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Molecular Effects Of Metolachlor Exposure On Human Cells, Sean Hartnett Jan 2010

Molecular Effects Of Metolachlor Exposure On Human Cells, Sean Hartnett

Dissertations and Theses @ UNI

Metolachlor is one of the most commonly used herbicides in the United States of America. Numerous studies have shown that exposure to this herbicide results in decreased cell proliferation, growth and reproductive ability in different organisms. However, pervious studies used high concentrations of metolachlor to see molecular effects. In the study presented here, we investigated the effects of metolachlor on human cells. Previous cell proliferation analysis from our laboratory has shown that metolachlor is capable of significantly inhibiting the growth of normal human fibroblasts and HepG2 cells at 1.6 parts per billion (ppb) and 50 ppb. We assessed cellular effects …

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Aldo Leopold’S Land Ethic And The Great Lakes: A Paradigm For Understanding The Morality Of Aquatic Invasive Species Management, M. Andrew Sanford, John Uglietta, Phd Jan 2010

Aldo Leopold’S Land Ethic And The Great Lakes: A Paradigm For Understanding The Morality Of Aquatic Invasive Species Management, M. Andrew Sanford, John Uglietta, Phd

Student Summer Scholars Manuscripts

Abstract: This essay explores what obligations we have to protect the Great lakes ecosystem from the threat of aquatic invasive species within the context of Aldo Leopold‟s seminal essay in environmental philosophy The Land Ethic. In this essay I argue that Leopold‟s land ethic provides a consistent and dynamic paradigm for how we perceive and protect the natural environment. The land ethic is summarized in what I call Leopold’s Edict which directs us to preserve the health and beauty of the natural environment. The land ethic implies that people interested in conservation must develop a firm understanding of what …

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Revision Of The Genus Erythromelana Townsend, 1919 (Diptera: Tachinidae) With Notes On Their Phylogeny And Diversification, Diego Javier Inclan Luna Jan 2010

Revision Of The Genus Erythromelana Townsend, 1919 (Diptera: Tachinidae) With Notes On Their Phylogeny And Diversification, Diego Javier Inclan Luna

Browse all Theses and Dissertations

The neotropics harbor an enormous diversity of tachinid flies, yet the fauna remains poorly known. The tribe Blondeliini is particularly diverse in this region and desperately needs taxonomic attention. Here, I present a revision of the neotropical genus Erythromelana Townsend including the redescription of three previously described species and the description of 11 new species. Two species previously assigned into this genus, are resurrected as distinct genera. Erythromelana species are widely distributed from southern Mexico to northern Argentina, with the Andes being a hotspot of diversity. Erythromelana are specialized on geometrids in the genus Eois, which mainly feed on plants …

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An Assessment Of White-Tailed Deer (Odocoileus Virginianus) Dynamics, Management, And Impacts In Highly Fragmented Landscapes, Bambi Shafer Jan 2010

An Assessment Of White-Tailed Deer (Odocoileus Virginianus) Dynamics, Management, And Impacts In Highly Fragmented Landscapes, Bambi Shafer

Browse all Theses and Dissertations

Habitat and forage selection by deer can cause local extinction of plant species. In my research, I asked: 1) How do deer population growth rates in urban parks change through time? 2) Are culling rates and deer densities correlated? 3) Are browse rates on Trillium spp. and deer densities correlated? I used FLIR deer census data from Davis Aviation and culling data from Five Rivers MetroParks (Montgomery County, Ohio). I found that deer population growth rates generally declined from 2003 to 2008. The number of deer culled was positively correlated to the deer densities. The browse rates of Trillium spp. …

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Taxonomy Versus Phylogeny Phylogeography Of Marsh Rabbits Without Hopping To Conclusions, Rosanna M. Tursi Jan 2010

Taxonomy Versus Phylogeny Phylogeography Of Marsh Rabbits Without Hopping To Conclusions, Rosanna M. Tursi

