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Full-Text Articles in Entire DC Network
Is Placenta Stem Cell Banking Worthwhile?, Chaya Nathan
Is Placenta Stem Cell Banking Worthwhile?, Chaya Nathan
The Science Journal of the Lander College of Arts and Sciences
Regenerative medicine has gained significant traction due to its potential to repair or replace damaged tissues and organs, with stem cell therapies emerging as a promising avenue for treating various diseases. While bone marrow-derived MSCs (BM-MSCs) are commonly used in clinical settings, their limitations, such as the invasive extraction procedure and limited proliferation capacity, underscore the need for alternative stem cell sources. Placenta-derived mesenchymal stem cells (PDMSCs) represent a promising solution, offering advantages such as greater proliferative capacity, faster expansion rates, and reduced risk of immune rejection compared to adult stem cells. The placenta is a rich source of MSCs, …
Can Organs Be Generated From A Patient’S Own Stem Cells?, David Heimowitz
Can Organs Be Generated From A Patient’S Own Stem Cells?, David Heimowitz
The Science Journal of the Lander College of Arts and Sciences
The global shortage of transplantable organs represents a critical medical challenge, with current organ donation systems meeting less than 10% of the worldwide need. This situation has spurred intensive research into regenerative medicine, particularly focusing on the potential of generating organs from a patient’s own stem cells. This review examines the current state of stem cell research and its applications in organ generation, analyzing both the progress made and the challenges that remain. Through a comprehensive analysis of recent literature and clinical trials, the study explores the fundamental principles of stem cell biology, current therapeutic applications, and the role of …
Limb Regeneration In Amphibians & Mammals, Jacob Mamrout
Limb Regeneration In Amphibians & Mammals, Jacob Mamrout
The Science Journal of the Lander College of Arts and Sciences
This thesis will give an in-depth analysis into the mechanisms of regeneration that amphibians use and how the blastema forms. It will also discuss genes and proteins that play a role including the P53 gene, Transforming Growth Factor Beta, CD59, and others. Regenerative potential of mammals will be discussed using the information found. Findings include that mammals may have regeneration potential because of the ability we have to deactivate certain genes to allow cells to dedifferentiate.
The Bidirectional Gut-Brain Axis: Impact Of Dysbiosis On Depression Through The Hpa Axis, Matan Shiller
The Bidirectional Gut-Brain Axis: Impact Of Dysbiosis On Depression Through The Hpa Axis, Matan Shiller
The Science Journal of the Lander College of Arts and Sciences
Emerging research suggests that depression is not solely a brain disorder but is deeply influenced by the gut microbiome. The gut-brain axis (GBA) is a bidirectional communication system linking the gastrointestinal system and the brain, modulating mood, behavior, and mental health. Gut microbiota produce metabolites, such as short-chain fatty acids (SCFAs) and tryptophan catabolites, that influence neurotransmission and the stress response via the hypothalamic-pituitary-adrenal (HPA) axis. Dysbiosis, or microbial imbalance, disrupts these pathways, contributing to a major depressive disorder (MDD). Evidence from germ-free animal studies and fecal microbiota transplants (FMT) highlights the role of gut microbiota in emotional regulation and …
Gut Microbiome Dysbiosis And Its Contribution To Carcinogenesis, Daphne Grabie
Gut Microbiome Dysbiosis And Its Contribution To Carcinogenesis, Daphne Grabie
The Science Journal of the Lander College of Arts and Sciences
The gut microbiome, a diverse community of microorganisms within the gastrointestinal (GI) tract, plays a pivotal role in maintaining health through digestion, immune regulation, and homeostasis. Emerging evidence links gut microbiome dysbiosis—a disruption in its composition and function—to the development and progression of various cancers, particularly within the GI tract. This review explores the multifaceted relationship between the gut microbiome and carcinogenesis, highlighting key microbial mechanisms, including chronic inflammation, production of carcinogenic metabolites, and immune modulation. Specific pathogens such as Fusobacterium nucleatum, Escherichia coli, and Helicobacter pylori are implicated in colorectal, gastric, and esophageal cancers, respectively, through pathways that promote …
Battling Infertility, Shirah Abrahams
Battling Infertility, Shirah Abrahams
The Science Journal of the Lander College of Arts and Sciences
Infertility is a complex condition that affects men and women equally and is defined by failure to achieve pregnancy after a year of trying to conceive. This paper addresses both environmental contributions to infertility, such as the effects of smoking, poor nutrition, and exposure to radiation, as well as biological contributors. Biological factors that contribute to infertility include sperm DNA fragmentation, chromosomal mutations, anovulatory dysfunction, and tubule blockages. This paper delves into various treatment options to improve fertility in both males and females, including medications, lifestyle adaptations, and surgeries. These treatment options can restore and improve ovulatory function, sperm motility …
