Open Access. Powered by Scholars. Published by Universities.®
Science and Technology Studies Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Science and Technology Studies
First In Vitro Evidence Of Modulated Electro-Hyperthermia Treatment Performance In Combination With Megavoltage Radiation By Clonogenic Assay, Marjorie Mcdonald, Stephanie Corde, Michael L. F Lerch, Anatoly B. Rosenfeld, Michael A. Jackson, Moeava Tehei
First In Vitro Evidence Of Modulated Electro-Hyperthermia Treatment Performance In Combination With Megavoltage Radiation By Clonogenic Assay, Marjorie Mcdonald, Stephanie Corde, Michael L. F Lerch, Anatoly B. Rosenfeld, Michael A. Jackson, Moeava Tehei
Faculty of Engineering and Information Sciences - Papers: Part B
Modulated electro-hyperthermia (mEHT) is a form of hyperthermia used in the treatment of cancer. It is a variation that relies on a particular form of enhanced selectivity to enable more effective cancerous cell death yet maintaining the integrity of healthy non-cancerous cells. It is yet to successfully make the major step into the wider medical community despite several encouraging trials. In this study, we investigate mEHT from an in vitro perspective. We demonstrate a supra-additive effect on 9 L gliosarcoma cells when exposed to mEHT in combination with MV X-ray radiation. The supra-additive effect is hypothesized to be induced by …
Radiosensitisation Enhancement Effect Of Brudr And Ta2o5 Nsps In Combination With 5-Fluorouracil Antimetabolite In Kilovoltage And Megavoltage Radiation, Marjorie Mcdonald, Sianne Oktaria, Konstantin K. Konstantinov, Anatoly B. Rosenfeld, Michael L. F Lerch, Stephanie Corde, Moeava Tehei
Radiosensitisation Enhancement Effect Of Brudr And Ta2o5 Nsps In Combination With 5-Fluorouracil Antimetabolite In Kilovoltage And Megavoltage Radiation, Marjorie Mcdonald, Sianne Oktaria, Konstantin K. Konstantinov, Anatoly B. Rosenfeld, Michael L. F Lerch, Stephanie Corde, Moeava Tehei
Faculty of Engineering and Information Sciences - Papers: Part B
This article demonstrates in vitro a synergistic effect on 9L gliosarcoma cells when exposed to bromodeoxyuridine (BrUdR) and a low concentration (100 times lower than the IC50) of 5-Fluorouracil (5-FU), in combination with x-ray irradiation. The synergy is brought about by several important factors including the x-ray beam energy, atomic number of the BrUdR (Z = 35), effectiveness of 5-FU in reducing the available repair processes and distribution of the BrUdR in and around the 9L cells (32% of the total substitution of BrUdR for thymidine into nucleus DNA). Our results show that the synergistic effect, evident in an optimised …