Psychology Commons^™

Subjective Well-Being And Bilateral Anterior Insula Functional Connectivity After Exercise Intervention In Older Adults With Mild Cognitive Impairment, Junyeon Won, Kristy A. Nielson, J. Smith Carson

Psychology Faculty Research and Publications

While it is well known that exercise training is associated with improvement in subjective well-being among older adults, it is unclear if individuals with cognitive impairment experience the same effects elicited by exercise on subjective well-being. We further explored whether the bilateral anterior insula network may be an underlying neural mechanism for the exercise training-related improvements in subjective well-being. We investigated the effects of exercise training on subjective well-being in older adults (78.4 ± 7.1 years) with mild cognitive impairment (MCI; n = 14) and a cognitively normal (CN; n = 14) control group. We specifically assessed the relationship between …

Resting Cerebral Blood Flow After Exercise Training In Mild Cognitive Impairment, Alfonso J. Alfini, Lauren R. Weiss, Kristy A. Nielson, Matthew D. Verber, J. Carson Smith

Psychology Faculty Research and Publications

Background:

Exercise training has been associated with greater cerebral blood flow (CBF) in cognitively normal older adults (CN). Alterations in CBF, including compensatory perfusion in the prefrontal cortex, may facilitate changes to the brain’s neural infrastructure.

Objective:

To examine the effects of a 12-week aerobic exercise intervention on resting CBF and cognition in CN and those with mild cognitive impairment (MCI). We hypothesized individuals with MCI (vs. CN) would exhibit greater whole brain CBF at baseline and that exercise would mitigate these differences. We also expected CBF changes to parallel cognitive improvements.

Methods:

Before and after a 12-week exercise intervention, …

Interactive Effects Of Physical Activity And Apoe-Ε4 On White Matter Tract Diffusivity In Healthy Elders, J. Carson Smith, Melissa A. Lancaster, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Ken Sakaie, Stephen M. Rao

Psychology Faculty Research and Publications

Older adult apolipoprotein-E epsilon 4 (APOE-ε4) allele carriers vary considerably in the expression of clinical symptoms of Alzheimer's disease (AD), suggesting that lifestyle or other factors may offer protection from AD-related neurodegeneration. We recently reported that physically active APOE-ε4 allele carriers exhibit a stable cognitive trajectory and protection from hippocampal atrophy over 18 months compared to sedentary ε4 allele carriers. The aim of this study was to examine the interactions between genetic risk for AD and physical activity (PA) on white matter (WM) tract integrity, using diffusion tensor imaging (DTI) MRI, in this cohort of healthy older adults (ages …

Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith

Psychology Faculty Research and Publications

Cortical atrophy is a biomarker of Alzheimer’s disease (AD) that correlates with clinical symptoms. This study examined changes in cortical thickness from before to after an exercise intervention in mild cognitive impairment (MCI) and healthy elders. Thirty physically inactive older adults (14 MCI, 16 healthy controls) underwent MRI before and after participating in a 12-week moderate intensity walking intervention. Participants were between the ages of 61 and 88. Change in cardiorespiratory fitness was assessed using residualized scores of the peak rate of oxygen consumption (V̇O_2peak) from pre- to post-intervention. Structural magnetic resonance images were processed using FreeSurfer v5.1.0. …

Physical Activity Reduces Hippocampal Atrophy In Elders At Genetic Risk For Alzheimer's Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Kathleen Hazlett, Christina Marie Figueroa, Cassandra Kandah, Christina D. Kay, Monica Matthews, Stephen M. Rao

Psychology Faculty Research and Publications

We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer's disease (AD). Hippocampal volume was measured from structural magnetic resonance imaging (MRI) scans administered at baseline and at an 18-month follow-up in 97 healthy, cognitively intact older adults. Participants were classified as High or Low PA based on a self-report questionnaire of frequency and intensity of exercise. Risk status was defined by the presence or absence of the apolipoprotein E-epsilon 4 (APOE-ε4) allele. Four subgroups were studied: Low Risk/High PA ( …

Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao

Psychology Faculty Research and Publications

Leisure-time physical activity (PA) and exercise training are known to help maintain cognitive function in healthy older adults. However, relatively little is known about the effects of PA on cognitive function or brain function in those at increased risk for Alzheimer’s disease through the presence of the apolipoproteinE epsilon4 (APOE-ε4) allele, diagnosis of mild cognitive impairment (MCI), or the presence of metabolic disease. Here, we examine the question of whether PA and exercise interventions may differentially impact cognitive trajectory, clinical outcomes, and brain structure and function among individuals at the greatest risk for AD. The literature suggests that the protective …

Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber

Psychology Faculty Research and Publications

Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …

Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Matthew D. Verber, Sally Durgerian, Piero Antuono, Alissa M. Butts, Nathan C. Hantke, Melissa A. Lancaster, Stephen M. Rao

Psychology Faculty Research and Publications

The effect of physical activity (PA) on functional brain activation for semantic memory in amnestic mild cognitive impairment (aMCI) was examined using event-related functional magnetic resonance imaging during fame discrimination. Significantly greater semantic memory activation occurred in the left caudate of High- versus Low-PA patients, (P=0.03), suggesting PA may enhance memory-related caudate activation in aMCI.

Interactive Effects Of Physical Activity And Apoe-Ε4 On Bold Semantic Memory Activation In Healthy Elders, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao

Psychology Faculty Research and Publications

Evidence suggests that physical activity (PA) is associated with the maintenance of cognitive function across the lifespan. In contrast, the apolipoproteinE-ε4 (APOE-ε4) allele, a genetic risk factor for Alzheimer's disease (AD), is associated with impaired cognitive function. The objective of this study was to examine the interactive effects of PA and APOE-ε4 on brain activation during memory processing in older (ages 65–85) cognitively intact adults. A cross-sectional design was used with four groups (n = 17 each): (1) Low Risk/Low PA; (2) Low Risk/High PA; (3) High Risk/Low PA; and (4) High Risk/High PA. PA level was based on …