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- Childhood anxiety disorders (3)
- Mood dysregulation (3)
- Neurobiology (3)
- Appetite (2)
- Conditioned avoidance response (2)
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- Flavor preferences (2)
- Food sensory evaluation (2)
- Nutrients (2)
- Phencyclidine (2)
- Primates behavior (2)
- Rats (2)
- Sensitization (2)
- Tolerance (2)
- 22 kHz ultrasonic vocalization (1)
- Action planning (1)
- Adolescence antipsychotic treatment (1)
- Adolescence drug treatment (1)
- Adolescent girls (1)
- Adolescents (1)
- Alzheimer's disease (1)
- Alzheimer's disease – Diagnosis (1)
- Arousal (1)
- Asenapine (1)
- Attitude accessibility (1)
- Attitudes (1)
- Baboon (1)
- Body image (1)
- Brain derived neurotrophic factor (1)
- Bystander (1)
- Caffeine (1)
Articles 1 - 26 of 26
Full-Text Articles in Psychology
Iptakalim Attenuates Self-Administration And Acquired Goal-Tracking Behavior Controlled By Nicotine, S. Charntikov, N. Swalve, Steven T. Pittenger, K. Fink, S. Schepers, G. C. Hadlock, A. E. Fleckenstein, G. Hu, Ming Li, Rick A. Bevins
Iptakalim Attenuates Self-Administration And Acquired Goal-Tracking Behavior Controlled By Nicotine, S. Charntikov, N. Swalve, Steven T. Pittenger, K. Fink, S. Schepers, G. C. Hadlock, A. E. Fleckenstein, G. Hu, Ming Li, Rick A. Bevins
Department of Psychology: Faculty Publications
Iptakalim is an ATP-sensitive potassium channel opener, as well as an a4b2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Pretreatment with iptakalim diminishes nicotine-induced dopamine (DA) and glutamate release in the nucleus accumbens. This neuropharmacological profile suggests that iptakalim may be useful for treatment of nicotine dependence. Thus, we examined the effects of iptakalim in two preclinical models. First, the impact of iptakalim on the interoceptive stimulus effect of nicotine was evaluated by training rats in a discriminated goal-tracking task that included intermixed nicotine (0.4 mg/kg, SC) and saline sessions. Sucrose was intermittently presented in a responseindependent manner only on nicotine sessions. …
Repeated Asenapine Treatment Produces A Sensitization Effect In Two Preclinical Tests Of Antipsychotic Activity, Rongyin Qin, Yingzhu Chen, Ming Li
Repeated Asenapine Treatment Produces A Sensitization Effect In Two Preclinical Tests Of Antipsychotic Activity, Rongyin Qin, Yingzhu Chen, Ming Li
Department of Psychology: Faculty Publications
Among several commonly used atypical antipsychotic drugs, olanzapine and risperidone cause a sensitization effect in the conditioned avoidance response (CAR) and phencyclidine (PCP)- induced hyperlocomotion paradigms – two well established animal tests of antipsychotic drugs, whereas clozapine causes a tolerance effect. Asenapine is a novel antipsychotic drug recently approved for the treatment of schizophrenia and manic disorders. It shares several receptor binding sites and behavioral features with other atypical antipsychotic drugs. However, it is not clear what type of repeated effect (sensitization or tolerance) asenapine would induce, and whether such an effect is transferrable to other atypicals. In this study, …
Day-Night Differences In Neural Activation In Histaminergic And Serotonergic Areas With Putative Projections To The Cerebrospinal Fluid In A Diurnal Brain, Alexandra Castillo-Ruiz, Andrew J. Gall, Laura Smale, Antonio A. Nunez
Day-Night Differences In Neural Activation In Histaminergic And Serotonergic Areas With Putative Projections To The Cerebrospinal Fluid In A Diurnal Brain, Alexandra Castillo-Ruiz, Andrew J. Gall, Laura Smale, Antonio A. Nunez
Faculty Publications
In nocturnal rodents, brain areas that promote wakefulness have a circadian pattern of neural activation that mirrors the sleep/wake cycle, with more neural activation during the active phase than during the rest phase. To investigate whether differences in temporal patterns of neural activity in wake-promoting regions contribute to differences in daily patterns of wakefulness between nocturnal and diurnal species, we assessed Fos expression patterns in the tuberomammillary (TMM), supramammillary (SUM), and raphe nuclei of male grass rats maintained in a 12:12 h light-dark cycle. Day-night profiles of Fos expression were observed in the ventral and dorsal TMM, in the SUM, …
Sensory-Specific Appetition: Postingestive Detection Of Glucose Rapidly Promotes Continued Consumption Of A Recently Encountered Flavor, Kevin P. Myers, Marisa S. Taddeo, Emily K. Richards
