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Articles 2881 - 2910 of 39322
Full-Text Articles in Entire DC Network
Two Draft Genome Assemblies Of Staphylococcus Aureus Strains Isolated From A Cheek Swab Of A Healthy Female Participant, Alex Kula, Sandra Jablonska, Lexi Avalos, Tyler Jensen, Helen Appleberry, Catherine Putonti
Two Draft Genome Assemblies Of Staphylococcus Aureus Strains Isolated From A Cheek Swab Of A Healthy Female Participant, Alex Kula, Sandra Jablonska, Lexi Avalos, Tyler Jensen, Helen Appleberry, Catherine Putonti
Biology: Faculty Publications and Other Works
Staphylococcus aureus is an opportunistic pathogen often commensal within the nasal and oral cavities. Here we present the genomes of S. aureus O139-S and O139-NS, both isolated from the cheek swab of a healthy female participant. While found in the same sample, the two strains displayed distinct colony morphologies.
Draft Genomes Of Klebsiella Aerogenes, Klebsiella Huaxiensis, And Klebsiella Michiganensis Isolates From The Urinary Tract, Alex Kula, Muna Arman, Helen Appleberry, Alan J. Wolfe, Catherine Putonti
Draft Genomes Of Klebsiella Aerogenes, Klebsiella Huaxiensis, And Klebsiella Michiganensis Isolates From The Urinary Tract, Alex Kula, Muna Arman, Helen Appleberry, Alan J. Wolfe, Catherine Putonti
Biology: Faculty Publications and Other Works
Several Klebsiella spp. can be the cause of urinary tract infections. Here we present the draft genome assemblies for four urinary isolates of three Klebsiella spp.: Klebsiella aerogenes UMB7541, Klebsiella michiganensis UMB11142 and UMB11423, and Klebsiella huaxiensis UMB11391 to further explore the genetic diversity of Klebsiella in the urinary tract.
Draft Genomes Of Neisseria Perflava Umb0578, Proteus Mirabilis Umb8339, And Enterococcus Faecalis Umb7967 Isolated From Urine Samples, Alex Kula, Ali Khan, Megan Martinez, Jevan Terry, Helen Appleberry, Alan J. Wolfe, Catherine Putonti
Draft Genomes Of Neisseria Perflava Umb0578, Proteus Mirabilis Umb8339, And Enterococcus Faecalis Umb7967 Isolated From Urine Samples, Alex Kula, Ali Khan, Megan Martinez, Jevan Terry, Helen Appleberry, Alan J. Wolfe, Catherine Putonti
Biology: Faculty Publications and Other Works
The urinary tract of females harbors a variety of microorganisms, both for those with and without symptoms. Here, we present the draft genome sequences of three isolates from urine samples—Neisseria perflava UMB0578, Proteus mirabilis UMB8339, and Enterococcus faecalis UMB7967.
Draft Genomes Of One Staphylococcus Haemolyticus And Five Staphylococcus Lugdunensis Strains Isolated From Catheterized Urine Samples Of Females, Helen Appleberry, Haaris Anjum, Taleah Cage, Kayla Jarm, Haashir Khan, Lizzie Proctor, Junelle Saroca, Alan J. Wolfe, Catherine Putonti, Alex Kula
Draft Genomes Of One Staphylococcus Haemolyticus And Five Staphylococcus Lugdunensis Strains Isolated From Catheterized Urine Samples Of Females, Helen Appleberry, Haaris Anjum, Taleah Cage, Kayla Jarm, Haashir Khan, Lizzie Proctor, Junelle Saroca, Alan J. Wolfe, Catherine Putonti, Alex Kula
Biology: Faculty Publications and Other Works
Although Staphylococcus haemolyticus and Staphylococcus lugdunensis are members of the normal human flora, they also can cause infection. Here, we present the draft genomes of five strains of S. lugdunensis and one strain of S. haemolyticus isolated from transurethral catheterized urine samples from different females experiencing lower urinary tract symptoms.
