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Relative Sensitivity Of Magnetic Resonance Spectroscopy And Quantitative Magnetic Resonance Imaging To Cognitive Function Among Nondemented Individuals Infected With Hiv, Robert H. Paul, Thomas M. Ernst, Adam M. Brickman, Constantin T. Yiannoutsos, David F. Tate, Ronald A. Cohen, Bradford A. Navia
Relative Sensitivity Of Magnetic Resonance Spectroscopy And Quantitative Magnetic Resonance Imaging To Cognitive Function Among Nondemented Individuals Infected With Hiv, Robert H. Paul, Thomas M. Ernst, Adam M. Brickman, Constantin T. Yiannoutsos, David F. Tate, Ronald A. Cohen, Bradford A. Navia
Robert Paul
In the present study, we examined the relationships among cognitive function, magnetic resonance spectroscopy (MRS) brain metabolite indices measured in the basal ganglia, and quantitative magnetic resonance imaging (MRI) of the caudate nucleus and the putamen in the earliest stages of HIV-related cognitive involvement. Participants included 22 HIV-positive individuals and 20 HIV-negative individuals. HIV-positive individuals performed significantly more poorly than the HIV-negative individuals on several cognitive measures. In addition, the choline/creatine ratio was significantly higher and the N-acetyl aspartate/choline ratio was significantly lower among HIV patients. The caudate and putamen sizes were smaller among HIV-positive patients compared with controls; however, …