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Cognitive Behavioral Therapy Is Associated With Enhanced Cognitive Control Network Activity In Major Depression And Posttraumatic Stress Disorder, Zhen Yang, Desmond Oathes, Kristin Linn, Steven Bruce, Theodore Satterthwaite, Philip Cook, Emma Satchell, Haochang Shou, Yvette Sheline
Cognitive Behavioral Therapy Is Associated With Enhanced Cognitive Control Network Activity In Major Depression And Posttraumatic Stress Disorder, Zhen Yang, Desmond Oathes, Kristin Linn, Steven Bruce, Theodore Satterthwaite, Philip Cook, Emma Satchell, Haochang Shou, Yvette Sheline
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BACKGROUND: Both major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are characterized by depressive symptoms, abnormalities in brain regions important for cognitive control, and response to cognitive behavioral therapy (CBT). However, whether a common neural mechanism underlies CBT response across diagnoses is unknown. METHODS: Brain activity during a cognitive control task was measured using functional magnetic resonance imaging in 104 participants: 28 patients with MDD, 53 patients with PTSD, and 23 healthy control subjects; depression and anxiety symptoms were determined on the same day. A patient subset (n = 31) entered manualized CBT and, along with controls (n = …