Evolutionary Patterns Of Anolis Lizard Skulls: An Investigation In Geometric Morphometrics And An Educational Exploration Of Structure And Function, Katherine Beyer Starr
Evolutionary Patterns Of Anolis Lizard Skulls: An Investigation In Geometric Morphometrics And An Educational Exploration Of Structure And Function, Katherine Beyer Starr
Master's Theses
This study explores the evolutionary patterns of Anolis lizard skulls and integrates findings into a curriculum focused on elucidating the structure and function of a lizard's head. The first objective was to develop an understanding of how the evolutionary patterns, of an extraordinary group of lizards (Anolis) compares to their relatives. Most of the prior research on Anolis morphology has focused on the post-cranium because of its significance towards subdivision of the arboreal habitat. But the group’s remarkable diversity in head shape has been seriously under-investigated. By performing geometric morphometric analysis of skull shape across a large sample of anoles …
Sleep Restores An Optimal Computational Regime In Cortical Networks, Yifan Xu
Sleep Restores An Optimal Computational Regime In Cortical Networks, Yifan Xu
Arts & Sciences Graduate Student Theses and Dissertations
Computation within the brain necessitates consistency and robustness, as no complex system can function effectively without these fundamental attributes. However, maintaining this robustness requires active efforts due to the inevitable perturbations (Turrigiano & Nelson, 2004). To unlock the unifying principle of how brain works, it is essential to identify an optimal set point that the system strives to maintain and restore, ensuring stability and functionality. Our lab recently demonstrated that cortical dynamics are homeostatically organized around criticality (Ma et al., 2019), a computational regime that optimizes information processing, such as information capacity and dynamic range (Shew & Plenz, 2013). This …
Illuminating The Twilight Zone: In-Situ Imaging Facilitates Discovery Of Mesopelagic Plankton Dynamics And Community Structure, Alexander Barth
Illuminating The Twilight Zone: In-Situ Imaging Facilitates Discovery Of Mesopelagic Plankton Dynamics And Community Structure, Alexander Barth
Theses and Dissertations
Ocean ecosystems provide both food and regulation of climate. Much of ocean ecosystem functioning occurs through processes in the pelagic, where plankton are the dominant organisms. While plankton have been researched for several centuries, recent advances in technology are greatly improving the ability to better understand plankton and how their communities are structured. Specifically, in-situ imaging allows oceanographers and plankton ecologists to better sample fragile taxa and record organisms’ true traits at high frequencies. These tools can facilitate investigation into new topics in plankton ecology and better understand critically understudied habitats, like the mesopelagic of open-ocean systems. However, in-situ imaging …
Island Hopping In The Tropics: Conservation Genetics, Speciation, And Biogeography In The Iconic Flowering Plant Group Hibiscus Sect. Lilibiscus, Brock Mashburn
Island Hopping In The Tropics: Conservation Genetics, Speciation, And Biogeography In The Iconic Flowering Plant Group Hibiscus Sect. Lilibiscus, Brock Mashburn
Arts & Sciences Graduate Student Theses and Dissertations
Islands have played a crucial role in evolutionary biology, providing key insights for both Charles Darwin and Alfred Russel Wallace in formulating their theories of evolution. The development of Island Biogeography Theory and the General Dynamic Model of oceanic island biogeography have formed the theoretical foundation of island studies over the last sixty years, leading to substantial advancements in our understanding of biodiversity evolution. Despite their critical value for evolutionary theory, islands face unprecedented ecological collapse, with species on islands facing significantly higher extinction rates than on continents. The island extinction crisis highlights the need for integrating conservation perspectives into …
Germline Genetic Determinates Of Cancer And Pre-Malignant Conditions, Jie Liu
Germline Genetic Determinates Of Cancer And Pre-Malignant Conditions, Jie Liu
Arts & Sciences Graduate Student Theses and Dissertations
Cancer is a genetic disease stemming from a combination of inherited and acquired mutations. In my thesis, we sought to characterize how germline genetic variation affects acquired clonal expansions in normal tissues and its progression to malignancy. In Chapter 2, we studied the impact of germline genetic variation on clonal hematopoiesis (CH) in 731,835 individuals. We identified 22 novel CH predisposition genes, most of which predispose to CH driven by specific mutational events. CH predisposition genes contribute to unique somatic landscapes reflecting the influence of germline genetic backdrop on gene-specific CH fitness. Correspondingly, somatic-germline interactions influence the risk of CH …
Investigating The Presence Of Bacterial Phytoplasma Disease In Grasses Of Central Texas And Their Associated Hemiptera, Danielle Rios
Investigating The Presence Of Bacterial Phytoplasma Disease In Grasses Of Central Texas And Their Associated Hemiptera, Danielle Rios
Masters Theses (Archived)
No abstract provided.
