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Full-Text Articles in Psychology
“Loss Of Control” In Alcoholism And Drug Addiction: A Neuroscientific Interpretation, Michael Lyvers
“Loss Of Control” In Alcoholism And Drug Addiction: A Neuroscientific Interpretation, Michael Lyvers
Mike Lyvers
Considerable neurological evidence indicates that the prefrontal cortex mediates complex "executive" functions including behavioral autonomy and self-control. Given that impairments of self-control are characteristic of alcoholism and other drug addictions, frontal lobe dysfunction may play a significant role in such compulsive behaviors. Consistent with this idea, recent research using brain imaging, neuropsychological testing, and other techniques has revealed that the frontal lobes are particularly vulnerable to the acute and chronic effects of addictive drugs, especially alcohol and cocaine. Evidence implicating a hyperdopaminergic mechanism of acute and chronic drug-induced frontal lobe dysfunction and interactions with premorbid factors and stress are discussed.
Characterization Of The Behavioral And Neurochemical Effects Of Nicotine Withdrawal In Adolescent And Adult Rats., Luis Alberto Natividad
Characterization Of The Behavioral And Neurochemical Effects Of Nicotine Withdrawal In Adolescent And Adult Rats., Luis Alberto Natividad
Open Access Theses & Dissertations
Previous studies have demonstrated that the behavioral effects of nicotine withdrawal are lower in adolescent versus adult rats. However, the neurochemical mechanisms that mediate these developmental differences are presently unclear. Much work has shown that nicotine reward is mediated via enhanced dopamine neurotransmission in the mesolimbic pathway which originates in the ventral tegmental area (VTA) and terminates in several forebrain structures including the nucleus accumbens (NAcc). More recently, studies have shown that nicotine withdrawal produces a decrease in NAcc dopamine transmission, an effect that is believed to serve as a neurochemical marker of withdrawal in adult rodents. The goal of …