Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- Washington University in St. Louis (98)
- Old Dominion University (95)
- University of Nebraska - Lincoln (95)
- TÜBİTAK (85)
- University of Montana (65)
-
- City University of New York (CUNY) (52)
- University of South Florida (51)
- Utah State University (51)
- Nova Southeastern University (50)
- The University of Southern Mississippi (47)
- University of Nebraska at Omaha (47)
- University of Texas at El Paso (45)
- Smith College (44)
- Technological University Dublin (44)
- University of New Mexico (44)
- The Texas Medical Center Library (42)
- University of South Carolina (41)
- Munster Technological University (40)
- Illinois State University (39)
- Prairie View A&M University (34)
- Liberty University (33)
- University of Arkansas, Fayetteville (33)
- University of Texas Rio Grande Valley (32)
- Karbala International Journal of Modern Science (31)
- Montclair State University (31)
- Portland State University (31)
- University of Missouri, St. Louis (31)
- Georgia Southern University (30)
- Wright State University (29)
- Western Kentucky University (28)
- Keyword
-
- Biology (51)
- COVID-19 (51)
- SARS-CoV-2 (44)
- Ticks (37)
- Microbiology (36)
-
- Antibiotic resistance (33)
- Bacteria (32)
- Climate change (26)
- Humans (26)
- Inflammation (26)
- Immunology (25)
- Disease (23)
- Microbiome (23)
- Animals (22)
- Biological Sciences (22)
- Infectious disease (22)
- Malaria (22)
- Batrachochytrium dendrobatidis (21)
- Biofilm (21)
- Conservation (21)
- Ixodes scapularis (21)
- Immunity (20)
- Infection (20)
- Lyme disease (20)
- Tuberculosis (20)
- Evolution (19)
- Parasites (19)
- 1.6 BIOLOGICAL SCIENCES (18)
- Amphibians (18)
- Parasite (18)
- Publication Year
- Publication
-
- Biological Sciences Faculty Publications (154)
- Biology Faculty Publications (104)
- Arts & Sciences Graduate Student Theses and Dissertations (89)
- Turkish Journal of Biology (85)
- Theses and Dissertations (59)
-
- Faculty Publications (55)
- Honors Theses (55)
- Open Access Theses & Dissertations (45)
- Biological Sciences: Faculty Publications (42)
- Biology ETDs (41)
- School of Biological Sciences: Faculty Publications (39)
- Electronic Theses and Dissertations (38)
- Biology Faculty Publications and Presentations (33)
- Applications and Applied Mathematics: An International Journal (AAM) (32)
- SURE Journal: Science Undergraduate Research Experience Journal (32)
- Karbala International Journal of Modern Science (31)
- Scott L. Gardner Publications (31)
- Publications and Research (30)
- Biology Faculty Articles (27)
- USF Tampa Graduate Theses and Dissertations (27)
- Dissertations (26)
- Faculty Publications and Presentations (26)
- Faculty, Staff and Students Publications (26)
- Department of Biological Sciences Publications (25)
- The Science Journal of the Lander College of Arts and Sciences (24)
- Masters Theses (22)
- Tanzania Journal of Science (22)
- Biology Department Faculty Works (21)
- Faculty Publications – Biological Sciences (21)
- Integrative Biology Faculty and Staff Publications (20)
- Publication Type
- File Type
Articles 721 - 750 of 2552
Full-Text Articles in Entire DC Network
Surveillance And Dynamics Of Bacteria And Resistance Genes In Humans And Hospitals, Alaric Wences D'Souza
Surveillance And Dynamics Of Bacteria And Resistance Genes In Humans And Hospitals, Alaric Wences D'Souza
Arts & Sciences Graduate Student Theses and Dissertations
Bacteria live in, on, and around us. These bacteria affect human health through beneficial commensal interactions that promote normal development and through harmful infections or perturbations leading to disease. Understanding the prevalence, spread, and resilience of these bacteria in humans and human environments is critical to clinical medicine and epidemiology. I investigated environmental and human resident bacteria to understand dynamics in bacterial communities and how these dynamics may impact human health.Hospitals are one critical location of human-bacterial interactions. Bacteria can contaminate hospital surfaces from patients or environmental sources and subsequently transmit from surfaces to vulnerable patients. I analyzed bacteria from …