Sensory-Specific Appetition: Postingestive Detection Of Glucose Rapidly Promotes Continued Consumption Of A Recently Encountered Flavor, Kevin P. Myers, Marisa S. Taddeo, Emily K. Richards
Faculty Journal Articles
It is generally thought that macronutrients stimulate intake when sensed in the mouth (e.g., sweet taste) but as food enters the GI tract its effects become inhibitory, triggering satiation processes leading to meal termination. Here we report experiments extending recent work (see [1]) showing that under some circumstances nutrients sensed in the gut produce a positive feedback effect, immediately promoting continued intake. In one experiment, rats with intragastric (IG) catheters were accustomed to consuming novel flavors in saccharin daily while receiving water infused IG (5 ml/15 min). The very first time glucose (16% w/w) was infused IG instead of water, …
Lesions Of The Intergeniculate Leaflet Lead To A Reorganization In Circadian Regulation And A Reversal In Masking Responses To Photic Stimuli In The Nile Grass Rat, Andrew J. Gall, Laura Smale, Lily Yan, Antonio A. Nunez
Lesions Of The Intergeniculate Leaflet Lead To A Reorganization In Circadian Regulation And A Reversal In Masking Responses To Photic Stimuli In The Nile Grass Rat, Andrew J. Gall, Laura Smale, Lily Yan, Antonio A. Nunez
Faculty Publications
Light influences the daily patterning of behavior by entraining circadian rhythms and through its acute effects on activity levels (masking). Mechanisms of entrainment are quite similar across species, but masking can be very different. Specifically, in diurnal species, light generally increases locomotor activity (positive masking), and in nocturnal ones, it generally suppresses it (negative masking). The intergeniculate leaflet (IGL), a subdivision of the lateral geniculate complex, receives direct retinal input and is reciprocally connected with the primary circadian clock, the suprachiasmatic nucleus (SCN). Here, we evaluated the influence of the IGL on masking and the circadian system in a diurnal …
Witnessing Reconciliation Reduces Arousal Of Bystanders In A Baboon Group (Papio Hamadryas Hamadryas), Peter G. Judge, Katherine A. Bachmann
Witnessing Reconciliation Reduces Arousal Of Bystanders In A Baboon Group (Papio Hamadryas Hamadryas), Peter G. Judge, Katherine A. Bachmann
Faculty Journal Articles
Reconciliation is the occurrence of friendly behaviour between opponents shortly after an aggressive conflict. In primate groups, reconciliation reduces aggression and post-conflict arousal. Aggression within a group can also increase arousal of bystanders (e.g. increase bystanders’ rates of self-directed behaviour). Since reconciliation reduces aggression between opponents, we tested whether it also reduces self-directed behaviour in bystanders. Following aggression in a captive group of hamadryas baboons, one observer conducted a focal sample on one of the combatants to document reconciliation and a second observer simultaneously conducted a focal sample on a randomly selected bystander. Matched control observations were then collected on …
Attitude Accessiblity As A Determinant Of Object Construal And Evaluation, Alison I. Young, Russell H. Fazio
Attitude Accessiblity As A Determinant Of Object Construal And Evaluation, Alison I. Young, Russell H. Fazio
Faculty Scholarship – Psychology
Attitude accessibility, the ease with which a given attitude comes to mind, has been demonstrated to affect attention. The current experiments focus on the construal of multiply-categorizable objects. They seek to provide evidence that (a) construals toward which individuals have more accessible attitudes, i.e., those that are more attitude-evoking, are more likely to influence the evaluation of related objects and that (b) this effect of attitude accessibility on construal processes can be extended to a whole series of objects which vary along multiple dimensions. Experiment 1 provides evidence that construals whose related attitudes were made more accessible via attitude rehearsal …
The Effects Of Selected Drugs On The Memory Recall Of Sleep Deprived Mice, Jenn Pauldurai
The Effects Of Selected Drugs On The Memory Recall Of Sleep Deprived Mice, Jenn Pauldurai
Senior Research Projects
Humans often make use of the neurotransmission altering effects of drugs such as caffeine, ephedrine, and ethanol. These drugs induce changes in memory and learning ability, specifically when used for sleep deprivation. English white mice (Mus musculus) have been shown to exhibit similar cognitive changes when administered drugs while sleep deprived. A sample of 20 mice was divided into three experimental groups (each group receiving a different drug) and one control group. Maze-testing demonstrated that mice performance decreased with sleep deprivation (Treatment-1) but all groups returned to baseline performance when injected (IP) with selected drugs (Treatment-2), regardless of …
