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Full-Text Articles in Psychology
Hiv Dna Reservoir Increases Risk For Cognitive Disorders In Cart-Nave Patients, Robert H. Paul, Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda
Hiv Dna Reservoir Increases Risk For Cognitive Disorders In Cart-Nave Patients, Robert H. Paul, Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda
Robert Paul
Objectives Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. These reservoirs remain present despite cART. The objective of this study was to determine if the level of HIV DNA in CD14+ enriched monocytes predicted cognitive impairment and brain injury. Methods We enrolled 61 cART-naïve HIV-infected Thais in a prospective study and measured HIV DNA in CD14+ enriched monocyte samples in a blinded fashion. We determined HAND diagnoses by consensus panel and all participants underwent magnetic resonance spectroscopy (MRS) …
Understanding Reported Cognitive Dysfunction In Older Adults With Cardiovascular Disease, Robert H. Paul, John Gunstad, Ronald A. Cohen, David F.
Understanding Reported Cognitive Dysfunction In Older Adults With Cardiovascular Disease, Robert H. Paul, John Gunstad, Ronald A. Cohen, David F.
Robert Paul
High HIV-1 DNA (HIV DNA) levels in peripheral blood mononuclear cells (PBMC) correlate with HIV-1-associated dementia (HAD) in patients on highly active antiretroviral therapy (HAART). If this relationship also exists among HAART-naïve patients, then HIV DNA may be implicated in the pathogenesis of HAD. In this study, we evaluated the relationship between HIV DNA and cognition in subjects naïve to HAART in a neuro AIDS cohort in Bangkok, Thailand. Subjects with and without HAD were recruited and matched for age, gender, education, and CD4 cell count. PBMC and cellular subsets were analyzed for HIV DNA using real-time PCR. The median …
Application Of A Novel Quantitative Tractography Based Analysis Of Diffusion Tensor Imaging To Examine Fiber Bundle Length In Human Cerebral White Matter, Robert H. Paul, Laurie M. Baker, Ryan P. Cabeen, Sarah Cooley
Application Of A Novel Quantitative Tractography Based Analysis Of Diffusion Tensor Imaging To Examine Fiber Bundle Length In Human Cerebral White Matter, Robert H. Paul, Laurie M. Baker, Ryan P. Cabeen, Sarah Cooley
Robert Paul
This paper reviews basic methods and recent applications of length-based fiber bundle analysis of cerebral white matter using diffusion magnetic resonance imaging (dMRI). Diffusion weighted imaging (DWI) is a dMRI technique that uses the random motion of water to probe tissue microstructure in the brain. Diffusion tensor imaging (DTI) is an extension of DWI that measures the magnitude and direction of water diffusion in cerebral white matter, using either voxel-based scalar metrics or tractography-based analyses. More recently, quantitative tractography based on diffusion tensor imaging (qtDTI) technology has been developed to help quantify aggregate structural anatomical properties of white matter fiber …
The Relationship Between Early Life Stress And Microstructural Integrity Of The Corpus Callosum In A Non-Clinical Population, Robert H. Paul, Lorrie Henry, Stuart M. Grieve, Thomas J. Guilmette
The Relationship Between Early Life Stress And Microstructural Integrity Of The Corpus Callosum In A Non-Clinical Population, Robert H. Paul, Lorrie Henry, Stuart M. Grieve, Thomas J. Guilmette
Robert Paul
Background: Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain. Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain. Methods: In the present study we evaluated this relationship in healthy non-clinical participants using diffusion tensor imaging (DTI) and self-reported history of ELS. …