Digital Commons Network^™

Impact Of A Tlr9 Agonist And Broadly Neutralizing Antibodies On Hiv-1 Persistence: The Randomized Phase 2a Titan Trial, Jesper D. Gunst, Jesper Falkesgaard Højen, Marie H. Pahus, Miriam Rosás-Umbert, Birgitte Stiksrud, James Mcmahon, Paul Denton, Henrik Nielsen, Isik S. Johansen, Thomas Benfield, Steffen Leth, Jan Gerstoft, Lars Østergaard, Mariane H. Schleimann, Rikke Olesen, Henrik Støvring, Line K. Vibholm, Nia Weis, Anne M. Dyrhol-Riise, Karen B.H. Pedersen, Jillian S.Y. Lau, Dennis C. Copertino, Noemi Linden, Tan T. Huynh, Victor Ramos, Rl Brad Jones, Sharon R. Lewin, Martin Tolstrup, Thomas A. Rasmussen, Michel C. Nussenzweig, Marina Caskey, Dag Henrik Reikvam, Ole Schmeltz Søgaard

Biology Faculty Publications

Inducing antiretroviral therapy (ART)-free virological control is a critical step toward a human immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double-blinded trial, 43 people (85% males) with HIV-1 on ART were randomized to (1) placebo/placebo, (2) lefitolimod (TLR9 agonist)/placebo, (3) placebo/broadly neutralizing anti-HIV-1 antibodies (bNAbs) or (4) lefitolimod/bNAb. ART interruption (ATI) started at week 3. Lefitolimod was administered once weekly for the first 8 weeks, and bNAbs were administered twice, 1 d before and 3 weeks after ATI. The primary endpoint was time to loss of virologic control after ATI. The median delay in time to …

Dfcp1 Regulates Lipid Droplet Catabolism In An Ntpase-Dependent Manner, Victoria Anne Ismail

Arts & Sciences Graduate Student Theses and Dissertations

Lipid Droplets (LDs) are lipid storage organelles that can be readily tapped to resupply cells with energy or lipid building blocks, and, therefore, play a central role in cellular metabolism. It has emerged that Double FYVE Domain Containing Protein 1 (DFCP1), which has routinely been used as a marker for early autophagy, is an LD-associated protein and is implicated in establishing contacts between the endoplasmic reticulum (ER) and LDs, but little is known about DFCP1’s function or how it influences either autophagy or LD metabolism. Here, we show that DFCP1 contains a novel NTPase domain that regulates its assembly onto …

Drives Blunted By Time: The Effects Of Aging On Motivational Behaviors And Responses To Social Isolation In Mice, Hanyue Lei

Arts & Sciences Graduate Student Theses and Dissertations

Mental health in the elderly is an escalating social problem as the world population ages rapidly. Older adults are more susceptible to stressors like social isolation, which is a common risk factor for many mental disorders and health issues. However, how aging affects specific mental functions like motivational drive and stress responses, as well as the underlying neurobiological mechanisms, remains largely unstudied. We comprehensively examined behavioral phenotypes in both young and aged mice under the normal grouped-housing condition versus chronic social isolation treatment. The results suggested that natural aging and social isolation both impaired motivational behaviors and induce depressive- and …

The Role Of Gardnerella In Bacterial Vaginosis And Facilitating Colonization By Neisseria Gonorrhoeae, Sydney Rose Morrill

Arts & Sciences Graduate Student Theses and Dissertations

Bacterial vaginosis (BV) is a condition of vaginal flora that affects about 1/3 of reproductive age women. The optimal vaginal microbiome is thought to be one dominated by Lactobacillus species. In the BV-positive microbiome, this lactobacillus-dominance is replaced by an outgrowth of diverse anaerobic bacteria. BV has been clinically linked to a number of negative health outcomes, including preterm birth, infertility, cervical dysplasia, and an increased risk of sexually-transmitted infections (STIs) such as gonorrhea. The underlying cause(s) of BV have been debated in the literature for over half a century. In 1955, it was first reported that a bacterium now …