The Eden Project: A City Wide Youth Conference And Fashion Show To Increase Body Image And Self-Esteem In Adolescent Girls, Nicole R. Parsons
The Eden Project: A City Wide Youth Conference And Fashion Show To Increase Body Image And Self-Esteem In Adolescent Girls, Nicole R. Parsons
Honors Program Projects
This paper focuses on the development of body image and self-esteem in adolescent girls and discusses the impact both positive and negative factors can have during this developmental stage of life. It argues the idea that a girl’s positive feelings regarding her external appearance can drastically influence her self-esteem, which in turn affects how she treats herself, as well how she allows others to treat her. This paper also follows the history of fashion shows, discussing their influence in media outlets that adolescent girls often turn to when searching for an identity in this culture. Pulling from a Christian perspective, …
Lateralized Difference In Tympanic Membrane Temperature: Emotion And Hemispheric Activity, Ruth E. Propper, Tad T. Brunyé
Lateralized Difference In Tympanic Membrane Temperature: Emotion And Hemispheric Activity, Ruth E. Propper, Tad T. Brunyé
Department of Psychology Faculty Scholarship and Creative Works
We review literature examining relationships between tympanic membrane temperature (TMT), affective/motivational orientation, and hemispheric activity. Lateralized differences in TMT might enable real-time monitoring of hemispheric activity in real-world conditions, and could serve as a corroborating marker of mental illnesses associated with specific affective dysregulation. We support the proposal that TMT holds potential for broadly indexing lateralized brain physiology during tasks demanding the processing and representation of emotional and/or motivational states, and for predicting trait-related affective/motivational orientations. The precise nature of the relationship between TMT and brain physiology, however, remains elusive. Indeed the limited extant research has sampled different participant populations …
Is Brain-Derived Neurotrophic Factor A Possible Mechanism Underlying Risperidone Sensitization In Adolescent Rats?, Qing Shu, Gang Hu, Ming Li
Is Brain-Derived Neurotrophic Factor A Possible Mechanism Underlying Risperidone Sensitization In Adolescent Rats?, Qing Shu, Gang Hu, Ming Li
Department of Psychology: Faculty Publications
Risperidone is one of the most widely used atypical antipsychotic drugs and is approved for the treatment of mental disorders (eg. schizophrenia, autism) in children and adolescents. The present study investigated the repeated treatment effect of risperidone and associated neurotropic mechanism in the phencyclidine (PCP)-induced hyperlocomotion model in adolescent rats. We examined whether repeated risperidone treatment would cause a sensitized inhibition of PCP-induced hyperlocomotion in adolescent rats, and whether such a sensitization effect was mediated by risperidone-induced alterations in Brain-Derived Neurotrophic Factor (BDNF), an important biomarker which plays a role in neuropathology of schizophrenia and action of antipsychotic medications. Male …
Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers
Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers
Faculty Journal Articles
Rats learn to prefer flavors associated with postingestive effects of nutrients. The physiological signals underlying this postingestive reward are unknown. We have previously shown that rats readily learn to prefer a flavor that was consumed early in a multi-flavored meal when glucose is infused intragastrically (IG), suggesting rapid postingestive reward onset. The present experiments investigate the timing of postingestive fat reward, by providing distinctive flavors in the first and second halves of meals accompanied by IG fat infusion. Learning stronger preference for the earlier or later flavor would indicate when the rewarding postingestive effects are sensed. Rats consumed sweetened, calorically-dilute …
Childhood Rage: Diagnosis And Treatment Strategies For Severe Mood Dysregulation - Part 2: Diagnosis And Treatment, Gary A. Sibcy, John Kuhnley
Childhood Rage: Diagnosis And Treatment Strategies For Severe Mood Dysregulation - Part 2: Diagnosis And Treatment, Gary A. Sibcy, John Kuhnley
Faculty Publications and Presentations
No abstract provided.
