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Full-Text Articles in Science and Technology Studies
A Comparative Analysis Of Multichannel Data Acquisition Systems For Quality Assurance In External Beam Radiation Therapy, Iolanda Fuduli, Claudiu Porumb, Anthony Espinoza, Abdullah Aldosari, Martin Carolan, Michael Lf Lerch, Peter E. Metcalfe, Anatoly Rosenfeld, Marco Petasecca
A Comparative Analysis Of Multichannel Data Acquisition Systems For Quality Assurance In External Beam Radiation Therapy, Iolanda Fuduli, Claudiu Porumb, Anthony Espinoza, Abdullah Aldosari, Martin Carolan, Michael Lf Lerch, Peter E. Metcalfe, Anatoly Rosenfeld, Marco Petasecca
Anthony A Espinoza Mr
The paper presents a comparative study performed by the Centre of Medical Radiation Physics (CMRP) on three multichannel Data Acquisition Systems (DAQ) based on different analogue front-ends to suit a wide range of radiotherapy applications. The three front-ends are: a charge-to-frequency converter developed by INFN Torino, an electrometer and a charge-to-digital converter (both commercial devices from Texas Instruments). For the first two (named DAQ A and B), the CMRP has designed the read-out systems whilst the third one (DAQ C) comes with its own evaluation board. For the purpose of the characterization DAQ A and DAQ B have been equipped …
X-Tream: A Novel Dosimetry System For Synchrotron Microbeam Radiation Therapy, M Petasecca, A Cullen, I Fuduli, A Espinoza, C Porumb, C Stanton, A H. Aldosari, E Brauer-Krisch, H Requardt, A Bravin, V Perevertaylo, Anatoly B. Rosenfeld, M L. F Lerch
X-Tream: A Novel Dosimetry System For Synchrotron Microbeam Radiation Therapy, M Petasecca, A Cullen, I Fuduli, A Espinoza, C Porumb, C Stanton, A H. Aldosari, E Brauer-Krisch, H Requardt, A Bravin, V Perevertaylo, Anatoly B. Rosenfeld, M L. F Lerch
Anthony A Espinoza Mr
Microbeam Radiation Therapy (MRT) is a radiation treatment technique under development for inoperable brain tumors. MRT is based on the use of a synchrotron generated X-ray beam with an extremely high dose rate ( ~ 20 kGy/sec), striated into an array of X-ray micro-blades. In order to advance to clinical trials, a real-time dosimeter with excellent spatial resolution must be developed for absolute dosimetry. The design of a real-time dosimeter for such a radiation scenario represents a significant challenge due to the high photon flux and vertically striated radiation field, leading to very steep lateral dose gradients. This article analyses …
Synchrotron Radiation Computed Tomography Station At The Esrf Biomedical Beamline, C Nemoz, S Bayat, G Berruyer, T Brochard, P Coan, G Le Duc, J Keyrilainen, S Monfraix, M Renier, H Requardt, A Bravin, P Tafforeau, J F. Adam, M C. Biston, C Boudou, A M. Charvet, S Corde, H Elleaume, F Esteve, A Joubert, J Rousseau, I Tropres, M Fernandez, L Porra, P Suortti, S Fiedler, W Thomlinson
Synchrotron Radiation Computed Tomography Station At The Esrf Biomedical Beamline, C Nemoz, S Bayat, G Berruyer, T Brochard, P Coan, G Le Duc, J Keyrilainen, S Monfraix, M Renier, H Requardt, A Bravin, P Tafforeau, J F. Adam, M C. Biston, C Boudou, A M. Charvet, S Corde, H Elleaume, F Esteve, A Joubert, J Rousseau, I Tropres, M Fernandez, L Porra, P Suortti, S Fiedler, W Thomlinson
Stéphanie Corde
The different tomography imaging modalities of the ESRF Medical Beamline are described and research applications are presented
Synchrotron Radiation Based Experimental Determination Of The Optimal Energy For Cell Radiotoxicity Enhancement Following Photoelectric Effect On Stable Iodinated Compounds, S Corde, A Joubert, J F. Adam, A M. Charvet, J F. Le Bas, F Esteve, H Elleaume, J Balosso
Synchrotron Radiation Based Experimental Determination Of The Optimal Energy For Cell Radiotoxicity Enhancement Following Photoelectric Effect On Stable Iodinated Compounds, S Corde, A Joubert, J F. Adam, A M. Charvet, J F. Le Bas, F Esteve, H Elleaume, J Balosso
Stéphanie Corde
This study was designed to experimentally evaluate the optimal X-ray energy for increasing the radiation energy absorbed in tumours loaded with iodinated compounds, using the photoelectric effect. SQ20B human cells were irradiated with synchrotron monochromatic beam tuned at 32.8, 33.5, 50 and 70 keV. Two cell treatments were compared to the control: cells suspended in 10 mg ml1 of iodine radiological contrast agent or cells pre-exposed with 10 mM of iodo-desoxyuridine (IUdR) for 48 h. Our radiobiological end point was clonogenic cell survival. Cells irradiated with both iodine compounds exhibited a radiation sensitisation enhancement. Moreover, it was energy dependent, with …
Advanced Semiconductor Dosimetry In Radiation Therapy, Anatoly B. Rosenfeld
Advanced Semiconductor Dosimetry In Radiation Therapy, Anatoly B. Rosenfeld
Anatoly Rozenfeld
Modern radiation therapy is very conformal, resulting in a complexity of delivery that leads to many small radiation fields with steep dose gradients, increasing error probability. Quality assurance in delivery of such radiation fields is paramount and requires real time and high spatial resolution dosimetry. Semiconductor radiation detectors due to their small size, ability to operate in passive and active modes and easy real time multichannel readout satisfy many aspects of in vivo and in a phantom quality assurance in modern radiation therapy. Update on the recent developments and improvements in semiconductor radiation detectors and their application for quality assurance …
X-Tream: A Novel Dosimetry System For Synchrotron Microbeam Radiation Therapy, M Petasecca, A Cullen, I Fuduli, A Espinoza, C Porumb, C Stanton, A H. Aldosari, E Brauer-Krisch, H Requardt, A Bravin, V Perevertaylo, Anatoly B. Rosenfeld, M L. F Lerch
X-Tream: A Novel Dosimetry System For Synchrotron Microbeam Radiation Therapy, M Petasecca, A Cullen, I Fuduli, A Espinoza, C Porumb, C Stanton, A H. Aldosari, E Brauer-Krisch, H Requardt, A Bravin, V Perevertaylo, Anatoly B. Rosenfeld, M L. F Lerch
Anatoly Rozenfeld
Microbeam Radiation Therapy (MRT) is a radiation treatment technique under development for inoperable brain tumors. MRT is based on the use of a synchrotron generated X-ray beam with an extremely high dose rate ( ~ 20 kGy/sec), striated into an array of X-ray micro-blades. In order to advance to clinical trials, a real-time dosimeter with excellent spatial resolution must be developed for absolute dosimetry. The design of a real-time dosimeter for such a radiation scenario represents a significant challenge due to the high photon flux and vertically striated radiation field, leading to very steep lateral dose gradients. This article analyses …