Estuarine Microbial Community Composition And Efficiency Changes In Response To Vibrio Parahaemolyticus Exposure, Sarah Mulligan
Estuarine Microbial Community Composition And Efficiency Changes In Response To Vibrio Parahaemolyticus Exposure, Sarah Mulligan
Theses and Dissertations
Vibrio parahaemolyticus is a pathogenic bacterium whose full impact on natural estuarine phytoplankton communities has not been fully resolved. The primary goal of this research was to test how the addition of V. parahaemolyticus to a natural estuarine microbial community would impact the other microbes present. We hypothesized V. parahaemolyticus exposure would reduce phytoplankton biomass and alter the composition of phytoplankton and bacterial communities. Experimental bioassays (60h) were used to assess the effects of the presence of V. parahaemolyticus . Samples for measurements of chemotaxonomic photopigment concentrations, 16S sequencing-based community composition, photosynthetic efficiency, cell density, and V. parahaemolyticus abundance were …
Histories Of Stress: A Life Course Approach To Population Health In Late Medieval And Early Modern Berlin, Emily Brennan
Histories Of Stress: A Life Course Approach To Population Health In Late Medieval And Early Modern Berlin, Emily Brennan
Theses and Dissertations
Given our current climate crisis and urban population increases, researchers are increasingly interested in the health outcomes at the intersection of climate change and urbanization. Since climate change and urbanization affects human health in a variety of ways, more work is needed in diverse cultural contexts to understand temporal and geographic variations of such phenomena more fully. Using skeletal individuals from 13th – 18th century Berlin (n = 387), this project analyses demographic and health trends from the founding of the city in the late medieval period (c. 1200 – 1500) to the early modern period, when the …
The Effects Of High Fat Diet On Lipid Deposition In Skeletal Muscle, Alexander Huss
The Effects Of High Fat Diet On Lipid Deposition In Skeletal Muscle, Alexander Huss
Theses and Dissertations
By the year 2030, almost 50% of adults in the United States are expected to be obese. Obesity has been shown to increase the risk of several chronic metabolic diseases, several cancers, and is associated with impaired skeletal muscle function and metabolism. Despite this, little it is known about the role of altered muscle lipid homeostasis, lipid droplet dynamics, and lipid droplet-mitochondrial interactions in contributing to muscle dysfunction in obesity. Therefore, we sought to investigate the impact of high-fat diet induced obesity on overall skeletal muscle lipid deposition, intramyocellular lipid droplet content and morphology, and lipid droplet-mitochondrial contact. Male C57/BL6 …
Effects Of Mmp14 Overexpression On Cardiac And Ovarian Connective Tissue And Myocyte Size In Pregnant And Post-Partum Mice, Emily Catherine Walliser
Effects Of Mmp14 Overexpression On Cardiac And Ovarian Connective Tissue And Myocyte Size In Pregnant And Post-Partum Mice, Emily Catherine Walliser
Theses and Dissertations
The main protein component of extracellular matrix is collagen, which fills spaces and supports cells. In the heart, collagen provides the scaffolding for cardiomyocytes and aids in contractile forces. In the ovary, collagen gives follicles their structural support. MMP14 or membrane type 1 matrix metalloproteinase is a membrane bound proteinase that cleaves extracellular matrix proteins, including collagen I and III. Recent studies have shown that overexpression of MMP14 influences collagen content in the heart, and elevated MMP14 has also been linked to ovarian cancer. In the current study, we investigate the effects of overexpression of a human MMP14 (hMMP14) transgene …
Understanding The Role Of Host Derived Interleukin 1 Alpha In Breast Cancer Progression, Manikanda Raja Keerthi Raja
Understanding The Role Of Host Derived Interleukin 1 Alpha In Breast Cancer Progression, Manikanda Raja Keerthi Raja
Theses and Dissertations
In breast cancer research, Interleukin-1 alpha (IL1α) remains a lesser-explored frontier, while its counterpart, Interleukin-1 beta, has garnered extensive scrutiny and understanding. To address this knowledge gap, our investigation leveraged the MMTVdriven HER2+ orthotopic model in Wildtype (WT) and IL1α-/- mice. Our approach demonstrated tumor regression in IL1α-/- mice at the 2-week timepoint, while WT tumors grew exponentially. At 2 weeks, IL1α-/- mice exhibited an immune "hot" microenvironment with increased CD45+ immune cells, particularly CD11b+ myeloid, and CD8+ T cells. CD8+ cells in IL1α-/- mice showed enhanced anti-tumor cytokine production and proliferative capability, with …
Developing Tools To Study The Effect Of The Mechanical Environment On Plant Cell Growth And Morphogenesis, Ryan Calcutt
