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The Role Of An Abc Transporter As A Steroid Antagonist In Drosophila, Gregory King, Andrew Andres Aug 2011

The Role Of An Abc Transporter As A Steroid Antagonist In Drosophila, Gregory King, Andrew Andres

Undergraduate Research Opportunities Program (UROP)

Drosophila melanogaster are holometabolous insects that have several distinct life stages including larvae and a winged adult. The larval stage is mainly a time of feeding and growth, while the adult stage is optimized for sexual reproduction and dissemination. The larval stage can itself be divided into three time periods, or instars: 1st (L1), 2nd (L2), and 3rd (L3) (Figure 1). Larval growth – both between instars and beyond – depends on specific signaling pathways controlled by a cholesterol derived steroid, 20-hydroxyecdysone (20E). Although 20E is a systemic developmental signal, little is known about the molecular details of how different …

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Evaluating Species Responses To Climate Change Using Ecological Niche Modeling And Genetic Data, Jeanette Perry Aug 2011

Evaluating Species Responses To Climate Change Using Ecological Niche Modeling And Genetic Data, Jeanette Perry

Undergraduate Research Opportunities Program (UROP)

The current and projected future warming trends together with degradation of habitats throughout much of the Great Basin and Columbian Plateau represent real threats to many species occupying these regions. If we can determine the impacts of past climatic changes on the distribution of species, we can obtain a better understanding of the future impacts of projected climatic trends on many species in these regions. My results with the Great Basin Pocket Mouse (Perognathus parvus) may be relevant to conservation ecologists and resource managers attempting to protect several Endangered Species Act candidates, such as the pygmy cottontail (Brachylagus idahoensis). I …

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Scorpions In The Modern Cuban Culture: An Introductory Iconography, Luis F. De Armas Aug 2011

Scorpions In The Modern Cuban Culture: An Introductory Iconography, Luis F. De Armas

Euscorpius

Some graphic examples of the role of scorpions in the present-day culture of Cuba are presented. They include tattoos, jewels, carpets, caps, and drawings by children, among other objects of personal or social usage. Increased use of this arachnid as a cultural element among Cuban people during last 50 years seems to be directly related with globalization, mostly through the TV and movies.

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On Fabre’S Traces: An Important Contributor To The Knowledge Of Buthus Occitanus (Amoreux, 1789), Marco Colombo Aug 2011

On Fabre’S Traces: An Important Contributor To The Knowledge Of Buthus Occitanus (Amoreux, 1789), Marco Colombo

Euscorpius

Jean-Henri Casimir Fabre (1823–1915) has probably been one of the most important entomologists of the world in the last two centuries, leaving to posterity a huge amount of manuscripts and books. The Languedoc yellow scorpion, Buthus occitanus (Amoreaux, 1789), has been one of his objects of study: many of its behaviours, including the famous “promenade a deux”, have been described by the careful eye of the French entomologist, giving an interesting contribution to modern scorpiology

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The First Record Of The Family Euscorpiidae (Arachnida: Scorpiones) From Central China, With A Key Of Chinese Species Of The Genus Scorpiops, Zhi-Yong Di, Ya-Wen He, Zhi-Jian Cao, Ying-Liang Wu, Wen-Xin Li Aug 2011

The First Record Of The Family Euscorpiidae (Arachnida: Scorpiones) From Central China, With A Key Of Chinese Species Of The Genus Scorpiops, Zhi-Yong Di, Ya-Wen He, Zhi-Jian Cao, Ying-Liang Wu, Wen-Xin Li

Euscorpius

The genus Scorpiops (Euscorpiidae) is recorded for the first time in Central China. Two immature specimens of a form belonging to Scorpiops hardwickii (Gervais, 1843) “complex” were collected from Huzhaoshan Mountains in Hubei Province. A discussion of Chinese species of genus Scorpiops is provided, as well as a key of Scorpiops from China.