Attachments And Neurobiology: Helping Children With Anxiety Disorders And Severe Mood Dysregulation, Gary A. Sibcy, John Kuhnley
Attachments And Neurobiology: Helping Children With Anxiety Disorders And Severe Mood Dysregulation, Gary A. Sibcy, John Kuhnley
Faculty Publications and Presentations
No abstract provided.
Treating Severely Depressed Adolescents With Integrated, Relational, Cognitive Therapy, Gary A. Sibcy
Treating Severely Depressed Adolescents With Integrated, Relational, Cognitive Therapy, Gary A. Sibcy
Faculty Publications and Presentations
No abstract provided.
Childhood Rage: Diagnosis And Treatment Strategies For Severe Mood Dysregulation - Part 1: Understanding Rage, Gary A. Sibcy, John Kuhnley
Childhood Rage: Diagnosis And Treatment Strategies For Severe Mood Dysregulation - Part 1: Understanding Rage, Gary A. Sibcy, John Kuhnley
Faculty Publications and Presentations
No abstract provided.
Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant
Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant
Calvert Undergraduate Research Awards
According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; 4th ed. Revised; American Psychiatric Association) and (BPSD) there are many behavioral, physiological, and psychological issues that have been correlated with the progression of the Alzheimer’s disease and other dementias. Examples of these issues include; emotional regulation problems, variations in eating behavior, and an advancing decline in memory. Though certain symptoms of the disease seem to be widely universal, current literature shows that a number of disparities do exist. There are several differences between and within populations suffering from Alzheimer’s disease and dementia that are influenced by various …
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
McNair Poster Presentations
Schizophrenia is a chronic debilitating brain disorder, which affects approximately one percent of the adult population worldwide. The symptoms of schizophrenia are commonly divided into three broad classes: positive symptoms, negative symptoms, and cognitive disturbances (Kay, et al., 1987). The positive symptoms of schizophrenia include hallucinations, delusions, and disorganized thinking, while the negative symptoms include affective flattening, social withdrawal, and an inability to plan and carry out future activities. The cognitive disturbances exhibited in schizophrenia include deficits in spatial reference and working memory as well as difficulties with focus and attention (Lewis et. al., 2007). Several models have been proposed …
The Role Of Pubertal Timing And Temperamental Vulnerability In Adolescents’ Internalizing Symptoms, Lisa J. Crockett, Gustavo Carlo, Jennifer M. Wolff, Meredith O. Hope
The Role Of Pubertal Timing And Temperamental Vulnerability In Adolescents’ Internalizing Symptoms, Lisa J. Crockett, Gustavo Carlo, Jennifer M. Wolff, Meredith O. Hope
Department of Psychology: Faculty Publications
This longitudinal study examined the joint role of pubertal timing and temperament variables (emotional reactivity and self-regulation) in predicting adolescents’ internalizing symptoms. The multiethnic sample included 1,025 adolescent girls and boys followed fromage 11 to age 15 (Mage¼11.03 years at Time 1). In structural equation models, age 11 measures of pubertal timing, emotional reactivity, and self-regulation and their interactions were used to predict adolescents’ internalizing behavior concurrently and at age 15. Results indicated that, among girls, early pubertal timing, higher emotional reactivity, and lower self-regulation predicted increased internalizing behavior. In addition, self-regulation moderated the effect of pubertal timing such that …
Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li
Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li
Department of Psychology: Faculty Publications
Disruption of conditioned avoidance response (CAR) in rodents is one trademark feature of many antipsychotic drugs. In adult rats, repeated olanzapine (OLZ) treatment causes an enhanced disruption of avoidance response (sensitization), whereas repeated clozapine (CLZ) treatment causes a decreased disruption (tolerance). The present study addressed (1) whether OLZ sensitization and CLZ tolerance can be induced in adolescent rats, and (2) the extent to which OLZ sensitization and CLZ tolerance induced in adolescence persists into adulthood. Male adolescent Sprague–Dawley rats (approximate postnatal days (BP) 43–47) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10 or 20 …
The Interface Between Morphology And Action Planning: A Comparison Of Two Species Of New World Monkeys, Stacey L. Zander, Dan J. Weiss, Peter G. Judge
The Interface Between Morphology And Action Planning: A Comparison Of Two Species Of New World Monkeys, Stacey L. Zander, Dan J. Weiss, Peter G. Judge
Faculty Journal Articles