Electronic Theses and Dissertations

Subspecific taxonomic designations solely based on morphological characters can often lead to erroneous assumptions about the evolutionary history of populations. This study sought to investigate evolutionary questions and conservation implications associated with morphological subspecific designations of island populations. To this end, I focused my attention on the Lower Keys of Florida, a unique chain of islands with well-known geologic history and rich in endemic, endangered subspecies. I employed genetic analyses to evaluate historical variation and contemporary restriction of gene flow between the endangered Lower Keys marsh rabbit (Sylvilagus palustris hefneri) and its sister mainland taxa. A Bayesian phylogeny using 1063 …

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Courtship And Copulation In Glaucous-Winged Gulls, Larus Glaucescens, Kelly M. Mcwilliams Jan 2010

Courtship And Copulation In Glaucous-Winged Gulls, Larus Glaucescens, Kelly M. Mcwilliams

Master's Theses

Using video recordings and scan counts, I examined the occurrence, sequences, and durations of behavior and environmental factors associated with courtship and copulation in glaucous-winged gulls, Larus glaucescens. Males and females in a pair had equivalent pre- and post-Mount behavior occurrences and durations. The main courtship sequence was Head Toss -- Courtship Beg/Respond -- Mounted/Mount, and felames appeared to initiate transitions between these pre-Mount behaviors. More Mounts occurred during the egg-laying stage of the breeding season, but copulation duration, wing-flag duration, and cloacal contacts per copulation showed no significant differences across sampling periods. Poisson analysis showed no significant grouping …

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Temporal And Biochemical Aspects Of Sindbis Virus Dissemination In The Mosquito Host, Kristen A. Ciano Jan 2010

Temporal And Biochemical Aspects Of Sindbis Virus Dissemination In The Mosquito Host, Kristen A. Ciano

UNF Graduate Theses and Dissertations

The prototype Alphavirus, Sindbis virus (SIN), relies on cyclic transmission between the mosquito and vertebrate hosts in order to be maintained in nature. This broad host range suggests that alphaviruses use a universally expressed molecule for attachment. Heparan sulfate proteoglycan (HSPG), a ubiquitous SIN receptor present on the cell surface of most eukaryotic cells, has been reported in the salivary glands and midguts of mosquitoes. These organs are essential for virus transmission from this hematophageous invertebrate. Variable host cell response in the mosquito following intrathoracic inoculation with SIN has been documented. In this study, per os infection of Aedine …

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A Comparison Of Tooth Wear And Breakage In Rancho La Brea Sabertooth Cats And Dire Wolves Across Time, Wendy J. Binder Jan 2010

A Comparison Of Tooth Wear And Breakage In Rancho La Brea Sabertooth Cats And Dire Wolves Across Time, Wendy J. Binder

Biology Faculty Works

The carnivores preserved in the late Pleistocene Rancho La Brea tar seep deposits display a remarkably high incidence of teeth broken in life as compared with modern species. In a previous study examining tooth breakage, tooth wear and individual age of Canis dirus over different periods in time, we found that Pit 13 C. dirus (about 15,000 years before present [ybp]) exhibited heavier tooth wear and fractured their teeth about three times more often than those of the younger Pit 61/67 (about 12,000 ybp). No significant difference was found in the age structure of the population, suggesting this came from …

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The Influence Of Stored Product Mites On The Function Of Skin Microvascular Endothelial Cells, Jennifer Graff Curp Jan 2010

The Influence Of Stored Product Mites On The Function Of Skin Microvascular Endothelial Cells, Jennifer Graff Curp

Browse all Theses and Dissertations

The prevalence of allergenic diseases and sensitization to stored product mites is increasing worldwide. Stored product mites are prevalent in homes, foods, and some work environments. Stored product mites need to be further studied so we can characterize their inflammatory properties to understand their role in skin disease, and provide proper treatment to patients with mite allergies. The purpose of the study was to show the role of stored product mites in modulating the inflammatory and immune response to human dermal endothelial cells in the skin. The epidermis serves as the first line of defense between the body and the …

