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Full-Text Articles in Psychology
Role Of The Α1 Blocker Doxazosin In Alcoholism: A Proof-Of-Concept Randomized Controlled Trial, George A. Kenna, Carolina L. Haass-Koffler, William H. Zywiak, Steven M. Edwards, Michael B. Brickley, Robert M. Swift, Lorenzo Leggio
Role Of The Α1 Blocker Doxazosin In Alcoholism: A Proof-Of-Concept Randomized Controlled Trial, George A. Kenna, Carolina L. Haass-Koffler, William H. Zywiak, Steven M. Edwards, Michael B. Brickley, Robert M. Swift, Lorenzo Leggio
Department of Psychology: Faculty Publications
Evidence suggests that the norepinephrine system represents an important treatment target for alcohol dependence (AD) and the α1-blocker prazosin may reduce alcohol drinking in rodents and alcoholic patients. The α1-blocker doxazosin demonstrates a more favorable pharmacokinetic profile than prazosin, but has never been studied for AD. A double-blind placebo-controlled randomized clinical trial was conducted in AD individuals seeking outpatient treatment. Doxazosin or matched placebo was titrated to 16 mg/day (or maximum tolerable dose). Drinks per week (DPW) and heavy drinking days (HDD) per week were the primary outcomes. Family history density of alcoholism (FHDA), severity of AD and gender were …
Clarifying Observed Relationships Between Protective Behavioral Strategies And Alcohol Outcomes: The Importance Of Response Options, Abby L. Braitman, James M. Henson, Kate B. Carey
Clarifying Observed Relationships Between Protective Behavioral Strategies And Alcohol Outcomes: The Importance Of Response Options, Abby L. Braitman, James M. Henson, Kate B. Carey
Psychology Faculty Publications
Protective behavioral strategies (PBS), or harm-reduction behaviors that can potentially reduce alcohol consumption or associated problems, have been assessed in varied ways throughout the literature. Existing scales vary in focus (i.e., broad vs. narrow), and importantly, in response options (i.e., absolute frequency vs. contingent frequency). Absolute frequency conflates PBS use with number of drinking occasions, resulting in inconsistencies in the relationship between PBS use and alcohol outcomes, whereas contingent frequency is less precise, which could reduce power. The current study proposes the use of absolute frequencies to maximize precision, with an adjustment for number of drinking days to extricate PBS …