Developing Tools To Study The Effect Of The Mechanical Environment On Plant Cell Growth And Morphogenesis, Ryan Calcutt
Arts & Sciences Graduate Student Theses and Dissertations
Mechanical forces are omnipresent in life on Earth and responses to force can be found across all three domains of life. The colonization of land by plants approximately 500 million years ago, an event that shaped life on Earth as we know it, involved adaptation from a relatively homogeneous fluid mechanical environment to a highly heterogeneous and mechanically diverse terrestrial environment. Evolution of multicellularity would present new mechanical challenges for land plants, not only from externally generated forces, but also from mechanical linkage to neighboring cells through the cell wall. Coordination of cell growth and an indeterminate body plan requires …
The Experience Of Homelessness And Its Effects On Gut Eubiosis, Kamerin Villagomez
The Experience Of Homelessness And Its Effects On Gut Eubiosis, Kamerin Villagomez
University Honors Theses
Microorganisms which populate the human gastrointestinal tract (GIT) have a profound effect on overall human health. The relationship between host health and eubiosis, or balance, of the GIT microbiome is symbiotic and can have reciprocal relationships with quality of sleep, quality of diet, stress and mental health, and the experience of pain. These specific aspects of health are unique in populations experiencing homelessness due to the multi-dimensional and complex nature of their lived experience. Very few studies explore populations experiencing homelessness, with even fewer investigating the intersection between this population and the human GIT microbiome. It is important to do …
Phylotranscriptomic Relationships Of The Oophila Clade Of Green Algae Associated To Amphibian Egg Masses, Ryan Kerney, Miguel Vences, Maria Sachs, Iker Irisarri, Fabian Bartels, Pontus Eriksson, Sven Künzel, Atsushi Kurabayashi, Ane Laugen, Zachary Vegso, Cory Bishop, Hartmut Arndt
Phylotranscriptomic Relationships Of The Oophila Clade Of Green Algae Associated To Amphibian Egg Masses, Ryan Kerney, Miguel Vences, Maria Sachs, Iker Irisarri, Fabian Bartels, Pontus Eriksson, Sven Künzel, Atsushi Kurabayashi, Ane Laugen, Zachary Vegso, Cory Bishop, Hartmut Arndt
Biology Faculty Publications
Green algae usually assigned to the genus Oophila are known to colonize egg capsules of amphibian egg masses across the Nearctic and Palearctic regions. We study the phylogenetic relationships of these algae using a phylotranscriptomic data set of 76 protein-coding single-copy nuclear genes. Our data set includes novel RNAseq data for six amphibian-associated and five free-living green algae, and draft genomes of two of the latter. Within the Oophila clade (nested within Moewusinia), we find samples from two European frogs (Rana dalmatina and R. temporaria) closely related to those of the North American frog R. aurora (Oophila …
A Comparison Of Diploid And Triploid Eastern Oysters For Aquaculture Production Under Extreme Temperatures And Salinities, Joshua H. Kim
A Comparison Of Diploid And Triploid Eastern Oysters For Aquaculture Production Under Extreme Temperatures And Salinities, Joshua H. Kim
LSU Master's Theses
Off-bottom aquaculture of Eastern oysters (Crassostrea virginica) is a nascent industry that is increasingly supported by the use of triploid oysters, which grow faster than diploids. Despite their growth advantage, elevated triploid mortality compared to diploids under high temperature, low salinity, or a combination of these conditions challenge consistent triploid production. Identifying the environmental thresholds at which differential triploid mortality occurs and predicting its economic impact are important to informing decision-making in oyster aquaculture. The goal of this thesis was to compare the biological and economic performance of diploid and triploid oysters under high temperature and low salinity conditions. …
Mitochondrial Network Reorganization And Transient Expansion During Oligodendrocyte Generation, Xhoela Bame, Robert A. Hill
Mitochondrial Network Reorganization And Transient Expansion During Oligodendrocyte Generation, Xhoela Bame, Robert A. Hill
Dartmouth Scholarship
Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes of the brain. This process persists throughout life and is essential for recovery from neurodegeneration. To better understand the cellular checkpoints that occur during oligodendrogenesis, we determined the mitochondrial distribution and morphometrics across the oligodendrocyte lineage in mouse and human cerebral cortex. During oligodendrocyte generation, mitochondrial content expands concurrently with a change in subcellular partitioning towards the distal processes. These changes are followed by an abrupt loss of mitochondria in the oligodendrocyte processes and myelin, coinciding with sheath compaction. This reorganization and extensive expansion and depletion take 3 days. Oligodendrocyte mitochondria …
