal restoration and one superior technique has not been found to be the best. Arbuscular mycorrhizal fungi (AMF) supply a range of limiting nutrients (N, P, Fe, and Zn) to the host plant while improving dune stability. This study aimed to assess and compare the diversity of the indigenous AMF community associated with sea oats …

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Legacies Align With Colby’S Acquisition Of Allen And Benner Islands, Bob Keyes Aug 2022

Legacies Align With Colby’S Acquisition Of Allen And Benner Islands, Bob Keyes

Colby Magazine

The College creates a 500-acre island campus in Muscongus Bay

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Application Of Sulfur Sad To Small Crystals With A Large Asymmetric Unit And Anomalous Substructure, Tung Chung Mou, Baisen Zeng, Tzanko I. Doukov, Stephen R. Sprang Aug 2022

Application Of Sulfur Sad To Small Crystals With A Large Asymmetric Unit And Anomalous Substructure, Tung Chung Mou, Baisen Zeng, Tzanko I. Doukov, Stephen R. Sprang

Biological Sciences Faculty Publications

The application of sulfur single-wavelength anomalous dispersion (S-SAD) to determine the crystal structures of macromolecules can be challenging if the asymmetric unit is large, the crystals are small, the size of the anomalously scattering sulfur structure is large and the resolution at which the anomalous signals can be accurately measured is modest. Here, as a study of such a case, approaches to the SAD phasing of orthorhombic Ric-8A crystals are described. The structure of Ric-8A was published with only a brief description of the phasing process [Zeng et al. (2019), Structure, 27, 1137-1141]. Here, alternative approaches to determining the 40-atom …

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Signatures Of Genome Evolution In Two Divergent Lizard Species From Texas, Jose A. Maldonado Aug 2022

Signatures Of Genome Evolution In Two Divergent Lizard Species From Texas, Jose A. Maldonado

Biology Dissertations - Archive

The continual reduction of the cost of high-throughput sequencing is now making it feasible to sequence large genomic and transcriptomic datasets for non-model organisms. Many of these under study non-model organisms have no available molecular data available. Yet, many of these organisms are of interest for their usefulness in addressing long-standing unanswered questions in the field of evolutionary biology or of conservational concern and need immediate intervention. Now we can quickly generate large datasets for these organisms, and here we generate two large datasets for lizards that are both of in interest in the genus Holbrookia and Aspidoscelis. In chapter …

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Elucidating The Molecular Genetic Basis Of Behaviors Related To The Loser Effect, Marquerite Alizabeth Herzog Aug 2022

Elucidating The Molecular Genetic Basis Of Behaviors Related To The Loser Effect, Marquerite Alizabeth Herzog

Biology Dissertations - Archive

Across the animal kingdom, when individuals experience social defeat (losing an aggressive conflict with a conspecific), it elicits stereotypical loser behavior such as isolation or submissiveness. In many species, social defeat is a precursor to the "loser effect" (LE), the propensity for individuals who lose a contest to lose subsequent competitions. Experiments in rodent systems reveal physiological consequences of social defeat and loser behaviors, but underlying genetic mechanisms of the LE remain elusive. Furthermore, of the recent studies investigating gene expression changes associated with social defeat, there is little focus on the recovery of LE, wherein some animals naturally exit …

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Microbial Diversity And Immunogenetics Of Whiptail Lizards (Aspidoscelis), Kathleen Currie Aug 2022

Microbial Diversity And Immunogenetics Of Whiptail Lizards (Aspidoscelis), Kathleen Currie

Biology Dissertations - Archive

Whiptail lizards of the genus Aspidoscelis are a complex of both sexual and asexual species with distributions in the United States, Mexico, and Central America. The parthenogenetic lineages arose through hybridization events between divergent sexual species; further backcrossing of the diploid parthenogens to the parentals is possible, and even hybridization with a third species produce triploid lineages. Here, we leverage the unique biology of whiptail lizards to evaluate and compare gut microbial communities between reproductive modes, investigate whether host genetic variation correlates with microbial diversity, and characterize MHC class II beta genes.

