Psychology Commons^™

Mapping Out Learning: How Aerobic Exercise, Sex And Alzheimer's Disease Impact Learning, Grace G. Bouker

Senior Independent Study Theses

Exercise has the power to ameliorate the outward symptoms of Alzheimer’s Disease (AD) by rescuing hippocampal-dependent learning and memory. The goal of this research was to map out how exercise and sex impact behavioral learning in AD mouse models by looking outside of the traditional measurements in the Morris water maze (MWM), as they fail to describe the process of learning itself. I calculated heading error at maximum velocity, manually categorized search strategy in the MWM across trials, and determined flexibility in the probe trial for transgenic and wild-type mice who were exposed to exercise or control housing. Mice significantly …