Heterogeneity Of Human Tissue-Resident Lymphocytes, Natalia Jaeger

Arts & Sciences Graduate Student Theses and Dissertations

The immune system plays a critical role in maintaining tissue homeostasis and defending against pathogens. Recent discoveries have highlighted the significance of tissue-resident memory T cells (TRM) and Innate Lymphoid Cells (ILCs) in tissue immunity. TRM exhibit memory-like properties, persist long-term in various tissues, and express markers such as CD69, CD103, and transcription factors like Hobit and Blimp-1. Similarly, ILCs, considered the innate counterparts of T cells, are abundant at barrier organs and mucosal sites, sharing similar markers and transcriptional factors with TRM, and rapidly responding to insults. Unraveling the heterogeneity and function of tissue-resident lymphocytes is crucial for understanding …

Scents Of Place: Exploring Self, Place And Planet Through Botanical Fragrance, Jennifer L. Kitson, Donna M. Sweigart

Open Educational Resources

This learning module provides instructors with an experiential field guide for introducing students to the United Nations Inner Development Goals Framework through self-guided mindful smelling activities and reflection prompts related to botanical fragrance. The interdisciplinary nature of this module allows for use or adaptation in a wide range of courses looking for outdoor, place-based and self-guided experiential learning to explore the role of botanical fragrance for people, plants and pollinators. The overarching goal is to deepen students’ connections to their senses (and scents) of self, place and planet through exploring botanical fragrance with mindful smelling. The learning activities in this …

Multi-Species Host Use By The Parasitoid Fly Ormia Lineifrons, Kyle J. Rogers, Oliver M. Beckers

Faculty & Staff Research and Creative Activity

Antagonistic species relationships such as parasitoid/host interactions lead to evolutionary arms races between species. Many parasitoids use more than one host species, requiring the parasitoid to adapt to multiple hosts, sometimes being the leader or the follower in the evolutionary back-and-forth between species. Thus, multi-species interactions are dynamic and show temporary evolutionary outcomes at a given point in time. We investigated the interactions of the multivoltine parasitoid fly Ormia lineifrons that uses different katydid hosts for each of its fly generations sequentially over time. We hypothesized that this fly is adapted to utilizing all hosts equally well for the population …

Tafopathies Result From Derangements In Transcriptional Regulation Of Metabolism, Jamison Maxwell Leid

Arts & Sciences Graduate Student Theses and Dissertations

Cardiogenesis and the maintenance of cardiac physiology necessitate dynamic and carefully coordinated transcription programs. Studies in a many systems – both in vitro and in vivo – have elucidated critical signaling pathways, including Bmp, Fgf, Wnt, and Notch that induce a cardiogenic transcription program, thereby driving cardiac specification and differentiation. Recently, studies have discovered additional regulation at the epigenetic level that contributes to the tight temporal and spatial control of cardiac gene expression during development. Because transcriptional regulation is essential to cardiogenesis, changes in transcriptional regulation result in developmental defects, including but not limited to CHDs, the leading inborn cause …

In Vitro Antioxidant, Anti-Inflammatory, And Photoprotective Activities Of Aqueous Extract Of The Endemic Plant Hammada Scoparia L. From Algeria, Benine Chaima, Djahra Ali Boutlelis, Laiche Ammar Touhami, Tlili Hajer, Tliba Ali, Ben Arfa Abdelkarim, Najjaa Hanen

Karbala International Journal of Modern Science

This study aimed to analyze the chemical profile and evaluate the biological activities of the aqueous extract of H. Scoparia, an endemic plant found in Southeastern Algeria. The aqueous extract was subjected to phytochemical screening, RP-HPLC, and FT-IR analysis. The anti-inflammatory activity was examined using the protein denaturation method, and the photoprotective activity was evaluated using UV-Visible spectrophotometry. The antioxidant activity was assessed using ABTS, DPPH, and FRAP assays. The study found the presence of various secondary metabolites such as polyphenols, tannins, and saponins. This study suggests that H. Scoparia extract has the potential as a natural source of bio-actives …

Evidence That Bivalve Burrowing Is Mediated By Serotonin Receptors: Activation Of Foot Inflation And Protrusion By Serotonin, Serotonergic Ligands And Ssri-Type Antidepressants In Three Species Of Freshwater Bivalve, Peter P. Fong, Rebecca Blaszczyk, Mary Butler, Jake Stergio

