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Full-Text Articles in Gerontology
Cytotoxic T Cell Response To Influenza Vaccination In Older Adults, Caroline R. Letter
Cytotoxic T Cell Response To Influenza Vaccination In Older Adults, Caroline R. Letter
Chemistry & Biochemistry Theses & Dissertations
Influenza infections result in activation of cellular and humoral immune responses, leading to stimulation of cytotoxic T cells (CTL) and helper T cells with subsequent viral clearance.
By using an assay of granzyme B activity, the in vivo cellular-mediated immune response of old adults was found to be significantly decreased in comparison to young adults. The effect of aging on the CTL response was further investigated via enzyme-linked immunospot technique. A significant increase in number of virus-specific T cells occurred in older adults after vaccination, although the magnitude of the CTL response decreased in comparison to young adults. These data …