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Environmental Isolate Developing Antibiotic Resistance By Complementation, Mary Ridgeway, Ashley Fink, David Mitchell Aug 2023

Environmental Isolate Developing Antibiotic Resistance By Complementation, Mary Ridgeway, Ashley Fink, David Mitchell

Biology Faculty Publications

Antibiotic resistance is a growing concern within the scientific community. With few new antibiotics being introduced and an increasing number of resistant microbes, routine bacterial infections are becoming more difficult to treat in clinics and hospitals. The purpose of this study is to compare the ability of two environmental isolates – Staphylococcus aureus (S. aureus) and Exiguobacterium undae (E. undae) to grow in solutions of increasing concentrations of tetracycline and ciprofloxacin. After the bacteria showed grow in the solutions, antibiotic susceptibility was tested by examining zones of inhibition on Trypticase Soy Agar (TSA) plates. Our results …


Comparative Polar And Lipid Plasma Metabolomics Differentiate Kshv Infection And Disease States, Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry, John R. Ngowi, Owen Ngalamika, Andrew G. Chapple, Julius Mwaiselage, Charles Wood, John T. West, Jiri Adamec Aug 2023

Comparative Polar And Lipid Plasma Metabolomics Differentiate Kshv Infection And Disease States, Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry, John R. Ngowi, Owen Ngalamika, Andrew G. Chapple, Julius Mwaiselage, Charles Wood, John T. West, Jiri Adamec

School of Biological Sciences: Faculty Publications

Background Kaposi sarcoma (KS) is a neoplastic disease etiologically associated with infection by the Kaposi sarcoma-associated herpesvirus (KSHV). KS manifests primarily as cutaneous lesions in individuals due to either age (classical KS), HIV infection (epidemic KS), or tissue rejection preventatives in transplantation (iatrogenic KS) but can also occur in individuals, predominantly in sub-Saharan Africa (SSA), lacking any obvious immune suppression (endemic KS). The high endemicity of KSHV and human immunodeficiency virus-1 (HIV) co-infection in Africa results in KS being one of the top 5 cancers there. As with most viral cancers, infection with KSHV alone is insufficient to induce tumorigenesis. …


Comparative Polar And Lipid Plasma Metabolomics Differentiate Kshv Infection And Disease States, Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry, John R. Ngowi, Owen Ngalamika, Andrew G. Chapple, Julius Mwaiselage, Charles Wood, John T. West, Jiri Adamec Aug 2023

Comparative Polar And Lipid Plasma Metabolomics Differentiate Kshv Infection And Disease States, Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry, John R. Ngowi, Owen Ngalamika, Andrew G. Chapple, Julius Mwaiselage, Charles Wood, John T. West, Jiri Adamec

School of Biological Sciences: Faculty Publications

Background Kaposi sarcoma (KS) is a neoplastic disease etiologically associated with infection by the Kaposi sarcoma-associated herpesvirus (KSHV). KS manifests primarily as cutaneous lesions in individuals due to either age (classical KS), HIV infection (epidemic KS), or tissue rejection preventatives in transplantation (iatrogenic KS) but can also occur in individuals, predominantly in sub-Saharan Africa (SSA), lacking any obvious immune suppression (endemic KS). The high endemicity of KSHV and human immunodeficiency virus-1 (HIV) co-infection in Africa results in KS being one of the top 5 cancers there. As with most viral cancers, infection with KSHV alone is insufficient to induce tumorigenesis. …


Table Of Contents Aug 2023

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Environmental Bacteriophage Presence In Drainage Ponds At Coastal Carolina University, Hailey Oldfield, Alexei E. Chesnutwood, Gabriella A. Caldwell, Shiraz C. Cohen, Paul E. Richardson Aug 2023

Environmental Bacteriophage Presence In Drainage Ponds At Coastal Carolina University, Hailey Oldfield, Alexei E. Chesnutwood, Gabriella A. Caldwell, Shiraz C. Cohen, Paul E. Richardson

Journal of the South Carolina Academy of Science

No abstract provided.


Developing A Safe And Effective Papillomavirus Screen To Be Used On College Students At A South Carolina University, Owen R. Smith, Nicole E. Frantz, Emily E. Bishop, Rahjai G. Thomas, Paul E. Richardson Aug 2023

Developing A Safe And Effective Papillomavirus Screen To Be Used On College Students At A South Carolina University, Owen R. Smith, Nicole E. Frantz, Emily E. Bishop, Rahjai G. Thomas, Paul E. Richardson

Journal of the South Carolina Academy of Science

No abstract provided.


