Gerontology Commons^™

Designing A Human-Centered Intelligent System To Monitor & Explain Abnormal Patterns Of Older Adults, Min Hun Lee, Daniel P. Siewiorek, Alexandre Bernardino

Research Collection School Of Computing and Information Systems

Older adult care technologies are increasingly explored to support the independent living of older adults by monitoring their abnormal activities and informing caregivers to provide intervention if necessary. However, the adoption of these technologies remains challenging due to several factors (e.g. lack of usability). In this work, we present a human-centered, intelligent system for older adult care. Our proposed designs of the system were created based on the findings from a focus group session with caregivers. This system monitors the abnormal activities of an older adult using wireless motion sensors and machine learning models. In addition, unlike previous work that …

Iot-Enabled Eldercare Technology, Watchanan Chantapakul

English Language Institute

The world’s population is changing as people are growing older. Leveraging technology for eldercare is important in this century. It can enable many eldercare applications effectively.

Post-Acquisition Processing Confounds In Brain Volumetric Quantification Of White Matter Hyperintensities, Ahmed A. Bahrani, Omar M. Al-Janabi, Erin L. Abner, Shoshana H. Bardach, Richard J. Kryscio, Donna M. Wilcock, Charles D. Smith, Gregory A. Jicha

Neurology Faculty Publications

BACKGROUND: Disparate research sites using identical or near-identical magnetic resonance imaging (MRI) acquisition techniques often produce results that demonstrate significant variability regarding volumetric quantification of white matter hyperintensities (WMH) in the aging population. The sources of such variability have not previously been fully explored.

NEW METHOD: 3D FLAIR sequences from a group of randomly selected aged subjects were analyzed to identify sources-of-variability in post-acquisition processing that can be problematic when comparing WMH volumetric data across disparate sites. The methods developed focused on standardizing post-acquisition protocol processing methods to develop a protocol with less than 0.5% inter-rater variance.

RESULTS: A series …

Mechanics Of Phenotypic Aging Trajectories In C. Elegans And Humans, William Zhang

Arts & Sciences Electronic Theses and Dissertations

Overall, my dissertation integrates longitudinal measurements of physiology to investigate the aging process. In the first half, I examine the surprising and largely unexplained degree of variation in lifespan within even homogeneous populations. I sought to understand how physiological aging differs between long- and short-lived individuals within a population of genetically identical C. elegans reared in a homogeneous environment. Using a novel culture apparatus, I longitudinally monitored aspects of aging physiology across a large population of isolated individuals. Aggregating several measures into an overall estimate of senescence, I find that long- and short-lived individuals start adulthood on an equal physiological …

It Is All About (U)Biquitin: Role Of Altered Ubiquitin-Proteasome System And Uchl1 In Alzheimer Disease, Antonella Tramutola, Fabio Di Domenico, Eugenio Barone, Marzia Perluigi, D. Allan Butterfield

Chemistry Faculty Publications

Free radical-mediated damage to macromolecules and the resulting oxidative modification of different cellular components are a common feature of aging, and this process becomes much more pronounced in age-associated pathologies, including Alzheimer disease (AD). In particular, proteins are particularly sensitive to oxidative stress-induced damage and these irreversible modifications lead to the alteration of protein structure and function. In order to maintain cell homeostasis, these oxidized/damaged proteins have to be removed in order to prevent their toxic accumulation. It is generally accepted that the age-related accumulation of “aberrant” proteins results from both the increased occurrence of damage and the decreased efficiency …

Shineseniors: Personalized Services For Active Ageing-In-Place, Liming Bai, Alex I. Gavino, Wei Qi Lee, Jungyoon Kim, Na Liu, Hwee-Pink Tan, Hwee Xian Tan, Lee Buay Tan, Xiaoping Toh, Alvin Cerdena Valera, Elina Jia Yu, Alfred Wu, Mark S. Fox

Research Collection School Of Computing and Information Systems

Singapore faces a major challenge in providing care and support for senior citizens due to its rapidlyageing population and declining old-age support ratio. The concept of Ageing-in-Place was introduced by the Singapore government [1] to allow older people to live independently in their own homes and communities so that the need for institutionalised care will only be utilised when necessary. We have three fundamental questions that this project will answer: 1. How to make community care serviceseffective through innovations in care delivery? How to lower the cost of service delivery and improve 2. productivity of caregivers, by leveraging information and …