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The Role Of Skeletal Development In Body Size Evolution Of Two North American Frogs, Sarah Beth Havens Jan 2010

The Role Of Skeletal Development In Body Size Evolution Of Two North American Frogs, Sarah Beth Havens

Masters Theses

"In order to better understand the evolution of miniaturization in Acris blanchardi, a North American Hylid with a unique life history and of ecological interest in the United States. The development and ossification sequences of 48 larvae, 5 juveniles and 5 adult A. blanchardi were examined. The adult was described by Maglia et al. (2007) to be a miniature and to display morphological novelties. In addition, 44 larvae, 2 juvenile and 5 adults of Pseudacris crucifer a closely related frog that has been suggested to be a miniature, were examined. The cranial and postcranial adult elements of this species, as …

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Analysis Of Mirna Modifications, Bin Yu, Xuemei Chen Jan 2010

Analysis Of Mirna Modifications, Bin Yu, Xuemei Chen

School of Biological Sciences: Faculty Publications

After transcription, a large number of cellular RNAs employ modifications to increase their diversity and functional potential. Modifications can occur on the base, ribose, or both, and are important steps in the maturation of many RNAs. Our lab recently showed that plant microRNAs (miRNAs) possess a 2′-O-methyl group on the ribose of the 3′ terminal nucleotide, and that this methyl group is added after miRNA/miRNA* formation. One function of this modification is to protect miRNAs from 3′ terminal uridylation by an unknown enzymatic activity. It is possible that uridylation of miRNAs triggers their degradation. Here we describe a …

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Increased Dendrite Branching In Aβpp/Ps1 Mice And Elongation Of Dendrite Arbors By Fasudil Administration, Brian A. Couch, George J. Demarco, Shannon L. Gourley, Anthony J. Koleske Jan 2010

Increased Dendrite Branching In Aβpp/Ps1 Mice And Elongation Of Dendrite Arbors By Fasudil Administration, Brian A. Couch, George J. Demarco, Shannon L. Gourley, Anthony J. Koleske

School of Biological Sciences: Faculty Publications

Amyloid-β (Aβ) overproduction and dendrite arbor atrophy are hallmarks of Alzheimer’s disease. The RhoA GTPase (Rho) signals through Rho kinase (ROCK) to control cytoskeletal dynamics and regulate neuron structure. Hyperactive Rho signaling destabilizes neurons leading to dendritic regression that can be rescued by genetic or pharmacological reduction of ROCK signaling. To understand what effect reduced ROCK signaling has on the dendrite arbors of mice that overproduce Aβ, we administered the ROCK inhibitor fasudil to AβPP/PS1 transgenic mice. We report that increased dendrite branching occurs in AβPP/PS1 mice and that fasudil promotes …

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Mitochondrial-Nuclear Epistasis Affects Fitness Within Species But Does Not Contribute To Fixed Incompatibilities Between Species Of Drosophila, Kristi L. Montooth, Colin D. Meiklejohn, Dawn N. Abt, David M. Rand Jan 2010

Mitochondrial-Nuclear Epistasis Affects Fitness Within Species But Does Not Contribute To Fixed Incompatibilities Between Species Of Drosophila, Kristi L. Montooth, Colin D. Meiklejohn, Dawn N. Abt, David M. Rand

School of Biological Sciences: Faculty Publications

Efficient mitochondrial function requires physical interactions between the proteins encoded by the mitochondrial and nuclear genomes. Co-evolution between these genomes may result in the accumulation of incompatibilities between divergent lineages. We test whether mitochondrialnuclear incompatibilities have accumulated within the Drosophila melanogaster species subgroup by combining divergent mitochondrial and nuclear lineages and quantifying the effects on relative fitness. Precise placement of nine mtDNAs from D. melanogaster, D. simulans and D. mauritiana into two D. melanogaster nuclear genetic backgrounds reveals significant mitochondrial-nuclear epistasis affecting fitness in females. Combining the mitochondrial genomes with three different D. melanogaster X chromosomes reveals significant epistasis …