Behind The Headlines: Strategies For Critical Consumption Of Science News, Mackenzie Gerringer Aug 2023

Behind The Headlines: Strategies For Critical Consumption Of Science News, Mackenzie Gerringer

Myth and Science, 2023-24

In this discussion-based class, learners will: 1) understand the paths information takes from the lab bench or the field to news headlines, 2), reflect upon how misinformation and disinformation impact society, 3) develop individual strategies for critical media consumption, and 4) practice productive communication about science news, integrating perspectives from multiple disciplines. Bring your ideas, let's strategize!


Go Big Or Go Home: Divergence In Morphology And Behavior Between Island And Islet Populations Of The San Cristóbal Lava Lizard (Microlophus Bivittatus), Emilio J. Mancero Aug 2023

Go Big Or Go Home: Divergence In Morphology And Behavior Between Island And Islet Populations Of The San Cristóbal Lava Lizard (Microlophus Bivittatus), Emilio J. Mancero

Masters Theses

Rapid divergence in body size is a well-documented phenomenon among island species, associated with macroevolutionary processes of diversification and adaptive radiation. The effect of insularity in determining larger body size as an optimal phenotype is primarily attributed to lower predation and greater intraspecific competition on islands. Our study examined interpopulation variation in morphology, social behavior and predator avoidance in Galápagos lava lizards endemic to San Cristóbal island (Microlophus bivittatus), and the nearby islet Isla Lobos. Islet populations have fewer competitors than those on the island, where native and introduced predators are abundant. We simulated interactions with predators and …


Celebrating Leeuwenhoek’S Life 300 Years Later, Alan L. Gillen Aug 2023

Celebrating Leeuwenhoek’S Life 300 Years Later, Alan L. Gillen

Faculty Publications and Presentations

Antony van Leeuwenhoek entered eternity 300 years ago (August 26, 1723). He made hundreds of discoveries with his simple microscope. Perhaps his most notable discovery was of bacteria and its many shapes. He found great joy in God [http://answersingenesis.org/god/] ’s smallest creatures. I believe that his curiosity about the world, fueled by his belief in biblical creation [http://answersingenesis.org/creation/] , led to his discovery of bacteria. In a similar manner, his curiosity of blood led to his discovery of red corpuscles and capillaries. He remained a curious man until the last days of his life 300 years …


Anterior Chamber Depth In Mice Is Controlled By Several Quantitative Trait Loci, Demelza R. Larson, Allysa J. Kimber, Kacie J. Meyer, Michael G. Anderson Aug 2023

Anterior Chamber Depth In Mice Is Controlled By Several Quantitative Trait Loci, Demelza R. Larson, Allysa J. Kimber, Kacie J. Meyer, Michael G. Anderson

Biology Faculty Publications

Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a small fraction of the phenotypic variability. The purpose of this study was to identify additional ACD-influencing loci using strains of mice. Cohorts of 86 N2 and 111 F2 mice were generated from crosses between recombinant inbred BXD24/TyJ and wild-derived CAST/EiJ mice. Using anterior chamber optical coherence tomography, mice were phenotyped at 10–12 weeks of age, genotyped based on 93 genome-wide SNPs, and subjected to quantitative trait locus (QTL) analysis. In an analysis of ACD among …


The Return Of Malaria To The Usa: Did God Create Parasites To Make Us Sick?, Alan L. Gillen Aug 2023

The Return Of Malaria To The Usa: Did God Create Parasites To Make Us Sick?, Alan L. Gillen

Faculty Publications and Presentations

Summer 2023, the Centers for Disease Control and Prevention reported several cases of locally acquired malaria in Florida, Texas, and Maryland, meaning that patients were infected within the US—the first such cases in over two decades (CDC 2023). The significance of the cases and how individuals and public health officials should respond to the situation is still unknown. The CDC is collaborating with state health departments on an investigation of seven locally acquired cases of Plasmodium vivax malaria in Sarasota County, Florida, and one case in Cameron County, Texas, and Maryland near Washington DC. There is no evidence to suggest …


A Human Stat3 Gof Variant Alters T Cell Function To Drive Skin Inflammation, Kelsey Adele Toth Aug 2023

A Human Stat3 Gof Variant Alters T Cell Function To Drive Skin Inflammation, Kelsey Adele Toth

