Science and Technology Studies Commons^™

First In Vitro Evidence Of Modulated Electro-Hyperthermia Treatment Performance In Combination With Megavoltage Radiation By Clonogenic Assay, Marjorie Mcdonald, Stephanie Corde, Michael L. F Lerch, Anatoly B. Rosenfeld, Michael A. Jackson, Moeava Tehei

Faculty of Engineering and Information Sciences - Papers: Part B

Modulated electro-hyperthermia (mEHT) is a form of hyperthermia used in the treatment of cancer. It is a variation that relies on a particular form of enhanced selectivity to enable more effective cancerous cell death yet maintaining the integrity of healthy non-cancerous cells. It is yet to successfully make the major step into the wider medical community despite several encouraging trials. In this study, we investigate mEHT from an in vitro perspective. We demonstrate a supra-additive effect on 9 L gliosarcoma cells when exposed to mEHT in combination with MV X-ray radiation. The supra-additive effect is hypothesized to be induced by …

Radiosensitisation Enhancement Effect Of Brudr And Ta2o5 Nsps In Combination With 5-Fluorouracil Antimetabolite In Kilovoltage And Megavoltage Radiation, Marjorie Mcdonald, Sianne Oktaria, Konstantin K. Konstantinov, Anatoly B. Rosenfeld, Michael L. F Lerch, Stephanie Corde, Moeava Tehei

Faculty of Engineering and Information Sciences - Papers: Part B

This article demonstrates in vitro a synergistic effect on 9L gliosarcoma cells when exposed to bromodeoxyuridine (BrUdR) and a low concentration (100 times lower than the IC50) of 5-Fluorouracil (5-FU), in combination with x-ray irradiation. The synergy is brought about by several important factors including the x-ray beam energy, atomic number of the BrUdR (Z = 35), effectiveness of 5-FU in reducing the available repair processes and distribution of the BrUdR in and around the 9L cells (32% of the total substitution of BrUdR for thymidine into nucleus DNA). Our results show that the synergistic effect, evident in an optimised …

Cyberknife® Fixed Cone And Iris™ Defined Small Radiation Fields: Assessment With A High-Resolution Solid-State Detector Array, Giordano Biasi, Marco Petasecca, Susanna Guatelli, Martin A. Ebert, Garry Grogan, Benjamin Hug, Jonathan Lane, Vladimir Perevertaylo, Tomas Kron, Anatoly B. Rosenfeld

Faculty of Engineering and Information Sciences - Papers: Part B

Purpose

The challenges of accurate dosimetry for stereotactic radiotherapy (SRT) with small unflattened radiation fields have been widely reported in the literature. In this case, suitable dosimeters would have to offer a submillimeter spatial resolution. The CyberKnife^® (Accuray Inc., Sunnyvale, CA, USA) is an SRT‐dedicated linear accelerator (linac), which can deliver treatments with submillimeter positional accuracy using circular fields. Beams are delivered with the desired field size using fixed cones, the InCise™ multileaf collimator or a dynamic variable‐aperture Iris™ collimator. The latter, allowing for field sizes to be varied during treatment delivery, has the potential to decrease treatment time, …

Investigation Of Track Structure And Condensed History Physics Models For Applications In Radiation Dosimetry On A Micro And Nano Scale In Geant4, Peter Lazarakis, Sebastien Incerti, Vladimir N. Ivanchenko, Ioanna Kyriakou, Dimitris Emfietzoglou, Stephanie Corde, Anatoly B. Rosenfeld, Michael L. F Lerch, Moeava Tehei, Susanna Guatelli

Faculty of Engineering and Information Sciences - Papers: Part B

Monte Carlo methods apply various physical models, either condensed history (CH) or track structure (TS), to simulate the passage of radiation through matter. Both CH and TS models continue to be applied to radiation dosimetry investigations on a micro and nano scale. However, as there has been no systematic comparison of the use of these models for such applications there can be no quantification of the uncertainty that is being introduced by the choice of physics model. A comparison of CH and TS models available in Geant4, along with a quantification of the differences in calculated quantities on a micro …