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Synaptic Clustering Of Psd-95 Is Regulated By C-Abl Through Tyrosine Phosphorylation, Karen Perez De Arce, Lorena Varela-Nallar, Olivia Farias, Alejandra Cifuentes, Paulina Bull, Brian A. Couch, Anthony J. Koleske, Nibaldo C. Inestrosa, Alejandra R. Alvarez Jan 2010

Synaptic Clustering Of Psd-95 Is Regulated By C-Abl Through Tyrosine Phosphorylation, Karen Perez De Arce, Lorena Varela-Nallar, Olivia Farias, Alejandra Cifuentes, Paulina Bull, Brian A. Couch, Anthony J. Koleske, Nibaldo C. Inestrosa, Alejandra R. Alvarez

School of Biological Sciences: Faculty Publications

The c-Abl tyrosine kinase is present in mouse brain synapses, but its precise synaptic function is unknown. We found that c-Abl levels in the rat hippocampus increase postnatally, with expression peaking at the first postnatal week. In 14 d in vitro hippocampal neuron cultures, c-Abl localizes primarily to the postsynaptic compartment, in which it colocalizes with the postsynaptic scaffold protein postsynaptic density protein-95 (PSD-95) in apposition to presynaptic markers. c-Abl associates with PSD-95, and chemical or genetic inhibition of c-Abl kinase activity reduces PSD-95 tyrosine phosphorylation, leading to reduced PSD-95 clustering and reduced synapses in treated neurons. c-Abl can phosphorylate …

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Compositions And Methods For Controlling Plant Parasitic Nematodes, Harold N. Trick, Judith L. Roe, Timothy C. Todd, Michael A. Herman Jan 2010

Compositions And Methods For Controlling Plant Parasitic Nematodes, Harold N. Trick, Judith L. Roe, Timothy C. Todd, Michael A. Herman

School of Biological Sciences: Faculty Publications

The present invention relates to compositions and methods for controlling nematode infestation of plants. In particular, the present invention provides vectors comprising sequences designed to control nematodes by RNA interference (RNAi) and transgenic plants transformed with Such vectors.

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Conservation Status And Habitat Use Of The West Virginia Spring Salamander (Gyrinophilus Subterraneus) And Spring Salamander (G. Porphyriticus) In General Davis Cave, Greenbrier Co., West Virginia, Matthew L. Niemiller, Michael S. Osbourn, Dante B. Fenolio, Thomas K. Pauley, Brian T. Miller, John R. Holsinger Jan 2010

Conservation Status And Habitat Use Of The West Virginia Spring Salamander (Gyrinophilus Subterraneus) And Spring Salamander (G. Porphyriticus) In General Davis Cave, Greenbrier Co., West Virginia, Matthew L. Niemiller, Michael S. Osbourn, Dante B. Fenolio, Thomas K. Pauley, Brian T. Miller, John R. Holsinger

Biological Sciences Faculty Publications

The West Virginia Spring Salamander (Gyrinophilus subterraneus) is one of four obligate cave-dwelling species of plethodontid salamanders found east of the Mississippi River in the United States. This species is endemic to a single cave system; General Davis Cave, in Greenbrier Co., West Virginia, where it is syntopic with the closely-related Spring Salamander (G. porphyriticus). Accordingly, the West Virginia Spring Salamander is a species of critical conservation concern. Because of it's conservation status and lack of data regarding the ecology and life history, particularly about population trends, we present data on relative abundance of and habitat …

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Racism, Eugenics, And Ernst Mayr’S Account Of Species, Ladelle Mcwhorter Jan 2010