Arts & Sciences Graduate Student Theses and Dissertations

Inborn errors of immunity (IEIs) are disorders caused by monogenic variants that lead to immune deficiency and dysregulation. Although rare, IEIs have shaped our understanding of how single genes function in the immune systems of both humans and mice. The identification of loss-of-function (LOF) and gain-of-function (GOF) variants in the highly conserved signal transducer and activator of transcription (STAT) family molecules have led to discoveries involving how STAT signaling affects immune cell development, differentiation, and the induction and regulation of immune responses. Germline GOF variants in STAT3 cause early-onset multi-organ autoimmunity and immune dysregulation. Patients with STAT3 GOF syndrome have …


Antimelanoma Activities Of Fused Thiazole Derivatives, Sanjay Adhikary Aug 2023

Antimelanoma Activities Of Fused Thiazole Derivatives, Sanjay Adhikary

Student Theses and Dissertations

Melanoma, a fatal type of skin cancer, is still incurable. To develop a possible cure, we synthesized fused thiazole derivatives, and found them to be potent anti-melanoma agents both in vitro and in vivo. Thiazolo ethisterone derivatives were remarkably cytotoxic to melanoma cell lines and inhibited colonization of oncogenic cells. Compounds, in vitro, inhibited three key mechanisms of metastasis; cell migration, adhesion, and invasiveness. The compounds caused mild G2/M phase mitotic cell cycle arrest and induced moderate apoptosis. 3, 4-Dihydroxy substituted thiazolo ethisterone (ET32) upregulated beta-Parvin (PARVB) expression (both mRNA and protein expressions) with a log2 fold change value around …


Structures Of The Insecticidal Toxin Complex Subunit Xpta2 Highlight Roles For Flexible Domains, Cole L Martin, David W Chester, Christopher D Radka, Lurong Pan, Zhengrong Yang, Rachel C Hart, Elad M Binshtein, Zhao Wang, Lisa Nagy, Lawrence J Delucas, Stephen G Aller Aug 2023

Structures Of The Insecticidal Toxin Complex Subunit Xpta2 Highlight Roles For Flexible Domains, Cole L Martin, David W Chester, Christopher D Radka, Lurong Pan, Zhengrong Yang, Rachel C Hart, Elad M Binshtein, Zhao Wang, Lisa Nagy, Lawrence J Delucas, Stephen G Aller

Faculty, Staff and Students Publications

The Toxin Complex (Tc) superfamily consists of toxin translocases that contribute to the targeting, delivery, and cytotoxicity of certain pathogenic Gram-negative bacteria. Membrane receptor targeting is driven by the A-subunit (TcA), which comprises IgG-like receptor binding domains (RBDs) at the surface. To better understand XptA2, an insect specific TcA secreted by the symbiont


Effect Of Age At Injury On Neuroinflammatory Response, Microstructural Outcomes, And Function Following Traumatic Brain Injury, Sydney J. Oswalt Reitz Aug 2023

Effect Of Age At Injury On Neuroinflammatory Response, Microstructural Outcomes, And Function Following Traumatic Brain Injury, Sydney J. Oswalt Reitz

Arts & Sciences Graduate Student Theses and Dissertations

Traumatic brain injury (TBI) is a significant public health concern. Elderly individuals are more likely to be hospitalized and die from a TBI than younger victims, and experience worse outcomes along a series of clinical and functional endpoints. Studies exploring the mechanisms responsible for these outcome disparities are limited. As aging has been demonstrated to enhance baseline neuroinflammatory profile and is associated with synaptopathic neurodegenerative conditions linked to TBI, this thesis study sought to better characterize the relationship between aging-related neuroinflammation, microstructural—including synaptic—endpoints, and functional outcome following TBI. To this end, mice were subjected to diffuse and focal experimental brain …


Inter-Areal Communication In Posterior Parietal Cortex Supporting Eye-Hand And Bimanual Coordination, Jung Uk Kang Aug 2023

Inter-Areal Communication In Posterior Parietal Cortex Supporting Eye-Hand And Bimanual Coordination, Jung Uk Kang