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Sarracenia Pitcher Plant-Associated Microbial Communities Differ Primarily By Host Species Across A Longitudinal Gradient, Jacob A. Heil, Charles J. Wolock, Naomi E. Pierce, Anne Pringle, Leonora S. Bittleston Aug 2022

Sarracenia Pitcher Plant-Associated Microbial Communities Differ Primarily By Host Species Across A Longitudinal Gradient, Jacob A. Heil, Charles J. Wolock, Naomi E. Pierce, Anne Pringle, Leonora S. Bittleston

Biology Faculty Publications and Presentations

Plant-associated microbial communities can profoundly affect plant health and success, and research is still uncovering factors driving the assembly of these communities. Here, we examine how geography versus host species affects microbial community structure and differential abundances of individual taxa. We use metabarcoding to characterize the bacteria and eukaryotes associated with five, often co-occurring species of Sarracenia pitcher plants (Sarraceniaceae) and three natural hybrids along the longitudinal gradient of the U.S. Gulf Coast, as well as samples from S. purpurea in Massachusetts. To tease apart the effects of geography versus host species, we focus first on sites with co-occurring …

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Niche And Dispersal Effects On Biodiversity, Community Composition And Species Co-Occurrences In Stream Ecosystems, Joseph Leonardo Mruzek Aug 2022

Niche And Dispersal Effects On Biodiversity, Community Composition And Species Co-Occurrences In Stream Ecosystems, Joseph Leonardo Mruzek

Biology Dissertations - Archive

Niche and dispersal processes are major ecological drivers of freshwater communities but their relative roles across latitudinal gradients, scales, and organismal groups are not well understood. Thus, we performed three studies with sub-continental datasets of stream algae, insects, and fish. In chapter 2 we predicted that: i) niche processes would dominate at high latitudes due to increased climatic stress, consistent with the physiological tolerance hypothesis and the Dobzhansky-MacArthur hypothesis and ii) dispersal limitation would prevail at low latitudes due to narrower niches and smaller range sizes, consistent with the dispersal-ecological specialization tradeoff hypothesis, the latitude-niche breadth hypothesis, and Rapoport’s rule. …

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Characterization Of Microbotryum Lychnidis-Dioicae Secreted Effector Proteins That Manipulate Its Host Plant, Silene Latifolia., Ming-Chang Tsai Aug 2022

Characterization Of Microbotryum Lychnidis-Dioicae Secreted Effector Proteins That Manipulate Its Host Plant, Silene Latifolia., Ming-Chang Tsai

Electronic Theses and Dissertations

The smut fungal species Microbotryum lychnidis-dioicae is an obligate phytopathogen colonizing the plant host, Silene latifolia. A significant feature of M. lychnidis-dioicae infection is that the fungus can replace pollen on the anthers of susceptible host plants with fungal teliospores, thus earning the fungus the name: anther smut disease of flowers. The fungus synthesizes and secretes effector proteins into the cells of the plant host during infection, and the protein-protein interactions may interfere with and modify metabolism, plant development, and gene expression of the host to allow fungal colonization. Two potential fungal effector proteins, MVLG_06175 and MVLG_05122, were identified …

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Investigating Gene Expression Changes In Daphnia: The Role Of Ems-Induced Mutations And Reproductive Modes, Marelize Snyman Aug 2022

Investigating Gene Expression Changes In Daphnia: The Role Of Ems-Induced Mutations And Reproductive Modes, Marelize Snyman

Biology Dissertations - Archive

Gene expression variation is a common source of phenotypic variation between species. Understanding how changes in gene expression are associated with a particular phenotype will aid in understanding the molecular basis and evolution of complex traits. For the first chapter, I investigated the role that changes in gene expression play in the origin of obligate parthenogenesis using the microcrustacean Daphnia pulex. I conducted a genome-wide differential expression and splicing analysis comparing early subitaneous and early resting egg production in OP D. pulex isolates to investigate the genes and mechanisms underlying these parthenogenetic modes. Results from the KEGG pathway and GO …