Biology Faculty Publications

Foot inflation and protrusion in bivalve mollusks is part of a sequence of events necessary for burrowing into the substrate. Although this process been observed after exogenous exposure to the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] and by some selective serotonin reuptake inhibitor (SSRI) type antidepressants, no study has shown that foot inflation and protrusion as a precursor to burrowing is under serotonergic control. In order to elucidate the physiological mechanism mediating this response, we tested over 2,000 freshwater bivalves in three species by exposing them to 5-HT, two 5-HT receptor agonists, two receptor antagonists and five antidepressants. Fingernail clams (Sphaerium striatinum), …

Corticosterone Alters Body Weight, But Not Metabolites, During Chronic Stress, Carolyn M. Bauer, M. A. Oranges, G. Firempong, L. M. Romero

Biology Faculty Works

The stress response is partially mediated by increased levels of circulating glucocorticoids. While the stress response may be adaptive in the short term, chronically elevated levels of glucocorticoids can be pathological. We aimed to verify that chronic stress causes metabolic dysregulation via increased corticosterone (Cort) exposure by monitoring free fatty acid (FFA) concentrations (evidence of fat breakdown), uric acid concentrations (evidence of protein breakdown), and organ weights (furcular fat, abdominal fat, liver, and pectoralis muscle) in chronically stressed juvenile house sparrows (Passer domesticus). The sparrows were chronically stressed for 3 wk by applying a series of rotating mild psychological stressors. …

Phylogenetic Relationships Of The Woodlouse Flies (Diptera: Rhinophorinae) And The Cluster Flies (Diptera: Polleniidae), Silvia Gisondi, Eliana Buenaventura, Arn Rytter Jensen, John O. Stireman, Silvio S. Nihei, Thomas Pape, Pierfilippo Cerretti

Biological Sciences Faculty Publications

Phylogenetic relationships within the oestroid subclades Rhinophorinae (Calliphoridae) and Polleniidae were reconstructed for the first time, applying a Sanger sequencing approach using the two protein-coding nuclear markers CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; 1794 bp) and MCS (molybdenum cofactor sulfurase; 2078 bp). Three genera of Polleniidae and nineteen genera of Rhinophorinae were analyzed together with a selection of taxa representing the major lineages of Oestroidea (non-rhinophorine Calliphoridae, Oestridae, Sarcophagidae, Tachinidae). The selected markers provide good resolution and moderate to strong support of the distal branches, but weak support for several deeper nodes. Polleniidae (cluster flies) emerge as monophyletic …

Reed Bamboos Drive Skull Shape Evolution In Bush Frogs Of The Western Ghats, Peninsular India, Kalpana Das, Mark-Oliver Rödel, Edward Stanley, Achyuthan N. Srikanthan, Kartik Shanker, Seenapuram Palaniswamy Vijayakumar

Student Publications [Scholarly]

Reed bamboo is a major ecological and economic resource for many animals, including humans. Nonetheless, the influence of this plant's evolutionary role on the morphology of animal species remains unexplored. Here, we investigated the significance of bamboo habitats as ecological opportunities in shaping the skull morphology of bush frogs (Raorchestes) from the Western Ghats, Peninsular India. We applied a three-dimensional (3D) geometric morphometric approach to capture the skull shape of 55 species of bush frogs. We visualized the skull shape variables in phylomorphospace with principal component analysis and performed phylogenetic generalized least-squares analysis to assess the impact of cranial size …

A Lizard Is Never Late: Squamate Genomics As A Recent Catalyst For Understanding Sex Chromosome And Microchromosome Evolution, Brendan J. Pinto, Tony Gamble, Chase H. Smith, Melissa A. Wilson

Biological Sciences Faculty Research and Publications

In 2011, the first high-quality genome assembly of a squamate reptile (lizard or snake) was published for the green anole. Dozens of genome assemblies were subsequently published over the next decade, yet these assemblies were largely inadequate for answering fundamental questions regarding genome evolution in squamates due to their lack of contiguity or annotation. As the “genomics age” was beginning to hit its stride in many organismal study systems, progress in squamates was largely stagnant following the publication of the green anole genome. In fact, zero high-quality (chromosome-level) squamate genomes were published between the years 2012 and 2017. However, since …

Computational Analysis Of Plasma Lipidomics From Mice Fed Standard Chow And Ketogenic Diet, Amy L. Seufert, James W. Hickman, Jaewoo Choi, Brooke A. Napier

