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Full-Text Articles in Psychology
Cannabinoid-Induced Behavioral Sensitization In Adolescent Sprague-Dawley Rats, Michelle Stone
Cannabinoid-Induced Behavioral Sensitization In Adolescent Sprague-Dawley Rats, Michelle Stone
Electronic Theses, Projects, and Dissertations
Adolescent cannabis use has grown because of increased availability and higher societal acceptance. This increase in cannabis use is problematic as adolescents who experiment with cannabis are more likely to abuse cannabis and experiment with other illicit drugs such as cocaine. The reason for the greater susceptibility to drugs use is unclear and may be the result of altered drug sensitivity after cannabis exposure. Thus, the present investigation used the behavioral sensitization paradigm to examine the behavioral response of early adolescent rats to the cannabinoid agonist CP 55,940 (CP) or cocaine after repeated cannabinoid administration. It was hypothesized that: (1) …
The Effect Of Early Life Photoperiod Manipulation On Cocaine-Induced Behavioral Sensitization In Male And Female Japanese Quail, Shannon Elizabeth Eaton
The Effect Of Early Life Photoperiod Manipulation On Cocaine-Induced Behavioral Sensitization In Male And Female Japanese Quail, Shannon Elizabeth Eaton
Theses and Dissertations--Psychology
Estrogens seem to play a role in the locomotor activating effects of cocaine. Japanese quail provide a good model for hormonal manipulation as alterations of their photoperiod controls hormone levels. The current study aims to examine the role of early life photoperiod manipulation in cocaine-induced behavioral sensitization in quail. It was expected that if quail were raised on a short photoperiod, they would have a reduction in gonadal hormones and this reduction in hormones would affect the acquisition of cocaine-induced behavioral sensitization. Quail were raised on an 8L:16D or a 16L:8D light cycle. Following 2 days of habituation, quail were …
Fluoxetine Exposure Results In Decreased Sensitivity To Cocaine And Sucrose Later In Life: A Study In Female C57bl/6 Mice, Francisco Javier Flores Ramirez
Fluoxetine Exposure Results In Decreased Sensitivity To Cocaine And Sucrose Later In Life: A Study In Female C57bl/6 Mice, Francisco Javier Flores Ramirez
Open Access Theses & Dissertations
Preclinical evidence indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to stress- and reward-related stimuli. However, these animal studies have been conducted, primarily, using male subjects. This is surprising, given that clinical data suggests that females have a higher likelihood, than their male counterparts, to be diagnosed with mood-related illnesses, and thus, be prescribed with psychotropic medications, mostly antidepressants. Therefore, to examine whether enduring reward-related alterations are exhibited as a result of antidepressant exposure, in female subjects specifically, we exposed C57BL/6 female mice to fluoxetine (FLX; 250 mg/l in their drinking water). Specifically, separate …
Cocaine Choice: A Novel Procedure For Investigating Neuronal Activation Mediating Cocaine Preference, Jonathan Jenn-Sheng Chow
Cocaine Choice: A Novel Procedure For Investigating Neuronal Activation Mediating Cocaine Preference, Jonathan Jenn-Sheng Chow
Theses and Dissertations--Psychology
Cocaine use disorder is a significant health problem, negatively impacting individuals afflicted. While preclinical self-administration research has provided invaluable insight into the neurobehavioral mechanisms that underlie cocaine abuse, cocaine use outside of the laboratory occurs within an environment where other goods are also available ubiquitously. Although there is an ever-increasing literature investigating drug vs. non-drug choice in rodent models and how alternative goods can compete with the subjective value of cocaine, the neurobiological mechanisms that are associated with cocaine preference remains largely unknown. Additionally, current drug vs. non-drug choice studies use procedures that confound preference with intake, such that preference …