Psychology Commons^™

Event-Related Potentials, Inhibition, And Risk For Alzheimer’S Disease Among Cognitively Intact Elders, Kathleen Hazlett Elverman, Elizabeth Rose Paitel, Christina Marie Figueroa, Ryan J. Mckindles, Kristy A. Nielson

Psychology Faculty Research and Publications

Background:

Despite advances in understanding Alzheimer’s disease (AD), prediction of AD prior to symptom onset remains severely limited, even when primary risk factors such as the apolipoprotein E (APOE) ɛ4 allele are known.

Objective:

Although executive dysfunction is highly prevalent and is a primary contributor to loss of independence in those with AD, few studies have examined neural differences underlying executive functioning as indicators of risk for AD prior to symptom onset, when intervention might be effective.

Methods:

This study examined event-related potential (ERP) differences during inhibitory control in 44 cognitively intact older adults (20 ɛ4+, 24 ɛ4-), …

A Systematic Review Of Cognitive Event-Related Potentials In Mild Cognitive Impairment And Alzheimer’S Disease, Elizabeth Rose Paitel, Marielle R. Samii, Kristy A. Nielson

Psychology Faculty Research and Publications

This systematic review examined whether event-related potentials (ERPs) during higher cognitive processing can detect subtle, early signs of neurodegenerative disease. Original, empirical studies retrieved from PsycINFO and PubMed were reviewed if they analyzed patterns in cognitive ERPs (≥150 ms post-stimulus) differentiating mild cognitive impairment (MCI), Alzheimer’s disease (AD), or cognitively intact elders who carry AD risk through the Apolipoprotein-E ε4 allele (ε4+) from healthy older adult controls (HC). The 100 studies meeting inclusion criteria (MCI = 47; AD = 47; ε4+ = 6) analyzed N200, P300, N400, and occasionally, later components. While there was variability across studies, patterns of reduced …