Quantitative Characterization Of Microbial Ecologies In Dysbiosis And Infection, Eric Keen
Quantitative Characterization Of Microbial Ecologies In Dysbiosis And Infection, Eric Keen
Arts & Sciences Graduate Student Theses and Dissertations
In 1973, Theodosius Dobzhansky famously wrote that nothing in biology makes sense except in the light of evolution. Today, nearly 50 years later, little in microbiology – or in biology, for that matter – makes sense except in the light of genomics. Microbial genomics populates the field with innumerable testable hypotheses for evaluation in vitro and in vivo, allows us to monitor microbial populations in real time and at a massive scale, and underpins our approach to entire domains of microbiology, including microbial evolution. In this Thesis, I present three studies from my graduate research united by their common theme …
(R1523) Abundant Natural Resources, Ethnic Diversity And Inclusive Growth In Sub-Saharan Africa: A Mathematical Approach, Juliet I. Adenuga, Kazeem B. Ajide, Anthonia T. Odeleye, Abayomi A. Ayoade
(R1523) Abundant Natural Resources, Ethnic Diversity And Inclusive Growth In Sub-Saharan Africa: A Mathematical Approach, Juliet I. Adenuga, Kazeem B. Ajide, Anthonia T. Odeleye, Abayomi A. Ayoade
Applications and Applied Mathematics: An International Journal (AAM)
The sub-Saharan African region is blessed with abundant natural resources and diverse ethnic groups, yet the region is dominated by the largest number of poor people worldwide due to inequitable distribution of national income. Existing statistics forecast decay in the quality of lives over the years compared to the continent of Asia that shares similar history with the region. In this paper, a-five dimensional first-order nonlinear ordinary differential equations was formulated to give insight into various factors that shaped dynamics of inclusive growth in sub-Saharan Africa. The validity test was performed based on ample mathematical theorems and the model was …
Development And Characterization Of Novel A Tcrm Antibody And Its Application As An Immune Checkpoint Blocker, Soroush Ghaffari
Development And Characterization Of Novel A Tcrm Antibody And Its Application As An Immune Checkpoint Blocker, Soroush Ghaffari
Biology Dissertations - Archive
Immunotherapy, the treatment of diseases via targeted immune system activation, has recently shown extraordinary success in clinical trials for multiple malignancies. In contrast to a routine therapeutic regimen for cancer, effective immunotherapies can stimulate the innate and adaptive immune system to marsh specific and durable responses against tumors. Immunotherapies come in many shapes and forms. Immune checkpoint blockade (ICB) is an example of immunotherapy that revolutionized the field of immuno-oncology. Considering the recent success of ICB therapies, the scientific community tried to discover new inhibitory molecules and pathways as a new target for cancer immunotherapy. Indeed, CD94/NKG2A receptor is an …
(R)-2,5-Dimethoxy-4-Iodoamphetamine [(R)-Doi] Influences Coping Strategies To An Escapable Social Stress, Kevin Thomas Krupp
(R)-2,5-Dimethoxy-4-Iodoamphetamine [(R)-Doi] Influences Coping Strategies To An Escapable Social Stress, Kevin Thomas Krupp
Dissertations and Theses
Depressive mood disorders are a leading cause of disability worldwide and pharmacological treatments for these disorders are inadequate, requiring new compounds with greater efficacy be investigated. The etiology of depression is heterogeneous; however, it is well established that stress exposure, and the proinflammatory effects of stress have a major role. Psychedelic compounds have rapid and long-lasting anxiolytic and antidepressive effects in humans and animal models of stress induced affective behavior. However, it is not completely understood how these compounds produce such rapid effects. We investigated whether the psychedelic compound (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI], a selective 5-HT2A partial agonist with potent anti-inflammatory properties, …
Toxicity Of Indoor Dust-Derived Trace Elements And Organic Contaminants Impact On Normal Human Colon Epithelial Cells, Noura Abdulrahman
