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Towards A More Effective Bidirectional Lstm-Based Learning Model For Human-Bacterium Protein-Protein Interactions, Huaming Chen, Jun Shen, Lei Wang, Yaochu Jin

Faculty of Engineering and Information Sciences - Papers: Part B

The identification of protein-protein interaction (PPI) is one of the most important tasks to understand the biological functions and disease mechanisms. Although numerous databases of biological interactions have been published in debt to advanced high-throughput technology, the study of inter-species protein-protein interactions, especially between human and bacterium pathogens, remains an active yet challenging topic to harness computational models tackling the complex analysis and prediction tasks. In this paper, we comprehensively revisit the prediction task of human-bacterium protein-protein interactions (HB-PPI), which is a first ever endeavour to report an empirical evaluation in learning and predicting HB-PPI based on machine learning models. …