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Full-Text Articles in Psychology
Circulating Endocannabinoids And Prospective Risk For Depression In Trauma-Injury Survivors, Jacklynn M. Fitzgerald, Samantha Chesney, Tara Sander Lee, Karen J. Brasel, Christine L. Larson, Cecilia J. Hillard, Terri A Deroon-Cassini
Circulating Endocannabinoids And Prospective Risk For Depression In Trauma-Injury Survivors, Jacklynn M. Fitzgerald, Samantha Chesney, Tara Sander Lee, Karen J. Brasel, Christine L. Larson, Cecilia J. Hillard, Terri A Deroon-Cassini
Psychology Faculty Research and Publications
Biological mechanisms associated with response to trauma may impact risk for depression. One such mechanism is endocannabinoid signaling (eCB), a neuromodulatory system comprised of the CB1 subtype of cannabinoid receptors (CB1R), encoded by the CNR1 gene, and two primary endogenous ligands: 2-arachidonoylglycerol (2-AG) and N-arachidonylethanolamine (AEA), hydrolyzed by monoacylglycerol lipase (gene name MGLL) and fatty acid amide hydrolase (gene name FAAH). Preclinical data suggest that eCB/CB1R signaling acts as a stress buffer and its loss or suppression increases depression-like behaviors. We examined circulating concentrations of the eCBs (2-AG and AEA) days and six months after a traumatic injury …