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Two Clinical Prediction Tools To Improve Tuberculosis Contact Investigation, Ruoran Li, Francesco Nordio, Chuan-Chin Huang, Carmen Contreras, Roger Calderon, Rosa Yataco, Jerome Galea, Zibiao Zhang, Mercedes C. Becerra, Leonid Lecca, Megan B. Murray
Two Clinical Prediction Tools To Improve Tuberculosis Contact Investigation, Ruoran Li, Francesco Nordio, Chuan-Chin Huang, Carmen Contreras, Roger Calderon, Rosa Yataco, Jerome Galea, Zibiao Zhang, Mercedes C. Becerra, Leonid Lecca, Megan B. Murray
Social Work Faculty Publications
Background: Efficient contact investigation strategies are needed for the early diagnosis of TB disease and treatment of latent TB infections.
Methods: Between September 2009 and August 2012, we conducted a prospective cohort study in Lima, Peru in which we enrolled and followed 14,044 household contacts of adult pulmonary TB patients. We used information from a subset of this cohort to derive two clinical prediction tools that identify contacts of TB patients at elevated risk of progressing to active disease by training multivariable models that predict (1) co-prevalent TB among all household contacts and (2) one-year incident TB among adult contacts. …