Biology Faculty Publications and Presentations

Dietary saturated fatty acids (SFAs) are upregulated in the blood circulation following digestion. A variety of circulating lipid species have been implicated in metabolic and inflammatory diseases; however, due to the extreme variability in serum or plasma lipid concentrations found in human studies, established reference ranges are still lacking, in addition to lipid specificity and diagnostic biomarkers. Mass spectrometry is widely used for identification of lipid species in the plasma, and there are many differences in sample extraction methods within the literature. We used ultra-high performance liquid chromatography (UPLC) coupled to a high-resolution hybrid triple quadrupole-time-of-flight (QToF) mass spectrometry (MS) …

The Revised Reference Genome Of The Leopard Gecko (Eublepharis Macularius) Provides Insight Into The Considerations Of Genome Phasing And Assembly, Brendan J. Pinto, Tony Gamble, Chase H. Smith, Shannon E. Keating, Justin C. Havird, Ylenia Chiari

Biological Sciences Faculty Research and Publications

Genomic resources across squamate reptiles (lizards and snakes) have lagged behind other vertebrate systems and high-quality reference genomes remain scarce. Of the 23 chromosome-scale reference genomes across the order, only 12 of the ~60 squamate families are represented. Within geckos (infraorder Gekkota), a species-rich clade of lizards, chromosome-level genomes are exceptionally sparse representing only two of the seven extant families. Using the latest advances in genome sequencing and assembly methods, we generated one of the highest-quality squamate genomes to date for the leopard gecko, Eublepharis macularius (Eublepharidae). We compared this assembly to the previous, short-read only, E. macularius reference genome …

Identifying Sources Of Antibiotic Resistance Genes In The Environment Using The Microbial Find, Inform, And Test Framework, Corinne Wiesner-Friedman, Rachelle E. Beattie, Jill R. Stewart, Krassimira R. Hristova, Marc L. Serre

Biological Sciences Faculty Research and Publications

Introduction: Antimicrobial resistance (AMR) is an increasing public health concern for humans, animals, and the environment. However, the contributions of spatially distributed sources of AMR in the environment are not well defined.

Methods: To identify the sources of environmental AMR, the novel microbial Find, Inform, and Test (FIT) model was applied to a panel of five antibiotic resistance-associated genes (ARGs), namely, erm(B), tet(W), qnrA, sul1, and intI1, quantified from riverbed sediment and surface water from a mixed-use region.

Results: A one standard deviation increase in the modeled contributions of elevated AMR from bovine sources or land-applied waste sources [land application …

The Dangers Of Staphylococcus Aureus And Antimicrobial Resistance, Madison Pines

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Methicillin-resistant Staphylococcus aureus (MRSA) is the etiological agent responsible for many problematic infections. The signs and symptoms of an infection caused by MRSA differ based on the route of transmission and type of infection. Staphylococcus aureus can secrete toxins that act as virulence factors and aid host invasion. Obesity, old age, being a health care worker, playing contact sports, living in a crowded place, hospitalization, recent antibiotic use, and HIV patients are more at risk of developing an infection caused by MRSA. An abundance of factors has contributed to antimicrobial resistance, like misuse of antibiotics in clinical and agricultural settings …

Generation Of Lexa Enhancer-Trap Lines In Drosophila By An International Scholastic Network, Cory J. Evans, Ella S. Kim, Arjun Rajan, Kathleen Chang, Sanath Govindarajan, Clara Gulick, Eva English, Bianca Rodriguez, Orion Bloomfield, Stella Nakada, Charlotte Beard, Sarah O’Connor, Sophia Mastroianni, Emma Downey, Matthew Feigenbaum, Caitlin Tolentino, Abigail Pace, Marina Khan, Soyoun Moon, Jordan Diprima, Amber Syed, Flora Lin, Yasmina Abukhadra, Isabella Bacon, John Beckerle, Sophia Cho, Nana Esi Donkor, Lucy Garberg, Ava Harrington, Mai Hoang, Nosa Lawani, Ayush Noori, Euwie Park

Biology Faculty Works

Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic, and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II, and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons. A subset of enhancer traps was expressed in …

Sex In The Noisy City: Changes In Vocal Behavior Patterns And Dopamine Neurochemistry In The Auditory System Of Oyster Toadfish (Opsanus Tau), Kelsey N. Hom