Racism, Eugenics, And Ernst Mayr’S Account Of Species, Ladelle Mcwhorter

Philosophy Faculty Publications

At his death at age one hundred in 2005, Ernst Mayr was hailed as the greatest evolutionary biologist of the twentieth century. His definition of species, published in 1942 in Systematics and the Origin of Species and known as the “biological species concept,” is familiar to every tenth grader: “Species are groups of interbreeding natural populations that are reproductively isolated from other such groups.” That definition, together with Mayr’s and Theodosius Dobzhansky’s theory of speciation, enabled the integration of modern genetics and Darwinian evolutionary theory. In this paper I will argue that it imported racism into the heart of modern …

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The Impact Of Microclimate On Branch Colonization By Neotropical Cerambycid Beetles, Christina Lee Jan 2010

The Impact Of Microclimate On Branch Colonization By Neotropical Cerambycid Beetles, Christina Lee

Dissertations and Theses

"Vertical stratification contributes to the great diversity of insects found in tropical rainforests. Due to differences in both biotic and abiotic factors, different strata of the forest provide different habitats for insects. A previous study in French Guiana revealed that wood-boring cerambycid beetles preferentially colonized branches at ground level in the dry season, but shifted to canopy level in the rainy season. The current beetle-rearing study was conducted to confirm the occurrence of this seasonal shift, explore possible causes, and to determine if similar microclimate conditions occurred at ground level in the dry season and the canopy level in the …

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Role Of Drosophila Rap/Fzr (Cdh1) In Retinal Axon Targeting And Its Interactions With Loco, Liprin-A And Ras, Marta Gronska Jan 2010

Role Of Drosophila Rap/Fzr (Cdh1) In Retinal Axon Targeting And Its Interactions With Loco, Liprin-A And Ras, Marta Gronska

Dissertations and Theses

The development of the wild type Drosophila compound eye involves stereotypical targeting of photoreceptor axons to the specific layers of the optic ganglion, medulla and lamina, in the third instar larvae. To test the hypothesis that ubiquitin ligases play an important role during retinal axon targeting we have examined the patterns of axon targeting in the developing eye of the retina aberrant in pattern (rap/fzr) mutants. Rap/Fzr is a homolog of mammalian Cdh1, an activator of anaphase promoting complex (APC), an E3 ubiquitin ligase. Previous work has shown that Rap/Fzr is required in cell cycle regulation, glia differentiation and pattern …

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Soil Variability And Its Influence On Plant Performance, Jeremy R. Klass Jan 2010

Soil Variability And Its Influence On Plant Performance, Jeremy R. Klass

Masters Theses

During recorded history, nearly all temperate deciduous forests in eastern North America have seen extensive agricultural land-use conversions. Persistent influences of agricultural disturbance continue to shape the diversity and composition of the plant community long after agriculture has ceased. While some measures of ecosystem functioning may recover relatively quickly from agricultural disturbance, other characteristics such as levels of organic matter, carbon, and phosphorus, may remain different from primary forests for much longer periods. The alteration of the original ecosystem due to agriculture practices has far reaching impacts on biotic and nutrient dynamics along with causing significant shifts in community composition …

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Population Ecotoxicology Of The Common Snapping Turtle In Agriculturally Impacted Lotic Ecosystems, Derrick L. Douros Jan 2010

Population Ecotoxicology Of The Common Snapping Turtle In Agriculturally Impacted Lotic Ecosystems, Derrick L. Douros

Masters Theses

Anthropogenic impacts on lotic systems, including pollutants, have had both direct and indirect negative effects on the aquatic habitats of the world. Goals of this study are: (1) Quantify atrazine, the atrazine metabolite diaminochlorotriazine (DACT), and glyphosate burdens in common snapping turtle (Chelydra serpentina) tissue from individuals collected within the Embarras River in Coles County, Illinois. (2) Quantify the atrazine, DACT, and glyphosate loads in water from the aquatic habitats in which common snapping turtles reside. (3) Quantify the relative abundance of all turtle species and movement patterns of common snapping turtles in this lotic ecosystem. Hoop nets and modified …