Arts & Sciences Graduate Student Theses and Dissertations

Understanding inter-areal communication is crucial for systems neuroscience. Much of the processing in the brain involves communication between different areas. Sensory areas must send information to motor areas, and motor areas must communicate with each other if different body parts are to be coordinated. For example, coordinating movements of the two arms likely requires interactions between motor areas in the two hemispheres. We therefore hypothesize that bimanual and eye-hand coordination relies on interhemispheric communication, and the most direct path for information exchange between the two hemispheres is through the corpus callosum. By reversibly blocking the callosal pathways connecting the left …


Seasonal Top-Down Effects Of Fish On Benthic Macroinvertebrates And Periphyton In A Coldwater Michigan Stream, Travis John Ellens Aug 2023

Seasonal Top-Down Effects Of Fish On Benthic Macroinvertebrates And Periphyton In A Coldwater Michigan Stream, Travis John Ellens

Masters Theses

Fish can have strong top-down effects on their prey through both direct predation and non-consumptive effects in streams. We conducted manipulative field experiments to test the strength of fish predation on benthic macroinvertebrates at the patch scale in Stegman Creek. Stegman Creek is a small (0.39 m3/s at baseflow), groundwater-fed stream in western Michigan with abundant mottled sculpin (Cottus bairdii) and brown trout (Salmo trutta) acting as benthic predators. We hypothesized that fish predation decreases macroinvertebrate density, thereby increasing periphyton biomass through a reduction in density of grazing macroinvertebrates. We placed paired predator-exclusion cages …


Unraveling The Molecular Basis Of Zinc Cluster Transcription Factor Specificity: A Comprehensive Study Of Half-Site Promoter Binding Interactions And Their Role In Gene Expression Regulation, Pamela Samantha Recio Aug 2023

Unraveling The Molecular Basis Of Zinc Cluster Transcription Factor Specificity: A Comprehensive Study Of Half-Site Promoter Binding Interactions And Their Role In Gene Expression Regulation, Pamela Samantha Recio

Arts & Sciences Graduate Student Theses and Dissertations

The regulation of gene expression relies on the complex interplay of transcription factors (TFs) that interact with DNA to control gene activity. Despite extensive research efforts, accurately predicting crucial aspects of the transcriptional process, such as TF occupancy in vivo, remains a challenging task. Existing thermodynamic models of TF function often fall short in explaining experimental observations, suggesting the presence of undiscovered biological mechanisms. This dissertation aims to unravel the underlying principles governing the binding specificity of Zinc cluster TFs and is organized into two chapters. Chapter 1 offers a comprehensive overview of transcriptional regulation in yeast, highlighting current TF …


Morphometric Analysis And Biochemical Estimation Of Wild Shrimps (Family: Penaeidae) Found In Coastal Waters Of Pakistan, Noor Us Saher, Syeda Hadiqa Noor Aug 2023

Morphometric Analysis And Biochemical Estimation Of Wild Shrimps (Family: Penaeidae) Found In Coastal Waters Of Pakistan, Noor Us Saher, Syeda Hadiqa Noor

Journal of Bioresource Management

The world recognition of Seafood nutritional value for human consumption remain consistent throughout the time. Different informations and aspects have been studied and considered and generated various data sets but limited informations found about the biochemical concentration of various fishery species caught in the Pakistan. Therefore, the recent study design to evaluate the proximate levels of components in the edible component (flesh) of commercial shrimp species were studied. Four shrimp species; Fenneropenaeus indicus, Metapenaeopsis stridulans, Metapenaeus stebbingi, and Parapenaeopsis stylifera were selected for the assessment of proximate composition. The selected shrimp species were collected from the fishery catch of Korangi …


Online Data Transmission Reduction Scheme For Energy Conservation In Wireless Video Sensor Networks, Iman Kadhum Abbood, Ali Kadhum Idrees Aug 2023

Online Data Transmission Reduction Scheme For Energy Conservation In Wireless Video Sensor Networks, Iman Kadhum Abbood, Ali Kadhum Idrees

Karbala International Journal of Modern Science

Wireless Video Sensor Networks (WVSNs) are networks of low-cost, low-power camera sensor nodes. These nodes communicate locally and process information to meet an application's goal. WVSNs are extensively used in diverse monitoring applications, such as security, military, industrial, medical, and environmental monitoring. However, the transmission of large amounts of data collected by video sensor nodes in WVSNs poses challenges in terms of energy consumption, bandwidth usage, and network congestion. Reducing energy for processing and transmitting data in WVSNs is difficult due to the huge amount of sensed data in real-time. To address this issue, this paper proposes an Online Data …