Toxicity Of Indoor Dust-Derived Trace Elements And Organic Contaminants Impact On Normal Human Colon Epithelial Cells, Noura Abdulrahman
Theses (2016-Present)
Indoor dust stands out as a burgeoning challenge in society due to its implication on people’s health. Exposure to toxic dust particles occurs in different ways that include inhalation, ingestion, and dermal contact. In the hindsight, many people spend most of their time indoors exposing themselves to high levels of dust. Notably, different groups of individuals present varied risk levels to the toxicity of particles with vulnerable persons being susceptible to adverse effects of these contaminants. This includes the elderly, children, and immunocompromised individuals. The study examines the impacts of two variables that are trace elements (TMD) and organic contaminants …
Large-Scale Genome Sampling Reveals Unique Immunity And Metabolic Adaptations In Bats, Diana D. Moreno Santillán, Tanya M. Lama, Yocelyn T. Gutierrez Guerrero, Alexis M. Brown, Paul Donat, Huabin Zhao, Stephen J. Rossiter, Laurel R. Yohe, Joshua H. Potter, Emma C. Teeling, Sonja C. Vernes, Kalina T.J. Davies, Eugene Myers, Graham M. Hughes, Zixia Huang, Federico Hoffmann, Angelique P. Corthals, David A. Ray, Liliana M. Dávalos
Large-Scale Genome Sampling Reveals Unique Immunity And Metabolic Adaptations In Bats, Diana D. Moreno Santillán, Tanya M. Lama, Yocelyn T. Gutierrez Guerrero, Alexis M. Brown, Paul Donat, Huabin Zhao, Stephen J. Rossiter, Laurel R. Yohe, Joshua H. Potter, Emma C. Teeling, Sonja C. Vernes, Kalina T.J. Davies, Eugene Myers, Graham M. Hughes, Zixia Huang, Federico Hoffmann, Angelique P. Corthals, David A. Ray, Liliana M. Dávalos
Biological Sciences: Faculty Publications
Comprising more than 1,400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity, and extraordinary immunity. Some of the molecular mechanisms underlying these unique adaptations includes DNA repair, metabolism and immunity. However, analyses have been limited to a few divergent lineages, reducing the scope of inferences on gene family evolution across the Order Chiroptera. We conducted an exhaustive comparative genomic study of 37 bat species, one generated in this study, encompassing a large number of lineages, with a particular emphasis on multi-gene family evolution across immune and metabolic genes. In agreement with previous analyses, we found lineage-specific …
From Microbes To Management: Spatial And Temporal Variations In Available Vegetation Affect The Gut Microbiota In A Population Of Free-Ranging Generalist Herbivores, Olivia K. Rodríguez
From Microbes To Management: Spatial And Temporal Variations In Available Vegetation Affect The Gut Microbiota In A Population Of Free-Ranging Generalist Herbivores, Olivia K. Rodríguez
Boise State University Theses and Dissertations
The effects of extrinsic environmental factors that shape ecological systems are not only seen at the macroscopic level, but additionally influence and govern the host-associated microbial communities of their mammalian hosts. These microbial communities are susceptible to the fluctuation of abiotic and biotic factors which affect their host organisms. The surge in the research of microbiota–communities of archaea, bacteria, fungi, and viruses residing in various environmental systems–has shown that these communities can profoundly influence animal health. As such, monitoring microbiota has allowed for a new approach to study animal health and physiology. This is of particular benefit in the conservation …
The Role Of The Serine/Threonine Phosphatase Pstp In The Mycobacterial Cell Wall Regulation, Farah Shamma
The Role Of The Serine/Threonine Phosphatase Pstp In The Mycobacterial Cell Wall Regulation, Farah Shamma
Biology Dissertations - Archive
Mycobacterium tuberculosis (Mtb) is the causative agent of the deadly infection Tuberculosis (TB). The current standard antibiotic regimen for TB treatment combines fours drugs to be taken for at least six months. Mtb shows intrinsic phenotypic tolerance to antibiotics contributing to the long treatment regimen. In addition, Mtb cells can achieve a non-replicating state exhibiting antibiotic tolerance, reduced metabolism and altered cell wall staining. The changes in the cell wall and reduced permeability to antibiotics in stressed cells suggest that the regulation of the cell wall is a major contributor to antibiotic tolerance. The mycobacterial cell wall consists of covalently …