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Leptodactylus Savagei, W. R. Heyer, Miriam M. Heyer, Rafael O. De Sá Jan 2010

Leptodactylus Savagei, W. R. Heyer, Miriam M. Heyer, Rafael O. De Sá

Biology Faculty Publications

Adult Leptodactylus savagei are large, the head is as wide as long or usually wider than long, and the hind limbs are moderate in length (Table 1; Heyer and Thompson (2000) provided definitions of adult size and leg length categories for Leptodactylus). Male vocal sacs are not visible externally. Sexually active males have hypertrophied forearms, usually 1 large black spine on each thumb, rarely with 1 large spine and a prepollical bump, and a pair of black chest spines. A pair of entire dorsolateral folds extend anteriorly from at least one_half to full distance from eye to groin, the …

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Abiotic Differences Between Green Turtle (Chelonia Mydas) Nests In Natural Beach And Engineered Dunes: Effects On Hatching Success, Martha Balfour Jan 2010

Abiotic Differences Between Green Turtle (Chelonia Mydas) Nests In Natural Beach And Engineered Dunes: Effects On Hatching Success, Martha Balfour

Electronic Theses and Dissertations

Habitat loss is among the biggest threats to conservation worldwide, so habitat restoration plays an increasing role in endangered species management. This is especially true for species with high site fidelity, such as nesting marine turtles. Sand replenishment is commonly used to restore coastal beaches after severe erosion events, and may affect marine turtles and other species that live or reproduce in that habitat. I investigated how abiotic characteristics of sand used in a dune restoration project at Archie Carr National Wildlife Refuge, Florida, affected reproduction of the federally-endangered green turtle (Chelonia mydas). Sand structure and composition can affect egg …

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Geographic Variation In Post-Mating Immune Gene Expression In Drosophila Melanogaster, Cheryl Ann Pinzone Jan 2010

Geographic Variation In Post-Mating Immune Gene Expression In Drosophila Melanogaster, Cheryl Ann Pinzone

Electronic Theses and Dissertations

An organism's immune response may vary due to pathogen pressure in its environment, as well as due to interactions with other organisms. These factors, along with geographic rules (i.e. Gloger's rule) may influence the geographic distribution of the immune response within populations of a species. Here we use real-time quantitative PCR to measure the immune gene expression in six populations collected along the eastern U.S. of Drosophila melanogaster after mating. Antimicrobial genes did not show significant differences in expression due to location, whereas we did observe differences in anti-fungal and pro-phenoloxidase (anti-macromolecule) related genes. These differences in anti-macromolecule resistance are …

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Estimating Diet And Food Selectivity Of The Lower Keys Marsh Rabbit Using Stable Isotope Analysis, Matthew James Gordon Jan 2010

Estimating Diet And Food Selectivity Of The Lower Keys Marsh Rabbit Using Stable Isotope Analysis, Matthew James Gordon

Electronic Theses and Dissertations

Understanding the effect of food abundance on feeding behavior can benefit conservation efforts in many ways, such as to determine whether impacted environments need food supplementation, whether different locations of threatened species contain different food abundances, or whether reintroduction sites are missing key components of a species’ diet. I studied the relationship between feeding behavior and food abundance in the Lower Keys marsh rabbit (Sylvilagus palustris hefneri), an endangered subspecies endemic to the lower Florida Keys. Specifically, my study set out to measure the relative abundance of the primary plants within the natural habitat of the Lower Keys marsh rabbit …

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Proteomic And Physiological Responses Of Leopard Sharks (Triakis Semifasciata) To Salinity Change, W. Wesley Dowd, B. N. Harris, J.J. Chech Jr, D. Kültz Jan 2010