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Scorpions In Ancient Egypt, Hisham K. El-Hennawy Aug 2011

Scorpions In Ancient Egypt, Hisham K. El-Hennawy

Euscorpius

The ancient Egyptians knew the scorpion and its toxicity, and venerated it since pre-dynastic era. They used the scorpion as a king's name, a name of a nome (county), and a symbol to their goddess, Serqet, that protects the body and the viscera of the dead, and that accompanies them in their journey to the afterlife. They had medical prescriptions and magical spells to heal the stings. Since the 5th dynasty, the title of a “Follower of Serket” was given to clever physicians. Scorpions are most famously depicted on Horus Cippus, a talisman featuring Horus the Child holding in his …

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Pectine Development In Scorpion Embryos And First And Second Instars, Roger D. Farley Aug 2011

Pectine Development In Scorpion Embryos And First And Second Instars, Roger D. Farley

Euscorpius

The pectines are complex sensory organs that extend from the ventral surface of the anterior opisthosoma (mesosoma) in all extant scorpions and nearly all the fossil scorpions that have been examined. The pectines are synapomorphic for the Order Scorpiones. In this investigation, the scanning electron microscope (SEM) was used to study the development of the pectines in representatives from five scorpion families. In the more basal families (e.g., Vaejovidae) with apoikogenic development, the pectines start to develop early with enlargement of the limb buds on the third opisthosomal segment. The primordial pectines become elongate lobes attached to the ventro-lateral surface …

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The First Record Of Upper Permian And Lower Triassic Scorpions From Russia (Chelicerata: Scorpiones), Victor Fet, Dmitry E. Shcherbakov, Michael E. Soleglad Aug 2011

The First Record Of Upper Permian And Lower Triassic Scorpions From Russia (Chelicerata: Scorpiones), Victor Fet, Dmitry E. Shcherbakov, Michael E. Soleglad

Euscorpius

Several small fragments of fossil scorpions are reported from two localities in Vologda Province, Russia, representing the Upper Permian (Severodvinian, correlated to Wuchiapingian) (Isady) and Lower Triassic just above the Permian-Triassic boundary (Induan) (Nedubrovo). Most observed structures are not diagnostic at genus or family level. The Isady leg fragment possesses ungues (claws), which are both denticulated and setaceous, and resembles a Carboniferous Eobuthus sp. (Eobuthidae). It is the latest record of this type of ungues, which are known in some Paleozoic scorpions (extinct suborder Mesoscorpiones); all extant scorpions have smooth claws without denticulation or setation.

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In Situ Infrared Videography Of Sand Scorpion Nighttime Surface Activity, Douglas D. Gaffin Aug 2011

In Situ Infrared Videography Of Sand Scorpion Nighttime Surface Activity, Douglas D. Gaffin

Euscorpius

Sand scorpions make burrows from which they emerge at night to seek mates and prey. Previous ecological studies have documented scorpion activities on the sand surface. Few studies, however, have videotaped scorpion movements in the context of understanding their sensory neurobiology. Our objective is to understand which signals guide scorpions as they emerge from and return to their burrows. Candidate stimuli include chemical trails, footsteps, celestial patterns, geomagnetic cues, humidity and/or temperature gradients, distinctive scents from the burrow, seismic echolocation, memory, or landmark orientation. We videotaped scorpions to learn whether they return to their burrows by the same path they …

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Further Considerations On The Species Of The Genus Orthochirus Karsch, 1891 From Africa, With Description Of Three New Species (Scorpiones: Buthidae), Wilson R. Lourenço, Elise-Anne Leguin Aug 2011

Further Considerations On The Species Of The Genus Orthochirus Karsch, 1891 From Africa, With Description Of Three New Species (Scorpiones: Buthidae), Wilson R. Lourenço, Elise-Anne Leguin

Euscorpius

New considerations are proposed regarding the African species of the genus Orthochirus Karsch, 1891. Two species, Orthochirus aristidis (Simon, 1882) and Orthochirus innesi Simon, 1910 have been the subject of several publications in the past decades; however, doubts remain about their exact identity and range of geographical distribution. In this note, their taxonomic status is reinvestigated. The type material is revised and the lectotype and paralectotypes are designated for O. aristidis. Revised diagnoses and illustrations are proposed for both species, and these are confirmed as valid. Three new species are described from Algeria, Morocco, and Mauritania. The total number …

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Polymorphism And Hybridization In Species Of Hottentotta Birula, 1908 (Scorpiones: Buthidae), Wilson R. Lourenço, Eric Ythier, Mark Stockmann, John L. Cloudsley-Thompson Aug 2011

Polymorphism And Hybridization In Species Of Hottentotta Birula, 1908 (Scorpiones: Buthidae), Wilson R. Lourenço, Eric Ythier, Mark Stockmann, John L. Cloudsley-Thompson