(R1412) Stability And Bifurcation Of A Cholera Epidemic Model With Saturated Recovery Rate, Huda Abdul-Satar, Raid K. Naji
(R1412) Stability And Bifurcation Of A Cholera Epidemic Model With Saturated Recovery Rate, Huda Abdul-Satar, Raid K. Naji
Applications and Applied Mathematics: An International Journal (AAM)
In this paper, a Cholera epidemic model is proposed and studied analytically as well as numerically. It is assumed that the disease is transmitted by contact with Vibrio cholerae and infected person according to dose-response function. However, the saturated treatment function is used to describe the recovery process. Moreover, the vaccine against the disease is assumed to be utterly ineffective. The existence, uniqueness and boundedness of the solution of the proposed model are discussed. All possible equilibrium points and the basic reproduction number are determined. The local stability and persistence conditions are established. Lyapunov method and the second additive compound …
Population Connectivity In Voles (Microtus Sp.) As A Gauge For Tall Grass Prairie Restoration In Midwestern North America, Marlis R. Douglas, Steven M. Mussmann, Tyler Chafin, Whitney J.B. Anthonysamy, Mark A. Davis, Matthew P. Mulligan, Robert L. Schooley, Wade Louis, Michael E. Douglas
Population Connectivity In Voles (Microtus Sp.) As A Gauge For Tall Grass Prairie Restoration In Midwestern North America, Marlis R. Douglas, Steven M. Mussmann, Tyler Chafin, Whitney J.B. Anthonysamy, Mark A. Davis, Matthew P. Mulligan, Robert L. Schooley, Wade Louis, Michael E. Douglas
Biological Sciences Faculty Publications and Presentations
Ecological restoration can promote biodiversity conservation in anthropogenically fragmented habitats, but effectiveness of these management efforts need to be statistically validated to determine ’success.’ One such approach is to gauge the extent of recolonization as a measure of landscape permeability and, in turn, population connectivity. In this context, we estimated dispersal and population connectivity in prairie vole (Microtus ochrogaster; N = 231) and meadow vole (M. pennsylvanicus; N = 83) within five tall-grass prairie restoration sites embedded within the agricultural matrix of midwestern North America. We predicted that vole dispersal would be constrained by the …
Active And Covert Infections Of Cricket Iridovirus And Acheta Domesticus Densovirus In Reared Gryllodes Sigillatus Crickets, Scott K. Sakaluk, Kristin Duffield, John Hunt, Ben M. Sadd, Brenda Oppert, José L. Ramirez, Karyna Rosario, Robert W. Behle
Active And Covert Infections Of Cricket Iridovirus And Acheta Domesticus Densovirus In Reared Gryllodes Sigillatus Crickets, Scott K. Sakaluk, Kristin Duffield, John Hunt, Ben M. Sadd, Brenda Oppert, José L. Ramirez, Karyna Rosario, Robert W. Behle
Faculty Publications – Biological Sciences
Interest in developing food, feed, and other useful products from farmed insects has gained remarkable momentum in the past decade. Crickets are an especially popular group of farmed insects due to their nutritional quality, ease of rearing, and utility. However, production of crickets as an emerging commodity has been severely impacted by entomopathogenic infections, about which we know little. Here, we identified and characterized an unknown entomopathogen causing mass mortality in a lab-reared population of Gryllodes sigillatus crickets, a species used as an alternative to the popular Acheta domesticus due to its claimed tolerance to prevalent entomopathogenic viruses. Microdissection of …
Molecular Characterization Of Neuraminidase Surface Proteins Of Influenzavirus B Isolates From Egypt, 1999-2008, Nadean Safwan Khedr
Molecular Characterization Of Neuraminidase Surface Proteins Of Influenzavirus B Isolates From Egypt, 1999-2008, Nadean Safwan Khedr
Archived Theses and Dissertations
No abstract provided.