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Phenology Effects On Productivity And Hatching-Asynchrony Of American Kestrels (Falco Sparverius) Across A Continent, Kathleen R. Callery, Sarah E. Schulwitz, Anjolene R. Hunt, Jason M. Winiarski, Christopher J. W. Mcclure, Richard A. Fischer, Julie A. Heath Aug 2022

Phenology Effects On Productivity And Hatching-Asynchrony Of American Kestrels (Falco Sparverius) Across A Continent, Kathleen R. Callery, Sarah E. Schulwitz, Anjolene R. Hunt, Jason M. Winiarski, Christopher J. W. Mcclure, Richard A. Fischer, Julie A. Heath

Biology Faculty Publications and Presentations

Optimal reproductive performance occurs when birds time reproduction to coincide with peak food availability. Deviation from optimal timing, or mismatch, can affect productivity, though birds may mediate some mismatch effects by altering their incubation behavior. We studied the consequences of nesting timing (i.e., clutch initiation relative to an index of spring start) on productivity across the breeding range of American kestrels (Falco sparverius) in the United States and southern Canada, and associations between nesting timing, incubation behavior, and hatching asynchrony. We used observations from long-term nest box monitoring, remote trail cameras, and community-scientist-based programs to obtain data on …

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Genome Sequence Of The Estuarine Synechococcus Sp. Strain Nb0720_010, Campbell A. Mackenzie, Marcia F. Marston, Javier F. Tabima, Nathan A. Ahlgren Aug 2022

Genome Sequence Of The Estuarine Synechococcus Sp. Strain Nb0720_010, Campbell A. Mackenzie, Marcia F. Marston, Javier F. Tabima, Nathan A. Ahlgren

Arts & Sciences Faculty Publications

Synechococcus spp. are unicellular cyanobacteria widely distributed in the world's oceans. We report the complete genome sequence of Synechococcus sp. strain NB0720_010, isolated from Narragansett Bay, Rhode Island. NB0702_10 has several large (.3,000-amino acid) protein-coding genes that may be important in its interactions with other cells, including grazers in estuarine habitats.

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The Susceptibility For Recreational Boating To Serve As A Vector For Harmful Algal Blooms, John Michael Thraen Aug 2022

The Susceptibility For Recreational Boating To Serve As A Vector For Harmful Algal Blooms, John Michael Thraen

Theses, Dissertations and Culminating Projects

To combat the spread of invasive and nuisance aquatic species, recreational boating has many recommendations and regulations in place for boaters to properly treat their boats in between uses in separate locations. While protection procedures are in place for preventing the spread of invasive mussel and plant species, there is no sufficient procedure in regard to the spread of cyanobacterial species. The objective of this study was to investigate whether common drying procedures employed in these treatment practices were capable of additionally preventing the spread of cyanobacterial species so as they may help prevent the spread of algal blooms throughout …

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Parasite Variability In The Invasive Crayfish, Faxonius Rusticus, In Northern New Jersey, Nathan Martin Klunk Aug 2022

Parasite Variability In The Invasive Crayfish, Faxonius Rusticus, In Northern New Jersey, Nathan Martin Klunk

Theses, Dissertations and Culminating Projects

The Northeast United States has been thoroughly invaded by the well-known invasive crayfish species Faxonius rusticus (rusty crayfish). Similar to the exploration of man to new regions, the spread of invasive species can cause the introduction of new diseases and parasites while conversely the invader has to deal with the already existing diseases and parasites. For crayfish, the most notable of these is a fungal plague, which has a poorly understood distribution in the United States. In this study, I collected rusty crayfish in Northern New Jersey to better understand the locations where they exist in the state. I also …

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N6-Methyladenosine Rna Modifications In Myogenesis / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Marina Danielle Infantado Aug 2022