Proteomic And Physiological Responses Of Leopard Sharks (Triakis Semifasciata) To Salinity Change, W. Wesley Dowd, B. N. Harris, J.J. Chech Jr, D. Kültz

Biology Faculty Works

Partially euryhaline elasmobranchs may tolerate physiologically challenging, variable salinity conditions in estuaries as a tradeoff to reduce predation risk or to gain access to abundant food resources. To further understand these trade-offs and to evaluate the underlying mechanisms, we examined the responses of juvenile leopard sharks to salinity changes using a suite of measurements at multiple organizational levels: gill and rectal gland proteomes (using 2-D gel electrophoresis and tandem mass spectrometry), tissue biochemistry (Na+/K+-ATPase, caspase 3/7 and chymotrypsin-like proteasome activities), organismal physiology (hematology, plasma composition, muscle moisture) and individual behavior. Our proteomics results reveal coordinated molecular responses to low salinity …

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Locomotion In Response To Shifting Climate Zones: Not So Fast, Martin E. Feder, Theodore Garland Jr., James H. Marden, Anthony J. Zera Jan 2010

Locomotion In Response To Shifting Climate Zones: Not So Fast, Martin E. Feder, Theodore Garland Jr., James H. Marden, Anthony J. Zera

School of Biological Sciences: Faculty Publications

Although a species’ locomotor capacity is suggestive of its ability to escape global climate change, such a suggestion is not necessarily straightforward. Species vary substantially in locomotor capacity, both ontogenetically and within/among populations, and much of this variation has a genetic basis. Accordingly, locomotor capacity can and does evolve rapidly, as selection experiments demonstrate. Importantly, even though this evolution of locomotor capacity may be rapid enough to escape changing climate, genetic correlations among traits (often due to pleiotropy) are such that successful or rapid dispersers are often limited in colonization or reproductive ability, which may be viewed as a trade-off. …

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"A Redescription Of Potamonautes Loveni, A Medically Important Feshwater Crab From Western Kenya And Eastern Uganda, East Africa" , Neil Cumberlidge, Paul F. Clark Jan 2010

"A Redescription Of Potamonautes Loveni, A Medically Important Feshwater Crab From Western Kenya And Eastern Uganda, East Africa" , Neil Cumberlidge, Paul F. Clark

Journal Articles

No abstract provided.

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"First Report Of Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab, Sinopotamon Yangtsekiense Bott, 1967, With Comments On Its Evolutionary Significance" , J Xue, Y Liu, Neil Cumberlidge, H X. Wu Jan 2010

"First Report Of Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab, Sinopotamon Yangtsekiense Bott, 1967, With Comments On Its Evolutionary Significance" , J Xue, Y Liu, Neil Cumberlidge, H X. Wu

Journal Articles

No abstract provided.

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Expression Of Hcmv Ie1 In The U87mg Cell Line Augments Resistance To Temozolomide , Richard A. Rovin, Johnathan Lawrence, Justin J. Segula, Robert J. Winn Jan 2010

Expression Of Hcmv Ie1 In The U87mg Cell Line Augments Resistance To Temozolomide , Richard A. Rovin, Johnathan Lawrence, Justin J. Segula, Robert J. Winn

Journal Articles

INTRODUCTION: Human cytomegalovirus (HCMV) DNA and protein are found in gliomas but not in normal brain or other primary brain tumors. The role of HCMV infection in glioma biology is unclear. While it is unlikely that HCMV infection causes glioma, viral proteins might impart a proliferative and antiapoptotic phenotype that confers a survival advantage. Does this oncomodulation translate into a clinically relevant effect in glioma cells? To answer this question, we compared the response of the U87IE1 and U87MG malignant glioma cell lines to temozolomide. U87IE1 cells are U87MG cells that have been genetically engineered to produce HCMV IE1 protein. …

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