Science and Technology Studies Commons^™

An Ontology-Driven Semantic Mash-Up Of Gene And Biological Pathway Information: Application To The Domain Of Nicotine Dependence, Satya S. Sahoo, Olivier Bodenreider, Joni L. Rutter, Karen J. Skinner, Amit P. Sheth

Kno.e.sis Publications

Objectives: This paper illustrates how Semantic Web technologies (especially RDF, OWL, and SPARQL) can support information integration and make it easy to create semantic mashups (semantically integrated resources). In the context of understanding the genetic basis of nicotine dependence, we integrate gene and pathway information and show how three complex biological queries can be answered by the integrated knowledge base.

Methods: We use an ontology-driven approach to integrate two gene resources (Entrez Gene and HomoloGene) and three pathway resources (KEGG, Reactome and BioCyc), for five organisms, including humans. We created the Entrez Knowledge Model (EKoM), an information model in OWL …

Semantic Web: Promising Technologies, Current Applications & Future Directions, Amit P. Sheth

Kno.e.sis Publications

No abstract provided.

Rdb2rdf: Incorporating Domain Semantics In Structured Data, Satya S. Sahoo

Kno.e.sis Publications

No abstract provided.

Traveling The Semantic Web Through Space, Theme And Time, Amit P. Sheth, Matthew Perry

Kno.e.sis Publications

In this installment of Semantics and Services, we further develop the idea of spatial, temporal, and thematic (STT) processing of semantic Web data and describe the Web infrastructure needed to support it. Starting from Ramesh Jain's vision of the EventWeb as a view of what's possible with a Web that better accommodates all three dimensions of event-related information (thematic, spatial, and temporal), we outline the architecture needed to support it and current research that aims to realize it.