N6-Methyladenosine Rna Modifications In Myogenesis / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Marina Danielle Infantado

Legacy Theses & Dissertations (2009 - 2024)

Myogenesis involves skeletal muscle stem cells (MuSCs) that produce and regenerate skeletal muscle during regular growth and repair. However, when this system fails to function normally, it can lead to musculoskeletal diseases like Duchenne Muscular Dystrophy (DMD). Therefore, it is important to study the molecular mechanisms behind this developmental process in order to seek therapies and solutions for these types of diseases. Our interest lies in the field of epitranscriptomics, which focuses on post-transcriptional ribonucleic acid (RNA) modifications, particularly N6-methyladenosine (m6A), which involves the addition of a methyl group to the adenosine nucleotide, a process that is mediated by the …

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Parallel Networks That Govern The Transcriptional Response To Stress, Serene Anne Durham Aug 2022

Parallel Networks That Govern The Transcriptional Response To Stress, Serene Anne Durham

Legacy Theses & Dissertations (2009 - 2024)

The transcription factor, p53, plays a pivotal role in the oversight of many stimulus-dependent pathways. Its ability to respond to a wide variety of cellular stress stimuli by activating a broad range of target genes has led it to be characterized as a stress-dependent transcription factor. Our research focuses on deconvoluting the varied transcriptional response to distinct stress signals in an attempt to define the regulatory strategies leading to gene activation after cell stress. We have found that distinct stress response networks, some of which are p53-independent, are converging at activation of a common set of target genes. Our data …

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Regional-Scale Climate-Induced Variation In Ant Physiology And Morphology, Daniel E. Murphy Aug 2022

Regional-Scale Climate-Induced Variation In Ant Physiology And Morphology, Daniel E. Murphy

Biology Theses

The biology of ectotherms such as insects is influenced by ambient thermal conditions. Ants are a ubiquitous and ecologically important group of insects and are well-established as bioindicators of thermal conditions. Ants are sensitive to the thermal extremes that vary with latitude, elevation, and land use, and these thermal gradients influence their spatial and temporal distributions. As a result, ants have evolved physiological and morphological thermal adaptations in response to the thermal environment of their habitats. These adaptations include increased physiological and morphological tolerance for temperature extremes. In Western New York (WNY), temperatures are temporally and spatially heterogeneous, changing with …

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Activation Of The Ppar Nuclear Receptors By Oxylipins And Their Potential Effects On Differentiation And Gene Expression In Myocytes, Jazmine Eccles Aug 2022

Activation Of The Ppar Nuclear Receptors By Oxylipins And Their Potential Effects On Differentiation And Gene Expression In Myocytes, Jazmine Eccles

All Theses

Obesity and non-alcoholic fatty liver diseases are a growing issue worldwide. Decreased expression of CYP2B6 is associated with obesity in humans and Cyp2b-null mice are diet-induced obese; however fatty liver disease is worse in humanized CYP2B6 transgenic mice than WT or Cyp2b-null mice despite lower obesity. CYP2B6 produces several oxylipins with preference for metabolism at the 9- and 13-positions with 9-HODE and 13-HODE (from linoleic acid; n-6), and 9-HOTrE and 13-HOTrE (from a-linolenic acid; n-3) preferentially produced. Oxylipins serve as signaling molecules for many processes, such as inflammatory pathways, lipid distribution, and lipid metabolism. Due to their diversity, oxylipins can …

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Evaluating The Impact Of Intersecting Research And Outreach Marine Science Programs On Elementary And Undergraduate Students, Randi J. Sims Aug 2022

Evaluating The Impact Of Intersecting Research And Outreach Marine Science Programs On Elementary And Undergraduate Students, Randi J. Sims

All Theses

Climate change is one of the most destructive forces our ocean is currently experiencing. Despite this, many students are not taught the basics of climate change science and ocean literacy in public school systems. My work seeks to combat these deficits through educational experiences in marine science for undergraduate and local elementary students through three studies incorporating marine-science based research and outreach. (1) Through undergraduate marine science research and outreach, students enrolled for long durations or with positive mentorship increased their conceptual understanding of marine science concepts, altered their attitudes towards climate change and science, and were more likely to …