Biogenesis Synthesis Of Zno Nps: Its Adsorption And Photocatalytic Activity For Removal Of Acid Black 210 Dye, Zahraa A. Najm, Mohammed A. Atiya, Ahmed K. Hassan Aug 2023

Biogenesis Synthesis Of Zno Nps: Its Adsorption And Photocatalytic Activity For Removal Of Acid Black 210 Dye, Zahraa A. Najm, Mohammed A. Atiya, Ahmed K. Hassan

Karbala International Journal of Modern Science

This study investigated the treatment of textile wastewater contaminated with Acid Black 210 dye (AB210) using zinc oxide nanoparticles (ZnO NPs) through adsorption and photocatalytic techniques. ZnO NPs were synthesized using a green synthesis process involving eucalyptus leaves as reducing and capping agents. The synthesized ZnO NPs were characterized using UV-Vis spectroscopy, SEM, EDAX, XRD, BET, Zeta potential, and FTIR techniques. The BET analysis revealed a specific surface area and total pore volume of 26.318 m2/g. SEM images confirmed the crystalline and spherical nature of the particles, with a particle size of 73.4 nm. A photoreactor was designed …


Dna Barcoding Of Springsnails (Mollusca, Gastropoda, Caenogastropoda) Endemic To The Trans-Pecos Region Of Texas (Usa), Kathryn E. Perez, Vanessa Saenz, Natalia Salazar-Lozano, Benjamin F. Schwartz, Benjamin T. Hutchins Aug 2023

Dna Barcoding Of Springsnails (Mollusca, Gastropoda, Caenogastropoda) Endemic To The Trans-Pecos Region Of Texas (Usa), Kathryn E. Perez, Vanessa Saenz, Natalia Salazar-Lozano, Benjamin F. Schwartz, Benjamin T. Hutchins

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

In desert environments, unique communities depend on groundwater from springs, including a diverse radiation of small (<5 >mm) snails found in the desert across the southwestern United States. Nearly all springsnail species are considered critically imperiled with their existence depending on maintenance of spring-flows in regions of declining water availability. Extant, endemic springsnails in the Trans-Pecos region of Texas include one species of Pseudotryonia Hershler, 2001, five nominal Tryonia W. Stimpson, 1865 (Cochliopidae) and seven Pyrgulopsis Call & Pilsbry, 1886 (Hydrobiidae). Four of these are classified as endangered under the US Endangered Species Act. Surveys for springsnails were conducted at …


Making The Error Bar Overlap Myth A Reality: Comparative Confidence Intervals, Frank S. Corotto Aug 2023

Making The Error Bar Overlap Myth A Reality: Comparative Confidence Intervals, Frank S. Corotto

Georgia Journal of Science

Many interpret error bars to mean that if they do not overlap the difference is statistically “significant”. This overlap rule is really an overlap myth; the rule does not hold true for any conventional type of error bar. There are rules of thumb for estimating P values, but it would be better to show error bars for which the overlap rule holds true. Here I explain how to calculate comparative confidence intervals which, when plotted as error bars, let us judge significance based on overlap or separation. Others have published on these intervals (the mathematical basis goes back to John …


Investigating The Salinity Tolerance Of The Swordtail (Xiphophorus Hellerii), Alexandra Megan Krak Aug 2023

Investigating The Salinity Tolerance Of The Swordtail (Xiphophorus Hellerii), Alexandra Megan Krak

College of Science and Health Theses and Dissertations

The swordtail, Xiphophorus hellerii, is a freshwater fish species native to Mexico and Central America and is commonly used in the tropical aquarium trade. Swordtails have been shown to have limited survival in 6 ‰ salinity (Nanda et al., 2016), suggesting they may have a greater salinity tolerance than previously expected. Using a gradual acclimation method, we examined the salinity tolerance and swim performance of this species. Freshwater-reared female swordtails were housed in 29-gallon aquaria. A control group was held in freshwater throughout the experiment. For the experimental group, the salinity was increased by 2 ‰ every week until 30 …


Impact Of Retinoic Acid Receptor Alpha Conditional Knockout On Ovarian Follicle Development In The Mouse, Zlata Bogin Aug 2023

Impact Of Retinoic Acid Receptor Alpha Conditional Knockout On Ovarian Follicle Development In The Mouse, Zlata Bogin