Mild Traumatic Brain Injury: Signs, Symptoms, And Intervention, Shoshana Levin
Mild Traumatic Brain Injury: Signs, Symptoms, And Intervention, Shoshana Levin
The Science Journal of the Lander College of Arts and Sciences
Mild traumatic brain injury (mTBI) is a specific type of brain injury, often referred to as a concussion. Relying on existing research, this paper will collect the data that is available on concussions, numerous methods of treatment, and the complications of repeated injury. mTBI precipitates a host of cognitive, physical, and emotional symptoms, all of which can severely affect one’s daily life if left untreated. This paper will also address a range of possible treatment methods, including but not limited to acupuncture, cognitive behavioral therapy, and physical therapy. The efficacy of a multifaceted approach to treatment is emphasized, combining opinions …
Full Issue: Volume 18, Number 2, Spring 2025
Full Issue: Volume 18, Number 2, Spring 2025
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 18, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2025.
Can Cystic Fibrosis Be Treated With Genetic Therapy?, Steve Silverberg
Can Cystic Fibrosis Be Treated With Genetic Therapy?, Steve Silverberg
The Science Journal of the Lander College of Arts and Sciences
This paper discusses the current and prospective treatment options for the fatal genetic disease cystic fibrosis. Cystic fibrosis (CF) is a rare recessive genetic disorder that is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which codes for a protein that is on the surface of a cell. This protein allows for the flow of chloride, bicarbonate, and sodium ions to pass through the cell wall, bringing water with it. When this protein doesn’t work, the lack of ions and water in extracellular fluid becomes too thick, causing a multitude of problems. The most common …
Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt
Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt
The Science Journal of the Lander College of Arts and Sciences
This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal …
Full Issue: Volume 19, Number 1, Fall 2025
Full Issue: Volume 19, Number 1, Fall 2025
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 19, Number 1 of The Science Journal of the Lander College of Arts and Sciences. Published Fall 2025.
Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert
Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert
The Science Journal of the Lander College of Arts and Sciences
Chronic stress has been increasingly recognized as a major contributor to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. This paper explores the correlation between chronic stress and neurodegeneration by reviewing population, clinical, and animal studies. Studies show that long-term stress disrupts the hypothalamic-pituitary-adrenal (HPA) axis, impairs hippocampal function, increases oxidative stress, and promotes neuroinflammation. These processes are all implicated in cognitive decline. The mechanisms through which these processes occur are discussed including elevated glucocorticoid levels, shortened telomeres, mitochondrial dysfunction, and the activity of pro-inflammatory microglia. Lastly, potential interventions are reviewed, including lifestyle modifications such …
Can Deadly Toxins Become Tools For Medicine?, Esther Gross
Can Deadly Toxins Become Tools For Medicine?, Esther Gross
The Science Journal of the Lander College of Arts and Sciences
Natural toxins, long feared as deadly poison, are increasingly being harnessed as powerful medicine. This paper explores the growing role of animal and plant toxins in modern medicine, tracing their use from ancient remedies to cutting-edge biomedical science. Through a study of their biochemical mechanisms, therapeutic applications, and clinical case histories, this paper draws attention to the remarkable specificity and potency of toxin-derived compounds for disease treatment in diabetes, chronic pain, cancer, cardiovascular disease, etc. This paper also investigates the scientific and practical barriers to the universal clinical application of toxins, such as issues of toxicity, cost, stability, and ethical …
Endometriosis & Natural Killer Cell Activity, Orelle Shakarchi
Endometriosis & Natural Killer Cell Activity, Orelle Shakarchi
The Science Journal of the Lander College of Arts and Sciences
Endometriosis is a condition found in females of reproductive age. It occurs when tissue, known as the endometrium, grows outside of its designated place- the uterus. It affects the reproductive organs such as the ovaries, fallopian tubes, and pelvic tissues. Endometriosis patients experience chronic pain and fertility issues. There has been a correlation between low cytotoxicity in Natural Killer (NK) cells and the development of the disease. NK cells are part of the human innate immunity system where they defend the body against tumors and any abnormal cells by performing apostasies A study done by the American Fertility Society, which …
Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer
Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer
The Science Journal of the Lander College of Arts and Sciences
The CRISPR/Cas gene editing tool was discovered in 2012 and since then has been researched extensively. It has many applications in the research and medical world and has been the topic of many discussions since its discovery. This paper describes several of the advantages of CRISPR; what it has been used for and the potential that it contains. Among those advantages are sickle cell treatment, Alzheimer’s treatment, coupling CRISPR with induced pluripotent stem cells(iPSCs), and the cancer battle. Also discussed in this paper are number of concerns that surround this new gene therapy. Among those are medical concerns and ethical …
Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh
Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh
The Science Journal of the Lander College of Arts and Sciences
Maternal prenatal stress (MPS) has a unique impact on the developing fetus and the child’s life post birth. Pregnancy is a highly anxious time for a lot of women. Many have pregnancy related concerns as well as overall stress from environmental and societal factors. However, this takes a toll on the fetus’s development which can later cause different cognitive and health outcomes in the child. During a time of stress, one’s HPA axis gets activated causing the release of various hormones, particularly cortisol and catecholamines. These hormones can cross the placental barrier called HSD11B2-11β-hydroxysteroid dehydrogenase 2, exposing the sensitive and …
The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss
The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss
The Science Journal of the Lander College of Arts and Sciences
The gastrointestinal (GI) system and the brain share a highly integrated relationship mediated by the gut–brain axis, with implications across a range of medical disciplines. Irritable bowel syndrome (IBS) is the most prevalent disorder of gut brain interaction (DGBI) which affects a significant portion of the global population, yet its pathophysiology has historically been poorly understood. This review examines the development and maintenance of IBS, drawing on literary sources to explore the gut–brain axis and disease expression which occurs as a result of its dysfunction. Common pathological features of IBS include visceral hypersensitivity, altered serotonin signaling, inappropriate immune activation, and …
What Are The Long-Term Health Implications Of Living Kidney Donation?, Yehudis Fasten
What Are The Long-Term Health Implications Of Living Kidney Donation?, Yehudis Fasten
The Science Journal of the Lander College of Arts and Sciences
Living kidney donation is the optimal long-term treatment for patients with end-stage renal disease (ESRD), also known as end-stage kidney disease (ESKD). However, it also raises concerns regarding the long-term health of donors. This paper explores the potential risks that living kidney donors (LKDs) may face, focusing on the potential development of ESRD and post-donation pregnancy risks, especially in relation to established ESRD risk factors such as hypertension and diabetes mellitus. It also examines the impact of genetic and familial predispositions, structural kidney changes, and proteinuria as contributors to future decline in kidney function. Concerns including reductions in erythropoietin (EPO) …
Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt
Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt
The Science Journal of the Lander College of Arts and Sciences
This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal …
Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen
Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen
The Science Journal of the Lander College of Arts and Sciences
Treatment Resistant Depression has become extremely prevalent with 30% of depression cases being unresolvable. Psychedelics specifically Lysergic Acid Diethylamide has been a newfound unconventional approach that has demonstrated significant benefits for depression. LSD is a hallucinogenic drug mainly acting on the serotonin receptors that leads to altered sensory and perception affecting mood. This research paper comprehensively examines animal and human studies on LSD’s healing properties and enduring effects. The studies find that LSD induces neuroplasticity, and alters gene expressions associated with synaptogenesis and neurogenesis. Additionally LSD affects the activity of different neurotransmitters in the central nervous system enhancing mood. Lastly …
Virtual Reality Cognitive Behavioral Therapy (Cbt) For Chronic Lower Back Pain, Peri Feinberg
Virtual Reality Cognitive Behavioral Therapy (Cbt) For Chronic Lower Back Pain, Peri Feinberg
The Science Journal of the Lander College of Arts and Sciences
No abstract provided.