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Building Communities Of Teaching Practice And Data-Driven Open Education Resources With Neon Faculty Mentoring Networks, Kusum Naithani, Megan Jones, Kristine L. Richmond Aug 2022

Building Communities Of Teaching Practice And Data-Driven Open Education Resources With Neon Faculty Mentoring Networks, Kusum Naithani, Megan Jones, Kristine L. Richmond

Biological Sciences Faculty Publications and Presentations

With the growing availability and accessibility of big data in ecology, we face an urgent need to train the next generation of scientists in data science practices and tools. One of the biggest barriers for implementing a data-driven curriculum in undergraduate classrooms is the lack of training and support for educators to develop their own skills and time to incorporate these principles into existing courses or develop new ones. Alongside the research goals of the NEON, providing education and training are key components for building a community of scientists and users equipped to utilize large-scale ecological and environmental data. To …

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Its Rdna Barcodes Clarify Molecular Diversity Of Aquatic Hyphomycetes, Ricardo Franco-Duarte, Isabel Fernandes, Vladislav Gulis, Fernanda Cássio, Cláudia Pascoal Aug 2022

Its Rdna Barcodes Clarify Molecular Diversity Of Aquatic Hyphomycetes, Ricardo Franco-Duarte, Isabel Fernandes, Vladislav Gulis, Fernanda Cássio, Cláudia Pascoal

Biology

Aquatic hyphomycetes are key microbial decomposers of allochthonous organic matter in freshwater ecosystems. Although their importance in carbon flow and food webs in streams is widely recognized, there are still gaps in our understanding of their molecular diversity and distribution patterns. Our study utilized the growing database of ITS rDNA barcodes of aquatic hyphomycetes (1252 sequences) and aimed to (i) produce new barcodes for some lesser-known taxa; (ii) clarify the taxonomic placement of some taxa at the class or order level, based on molecular data; and (iii) provide insights into the biogeographical origins of some taxa. This study increased the …

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Evaluating Molecular Xenomonitoring As A Tool For Lymphatic Filariasis Surveillance In Samoa, 2018–2019, Brady Mcpherson, Helen J. Mayfield, Angus Mclure, Katherine Gass, Take Naseri, Robert Thomsen, Steven A. Williams, Nils Pilotte, Therese Kearns, Patricia M. Graves, Colleen L. Lau Aug 2022

Evaluating Molecular Xenomonitoring As A Tool For Lymphatic Filariasis Surveillance In Samoa, 2018–2019, Brady Mcpherson, Helen J. Mayfield, Angus Mclure, Katherine Gass, Take Naseri, Robert Thomsen, Steven A. Williams, Nils Pilotte, Therese Kearns, Patricia M. Graves, Colleen L. Lau

Biological Sciences: Faculty Publications

Molecular xenomonitoring (MX), the detection of filarial DNA in mosquitoes using molecular methods (PCR), is a potentially useful surveillance strategy for lymphatic filariasis (LF) elimination programs. Delay in filarial antigen (Ag) clearance post-treatment is a limitation of using human surveys to provide an early indicator of the impact of mass drug administration (MDA), and MX may be more useful in this setting. We compared prevalence of infected mosquitoes pre- and post-MDA (2018 and 2019) in 35 primary sampling units (PSUs) in Samoa, and investigated associations between the presence of PCR-positive mosquitoes and Ag-positive humans. We observed a statistically significant decline …

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The Presence And Distribution Of Crotoxin In The Rock Rattlesnake (Crotalus Lepidus), Jade Mellor Aug 2022

The Presence And Distribution Of Crotoxin In The Rock Rattlesnake (Crotalus Lepidus), Jade Mellor