College of Science and Health Theses and Dissertations

When there is abnormal endocrine signaling in the follicles, infertility, and ovarian diseases such as polycystic ovarian syndrome (PCOS), premature ovarian failure (POF), and different types of ovarian cancers may occur. Retinoic acid (RA), a biologically active derivative of vitamin A, is a critical signaling molecule that plays a vital role in various physiological processes, including embryonic development, tissue differentiation, and reproductive function. RA has been observed to influence granulosa cell proliferation through a cell signaling cascade involving Retinoic Acid Receptors (RARs), which have three isoforms alpha, beta, and gamma. We characterized a new retinoic acid receptor alpha (RARA) conditional …


Characterization Of The Immune Deficiency Pathway During Female Meiosis In Drosophila Melanogaster, Sarah Mashburn Aug 2023

Characterization Of The Immune Deficiency Pathway During Female Meiosis In Drosophila Melanogaster, Sarah Mashburn

College of Science and Health Theses and Dissertations

Organisms can defend against pathogens by significantly increasing the diversity of their progeny, so that some progeny are more likely to survive infection. This led to the prediction that infection should cause an increase in recombination rates which was seen in a previous study. However, the mechanism that regulates recombination rates in response to infection is not understood and in that study they did not provide a mechanism for how that can occur. In an RNAi screen, our lab found the gene mustard (mtd) is required for normal recombination rates. This gene was previously shown to be part of the …


Observations Of 25 Ghz Methanol Masers In W51a, Peter Wagstaff Aug 2023

Observations Of 25 Ghz Methanol Masers In W51a, Peter Wagstaff

College of Science and Health Theses and Dissertations

High mass stars are important because they alone are responsible for creating the heavy elements in the Universe. The observation of high mass star formation remains a challenging problem in astronomy because high mass stars form in densely clustered environments at large distances from us. Therefore, high angular resolution observations are required to unravel the action taking place in these dense environments. Masers can be used to observe distant regions with high angular resolution because masers are compact and bright sources. Class I methanol masers are believed to form in outflows from protostars where the shock generated by the outflowing …


Morphological Diversity Of Neurocrania In Sharks (Chondrichthyes: Elasmobranchii) And Its Ecological And Evolutionary Implications, Jake J. Wood Aug 2023

Morphological Diversity Of Neurocrania In Sharks (Chondrichthyes: Elasmobranchii) And Its Ecological And Evolutionary Implications, Jake J. Wood

College of Science and Health Theses and Dissertations

Sharks occupy a wide range of ecological niches and lifestyle strategies attributed to their complex sensory system housed in their neurocranium. However, the diversity of neurocranial morphology in sharks and how the diversity may be related to their sensory capability have never been adequately surveyed. Therefore, the aims of this present study were: 1) to examine whether the relative sizes of rostral, olfactory, optic, and/or otic regions of neurocrania in sharks are related to their habitat, diet, and/or body form types; and 2) to investigate any possible patterns and insights into the ecology and evolution of sharks on the basis …


Targeting S. Maltophilia Biofilms With Phage Bfi2, Lydia Walther Aug 2023

Targeting S. Maltophilia Biofilms With Phage Bfi2, Lydia Walther

College of Science and Health Theses and Dissertations

Stenotrophomonas maltophilia is a multidrug resistant bacterium which can cause severe infections of the respiratory tract, soft tissue, and bloodstream, and its ability to form biofilms on medical implants and devices contributes to its role as a hospital-acquired pathogen (Brooke, 2021; Flores-Treviño et al., 2019). The rise of antibiotic resistance has prompted the search for new treatments against bacteria. Bacteriophages, or phages, are a promising alternative to antibiotics because they infect and kill bacteria (Ling et al., 2022). Phage therapy has gained recent attention as a life-saving treatment for antibiotic resistant infections (Racenis et al., 2023; Schooley et al., 2017). …


Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko Aug 2023

Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko

Karbala International Journal of Modern Science

The article discusses about the possibility of comparing the impact of ultrasonic treatment on fucolam and sodium algi-nate. The purpose was to study the effect of micronization on the sulfated heteropolysaccharide fucolam, analyzing its dispersed state and accessibility by reducing its molecular weight and increasing antioxidant activity. The optimization of the micronization process was carried out using the Box-Behnken Design (BBD) method, with a sonication time ranging from 15 to 45 min, power ranging from 50 to 100 W/cm2, and temperature between 30 °C and 40 °C. The fixed lower fucolam concentration was 0.1%. The results illustrated that sonochemical treatment …