Euscorpius

A new and well documented case of hybridization among scorpions is presented. It was obtained under laboratory conditions between Hottentotta jayakari (Pocock) and Hottentotta salei (Vachon) specimens of which had been collected in the northern and southern regions of Oman. Hybrids were successfully produced not only from F0 males and females, but also from F1 males and females, thereby attesting to the fact that the first generation obtained (F1), was completely fertile. Both F1 and F2 broods were composed of dark and pale morphs, indicating that the juveniles could inherit either one or …

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Redescription Of Tityus Pictus Pocock, 1893 And Tityus Smithii Pocock, 1893, With Notes On The Tityus Species From The Lesser Antilles (Scorpiones: Buthidae), Rolando Teruel Aug 2011

Redescription Of Tityus Pictus Pocock, 1893 And Tityus Smithii Pocock, 1893, With Notes On The Tityus Species From The Lesser Antilles (Scorpiones: Buthidae), Rolando Teruel

Euscorpius

In the present paper, the taxonomic status of Tityus pictus Pocock, 1893 and all of its junior synonyms is revised. Tityus smithii Pocock, 1893 is restored as a valid species, and the subspecies Tityus smithii microdon Pocock, 1893 (currently T. pictus microdon) is regarded as its junior synonym. Both T. pictus and T. smithii are redescribed, supplementary information on their morphological variability are given, and their geographical distribution is up- dated, including a new locality record for the latter. Also, the taxonomic position and relationships of all Lesser Antillean species of the genus are clarified: it is demonstrated that …

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Oyster Reefs As Natural Breakwaters Mitigate Shoreline Loss And Facilitate Fisheries, Steven B. Scyphers, Sean P. Powers, Kenneth L. Heck Jr., Dorothy Byron Aug 2011

Oyster Reefs As Natural Breakwaters Mitigate Shoreline Loss And Facilitate Fisheries, Steven B. Scyphers, Sean P. Powers, Kenneth L. Heck Jr., Dorothy Byron

University Faculty and Staff Publications

Shorelines at the interface of marine, estuarine and terrestrial biomes are among the most degraded and threatened habitats in the coastal zone because of their sensitivity to sea level rise, storms and increased human utilization. Previous efforts to protect shorelines have largely involved constructing bulkheads and seawalls which can detrimentally affect nearshore habitats. Recently, efforts have shifted towards “living shoreline” approaches that include biogenic breakwater reefs. Our study experimentally tested the efficacy of breakwater reefs constructed of oyster shell for protecting eroding coastal shorelines and their effect on nearshore fish and shellfish communities. Along two different stretches of eroding shoreline, …

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Scarification And Cultural Practice Of Four Lupine Species Native To The Great Basin, Covy Dennis Jones Aug 2011

Scarification And Cultural Practice Of Four Lupine Species Native To The Great Basin, Covy Dennis Jones

Theses and Dissertations

The Great Basin is North America's largest desert, encompassing 135 million acres. Grazing and other anthropogenic activities in the Great Basin have put heavy demands on the landscape over the last 150 years. Heavily grazed areas lack diversity which allows the spread of exotic weed species. Cheatgrass (Bromus tectorum L [Poaceae]) has invaded and shortened fire frequency intervals from historic 30—100 years to as few as three to five years. Post-fire reseeding of native species is requisite for restoration of highly invaded ecosystems thus, preventing complete conversion to exotic weeds. Most native shrubs and grasses are available for restoration …

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Rumbling In The Benthos: Acoustic Ecology Of The California Mantis Shrimp Hemisquilla Californiensis, E. Staaterman, C. Clark, A. Gallagher, M. Devries, T. Claverie, S. Patek Aug 2011

Rumbling In The Benthos: Acoustic Ecology Of The California Mantis Shrimp Hemisquilla Californiensis, E. Staaterman, C. Clark, A. Gallagher, M. Devries, T. Claverie, S. Patek

Faculty Publications, Biological Sciences

Although much research has focused on acoustic mapping and exploration of the benthic environment, little is known about the acoustic ecology of benthic organisms, particularly benthic crustaceans. Through the use of a coupled audio–video system, a hydrophone array, and an autonomous recording unit, we tested several hypotheses about the field acoustics of a benthic marine crustacean, Hemisquilla califor­niensis. Living in muddy burrows in southern California, these large mantis shrimp produce low frequency ‘rumbles’ through muscle vibrations. First, we tested whether acoustic signals are similar in the field and in the laboratory, and discovered that field-produced rumbles are more acoustically and …

