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Full-Text Articles in Psychology
Motor Timing Intraindividual Variability In Amnestic Mild Cognitive Impairment And Cognitively Intact Elders At Genetic Risk For Alzheimer’S Disease, Christina D. Kay, Michael Seidenberg, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, John L. Woodard, Stephen M. Rao
Motor Timing Intraindividual Variability In Amnestic Mild Cognitive Impairment And Cognitively Intact Elders At Genetic Risk For Alzheimer’S Disease, Christina D. Kay, Michael Seidenberg, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, John L. Woodard, Stephen M. Rao
Psychology Faculty Research and Publications
Introduction: Intraindividual variability (IIV) in motor performance has been shown to predict future cognitive decline. The apolipoprotein E-epsilon 4 (APOE-ε4) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the APOE-ε4 allele on the performance of asymptomatic healthy elders in comparison to individuals with amnestic MCI (aMCI) on a fine motor synchronization, paced finger-tapping task (PFTT).
Method: Two Alzheimer’s disease (AD) risk groups, individuals with aMCI (n = 24) and cognitively intact APOE-ε4 carriers (n = 41), and a control group consisting of cognitively intact APOE-ε4 noncarriers ( …