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The Critical Role Of Mechanism-Based Models For Understanding And Predicting Liposomal Drug Loading, Binding And Release Kinetics, Sweta Modi

Theses and Dissertations--Pharmacy

Liposomal delivery systems hold considerable promise for improvement of cancer therapy provided that critical formulation design criteria can be met. The main objective of the current project was to enable quality by design in the formulation of liposomal delivery systems by developing comprehensive, mechanism-based mathematical models of drug loading, binding and release kinetics that take into account not only the therapeutic requirement but the physicochemical properties of the drug, the bilayer membrane, and the intraliposomal microenvironment.

Membrane binding of the drug affects both drug loading and release from liposomes. The influence of bilayer composition and phase structure on the partitioning …

Ecological Restoration's Genetic Culture: Participation And Technology In The Making Of Landscapes, Jairus Rossi

Theses and Dissertations--Geography

Practitioners of ecological restoration are increasingly adopting a genetic perspective when recreating historical landscapes. Genes are often endowed with the capacity to reveal specific and distinct relationships between organisms and environments. In this dissertation, I examine how genetic technologies and concepts are shaping ecological restoration practices. This research is based on two and a half years of fieldwork in Chicago. I employed participant observation and semi-structured interviews to compare how restorationists in two plant science institutions employ genetic concepts in their projects. One institution uses high-tech genetic methods to guide practice while the other uses lower-tech genetic approaches. Each group …