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On The Number Of Trials Necessary For Stabilization Of Error-Related Brain Activity Across The Life Span, Jason Themanson, Matthew Pontifex, Mark Scudder, Michael Brown, Kevin O'Leary, Chien-Ting Wu, Charles Hillman
On The Number Of Trials Necessary For Stabilization Of Error-Related Brain Activity Across The Life Span, Jason Themanson, Matthew Pontifex, Mark Scudder, Michael Brown, Kevin O'Leary, Chien-Ting Wu, Charles Hillman
Jason R. Themanson, Ph.D
The minimum number of trials necessary to accurately characterize the error-related negativity (ERN) and the error positivity (Pe) across the life span was investigated using samples of preadolescent children, college-age young adults, and older adults. Event-related potentials and task performance were subsequently measured during a modified flanker task. Response-locked averages were created using sequentially increasing errors of commission in blocks of two. Findings indicated that across all age cohorts ERN and Pe were not significantly different relative to the within-participants grand average after six trials. Further, results indicated that the ERN and Pe exhibited excellent internal reliability in preadolescent children …
Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell
Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell
Howard Casey Cromwell
Abstract. Perinatal exposure to PCB has been reported to cause a variety of health effects including endocrine disruption, and immunologic, reproductive, neurologic, and behavioral deficits. In the present study, a mixture of two PCB congeners, one non-coplanar (PCB 47) and one coplanar (PCB 77), were administered to young female Sprague-Dawley rats by route of maternal dietary consumption (either 12.5 ppm or 25.0 ppm, w/w). Impact on learning and memory were examined by radial arm maze on postnatal day 24-27. After behavioral tests were completed, the rats were transcardially perfused, and brains were excised. Immunohistochemistry for ER- β was carried out …