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Genetic Moderators Of Cognitive Decline In The Health And Retirement Study, Shannon K. Runge
Genetic Moderators Of Cognitive Decline In The Health And Retirement Study, Shannon K. Runge
USF Tampa Graduate Theses and Dissertations
The current dissertation used a gene x environment (G x E) approach to examine the independent and interactive effects of specific genetic variants and participation in physical and cognitive/social activities (PA and CSA) on cognitive performance in 4,764 participants of the Health and Retirement Study. Using three-wave data, three sets of multi-level growth models were conducted to examine baseline, longitudinal, and interactive effects of genotype (i.e., ApoE, COMT, and BDNF) and CSA/PA on performance across five cognitive measures: immediate, delayed and total word recall, and serial 7s and backwards counting.
At baseline, the ApoE ε4 allele predicted …