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Factors That Affect Harem Stability In A Feral Horse (Equus Caballus) Population On Shackleford Banks Island, Nc, Jessa Madosky Aug 2011

Factors That Affect Harem Stability In A Feral Horse (Equus Caballus) Population On Shackleford Banks Island, Nc, Jessa Madosky

LSU New Orleans Theses and Dissertations

Mammal species often live in social groups, but the factors that promote group cohesion can be difficult to analyze due to the prevalence of strong group affiliations. Feral horses maintain stable harems of one or two males and several females, and harem stability is strongly related to individual fitness. Anecdotal evidence and an early study in the non-breeding season suggest that management of the Shackleford Banks island horses with immunocontraception reduces harem stability in the population, providing an opportunity to study the factors that influence harem stability. I investigated the effects of the immunocontraceptive PZP on harem stability during the …

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Interspecies Comparison Of Αii-Spectrin Abundance Between Chinook Salmon And Steelhead, Brielle D. Kemis, Ann L. Miracle, Katie A. Wagner, Christa M. Woodley Aug 2011

Interspecies Comparison Of Αii-Spectrin Abundance Between Chinook Salmon And Steelhead, Brielle D. Kemis, Ann L. Miracle, Katie A. Wagner, Christa M. Woodley

STAR Program Research Presentations

Salmonids, such as Chinook salmon (Oncorhynchus tshawytscha) and steelhead (O. mykiss), are a staple economic, recreational, tribal, and environmental resource, yet many populations are unsustainable. This study was part of a broad scale effort to monitor the impact of downstream migration obstacles on juvenile salmonid health and survival, which is an essential step towards increasing Smolt-to-Adult Return ratios (SARs). The objective of this study was to determine if juvenile Chinook salmon and steelhead exhibit differing quantities of alphaII-Spectrin Breakdown Products (SBDPs) over two consecutive spring migration periods, indicative of neurogenesis rate and/or biological response to head …

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Assessment Of The Risks Associated With The Release Of Abalone Sourced From Abalone Hatcheries For Enhancement Or Marine Grow-Out In The Open Ocean Areas Of Wa, Brian J. Jones, Warrick Fletcher Aug 2011

Assessment Of The Risks Associated With The Release Of Abalone Sourced From Abalone Hatcheries For Enhancement Or Marine Grow-Out In The Open Ocean Areas Of Wa, Brian J. Jones, Warrick Fletcher

Fisheries Research Reports

The virus that causes Abalone Viral Ganglioneuritis (AVG) is considered to be exotic to Western Australia (WA). The known distribution includes Victoria, Tasmania and Taiwan. There are a number of known strains of the virus; Tasmanian strains do not (to date) cause mortalities in wild abalone (but do so in farms and processing facilities). Victorian and Taiwanese strains cause high mortalities in wild abalone. Despite active surveillance, the virus has not been found in NSW, South Australia or Western Australia but there is a low likelihood that WA specific strains may exist undetected.

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Pilot Evaluation Of The Efficacy Of Electronic Monitoring On A Demersal Gillnet Vessel As An Alternative To Human Observers, R Evans, Brett Molony Aug 2011

Pilot Evaluation Of The Efficacy Of Electronic Monitoring On A Demersal Gillnet Vessel As An Alternative To Human Observers, R Evans, Brett Molony

Fisheries Research Reports

A large number of documents exist in peer reviewed and ‘grey’ scientific literature that describe ‘how to’ establish a generic observer program for bycatch. Rather than repeat the many reviews of establishing observer programs, this component of WAMSI project 4.4.1 undertook a pilot trial to test the efficacy of using Electronic Monitoring (EM) in place of on-board human observers to record and identify the catch composition of a commercial demersal gillnet vessel. Approximately 80% of all catch (including target, by-product and bycatch species), including interactions with threatened, endangered and protected species (TEPS) could be identified to the same taxon as …

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The Relationship Of Dominance, Reproductive State And Stress In A Non-Cooperative Breeder, The Domestic Horse (Equus Caballus), Carly Anne Sinderbrand Aug 2011

The Relationship Of Dominance, Reproductive State And Stress In A Non-Cooperative Breeder, The Domestic Horse (Equus Caballus), Carly Anne Sinderbrand