Embryonic Stem Cells Vs Induced Pluripotent Stem Cells For Tissue Engineering, Devora Weinstein
Embryonic Stem Cells Vs Induced Pluripotent Stem Cells For Tissue Engineering, Devora Weinstein
The Science Journal of the Lander College of Arts and Sciences
Both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are pluripotent, meaning that they can give rise to many types of cells. Consequently, they both represent incredible potential for applications in regenerative medicine and research models. This paper explores their similarities and critical molecular differences, especially in the context of tissue engineering. Through analysis of three peer-reviewed studies, the paper focuses on their respective advantages and limitations. One study used Raman spectroscopy to reveal higher nucleic acid content in iPSCs, possibly due to epigenetic memory. The second study utilized DNA methylation profiling and gene expression data to construct …
Factors Mediating The Reproductive Risk For Balanced Chromosomal Translocation Carriers, Talia Alter
Factors Mediating The Reproductive Risk For Balanced Chromosomal Translocation Carriers, Talia Alter
The Science Journal of the Lander College of Arts and Sciences
Reciprocal balanced translocations occur when one part of a chromosome is exchanged with another, resulting in zero net loss of genetic material. While individuals with a balanced translocation are phenotypically normal, a translocation can cause increased risk of infertility, recurrent pregnancy loss, and the birth of a child with unbalanced chromosomes. In order to adequately guide an individual in their reproductive decisions, geneticists must be able to assess the risk of the patient’s unique translocation. An analysis of three recent studies reveals several factors which play a role in mediating the effects of balanced translocations and directly affect reproductive risk …
Systematic Review Of Immunohistochemistry Protocols, Arpitha Parthasarathy
Systematic Review Of Immunohistochemistry Protocols, Arpitha Parthasarathy
Pitzer Senior Theses
Immunohistochemistry (IHC) is an essential technique in biological research that allows for the visualization and localization of proteins within tissue samples. This systematic review analyzes the most effective, efficient and reproducible protocols for IHC. It focuses on three critical steps: freezing, cryosectioning, and staining of skeletal muscle tissues in mice models. A total of 41, 44, and 48 articles on freezing, cryosectioning, and staining techniques, respectively, were analyzed, from reputable sources in biology like PubMed and Web of Science. Results showed the following. For freezing, the use of isopentane combined with liquid nitrogen appeared to be the best method, minimizing …
Crisis In The Current: A Proposed Study On The Impact Of Columbia River Basin Water Quality On Juvenile Chinook Salmon Survival, Olivia Buist-Thuillier
Crisis In The Current: A Proposed Study On The Impact Of Columbia River Basin Water Quality On Juvenile Chinook Salmon Survival, Olivia Buist-Thuillier
Pitzer Senior Theses
Salmon occupy a vital role in the ecosystem, economy, and indigenous culture of the Pacific Northwest of the United States, specifically within the Columbia River Basin. Of the five species of Pacific Salmon that live in the basin, Chinook salmon (Oncorhynchus tshawytscha) are the most widely commercially fished and are the largest. In recent years, Chinook Salmon populations have heavily declined from human influence. Rising temperatures from anthropogenic climate change, habitat destruction (dams, human presence), runoff from agricultural practices, and overfishing have all contributed to this decline. Because of their role as a keystone species and their cultural significance, there …
Bat Genomes Illuminate Adaptations To Viral Tolerance And Disease Resistance, Ariadna E. Morales, Yue Dong, Thomas Brown, Kaushal Baid, Dimitrios Georgios Kontopoulos, Victoria Gonzalez, Zixia Huang, Alexis Walid Ahmed, Arkadeb Bhuinya, Leon Hilgers, Sylke Winkler, Graham Hughes, Xiaomeng Li, Ping Lu, Yixin Yang, Bogdan M. Kirilenko, Paolo Devanna, Tanya M. Lama, Yomiran Nissan, Martin Pippel, Liliana M. Dávalos, Sonja C. Vernes, Sebastien J. Puechmaille, Stephen J. Rossiter, Yossi Yovel, Joseph B. Prescott, Andreas Kurth, David A. Ray, Burton K. Lim, Eugene Myers, Emma C. Teeling, Arinjay Banerjee
Bat Genomes Illuminate Adaptations To Viral Tolerance And Disease Resistance, Ariadna E. Morales, Yue Dong, Thomas Brown, Kaushal Baid, Dimitrios Georgios Kontopoulos, Victoria Gonzalez, Zixia Huang, Alexis Walid Ahmed, Arkadeb Bhuinya, Leon Hilgers, Sylke Winkler, Graham Hughes, Xiaomeng Li, Ping Lu, Yixin Yang, Bogdan M. Kirilenko, Paolo Devanna, Tanya M. Lama, Yomiran Nissan, Martin Pippel, Liliana M. Dávalos, Sonja C. Vernes, Sebastien J. Puechmaille, Stephen J. Rossiter, Yossi Yovel, Joseph B. Prescott, Andreas Kurth, David A. Ray, Burton K. Lim, Eugene Myers, Emma C. Teeling, Arinjay Banerjee
