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Taking The Perspective That A Depressive State Reflects Inflammation: Implications For The Use Of Antidepressants, Jill Littrell Dec 2014

Taking The Perspective That A Depressive State Reflects Inflammation: Implications For The Use Of Antidepressants, Jill Littrell

jill l littrell Dr.

This paper reviews both the evidence that supports the characterization of depression as an inflammatory disorder and the different biochemical mechanisms that have been postulated for the connection between inflammation and depression. This association offers credible explanation for the short term efficacy of antidepressants, which have short term anti-inflammatory effects. Evidence for those anti-inflammatory effects is discussed. Evidence of the contrary long-term effects of antidepressants, which increase rather than decrease inflammation, is also reviewed. It is argued that this increase in inflammation would predict an increase in chronicity among depressed patients that have been treated with antidepressants drugs, which has …


Partner Violence Assessment In Rural Health Care Clinic, Ann Coker, Vicki C. Flerx, Paige H. Smith, Daniel J. Whitaker, Mary Kay Fadden, Melinda Williams Sep 2012

Partner Violence Assessment In Rural Health Care Clinic, Ann Coker, Vicki C. Flerx, Paige H. Smith, Daniel J. Whitaker, Mary Kay Fadden, Melinda Williams

Dan Whitaker

Objectives. We sought to determine the frequency of intimatepartner violence by type in a large, clinic-based, nurse-administeredscreening and services intervention project.

Methods. A brief intimate partner violence screen, which includeditems to measure sexual and physical assaults and psychologicalbattering (using the Women’s Experience With Batteringscale) was administered to consenting women receiving care at1 of 8 rural clinics in South Carolina.

Results. Between April 2002 and August 2005, 4945 eligible womenwere offered intimate partner violence screening, to which 3664(74.1%) consented. Prevalence of intimate partner violence ina current (ongoing) relationship was 13.3%, and 939 women (25.6%)had experienced intimate partner violence at some point …