An Intronic Regulatory Element Limits Tcf7 Expression In Natural Killer Cells, Matthew Vincent Mccullen
An Intronic Regulatory Element Limits Tcf7 Expression In Natural Killer Cells, Matthew Vincent Mccullen
Arts & Sciences Graduate Student Theses and Dissertations
To provide protection against a broad spectrum of threats, the immune system must give rise to a diverse range of cell types each with specialized roles in host defense. Transcriptional regulation is achieved by interactions between transcription factors and non-coding cis-regulatory DNA elements such as promoters and enhancers. One of the most important transcription factors in lymphocyte development and function is TCF1 (encoded by the Tcf7 gene). TCF1 is required for the efficient development of both innate lymphocytes, such as NK cells, as well as adaptive T cells. TCF1 also regulates the functional abilities of these cell types, such as …
Insights From Open Conformations Of Ecmsck, Htrpv4, And Hhcn1 Into The Structural Basis Of Ligand-Regulated Ion Channel Gating, Jonathan Mount
Insights From Open Conformations Of Ecmsck, Htrpv4, And Hhcn1 Into The Structural Basis Of Ligand-Regulated Ion Channel Gating, Jonathan Mount
Arts & Sciences Graduate Student Theses and Dissertations
Ion channels are found in all domains of life and play fundamental roles in cellular signaling and response to environmental cues. The ability to accommodate the selective and rapid passage of ions across a cell membrane is conferrable by a myriad of protein folds with no singular one-size-fits-all approach. With the advent of the cryo-EM resolution revolution, substantial interest has developed for determining the molecular structures of conformational states that correspond to conductive and nonconductive forms of ion channels. By gaining insight into the structural mechanisms for ion channel gating, we can potentially reveal binding pockets for targeted small molecule …
Functional Genomics Approaches To Understanding The Impact Of Common And Rare Risk Variants On Microglia Function In Neurodegenerative Diseases, Shih-Feng You
Arts & Sciences Graduate Student Theses and Dissertations
Genome-wide association studies (GWAS) have identified more than 70 genetic loci that are linked to Alzheimer disease (AD) risk. Many of these risk genes are involved in microglial function, including MS4A4A, TREM2, and PLD3, suggesting a relationship between microglial phagocytosis, metabolism, inflammation, and AD pathogenesis. However, the mechanisms by which AD risk genes alter microglia function and contribute to disease remains inadequately explored. In this dissertation, I leveraged functional genomics methods to understand the impact of MS4A4A, TREM2, and PLD3 on microglia function in stem cell and mouse models as well as human brain tissue. MS4A4A is a microglial gene …
Predicting Cell Fate Using Single-Cell State And Lineage Information, Emily Grace Butka
Predicting Cell Fate Using Single-Cell State And Lineage Information, Emily Grace Butka
Arts & Sciences Graduate Student Theses and Dissertations
Humans begin as a single cell, with successive cell divisions ultimately giving rise to a complex organism comprised of innumerable highly specialized cells. In this process, cells begin as pluripotent stem cells and slowly shift towards these highly specialized identities. Several technological innovations have enabled scientists to measure and track many aspects of a single cell’s identity as these divisions occur, at increasingly large scale and rapidly declining cost. As a result, our fundamental understanding of cell identity has grown to encompass several layers of cellular dynamics, including aspects that are both intrinsic and extrinsic, transient and permanent, active and …
Investigating The Cellular Mechanisms Of Intracellular Ph Regulation During Exposure To High Co2., Dillon Flowers
Investigating The Cellular Mechanisms Of Intracellular Ph Regulation During Exposure To High Co2., Dillon Flowers
Biology Theses
There are at least two different strategies of pH regulation among fish. The first is coupled pH regulation (CPR), where regulation of blood pH facilitates tissue pH regulation; and the second is preferential intracellular pH (pHi) regulation (PPR), where tissue pH remains tightly regulated despite a sustained reduction in blood pH. The cellular and molecular mechanisms underlying the differences in pHi regulation are currently unknown. I investigated the mechanisms of pH regulation in fishes using Rainbow Trout (Oncorhynchus mykiss) and Channel Catfish (Ictalurus punctatus) which use CPR and PPR, respectively. Fish were exposed to elevated CO …