All Theses

Crotoxin and its homologs (hereafter all referred to as CTx) is a highly lethal heterodimeric beta-neurotoxin found in pitvipers (Crotalinae) and is the main driver of neurotoxic venom phenotypes (Type II). In contrast, hemorrhagic venom phenotypes (Type I) are characterized by high snake venom metalloproteinase expression and low toxicity. Although many rattlesnake species have been classified as either Type I or Type II, population level variation in venom phenotype has also been documented in several species. The presence or absence of CTx is the main component of this variation in venom phenotype and has been most widely studied in large-bodied …

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A Bioinformatics Analysis Of Microbial Diversity And Its Correlation With Human Lifestyle, Diet, And Health Variables, Alivia Ankrum, Kate Cooper Aug 2022

A Bioinformatics Analysis Of Microbial Diversity And Its Correlation With Human Lifestyle, Diet, And Health Variables, Alivia Ankrum, Kate Cooper

Theses/Capstones/Creative Projects

The abundant impact of microbiota on human physiology suggests a need for exploration into their impact on human health and disease. The American Gut Project (AGP) was established to aggregate microbiome sequencing data as well as health, diet, and lifestyle metadata. This study proposes to identify taxonomic species and build a phylogenetic tree representation from the AGP participant sample collection as well as find their respective alpha and beta diversity of all metadata variables based on patient questionnaire data. Additionally, this study will involve a chimeric sequence extraction from the 16S rRNA sequences of the AGP. The expected results are …

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Effects Of Ahcc On The Interaction Between T And B Lymphocytes, Sajina Poudel Aug 2022

Effects Of Ahcc On The Interaction Between T And B Lymphocytes, Sajina Poudel

Theses (2016-Present)

AHCC is a beta-glucan derived from the shiitake mushroom. It is used as an immune supplement and is known to boost the immune system. The mechanisms involved are increased lymphocyte proliferation and reduction of inflammation. The effects have been well studied in T cells. However, factors produced by T cells that affect B cells have not been studied. In this study, we explored the gene products stimulated by the AHCC exposure in T lymphocytes which play a role in B cell function. Data from a prior gene array experiment were used to delineate the effects of AHCC on the interaction …

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An Overview Of The Extracurricular Polysaccaride Production Of Probiotic Lactic Acid Bacteria, Olujimi Babajide Olowokere Aug 2022

An Overview Of The Extracurricular Polysaccaride Production Of Probiotic Lactic Acid Bacteria, Olujimi Babajide Olowokere

Theses (2016-Present)

The study focuses on a comprehensive review of lactic acid bacteria and their production of extracellular polysaccharide substrates (EPS). Two important factors are addressed in the work; and these are 1) identification of LAB stains found in the commercially sold daily milk, 2) significant factors impacting polysaccharide production. Motivation behind these focus points is to allow further inquiries and studies on exploring these strains of bacteria for human wellness promotion. With microbial EPS production being a recent interest of study among healthcare and food industries sectors, new species of bacteria are extensively exploited for further investigation to improve human health, …

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Screening Tcf19 And Kif18b To Determine Co-Regulation With Mybl1 In Triple Negative Breast Cancer Patient Tissues, Tyra Sharda Ivory Aug 2022

Screening Tcf19 And Kif18b To Determine Co-Regulation With Mybl1 In Triple Negative Breast Cancer Patient Tissues, Tyra Sharda Ivory

Theses (2016-Present)

The aggressive behavior in triple-negative breast cancer (TNBC) is due to genetic signaling events, which call for the comprehensive analyses of genes differentially regulated in the cancers. Our laboratory previously found that MYBL1 was over-expressed in a fraction of the TNBC, compared to some luminal, and other breast cancer subtypes. The MYBL1 gene is a proto-oncogene that serves as a strong transcriptional activator. The gene is involved in signaling events related to cell cycle signaling, differentiation, proliferation, and apoptosis, all which are differentially regulated in cancers. Because MYBL1 is a transcription regulator, involved in cancer-related mechanisms and differentially expressed in …

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