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University of Nebraska - Lincoln
Acute tryptophan depletion; sweet food; overweight; serotonin; obesity
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Acute Tryptophan Depletion And Sweet Food Consumption By Overweight Adults, Sherry L. Pagoto, Bonnie Spring, Dennis E. Mcchargue, Brian Hitsman, Malaina Smith, Bradley Appelhans, Donald Hedeker
Acute Tryptophan Depletion And Sweet Food Consumption By Overweight Adults, Sherry L. Pagoto, Bonnie Spring, Dennis E. Mcchargue, Brian Hitsman, Malaina Smith, Bradley Appelhans, Donald Hedeker
Department of Psychology: Faculty Publications
Serotonergic involvement has been implicated in preferential consumption of treat foods. We tested the effect of acute tryptophan depletion (ATD) on food consumption by overweight and lean adults with and without a history of recurrent major depressive disorder (MDD). ATD and taste-matched placebo challenges were administered double-blind in counter-balanced order. Participants were classified as lean (n = 36) or overweight (n=19) on the basis of body mass index (BMI). Total calorie, carbohydrate, protein, and sweet food consumption were assessed via a test meal 8-hours following ATD. Four food items of comparable palatability were offered as a part of the test: …