Genome-Wide Association Study Reveals Genetic Variants Associated With Hiv-1c Infection In A Botswana Study Population, Andrey Shevchenko, Daria V. Zhernakova, Sergey Malov, Aleksey Komissarov, Sofia Kolchanova, Gaik Tamazian, Alexey Antonik, Nikolay Cherkasov, Sergey Kliver, Anastasiia Turenko, Mikhail Rotkevich, Igor Evsyukov, David Vlahov, Prisca K. Thami, Simani Gaseitsiwe, Vladimir Novitsky, Myron Essex, Stephen James O'Brien
Genome-Wide Association Study Reveals Genetic Variants Associated With Hiv-1c Infection In A Botswana Study Population, Andrey Shevchenko, Daria V. Zhernakova, Sergey Malov, Aleksey Komissarov, Sofia Kolchanova, Gaik Tamazian, Alexey Antonik, Nikolay Cherkasov, Sergey Kliver, Anastasiia Turenko, Mikhail Rotkevich, Igor Evsyukov, David Vlahov, Prisca K. Thami, Simani Gaseitsiwe, Vladimir Novitsky, Myron Essex, Stephen James O'Brien
Biology Faculty Articles
Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (AP3B1, PTPRA, and NEO1) were shown to have significant association with HIV-1C acquisition. Each gene association was replicated within Botswana or in the United States–African American or United States–European American AIDS …
Comparative Phylogeography Across Multiple Scales: Small Mammals, Their Ecology, Pathogens, And Drivers Of Diversification, Schuyler W. Liphardt
Comparative Phylogeography Across Multiple Scales: Small Mammals, Their Ecology, Pathogens, And Drivers Of Diversification, Schuyler W. Liphardt
Biology ETDs
Comparative phylogeography has historically been defined as the study of how genetic variation of co-distributed species has been shaped by biogeographical history. This is a mature field of study out of which several techniques have been developed directed at identifying the role ecology and geography in diversification patterns across time. I employ the tools developed in classical comparative phylogeography across multiple taxonomic scales and across regions that historically have been understudied. My first two chapters study the complex history of host-switching, codiversification, and reassortment of hantaviruses in their mammal hosts across North America. By taking a host-centric comparative phylogeographic approach …
How Within-Host Priority Effects Between Specialist And Generalist Pathogens Affect Disease Risk, Jing Jiao, Michael H. Cortez
How Within-Host Priority Effects Between Specialist And Generalist Pathogens Affect Disease Risk, Jing Jiao, Michael H. Cortez
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Poliomyelitis Virus Vs Smallpox: An Ordinary Differential Equation Model Comparison, Kate Mcgough
Poliomyelitis Virus Vs Smallpox: An Ordinary Differential Equation Model Comparison, Kate Mcgough
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Breathing Can Be Dangerous: Coccidioides And The Diverse Community Of The Lung Mycobiome, Paris S. Salazar-Hamm
Breathing Can Be Dangerous: Coccidioides And The Diverse Community Of The Lung Mycobiome, Paris S. Salazar-Hamm
Biology ETDs
Coccidioidomycosis, caused by soil-dwelling species of Coccidioides, is endemic to the Southwestern United States. It can present as a mild respiratory illness to life-threatening disseminated infections.Multi-gene phylogenetics and tracing patient histories revealed the presence of both Coccidioides species in New Mexico, and Native Americans may represent an unrecognized risk group. A PCR method developed distinguishes Coccidioides species by targeting regions of the mitochondrial genome. Recent advancements in molecular genetics solidifies lungs are not sterile. Illumina community data from 199 small mammals from Arizona, California, and New Mexico demonstrated a great diversity of fungi inhabiting lung tissues. One dominant order, Onygenales, …
College Of Natural Sciences Scholarship Brunch Program, November 6th 2021, College Of Natural Sciences
College Of Natural Sciences Scholarship Brunch Program, November 6th 2021, College Of Natural Sciences
College of Natural Sciences Newsletters and Reports
This is the program for the first annual College of Natural Sciences Scholarship Brunch, held on November 6th, 2021 at McCrory Gardens.
Exploration Of Staphylococcus Aureus Immune Inhibitory Proteins’ Structures And Investigation Of Their Effects On Monocyte And T Cell Adhesion, Jena Elizabeth Bordelon
Exploration Of Staphylococcus Aureus Immune Inhibitory Proteins’ Structures And Investigation Of Their Effects On Monocyte And T Cell Adhesion, Jena Elizabeth Bordelon
Honors Capstones
No abstract provided.