Gnotobiotic Mouse Models For Characterizing The Role Of The Microbiota On Undernutrition And Early Postnatal Brain Development, Alexandra Elizabeth Byrne
Gnotobiotic Mouse Models For Characterizing The Role Of The Microbiota On Undernutrition And Early Postnatal Brain Development, Alexandra Elizabeth Byrne
Arts & Sciences Graduate Student Theses and Dissertations
Undernutrition is a serious global health challenge; it accounts for nearly half of all mortality for children under the age of 5. Worse, undernutrition is compounded by intergenerational inheritance and can be transmitted from mother to offspring. The burden of undernutrition is unequally distributed around the world, with South Asia and Sub-Saharan Africa accounting for almost 60% of the global childhood stunting. Undernutrition is detrimental to many aspects of development, including long-term deficits in neurodevelopment, and current interventions rarely ameliorate long-term cognitive and motor deficits. Therefore, other causes of undernutrition need to be elucidated in order to treat this epidemic …
Insulin-Independent Regulation Of Type 1 Diabetes Via Large Brown Adipocyte-Secreted Proteins And The Novel Glucagon Regulator, Nidogen2, Jeongmin Lee
Arts & Sciences Graduate Student Theses and Dissertations
Current treatments for type 1 diabetes (T1D) focus on insulin replacement. We demonstrate the therapeutic potential of a secreted protein fraction from embryonic brown adipose tissue (BAT), independent of insulin. The large molecular weight secreted fraction mediates insulin receptor-dependent recovery of euglycemia in a T1D animal model, nonobese diabetic (NOD) mice, by suppressing glucagon secretion. This fraction also promotes white adipocyte differentiation and browning, maintains healthy BAT, and enhances glucose uptake in adipose tissue, skeletal muscle, and liver. From this fraction, we identify nidogen-2 as a critical BAT-secreted protein that reverses hyperglycemia in NOD mice, inhibits glucagon secretion from pancreatic …
Investigation Of Photoperiodic Control Of Hypocotyl 1’S Role In Promoting Phytochrome B-Photobody Phase Separation, Sarah Anne Pardi
Investigation Of Photoperiodic Control Of Hypocotyl 1’S Role In Promoting Phytochrome B-Photobody Phase Separation, Sarah Anne Pardi
Arts & Sciences Graduate Student Theses and Dissertations
Light is arguably the most important environmental stimuli for all of plant growth and survival. Not only does light serve as an energy source via photosynthesis, it also serves as a signal for developmental programming. Plants perceive light through light-responsive proteins termed photoreceptors. Phytochromes are conserved red/far-red light photoreceptors. In the model plant Arabidopsis thaliana (thale cress), phytochrome B (phyB) is the primary red light photoreceptor. PhyB is involved in regulating almost all developmental processes throughout the plant’s life cycle, from seedling germination to flowering. In response to red light, phytochromes photoconvert to a biologically active form, transport from the …
The Clinical Significance And Genetic Origin Of P14arf, Anna Louise Grobelny Guthrie
The Clinical Significance And Genetic Origin Of P14arf, Anna Louise Grobelny Guthrie
Arts & Sciences Graduate Student Theses and Dissertations
The p14ARF tumor suppressor is the second most commonly mutated gene in Non-Small Cell Lung Cancer (NSCLC). p14ARF (p19ARF in mice) is encoded by the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene. The p14ARF tumor suppressor is known to play a fundamental role in cancer progression by regulating senescence, apoptosis, and proliferation. The primary function of p14ARF is to respond to oncogenic signals and activate the p53 tumor suppressor by inhibiting and sequestering the HDM2 (MDM2) oncogene. However, recent studies have uncovered multiple p53-independent functions of p14ARF, opening the door to a myriad of possible vulnerabilities in p14ARF-mutant tumors. Many current …
Corneal Epithelial Tissue Engineering Approaches To Treat Limbal Stem Cell Deficiency, Sasirekha K
Corneal Epithelial Tissue Engineering Approaches To Treat Limbal Stem Cell Deficiency, Sasirekha K
Theses and Dissertations
A clear healthy cornea is essential for visual acuity. As a self-renewing and regenerating tissue, the corneal epithelium has a stem cell pool, the limbus that acts as its proliferative reservoir. When limbal epithelial stem cells are destroyed or become dysfunctional, a pathological state known as limbal stem cell deficiency (LSCD) manifests. Damaged corneas have been successfully reconstructed by transplanting the cultured limbal epithelial stem cells. Limbal stem cell transplantation (LSCT) is one of the applicable and most challenging procedures in clinical ophthalmology for the reconstruction of the stratified ocular surface epithelium in patients with LSCD. Given the above challenge, …