Dissertations, Theses, and Capstone Projects

Intense anthropogenic noise can induce stress, behavioral changes, and even hearing loss in aquatic animals. However, there are few studies that have demonstrated how ecologically relevant noise affects aquatic life, and even fewer studies on the effect of noise on animals that require sound for reproduction. The oyster toadfish (Opsanus tau) is an excellent animal model to examine the effects of anthropogenic noise on behavior and neurochemistry since they use a reproductive call to find mates and live near urban areas like New York City. Despite living alongside the most populous city in the United States, these vocal …

Obesity And Renal Cell Carcinoma: Biological Mechanisms And Perspectives, Neha Venkatesh, Alberto Martini, Jennifer L Mcquade, Pavlos Msaouel, Andrew W Hahn

Faculty, Staff and Student Publications

Obesity, defined by body mass index (BMI), is an established risk factor for specific renal cell carcinoma (RCC) subtypes such as clear cell RCC, the most common RCC histology. Many studies have identified an association between obesity and improved survival after diagnosis of RCC, a potential "obesity paradox." Clinically, there is uncertainty whether improved outcomes observed after diagnosis are driven by stage, type of treatment received, or artifacts of longitudinal changes in weight and body composition. The biological mechanisms underlying obesity's influence on RCC are not fully established, but multiomic and mechanistic studies suggest an impact on tumor metabolism, particularly …

Lead Exposure Of Mainland Australia's Top Avian Predator, Jordan O. Hampton, Michael T. Lohr, Aaron J. Specht, Damien Nzabanita, Jasmin Hufschmid, Lee Berger, Kate Mcginnis, Jane Melville, Emma Bennett, James M. Pay

Research outputs 2022 to 2026

Lead (Pb) toxicity, through ingestion of lead ammunition in carcasses, is a threat to scavenging birds worldwide, but has received little attention in Australia. We analyzed lead exposure in the wedge-tailed eagle (Aquila audax), the largest raptor species found in mainland Australia and a facultative scavenger. Eagle carcasses were collected opportunistically throughout south-eastern mainland Australia between 1996 and 2022. Lead concentrations were measured in bone samples from 62 animals via portable X-ray fluorescence (XRF). Lead was detected (concentration > 1 ppm) in 84% (n = 52) of the bone samples. The mean lead concentration of birds in which lead was detected …

A Novel Grk3-Hdac2 Regulatory Pathway Is A Key Direct Link Between Neuroendocrine Differentiation And Angiogenesis In Prostate Cancer Progression, Samira Naderinezhad, Guoliang Zhang, Zheng Wang, Dayong Zheng, Mohit Hulsurkar, Michael Bakhoum, Ning Su, Han Yang, Tao Shen, Wenliang Li

Faculty, Staff and Students Publications

The mechanisms underlying the progression of prostate cancer (PCa) to neuroendocrine prostate cancer (NEPC), an aggressive PCa variant, are largely unclear. Two prominent NEPC phenotypes are elevated NE marker expression and heightened angiogenesis. Identifying the still elusive direct molecular links connecting angiogenesis and neuroendocrine differentiation (NED) is crucial for our understanding and targeting of NEPC. Here we found that histone deacetylase 2 (HDAC2), whose role in NEPC has not been reported, is one of the most upregulated epigenetic regulators in NEPC. HDAC2 promotes both NED and angiogenesis. G protein-coupled receptor kinase 3 (GRK3), also upregulated in NEPC, is a critical …

Roost Selection By Synanthropic Bats In Rural Kenya: Implications For Human-Wildlife Conflict And Zoonotic Pathogen Spillover, Reilly T. Jackson, Paul W. Webala, Joseph G. Ogola, Tamika J. Lunn, Kristian M. Forbes

Biological Sciences Faculty Publications and Presentations

Many wildlife species are synanthropic and use structures built by humans, creating a high-risk interface for human–wildlife conflict and zoonotic pathogen spillover. However, studies that investigate features of urbanizing areas that attract or repel wildlife are currently lacking. We surveyed 85 buildings used by bats and 172 neighbouring buildings unused by bats (controls) in southeastern Kenya during 2021 and 2022 and evaluated the role of microclimate and structural attributes in building selection. We identified eight bat species using buildings, with over 25% of building roosts used concurrently by multiple species. Bats selected taller cement-walled buildings with higher water vapour pressure …