Diagnostics To Support Elimination Of Lymphatic Filariasis-Development Of Two Target Product Profiles, Kimberly Y. Won, Katherine Gass, Marco Biamonte, Daniel Argaw Dagne, Camilla Ducker, Christopher Hanna, Achim Hoerauf, Patrick J. Lammie, Sammy M. Njenga, Rahmah Noordin, Kapa D. Ramaiah, Reda Ramzy, Ronaldo G.Carvalho Scholte, Anthony W. Solomon, Ashley A. Souza, Jordan Tappero, Emily Toubali, Gary J. Weil, Steven A. Williams, Jonathan D. King
Diagnostics To Support Elimination Of Lymphatic Filariasis-Development Of Two Target Product Profiles, Kimberly Y. Won, Katherine Gass, Marco Biamonte, Daniel Argaw Dagne, Camilla Ducker, Christopher Hanna, Achim Hoerauf, Patrick J. Lammie, Sammy M. Njenga, Rahmah Noordin, Kapa D. Ramaiah, Reda Ramzy, Ronaldo G.Carvalho Scholte, Anthony W. Solomon, Ashley A. Souza, Jordan Tappero, Emily Toubali, Gary J. Weil, Steven A. Williams, Jonathan D. King
Biological Sciences: Faculty Publications
As lymphatic filariasis (LF) programs move closer to established targets for validation elimination of LF as a public health problem, diagnostic tools capable of supporting the needs of the programs are critical for success. Known limitations of existing diagnostic tools make it challenging to have confidence that program endpoints have been achieved. In 2019, the World Health Organization (WHO) established a Diagnostic Technical Advisory Group (DTAG) for Neglected Tropical Diseases tasked with prioritizing diagnostic needs including defining use-cases and target product profiles (TPPs) for needed tools. Subsequently, disease-specific DTAG subgroups, including one focused on LF, were established to develop TPPs …
Biological Characterization Of Plasmodium Falciparum Mitochondrial Heat Shock Protein Pfhsp70-3: Possible Involvement In Malaria Pathogenesis, David O. Nyakundi, Aileen Boshoff
Biological Characterization Of Plasmodium Falciparum Mitochondrial Heat Shock Protein Pfhsp70-3: Possible Involvement In Malaria Pathogenesis, David O. Nyakundi, Aileen Boshoff
Tanzania Journal of Science
Malaria remains a global health burden accounting for many deaths and illnesses in sub-Saharan Africa notwithstanding many decades of research on the disease. P. falciparum, the causative agent of the most fatal form of malaria, expresses a repertoire of heat shock proteins (Hsp) that cushion the parasite against heat shocks as it shuttles between extreme temperatures in human and mosquito vector hosts. By so doing, such proteins promote parasite’s cytoprotection, survival and pathogenesis. Heat shock proteins are named according to their molecular weights and there are six P. falciparum Hsp70 (PfHsp70) found in various cell compartments with mitochondrial putative PfHsp70-3. …
Collections Education: The Extended Specimen And Data Acumen, Anna K. Monfils, Erica R. Krimmel, Debra L. Linton, Travis D. Marsico, Ashley B. Morris, Brad R. Ruhfel
Collections Education: The Extended Specimen And Data Acumen, Anna K. Monfils, Erica R. Krimmel, Debra L. Linton, Travis D. Marsico, Ashley B. Morris, Brad R. Ruhfel
Open Access Fund Publications
Biodiversity scientists must be fluent across disciplines; they must possess the quantitative, computational, and data skills necessary for working with large, complex data sets, and they must have foundational skills and content knowledge from ecology, evolution, taxonomy, and systematics. To effectively train the emerging workforce, we must teach science as we conduct science and embrace emerging concepts of data acumen alongside the knowledge, tools, and techniques foundational to organismal biology. We present an open education resource that updates the traditional plant collection exercise to incorporate best practices in twenty-first century collecting and to contextualize the activities that build data acumen. …
Developing Inside A Layer Of Germs—A Potential Role For Multiciliated Surface Cells In Vertebrate Embryos, Ryan R. Kerney
Developing Inside A Layer Of Germs—A Potential Role For Multiciliated Surface Cells In Vertebrate Embryos, Ryan R. Kerney
Biology Faculty Publications
This paper reviews current research on the microbial life that surrounds vertebrate embryos. Several clades are believed to develop inside sterile—or near-sterile—embryonic microhabitats, while others thrive within a veritable zoo of microbial life. The occurrence of embryo-associated microbes in some groups, but not others, is an under-appreciated transition (possibly transitions) in vertebrate evolution. A lack of comparable studies makes it currently impossible to correlate embryo-associated microbiomes with other aspects of vertebrate evolution. However, there are embryonic features that should instruct a more targeted survey. This paper concludes with a hypothesis for the role of multiciliated surface cells in amphibian and …
Intein Inhibitors As Novel Antimicrobials: Protein Splicing In Human Pathogens, Screening Methods, And Off-Target Considerations, Diana A. Wall, Chunyu Wang, Kenneth Mills, Christopher W. Lennon
Intein Inhibitors As Novel Antimicrobials: Protein Splicing In Human Pathogens, Screening Methods, And Off-Target Considerations, Diana A. Wall, Chunyu Wang, Kenneth Mills, Christopher W. Lennon