Recent research with several species of nonhuman primates suggests sophisticated motor-planning abilities observed in human adults may be ubiquitous among primates. However, there is considerable variability in the extent to which these abilities are expressed across primate species. In the present experiment, we explore whether the variability in the expression of anticipatory motor-planning abilities may be attributed to cognitive differences (such as tool use abilities) or whether they may be due to the consequences of morphological differences (such as being able to deploy a precision grasp). We compared two species of New World monkeys that differ in their tool use …
Capuchin Monkeys Exercise Self-Control By Choosing Token Exchange Over An Immediate Reward, Peter G. Judge, Jennifer L. Essler
Capuchin Monkeys Exercise Self-Control By Choosing Token Exchange Over An Immediate Reward, Peter G. Judge, Jennifer L. Essler
Faculty Journal Articles
Self-control is a prerequisite for complex cognitive processes such as cooperation and planning. As such, comparative studies of self-control may help elucidate the evolutionary origin of these capacities. A variety of methods have been developed to test for self-control in non-human primates that include some variation of foregoing an immediate reward in order to gain a more favorable reward. We used a token exchange paradigm to test for self-control in capuchin monkeys (Cebus apella). Animals were trained that particular tokens could be exchanged for food items worth different values. To test for self-control, a monkey was provided with …
Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers
Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers
Faculty Journal Articles
Rats learn to prefer flavors associated with postingestive effects of nutrients. The physiological signals underlying this postingestive reward are unknown. We have previously shown that rats readily learn to prefer a flavor that was consumed early in a multi-flavored meal when glucose is infused intragastrically (IG), suggesting rapid postingestive reward onset. The present experiments investigate the timing of postingestive fat reward, by providing distinctive flavors in the first and second halves of meals accompanied by IG fat infusion. Learning stronger preference for the earlier or later flavor would indicate when the rewarding postingestive effects are sensed. Rats consumed sweetened, calorically-dilute …
The Lives Of Others: Social Rationality In Animals, Jeffrey R. Stevens, Andrew J. King
The Lives Of Others: Social Rationality In Animals, Jeffrey R. Stevens, Andrew J. King
Jeffrey Stevens Publications
Darwin (1871) boldly claimed that humans and other animals differ very little in their cognition; a statement that has raised the ire of many scientists (Bolhuis & Wynne, 2009; Penn, Holyoak, & Povinelli, 2008). Rather than stating this continuity as a fact, we will explore the similarities and differences between humans and animals in the social rationality of their decision making. We find this a fruitful exercise because it can profit researchers of both humans and animals. Our purpose here is to provide an evolutionary background of social rationality: Why do animals attend to the lives of others? To this …
Short Communication: Powerless And Jobless? Comparing The Effects Of Powerless Speech And Speech Disorders On An Applicant’S Employability, Christian M. End, Katherine Saunders
Short Communication: Powerless And Jobless? Comparing The Effects Of Powerless Speech And Speech Disorders On An Applicant’S Employability, Christian M. End, Katherine Saunders
Faculty Scholarship
The present study examines the impact of a speech disorder (a lateral lisp) and powerless speech on an applicant’s hireability. College students (N = 113) reviewed an applicant’s resume, as well as a description of two occupations/job openings that varied in regard to necessitating speech. Participants listened to one of three interviews (speech disorder vs. powerless speech vs. control), indicated their willingness to hire the applicant, and then completed hire-ability and employability scales for both positions, as well as an impressions ratings form. Contrary to the hypotheses, few differences between the “employers” responses to the control and speech disorder applicants …
Placental Corticotropin-Releasing Hormone Mediates The Association Between Prenatal Social Support And Postpartum Depression, Jennifer Hahn-Holbrook, Christine Dunkel Schetter, Chander Arora, Calvin J. Hobel
Placental Corticotropin-Releasing Hormone Mediates The Association Between Prenatal Social Support And Postpartum Depression, Jennifer Hahn-Holbrook, Christine Dunkel Schetter, Chander Arora, Calvin J. Hobel
Psychology Faculty Articles and Research
Three decades of research point to both biological and psychological risk factors for postpartum depression, but very little research integrates the two. This study bridged this gap by testing whether prenatal social support predicted depressive symptoms at 8 weeks postpartum in a multiethnic sample of 210 women and whether the stress hormone placental corticotropinreleasing hormone (pCRH), measured at 19, 29, and 37 weeks’ gestation, mediated this relationship. We found that prenatal family support predicted significantly fewer depressive symptoms postpartum and more gradual increases in pCRH from 29 to 37 weeks’ gestation. Furthermore, steeper increases in pCRH during this same period …