Open Access. Powered by Scholars. Published by Universities.®
Public Affairs, Public Policy and Public Administration Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Public Affairs, Public Policy and Public Administration
Branched-Chain Amino Acids And Risk Of Breast Cancer, Oana A. Zeleznik, Raji Balasubramanian, Yumeng Ren, Deirdre K. Tobias, Bernard A. Rosner, Cheng Peng, Alaina M. Bever, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Samia Mora, Frank B. Hu, A. Heather Eliassen
Branched-Chain Amino Acids And Risk Of Breast Cancer, Oana A. Zeleznik, Raji Balasubramanian, Yumeng Ren, Deirdre K. Tobias, Bernard A. Rosner, Cheng Peng, Alaina M. Bever, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Samia Mora, Frank B. Hu, A. Heather Eliassen
Biostatistics and Epidemiology Faculty Publications Series
Background
Circulating branched-chain amino acid (BCAA) levels reflect metabolic health and dietary intake. However, associations with breast cancer are unclear. Methods
We evaluated circulating BCAA levels and breast cancer risk within the Nurses’ Health Study (NHS) and NHSII (1997 cases and 1997 controls). A total of 592 NHS women donated 2 blood samples 10 years apart. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer risk in multivariable logistic regression models. We conducted an external validation in 1765 cases in the Women’s Health Study (WHS). All statistical tests were 2-sided. Results
Among NHSII participants (predominantly premenopausal …
White Blood Cell Dna Methylation And Risk Of Breast Cancer In The Prostate, Lung, Colorectal, And Ovarian Cancer Screening Trial (Plco), Susan R. Sturgeon, J. Richard Pilsner, Kathleen F. Arcaro, Kaoru Ikuma, Haotian Wu, Soon-Mi Kim, Nayha Chopra-Tandon, Adam R. Karpf, Regina G. Ziegler, Catherine Schairer, Raji Balasubramanian, David A. Reckhow
White Blood Cell Dna Methylation And Risk Of Breast Cancer In The Prostate, Lung, Colorectal, And Ovarian Cancer Screening Trial (Plco), Susan R. Sturgeon, J. Richard Pilsner, Kathleen F. Arcaro, Kaoru Ikuma, Haotian Wu, Soon-Mi Kim, Nayha Chopra-Tandon, Adam R. Karpf, Regina G. Ziegler, Catherine Schairer, Raji Balasubramanian, David A. Reckhow
Biostatistics and Epidemiology Faculty Publications Series
Background
Several studies have suggested that global DNA methylation in circulating white blood cells (WBC) is associated with breast cancer risk.
Methods
To address conflicting results and concerns that the findings for WBC DNA methylation in some prior studies may reflect disease effects, we evaluated the relationship between global levels of WBC DNA methylation in white blood cells and breast cancer risk in a case-control study nested within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) cohort. A total of 428 invasive breast cancer cases and 419 controls, frequency matched on age at entry (55–59, 60–64, 65–69, ≥70 …