The Transcription Factor Chrebp Links Mitochondrial Lipidomes To Mitochondrial Morphology And Progression Of Diabetic Kidney Disease, Li Li, Jianyin Long, Koki Mise, Naravat Poungavrin, Philip L Lorenzi, Iqbal Mahmud, Lin Tan, Pradip K Saha, Yashpal S Kanwar, Benny H Chang, Farhad R Danesh

Faculty, Staff and Students Publications

A substantial body of evidence has established the contributions of both mitochondrial dynamics and lipid metabolism to the pathogenesis of diabetic kidney disease (DKD). However, the precise interplay between these two key metabolic regulators of DKD is not fully understood. Here, we uncover a link between mitochondrial dynamics and lipid metabolism by investigating the role of carbohydrate-response element-binding protein (ChREBP), a glucose-responsive transcription factor and a master regulator of lipogenesis, in kidney podocytes. We find that inducible podocyte-specific knockdown of ChREBP in diabetic db/db mice improves key biochemical and histological features of DKD in addition to significantly reducing mitochondrial fragmentation. …

Go Big Or Go Home: Divergence In Morphology And Behavior Between Island And Islet Populations Of The San Cristóbal Lava Lizard (Microlophus Bivittatus), Emilio J. Mancero

Masters Theses

Rapid divergence in body size is a well-documented phenomenon among island species, associated with macroevolutionary processes of diversification and adaptive radiation. The effect of insularity in determining larger body size as an optimal phenotype is primarily attributed to lower predation and greater intraspecific competition on islands. Our study examined interpopulation variation in morphology, social behavior and predator avoidance in Galápagos lava lizards endemic to San Cristóbal island (Microlophus bivittatus), and the nearby islet Isla Lobos. Islet populations have fewer competitors than those on the island, where native and introduced predators are abundant. We simulated interactions with predators and …

Environmental Bacteriophage Presence In Drainage Ponds At Coastal Carolina University, Hailey Oldfield, Alexei E. Chesnutwood, Gabriella A. Caldwell, Shiraz C. Cohen, Paul E. Richardson

Journal of the South Carolina Academy of Science

No abstract provided.

Celebrating Leeuwenhoek’S Life 300 Years Later, Alan L. Gillen

Faculty Publications and Presentations

Antony van Leeuwenhoek entered eternity 300 years ago (August 26, 1723). He made hundreds of discoveries with his simple microscope. Perhaps his most notable discovery was of bacteria and its many shapes. He found great joy in God [http://answersingenesis.org/god/] ’s smallest creatures. I believe that his curiosity about the world, fueled by his belief in biblical creation [http://answersingenesis.org/creation/] , led to his discovery of bacteria. In a similar manner, his curiosity of blood led to his discovery of red corpuscles and capillaries. He remained a curious man until the last days of his life 300 years …

Anterior Chamber Depth In Mice Is Controlled By Several Quantitative Trait Loci, Demelza R. Larson, Allysa J. Kimber, Kacie J. Meyer, Michael G. Anderson

Biology Faculty Publications

Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a small fraction of the phenotypic variability. The purpose of this study was to identify additional ACD-influencing loci using strains of mice. Cohorts of 86 N2 and 111 F2 mice were generated from crosses between recombinant inbred BXD24/TyJ and wild-derived CAST/EiJ mice. Using anterior chamber optical coherence tomography, mice were phenotyped at 10–12 weeks of age, genotyped based on 93 genome-wide SNPs, and subjected to quantitative trait locus (QTL) analysis. In an analysis of ACD among …

The Return Of Malaria To The Usa: Did God Create Parasites To Make Us Sick?, Alan L. Gillen

Faculty Publications and Presentations

Summer 2023, the Centers for Disease Control and Prevention reported several cases of locally acquired malaria in Florida, Texas, and Maryland, meaning that patients were infected within the US—the first such cases in over two decades (CDC 2023). The significance of the cases and how individuals and public health officials should respond to the situation is still unknown. The CDC is collaborating with state health departments on an investigation of seven locally acquired cases of Plasmodium vivax malaria in Sarasota County, Florida, and one case in Cameron County, Texas, and Maryland near Washington DC. There is no evidence to suggest …