Masters Theses & Specialist Projects

Animals that live in a social group are often organized in a hierarchy with rank determining access to resources. Maintaining a dominant position requires a high rate of energetically expensive aggressive displays and physical exertion. Lab based winnerloser studies, often conducted with individuals from non-social species, have shown that subordinates have higher stress hormone levels than dominant individuals (subordinatestress hypothesis). However, in carnivorous animals that are cooperative breeders, displays of aggression are associated with elevated stress hormone levels (dominancestress hypothesis). The effect of reproductive state on dominance and stress is not addressed within either of these hypotheses. The purpose of …

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Comprehension Of Functional Support By Enculturated Chimpanzees Pan Troglodytes, Anna M. Yocom, Sarah T. Boysen Aug 2011

Comprehension Of Functional Support By Enculturated Chimpanzees Pan Troglodytes, Anna M. Yocom, Sarah T. Boysen

Sentience Collection

Studies of causal understanding of tool relationships in captive chimpanzees have yielded disparate findings, particularly those reported by Povinelli & colleagues (2000) for tool tasks by laboratory chimpanzees. The present set of experiments tested nine enculturated chimpanzees on three versions of a support task, as described by Povinelli (2000), during which food rewards were presented in different experimental configurations. In Experiment 1, stimulus pairs included a choice between a cloth with a reward on the upper right corner or with a second reward off the cloth, adjacent to a corner, with the second pair comprised of a cloth with food …

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Spatial Distribution Of Human Elephant Conflict (Hec) And Characterization Of Crop-Raiding Elephants In Kasigau Region, Kenya, Simon Kasaine Kagwa Aug 2011

Spatial Distribution Of Human Elephant Conflict (Hec) And Characterization Of Crop-Raiding Elephants In Kasigau Region, Kenya, Simon Kasaine Kagwa

Masters Theses & Specialist Projects

Human-elephant conflict (HEC) is complex and a serious elephant conservation concern across Africa and Asia where elephants are found. HEC occurs whenever people and elephants share common interests. For HEC to be ameliorated and elephant conservation to be successful locally and regionally, the distribution and implications of HEC should be understood. The purpose of this study was to determine the spatial distribution of HECs and characterize elephant herds in terms of herd size responsible for crop-raiding in Kasigau. The study was generally guided by two working a priori hypotheses: (1) farms near the bush edge or livestock watering points will …

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Fisheries Occasional Publication No.99 - Review Of The Western Australian Rock Lobster Stock Assessment, Andre E. Punt, Department Of Fisheries Western Australia Aug 2011

Fisheries Occasional Publication No.99 - Review Of The Western Australian Rock Lobster Stock Assessment, Andre E. Punt, Department Of Fisheries Western Australia

Fisheries Occasional Publications

In 2000, the West Australian Rock Lobster (WRL) fishery became the first fishery in the world to be certified by the Marine Stewardship Council (MSC). At the annual audit in December 2010, the MSC’s independent certifying body, Scientific Certification Systems, set a number of conditions for ongoing certification. The most important condition under Principle 1, Stock Assessment, was to have an international stock assessment and modelling expert undertake a review of the latest version of the WRL Stock Assessment Report that has been used to provide advice for the management of the fishery, and 2010 stock assessment and 2010/11 management …

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Indian Ocean Territories Aquaculture Development Plan : The Cocos (Keeling) Islands And Christmas Island, Department Of Fisheries Aug 2011

Indian Ocean Territories Aquaculture Development Plan : The Cocos (Keeling) Islands And Christmas Island, Department Of Fisheries

Fisheries Occasional Publications

No abstract provided.

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Feeding Low-Fat Wet Distillers' Grains And Beef Quality, Asia Haack Aug 2011

Feeding Low-Fat Wet Distillers' Grains And Beef Quality, Asia Haack

Department of Animal Science: Dissertations, Theses, and Student Research

Feeding distillers grains to cattle decreases shelf life stability of retail displayed steaks due to the increased polyunsaturated fatty acid (PUFAs) content. High levels of PUFAs cause rapid oxidation of the fats in meat. To improve shelf life, a low-fat distillers grain ration, without solubles (LFWDG; 4.72% fat), was compared to a traditional diet containing wet distillers grains plus solubles (TWDGS; 6.91% fat) and a corn-based control diet (Corn; 3.64% fat). Strip loins (M. longissimus lumborum) from 45 USDA Choice steers (15 per dietary treatment) were selected to determine the effects of diet on fatty acid profile, fat composition, oxidation, …

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Variable Helper Effects, Ecological Conditions, And The Evolution Of Cooperative Breeding In The Acorn Woodpecker, Walter D. Koenig, Eric L. Walters, Joseph Haydock Aug 2011