Faculty & Staff Research and Creative Activity
Protein splicing is a post-translational process by which an intervening polypeptide, or intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with extein ligation. Although inteins are highly abundant in the microbial world, including within several human pathogens, they are absent in the genomes of metazoans. As protein splicing is required to permit function of essential proteins within pathogens, inteins represent attractive antimicrobial targets. Here we review key proteins interrupted by inteins in pathogenic mycobacteria and fungi, exciting discoveries that provide proof of concept that intein activity can be inhibited and that this inhibition has an effect …
Modest De Novo Reactivation Of Single Hiv-1 Proviruses In Peripheral Cd4+ T Cells By Romidepsin, Anne Sofie Kjaer, Steffen Leth, Christina V. Konrad, Jesper D. Gunst, Rasmus Nymann, Lars Østergaard, Ole S. Søgaard, Mariane H. Schleimann, Martin Tolstrup, Paul Denton
Modest De Novo Reactivation Of Single Hiv-1 Proviruses In Peripheral Cd4+ T Cells By Romidepsin, Anne Sofie Kjaer, Steffen Leth, Christina V. Konrad, Jesper D. Gunst, Rasmus Nymann, Lars Østergaard, Ole S. Søgaard, Mariane H. Schleimann, Martin Tolstrup, Paul Denton
Biology Faculty Publications
A cure for human immunodeficiency virus (HIV-1) is restricted by the continued presence of a latent reservoir of memory CD4+ T cells with proviruses integrated into their DNA despite suppressive antiretroviral therapy (ART). A predominant strategy currently pursued in HIV-1 cure-related research is the “kick and kill” approach, where latency reversal agents (LRAs) are used to reactivate transcription from integrated proviruses. The premise of this approach is that “kicking” latent virus out of hiding allows the host immune system to recognize and kill infected cells. Clinical trials investigating the efficacy of LRAs, such as romidepsin, have shown that these interventions …
Fisheries Science Update – October 2021: West Coast Demersal Scalefish Resource, Department Of Primary Industries And Regional Development, Western Australia
Fisheries Science Update – October 2021: West Coast Demersal Scalefish Resource, Department Of Primary Industries And Regional Development, Western Australia
Fisheries Occasional Publications
Key points: 2021 stock assessment outcomes • The West Coast Demersal Scalefish Resource (WCDSR) is halfway into a 20-year recovery plan following a period of overfishing in the 1990s and 2000s. • This latest assessment provides an important “health check” on the recovery status. • The recovery plan is based on maintaining recreational (including charter) and commercial sector’s total fishing mortality below catch limits and protecting key spawning aggregations to recover the WCDSR by 2030. • The Department of Primary Industries and Regional Development (DPIRD) tracks recovery progress by undertaking weight of evidence stock assessments of WCDSR indicator species dhufish …
Plastic-Eating Microbes: A New Potential Solution To Waste Mitigation?, Megan Forbes
Plastic-Eating Microbes: A New Potential Solution To Waste Mitigation?, Megan Forbes
University Honors Theses
Plastic waste is problematic for marine and terrestrial ecosystems due to the mass production of polyethylene terephthalate (PET) single use plastics. What is unclear is a well-thought-out solution to solve pollution problems that will not further damage the environment. Throughout this literature review, I will investigate the role microbes play in plastic degradation, and if plastic eating microbes are an effective solution to the plastic pollution problem. Polyethylene terephthalate (PET) is the chemical name for polyester. It is a clear, strong, and lightweight plastic that is typically used for food and beverage packaging, and other single-use purposes. The most well …
Celebrating The Stories Of Black Cellular Biologists And The Path Towards Diversity, Equity, And Inclusion In Stem, Henning Schneider, Nipun Chopra, Kenneth Brown, Scott Stetson, Wendy Tomamichel, Rebecca Kinney, Valerie O'Hair
Celebrating The Stories Of Black Cellular Biologists And The Path Towards Diversity, Equity, And Inclusion In Stem, Henning Schneider, Nipun Chopra, Kenneth Brown, Scott Stetson, Wendy Tomamichel, Rebecca Kinney, Valerie O'Hair
President Lori S. White Inauguration Symposium
Black scientists have made major contributions to their scientific communities, but their stories and work have not received well-deserved recognition due to systemic inequities within science and academia. By celebrating the stories of Black scientists, we aim to encourage students of color and underrepresented groups to pursue a caree in the natural sciences. Here we tell the stories of Ernest E. Just, Sandra A. Murray and Avery August, three Black cellular biologists from three different generations who have made major contributions to the scientific community using microscopy. The presented project is carried out as part of the Buehler Biomedical Imaging …