Biological Sciences: Faculty Publications
Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested to harbour more zoonotic viruses than any other mammalian order1. Infections in bats are largely asymptomatic2,3, indicating limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of disease resistance, the Bat1K project generated reference-quality genomes of ten bat species, including potential viral reservoirs. Here we describe a systematic analysis covering 115 mammalian genomes that revealed that signatures of selection in immune genes are more prevalent in bats than in other mammalian orders. We found an excess of immune gene adaptations in the ancestral chiropteran branch and …
Larval Environments Affect The Implementation Of The Sterile Insect Technique On Aedes Mosquitoes, Katherine G. Evans
Larval Environments Affect The Implementation Of The Sterile Insect Technique On Aedes Mosquitoes, Katherine G. Evans
Theses and Dissertations
Sterile Insect Technique (SIT) is an effective method for controlling pests and has been increasing in popularity to control Aedes mosquitoes. SIT involves inundating an area with sterilized male mosquitoes to reduce egg hatch and ultimately the number of wild adults. Previous research indicates that enacting mortality early in the larval life of Aedes mosquitoes can result in counter-productive effects, due to reduced competition among developing larvae. I hypothesize that the effectiveness of SIT at reducing adult populations is modified by densitydependent mortality and density-dependent growth among larvae. I performed two field-to-lab studies and developed an individual-based model to test …
A Novel Silver-Ruthenium-Based Antimicrobial Kills Gram-Negative Bacteria Through Oxidative Stress-Induced Macromolecular Damage, Patrick O. Tawiah
A Novel Silver-Ruthenium-Based Antimicrobial Kills Gram-Negative Bacteria Through Oxidative Stress-Induced Macromolecular Damage, Patrick O. Tawiah
Theses and Dissertations
The rise in drug-resistant bacteria, together with the decline in antibiotic development, requires new strategies for infectious disease control. Gram-negative pathogens are particularly challenging to combat due to their outer membrane. This study highlights the effectiveness of the silver-containing antimicrobial AGXX® against the Gram-negative bacterium Escherichia coli. AGXX® is a promising silver coating that presumably kills bacteria through the generation of reactive oxygen species (ROS). However, neither AGXX®’s mode of action is fully understood, nor have its effects on Gram-negative bacteria or bacterial response and defense mechanisms towards AGXX® been studied in detail. Here, I report that the bactericidal …
Programming Carcass Composition Through Gestational Nutrition, Sydni Elise Borders
Programming Carcass Composition Through Gestational Nutrition, Sydni Elise Borders
Electronic Theses and Dissertations
The objective of this study was to evaluate the influence of maternal nutrient restriction during mid-gestation on the performance of the dam, feeding performance, carcass composition, and genetic expression in the offspring. Cows (n = 46) were randomly assigned to one of two treatments based on global nutrient intake: 1) fed to achieve and/or maintain a BCS of 5 or 6 (Positive Energy Status [PES]; n = 24) or 2) fed to lose one BCS during 99 days of mid-gestation (Negative Energy Status [NES]; n = 22). Cows in NES had greater decreases (P < 0.05) in body fat stores and muscle mass, elevated NEFA concentrations, and displayed decreased (P < 0.05) DMI, HP, and GHG emissions. There were no differences in milk components or volume produced between treatments (P > 0.05). There were no differences in …
Electrical Homeostasis Of The Inner Mitochondrial Membrane Potential, Peyman Fahimi, Lázaro A. M. Castanedo, P. Thomas Vernier, Cherif F. Matta
Electrical Homeostasis Of The Inner Mitochondrial Membrane Potential, Peyman Fahimi, Lázaro A. M. Castanedo, P. Thomas Vernier, Cherif F. Matta
Bioelectrics Publications
The electric potential across the inner mitochondrial membrane must be maintained within certain bounds for the proper functioning of the cell. A feedback control mechanism for the homeostasis of this membrane potential is proposed whereby an increase in the electric field decreases the rate-limiting steps of the electron transport chain (ETC). An increase in trans-membrane electric field limits the rate of proton pumping to the inter-membrane gap by slowing the ETC reactions and by intrinsically induced electroporation that depolarizes the inner membrane. The proposed feedback mechanism is akin to a Le Chatelier's-type principle of trans-membrane potential feedback control.