Variable Helper Effects, Ecological Conditions, And The Evolution Of Cooperative Breeding In The Acorn Woodpecker, Walter D. Koenig, Eric L. Walters, Joseph Haydock

Biological Sciences Faculty Publications

The ecological conditions leading to delayed dispersal and helping behavior are generally thought to follow one of two contrasting scenarios: that conditions are stable and predictable, resulting in young being ecologically forced to remain as helpers (extrinsic constraints and the habitat saturation hypothesis), or that conditions are highly variable and unpredictable, leading to the need for helpers to raise young, at least when conditions are poor (intrinsic constraints and the hard life hypothesis). We investigated how variability in ecological conditions influences the degree to which helpers augment breeder fitness in the cooperatively breeding acorn woodpecker (Melanerpes formicivorus), a …

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Effects Of Osteopontin Single Nucleotide Polymorphisms On Bull Semen Quality, Chance L. Williams Aug 2011

Effects Of Osteopontin Single Nucleotide Polymorphisms On Bull Semen Quality, Chance L. Williams

Graduate Theses and Dissertations

Two groups of bulls were utilized to evaluate if single nucleotide polymorphisms (SNP) in the Bos taurus OPN gene (GenBank accession # AY878328.1) promoter region were related to bull semen quality variables as evaluated by computer assisted semen analysis (CASA). Group 1 consisted of 19 Angus and Balancer bulls, ranging in age from 5 to 8 years, which were collected weekly during a 2-month period (July 15, 2010 through September 19, 2010). Group 2 consisted of 16 Brahman influenced (1/8 to 3/16 Brahman) bulls, mean age = 1.1 ± 0.1 year, that were collected monthly for a 7 month period …

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The Role Of Crassostrea Virginica Hemocytes In Shell Formation: Ex Vivo Mineral Deposition By Cultured Hemocytes, Emily A. Untener, Douglas C. Hansen, Karolyn Hansen Aug 2011

The Role Of Crassostrea Virginica Hemocytes In Shell Formation: Ex Vivo Mineral Deposition By Cultured Hemocytes, Emily A. Untener, Douglas C. Hansen, Karolyn Hansen

Biology Faculty Publications

Abstract of Technical Paper Presented at the 103rd Annual Meeting National Shellfisheries Association Baltimore, Maryland March 27–31, 2011

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Effects Of Lactate Dehydrogenase Haplotypes And Body Condition On Beef Cow Production, Olfat Taleb Alaamri Aug 2011

Effects Of Lactate Dehydrogenase Haplotypes And Body Condition On Beef Cow Production, Olfat Taleb Alaamri

Graduate Theses and Dissertations

Lactate dehydrogenase (LDH) catalyzes the conversion of the pyruvate to lactate (forward) or lactate to pyruvate (reverse) in the last step of glycolysis. Objectives were to document the effects of LDH haplotypes and its SNPs, found in the promoter and coding sequence site, and body condition on beef cow production. Four single nucleotide polymorphisms (SNP) of LDH-B and Five single nucleotide polymorphisms of LDH-A were detected. Eight haplotypes of LDH-B were assigned with the same order of SNPs: G-348A, A-261G, N-222D, and C541A and four haplotypes of LDH-A were assigned with the same order of SNPs: T-327G, D-263C, G390A, A406G, …

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Effect Of The Infection With Porcine Reproductive And Respiratory Syndrome Virus On The Regulation Of Cytokines: Tumor Necrosis Factor-Alpha And Interleukin-10, Sakthivel Subramaniam Aug 2011

Effect Of The Infection With Porcine Reproductive And Respiratory Syndrome Virus On The Regulation Of Cytokines: Tumor Necrosis Factor-Alpha And Interleukin-10, Sakthivel Subramaniam

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Porcine reproductive and respiratory syndrome virus (PRRSV) causes late-term abortion in sows and pneumonia in growing piglets. PRRSV evades the host immune response by several mechanisms, including the modulation of cytokine secretions in infected pigs, which is the subject of this dissertation. Particularly, PRRSV reduces the secretion of the pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α) but increases the secretion of the anti-inflammatory cytokine interleukin-10 (IL-10). The latter effect, however, is PRRSV strain-specific. In this dissertation, we have examined mechanisms by which PRRSV regulates TNF-α and IL-10 expressions. The pathogenic strain FL12, derived from a PRRSV infectious clone, consistently suppressed TNF-α …

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