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Full-Text Articles in Psychology
Bone Marrow-Derived Microglia-Based Neurturin Delivery Protects Against Dopaminergic Neurodegeneration In A Mouse Model Of Parkinson's Disease, K. C. Biju, R. A. Santacruz, C. Chen, Q. Zhou, J. Yao, S. L. Rohrabaugh, R. A. Clark, James Lewis Roberts, Kimberley A. Phillips, S. Z. Imam, S. Li
Bone Marrow-Derived Microglia-Based Neurturin Delivery Protects Against Dopaminergic Neurodegeneration In A Mouse Model Of Parkinson's Disease, K. C. Biju, R. A. Santacruz, C. Chen, Q. Zhou, J. Yao, S. L. Rohrabaugh, R. A. Clark, James Lewis Roberts, Kimberley A. Phillips, S. Z. Imam, S. Li
Psychology Faculty Research
Although neurotrophic factors have long been recognized as potent agents for protecting against neuronal degeneration, clinical success in treating Parkinson's disease and other neurodegenerative disorders has been hindered by difficulties in delivery of trophic factors across the blood brain barrier (BBB). Bone marrow hematopoietic stem cell-based gene therapy is emerging as a promising tool for overcoming drug delivery problems, as myeloid cells can cross the BBB and are recruited in large numbers to sites of neurodegeneration, where they become activated microglia that can secrete trophic factors. We tested the efficacy of bone marrow-derived microglial delivery of neurturin (NTN) in protecting …