Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Psychology
The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber
The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber
Wayne State University Dissertations
In the neonatal intensive care unit (NICU) preterm infants are exposed to a multitude of stressors, which include both neonatal pain and reduced maternal care. Clinical and preclinical research has demonstrated that exposure to neonatal pain and reduced maternal care has a profound negative impact on brain and behavioral development. Currently, the biological mechanism by which both of these stressors impacts brain and behavioral outcomes remains widely unknown. To uncover a potential biological mechanism, the current dissertation project utilized a preclinical model of repetitive needle pokes and developed a novel model of reduced maternal care through tea-ball encapsulation. Briefly, rat …
Analgesia Followed By Long-Term Hyperalgesia Generated By Disinhibition Of The Basolateral Amygdala, Derek Atchley
Analgesia Followed By Long-Term Hyperalgesia Generated By Disinhibition Of The Basolateral Amygdala, Derek Atchley
Wayne State University Theses
Stress produces bimodal effects on pain peception. During exposure to a stressor pain responses are inibited (i.e. stress-induced analgesia). However, following long-term exposure to a stressor increases in responsiveness to painful stimuli may develop (i.e. stress-induced hyperalgesia). Here I evaluated how a key component of the subcortical defense circuit and target of stress hormones contributes to the development of both stress-induced analgesia and hyperalgesia. Bicuculline methiodide, a GABAA antagonist, injected into the basolateral amygdala was used to mimic the neural effects of a stressor or threat exposure. Immediately following injection pain responsiveness was decreased as measured by vocalizations after discharge …
Understanding The Role Of Nutritional Stress In The Adult And Developing Zebra Finch, Jessica Bayley Thompson
Understanding The Role Of Nutritional Stress In The Adult And Developing Zebra Finch, Jessica Bayley Thompson
Wayne State University Dissertations
Songbirds are particularly susceptible to stress during the sensitive period for song learning. Thus the developmental stress hypothesis (DSH) proposes that adult song reflects a male's early life environment during this period. Nutritional stress (NS) has been shown to cause deficits in song learning and adult song output that are salient to females. Female song birds consistently prefer control males over those raised under NS, yet the effects NS on females are still unclear. The hypothalamic-pituitary-adrenal axis (HPA) has been implicated in this process. However, evidence directly linking HPA functioning to the deficits due to NS have inconsistently shown elevations …
Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (Taeniopygia Guttata), Kimberly Anne Laplante
Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (Taeniopygia Guttata), Kimberly Anne Laplante
Wayne State University Dissertations
Stress and affiliative social relationships are bi-directionally related. It is well understood that social relationships can buffer the physiological response to a stressor. Conversely, there is some evidence to suggest that stress can affect the propensity to form a pair bond. Data from humans and prairie voles, monogamous rodents, suggest that activation of the hypothalamic-pituitary-adrenal axis (HPA) in males increases attraction for females. Across species, females are understudied, but evidence from the prairie vole suggests HPA activation impairs formation of partner preference, the first step in establishing a pair bond. Across taxa there is evidence that formation and maintenance of …